ATE137971T1 - Verfahren zum herstellen von arzneizusammensetzungen, die vecuroniumbromid enthalten - Google Patents
Verfahren zum herstellen von arzneizusammensetzungen, die vecuroniumbromid enthaltenInfo
- Publication number
- ATE137971T1 ATE137971T1 AT94906925T AT94906925T ATE137971T1 AT E137971 T1 ATE137971 T1 AT E137971T1 AT 94906925 T AT94906925 T AT 94906925T AT 94906925 T AT94906925 T AT 94906925T AT E137971 T1 ATE137971 T1 AT E137971T1
- Authority
- AT
- Austria
- Prior art keywords
- vial
- pct
- date aug
- vecuronium bromide
- analogue
- Prior art date
Links
- 229960004298 vecuronium bromide Drugs 0.000 title abstract 3
- VEPSYABRBFXYIB-PWXDFCLTSA-M vecuronium bromide Chemical compound [Br-].N1([C@@H]2[C@@H](OC(C)=O)C[C@@H]3CC[C@H]4[C@@H]5C[C@@H]([C@@H]([C@]5(CC[C@@H]4[C@@]3(C)C2)C)OC(=O)C)[N+]2(C)CCCCC2)CCCCC1 VEPSYABRBFXYIB-PWXDFCLTSA-M 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 239000000243 solution Substances 0.000 abstract 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 239000007853 buffer solution Substances 0.000 abstract 1
- 229960004424 carbon dioxide Drugs 0.000 abstract 1
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract 1
- 239000001569 carbon dioxide Substances 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002232 neuromuscular Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939302455A GB9302455D0 (en) | 1993-02-08 | 1993-02-08 | Process for preparing a pharmaceutical preparation having neuromuscular blocking activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE137971T1 true ATE137971T1 (de) | 1996-06-15 |
Family
ID=10730043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94906925T ATE137971T1 (de) | 1993-02-08 | 1994-02-08 | Verfahren zum herstellen von arzneizusammensetzungen, die vecuroniumbromid enthalten |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5681573A (de) |
| EP (1) | EP0682522B1 (de) |
| JP (1) | JPH08508244A (de) |
| AT (1) | ATE137971T1 (de) |
| AU (1) | AU688305B2 (de) |
| CA (1) | CA2152262C (de) |
| DE (1) | DE69400190T2 (de) |
| DK (1) | DK0682522T3 (de) |
| ES (1) | ES2089924T3 (de) |
| GB (1) | GB9302455D0 (de) |
| GR (1) | GR3020815T3 (de) |
| HU (1) | HU213468B (de) |
| NO (1) | NO952666D0 (de) |
| NZ (1) | NZ261582A (de) |
| WO (1) | WO1994017808A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5767112A (en) * | 1994-10-21 | 1998-06-16 | Poli Industria Chimica, S.P.A. | Muscle relaxant pharmaceutical compositions |
| IT1271031B (it) * | 1994-10-21 | 1997-05-26 | Poli Ind Chimica Spa | Composizioni farmaceutiche miorilassanti |
| WO2000044334A2 (en) * | 1999-01-28 | 2000-08-03 | Dinesh Shantilal Patel | Novel injectable muscle relaxant formulations |
| DE102005030423A1 (de) * | 2005-06-30 | 2007-01-04 | Inresa Arzneimittel Gmbh | Neue Formulierung für Vecuroniumbromid |
| CN101843593B (zh) * | 2009-03-27 | 2011-12-21 | 西安力邦制药有限公司 | 一种维库溴铵冻干制剂及其制备方法 |
| JP2016121073A (ja) * | 2014-12-24 | 2016-07-07 | ニプロ株式会社 | 注射剤用医薬組成物の製造方法 |
| CN107638391B (zh) * | 2016-07-22 | 2020-10-16 | 海南合瑞制药股份有限公司 | 一种注射用苯磺顺阿曲库铵组合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1138605A (en) * | 1965-02-19 | 1969-01-01 | Organon Labor Ltd | Improvements in or relating to new 2-ß,16-ß-diamino-androstanes |
| DE2962627D1 (en) * | 1978-09-05 | 1982-06-09 | Akzo Nv | Acid addition salts of 16-beta-monoquaternary ammonium derivatives of 2-beta, 16-beta-bis-piperidino-androstanes and pharmaceutical preparations containing same |
| GB8708886D0 (en) * | 1987-04-14 | 1987-05-20 | Akzo Nv | 2beta-morpholino-androstane derivatives |
| US5030633A (en) * | 1990-09-12 | 1991-07-09 | Williams Charles H | Use of androstane derivative against malignant hyperthermia |
| US5418226A (en) * | 1992-04-22 | 1995-05-23 | Akzo N.V. | Monoquaternary 2,16-bispiperidinylandrostane derivatives |
-
1993
- 1993-02-08 GB GB939302455A patent/GB9302455D0/en active Pending
-
1994
- 1994-02-08 AT AT94906925T patent/ATE137971T1/de not_active IP Right Cessation
- 1994-02-08 US US08/495,579 patent/US5681573A/en not_active Expired - Fee Related
- 1994-02-08 HU HU9502331A patent/HU213468B/hu not_active IP Right Cessation
- 1994-02-08 JP JP6517659A patent/JPH08508244A/ja active Pending
- 1994-02-08 ES ES94906925T patent/ES2089924T3/es not_active Expired - Lifetime
- 1994-02-08 DE DE69400190T patent/DE69400190T2/de not_active Expired - Fee Related
- 1994-02-08 CA CA002152262A patent/CA2152262C/en not_active Expired - Fee Related
- 1994-02-08 NZ NZ261582A patent/NZ261582A/en unknown
- 1994-02-08 DK DK94906925.6T patent/DK0682522T3/da active
- 1994-02-08 AU AU60395/94A patent/AU688305B2/en not_active Ceased
- 1994-02-08 EP EP94906925A patent/EP0682522B1/de not_active Expired - Lifetime
- 1994-02-08 WO PCT/EP1994/000358 patent/WO1994017808A1/en not_active Ceased
-
1995
- 1995-07-05 NO NO952666A patent/NO952666D0/no unknown
-
1996
- 1996-08-16 GR GR960402087T patent/GR3020815T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2089924T3 (es) | 1996-10-01 |
| CA2152262A1 (en) | 1994-08-18 |
| DK0682522T3 (da) | 1996-10-07 |
| NO952666L (no) | 1995-07-05 |
| HU213468B (en) | 1997-06-30 |
| CA2152262C (en) | 1999-08-17 |
| AU688305B2 (en) | 1998-03-12 |
| AU6039594A (en) | 1994-08-29 |
| JPH08508244A (ja) | 1996-09-03 |
| NO952666D0 (no) | 1995-07-05 |
| DE69400190D1 (de) | 1996-06-20 |
| GB9302455D0 (en) | 1993-03-24 |
| EP0682522B1 (de) | 1996-05-15 |
| US5681573A (en) | 1997-10-28 |
| DE69400190T2 (de) | 1996-12-12 |
| WO1994017808A1 (en) | 1994-08-18 |
| HUT72444A (en) | 1996-04-29 |
| NZ261582A (en) | 1997-02-24 |
| GR3020815T3 (en) | 1996-11-30 |
| EP0682522A1 (de) | 1995-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |