ES2089924T3 - Proceso para preparar composiciones farmaceuticas conteniendo bromuro de vercuronio. - Google Patents

Proceso para preparar composiciones farmaceuticas conteniendo bromuro de vercuronio.

Info

Publication number
ES2089924T3
ES2089924T3 ES94906925T ES94906925T ES2089924T3 ES 2089924 T3 ES2089924 T3 ES 2089924T3 ES 94906925 T ES94906925 T ES 94906925T ES 94906925 T ES94906925 T ES 94906925T ES 2089924 T3 ES2089924 T3 ES 2089924T3
Authority
ES
Spain
Prior art keywords
vial
pct
date aug
bromide
vercuronium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94906925T
Other languages
English (en)
Inventor
Frans Herwig Jan Jansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inpharm NV
Original Assignee
Inpharm NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inpharm NV filed Critical Inpharm NV
Application granted granted Critical
Publication of ES2089924T3 publication Critical patent/ES2089924T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCESO PARA PREPARAR UNA PREPARACION FARMACEUTICA QUE TENGA UNA ACTIVIDAD BLOQUEADORA NEUROMUSCULAR EN UN VIAL DISOLVIENDO BROMURO DE VECURONIO O UN ANALOGO DEL MISMO EN AGUA SATURADO CON CARBONODIOXIDO O UN SOLVENTE ORGANICO, LLENANDO LA SOLUCION ASI OBTENIDA EN EL VIAL PARA SUMINISTRAR EN EL MISMO LA DOSIFICACION UNITARIA REQUERIDA DE BROMURO DE VECURONIO O DEL ANALOGO DEL MISMO, ELIMINANDO EL SOLVENTE, POR EJEMPLO AGUA O UN SOLVENTE ORGANICO EN EL VIAL MEDIANTE LIOFILIZACION O EVAPORACION, Y CERRANDO HERMETICAMENTE EL VIAL. LA INVENCION TAMBIEN SE REFIERE A UN METODO PARA PREPARAR UNA SOLUCION ACUOSA PARA UNA INYECCION COMENZANDO A PARTIR DE DICHO VIAL MEDIANTE LA DISOLUCION DE LOS CONTENIDOS DEL VIAL BIEN EN UNA SOLUCION DE AMINOACIDOS DE CONCENTRACION SUFICIENTE PARA OBTENER UN PH FINAL FISIOLOGICO O BIEN EN UN SISTEMA NEUTRALIZADOR FARMACOLOGICAMENTE ACEPTABLE DE UN PH DE ENTRE 7 Y 7.4.
ES94906925T 1993-02-08 1994-02-08 Proceso para preparar composiciones farmaceuticas conteniendo bromuro de vercuronio. Expired - Lifetime ES2089924T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939302455A GB9302455D0 (en) 1993-02-08 1993-02-08 Process for preparing a pharmaceutical preparation having neuromuscular blocking activity

Publications (1)

Publication Number Publication Date
ES2089924T3 true ES2089924T3 (es) 1996-10-01

Family

ID=10730043

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94906925T Expired - Lifetime ES2089924T3 (es) 1993-02-08 1994-02-08 Proceso para preparar composiciones farmaceuticas conteniendo bromuro de vercuronio.

Country Status (15)

Country Link
US (1) US5681573A (es)
EP (1) EP0682522B1 (es)
JP (1) JPH08508244A (es)
AT (1) ATE137971T1 (es)
AU (1) AU688305B2 (es)
CA (1) CA2152262C (es)
DE (1) DE69400190T2 (es)
DK (1) DK0682522T3 (es)
ES (1) ES2089924T3 (es)
GB (1) GB9302455D0 (es)
GR (1) GR3020815T3 (es)
HU (1) HU213468B (es)
NO (1) NO952666L (es)
NZ (1) NZ261582A (es)
WO (1) WO1994017808A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1271031B (it) * 1994-10-21 1997-05-26 Poli Ind Chimica Spa Composizioni farmaceutiche miorilassanti
US5767112A (en) * 1994-10-21 1998-06-16 Poli Industria Chimica, S.P.A. Muscle relaxant pharmaceutical compositions
AU4428900A (en) * 1999-01-28 2000-08-18 Shshikant Prabhudas Kurani Novel injectable muscle relaxant formulations
DE102005030423A1 (de) * 2005-06-30 2007-01-04 Inresa Arzneimittel Gmbh Neue Formulierung für Vecuroniumbromid
CN101843593B (zh) * 2009-03-27 2011-12-21 西安力邦制药有限公司 一种维库溴铵冻干制剂及其制备方法
JP2016121073A (ja) * 2014-12-24 2016-07-07 ニプロ株式会社 注射剤用医薬組成物の製造方法
CN107638391B (zh) * 2016-07-22 2020-10-16 海南合瑞制药股份有限公司 一种注射用苯磺顺阿曲库铵组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1138605A (en) * 1965-02-19 1969-01-01 Organon Labor Ltd Improvements in or relating to new 2-ß,16-ß-diamino-androstanes
EP0008824B1 (en) * 1978-09-05 1982-04-28 Akzo N.V. Acid addition salts of 16-beta-monoquaternary ammonium derivatives of 2-beta, 16-beta-bis-piperidino-androstanes and pharmaceutical preparations containing same
GB8708886D0 (en) * 1987-04-14 1987-05-20 Akzo Nv 2beta-morpholino-androstane derivatives
US5030633A (en) * 1990-09-12 1991-07-09 Williams Charles H Use of androstane derivative against malignant hyperthermia
US5418226A (en) * 1992-04-22 1995-05-23 Akzo N.V. Monoquaternary 2,16-bispiperidinylandrostane derivatives

Also Published As

Publication number Publication date
EP0682522B1 (en) 1996-05-15
GR3020815T3 (en) 1996-11-30
NZ261582A (en) 1997-02-24
DK0682522T3 (da) 1996-10-07
CA2152262A1 (en) 1994-08-18
WO1994017808A1 (en) 1994-08-18
DE69400190T2 (de) 1996-12-12
HU213468B (en) 1997-06-30
US5681573A (en) 1997-10-28
HUT72444A (en) 1996-04-29
NO952666D0 (no) 1995-07-05
EP0682522A1 (en) 1995-11-22
JPH08508244A (ja) 1996-09-03
AU688305B2 (en) 1998-03-12
ATE137971T1 (de) 1996-06-15
NO952666L (no) 1995-07-05
GB9302455D0 (en) 1993-03-24
CA2152262C (en) 1999-08-17
DE69400190D1 (de) 1996-06-20
AU6039594A (en) 1994-08-29

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