ATE371021T1 - Immobilisierte biokatalysatoren für die herstellung von natürlichen nukleosiden und modifizierten analogen durch enzymatische transglykosylierungsreaktionen - Google Patents

Immobilisierte biokatalysatoren für die herstellung von natürlichen nukleosiden und modifizierten analogen durch enzymatische transglykosylierungsreaktionen

Info

Publication number
ATE371021T1
ATE371021T1 AT03425018T AT03425018T ATE371021T1 AT E371021 T1 ATE371021 T1 AT E371021T1 AT 03425018 T AT03425018 T AT 03425018T AT 03425018 T AT03425018 T AT 03425018T AT E371021 T1 ATE371021 T1 AT E371021T1
Authority
AT
Austria
Prior art keywords
production
natural nucleosides
immobilized biocatalyst
modified analogue
biocatalysts
Prior art date
Application number
AT03425018T
Other languages
English (en)
Inventor
Giancarlo Tonon
Emanuele Capra
Gaetano Orsini
Gabriele Zuffi
Original Assignee
Adorkem Technology Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adorkem Technology Spa filed Critical Adorkem Technology Spa
Application granted granted Critical
Publication of ATE371021T1 publication Critical patent/ATE371021T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/02—Pentosyltransferases (2.4.2)
    • C12Y204/02003—Uridine phosphorylase (2.4.2.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/18—Multi-enzyme systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/385—Pyrimidine nucleosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/02—Pentosyltransferases (2.4.2)
    • C12Y204/02001—Purine-nucleoside phosphorylase (2.4.2.1)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Saccharide Compounds (AREA)
AT03425018T 2003-01-16 2003-01-16 Immobilisierte biokatalysatoren für die herstellung von natürlichen nukleosiden und modifizierten analogen durch enzymatische transglykosylierungsreaktionen ATE371021T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03425018A EP1439220B1 (de) 2003-01-16 2003-01-16 Immobilisierte Biokatalysatoren für die Herstellung von natürlichen Nukleosiden und modifizierten Analogen durch enzymatische Transglykosylierungsreaktionen

Publications (1)

Publication Number Publication Date
ATE371021T1 true ATE371021T1 (de) 2007-09-15

Family

ID=32524299

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03425018T ATE371021T1 (de) 2003-01-16 2003-01-16 Immobilisierte biokatalysatoren für die herstellung von natürlichen nukleosiden und modifizierten analogen durch enzymatische transglykosylierungsreaktionen

Country Status (9)

Country Link
US (1) US20040142438A1 (de)
EP (1) EP1439220B1 (de)
AT (1) ATE371021T1 (de)
CY (1) CY1107015T1 (de)
DE (1) DE60315790T2 (de)
DK (1) DK1439220T3 (de)
ES (1) ES2292927T3 (de)
PT (1) PT1439220E (de)
SI (1) SI1439220T1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7241586B2 (en) * 2005-02-17 2007-07-10 Medtronic Minimed, Inc. Polypeptide formulations and methods for making, using and characterizing them
CN100379859C (zh) * 2005-03-04 2008-04-09 上海秋之友生物科技有限公司 固定化核苷磷酸化酶微生物及其在合成嘌呤核苷中的应用
US20070065922A1 (en) * 2005-09-21 2007-03-22 Metkinen Oy Biocatalytic synthesis of aminodeoxy purine N9-beta-D-nucleosides containing 3-amino-3-deoxy-beta-D-ribofuranose, 3-amino-2,3-dideoxy-beta-D-ribofuranose, and 2-amino-2-deoxy-beta-D-ribofuranose as sugar moieties
ES2343741T3 (es) * 2006-03-15 2010-08-09 Explora Laboratories Sa Un proceso para la inmovilizacion de celulas en una resina.
DE602006009282D1 (de) 2006-12-15 2009-10-29 Explora Lab Sa Verfahren zur Herstellung von Cladribin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5314810A (en) * 1987-11-25 1994-05-24 Meiji Seika Kaisha, Ltd. Fructose transferring enzyme absorbed on a granular carrier for production of fructooligosaccharides
IL90600A0 (en) * 1988-06-16 1990-01-18 Du Pont Polynucleotide phosphorylase immobilized on epoxy-activated beads
IL88618A (en) * 1988-12-07 1993-02-21 Bromine Compounds Ltd Chiral cyanohydrination of m-phenoxybenzaldehyde over polymer-supported cyclo (phenylalanyl- histidine)
US5187296A (en) * 1988-12-07 1993-02-16 Bromine Compounds Limited Cyanohydrination process
EP0596943B1 (de) * 1991-07-31 1996-11-20 Warner-Lambert Company Verfahren zur reinigung von pentostatin
JP4003093B2 (ja) * 1997-07-29 2007-11-07 東洋紡績株式会社 糖類の製造方法
ITMI20011537A1 (it) * 2001-07-19 2003-01-19 Pro Bio Sint Srl Transglicosilazione di nucleosidi mediante biocatalisi con enzimi immobilizzati e stabilizzati

Also Published As

Publication number Publication date
EP1439220B1 (de) 2007-08-22
PT1439220E (pt) 2007-11-28
US20040142438A1 (en) 2004-07-22
DE60315790D1 (de) 2007-10-04
EP1439220A1 (de) 2004-07-21
ES2292927T3 (es) 2008-03-16
CY1107015T1 (el) 2012-09-26
SI1439220T1 (sl) 2007-12-31
DE60315790T2 (de) 2008-06-05
DK1439220T3 (da) 2007-12-27

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