ES2084657T3 - Agente para el tratamiento de los trastornos del sistema de transmision cerebro-neural. - Google Patents
Agente para el tratamiento de los trastornos del sistema de transmision cerebro-neural.Info
- Publication number
- ES2084657T3 ES2084657T3 ES90302479T ES90302479T ES2084657T3 ES 2084657 T3 ES2084657 T3 ES 2084657T3 ES 90302479 T ES90302479 T ES 90302479T ES 90302479 T ES90302479 T ES 90302479T ES 2084657 T3 ES2084657 T3 ES 2084657T3
- Authority
- ES
- Spain
- Prior art keywords
- agent
- disorders
- brain
- treatment
- reduced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Abstract
DICHO AGENTE CONTIENE UN COMPUESTO DE FORMLA (I) O SUS SALES COMO INGREDIENTES ACTIVOS, DONDE AR Y AR'' SON FENIL O PIRIDIL QUE PUEDEN SER SUSTITUIDOS POR UN ALQUIL REBAJADO, UN ALCOXI REBAJADO, HALOGENO O ALQUILENIDIOXI REBAJADO, R ES HIDROGENO, ALQUIL REBAJADO, ALCOXI REBAJADO, HALOGENO O ALQUILENODIOXI REBAJADO; A ES UN ALQULENO DIRECTO O RAMIFICADO QUE TIENE 1 A 6 ATOMOS DE CARBONO; Y N ES 0 O 1; Y UN METODO PARA PREPARAR EL MISMO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6414889 | 1989-03-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2084657T3 true ES2084657T3 (es) | 1996-05-16 |
Family
ID=13249705
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90302479T Expired - Lifetime ES2084657T3 (es) | 1989-03-15 | 1990-03-08 | Agente para el tratamiento de los trastornos del sistema de transmision cerebro-neural. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5087627A (es) |
EP (1) | EP0388081B1 (es) |
JP (1) | JPH082875B2 (es) |
KR (1) | KR900014345A (es) |
AT (1) | ATE132038T1 (es) |
DE (1) | DE69024385T2 (es) |
DK (1) | DK0388081T3 (es) |
ES (1) | ES2084657T3 (es) |
GR (1) | GR3018565T3 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3831993A1 (de) * | 1988-09-21 | 1990-03-29 | Basf Ag | 2-hydroxy-3-phenoxy-propyl-substituierte piperazine und homo-piperazine, ihre herstellung und verwendung |
US5314885A (en) * | 1992-09-11 | 1994-05-24 | Mcneilab, Inc. | Cyclic benzylamino, benzylamido, and benzylimido antipsychotic agents |
GB9305282D0 (en) * | 1993-03-15 | 1993-05-05 | Ucb Sa | Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine |
JP3077047B2 (ja) * | 1993-04-16 | 2000-08-14 | 参天製薬株式会社 | 新規ピペラジン誘導体 |
PT790236E (pt) * | 1996-02-13 | 2004-04-30 | Pfizer | Pro-farmacos de 5-(2-(4-(1,2-benzisotiazol-3-il)-1-piperazinil)-etil-6-cloro-1,3-di-hidro-2h-indol-2-ona |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB863180A (en) * | 1957-12-17 | 1961-03-15 | Scient Res I For Practical Lif | Laevo-1:2-diphenyl-1-dimethylaminoethane and acid addition salts thereof |
JPS5247514B2 (es) * | 1972-10-07 | 1977-12-02 | ||
US3957788A (en) * | 1974-01-23 | 1976-05-18 | Dainippon Pharmaceutical Co., Ltd. | 1-substituted-4-(1,2-diphenylethyl)piperazine derivatives and their salts and the preparation thereof |
GB1545094A (en) * | 1976-12-14 | 1979-05-02 | Gist Brocades Nv | Piperazine derivatives |
AU562546B2 (en) * | 1981-12-02 | 1987-06-11 | Ferrosan A.B. | 1-piperazinocarboxylates, process for their preparation and pharmaceutical compositions containing them |
GB8320701D0 (en) * | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agent |
JPH0745471B2 (ja) * | 1986-12-04 | 1995-05-17 | 参天製薬株式会社 | ピペラジン誘導体 |
JP2683670B2 (ja) * | 1988-06-28 | 1997-12-03 | 雅春 吐前 | ボウリング球の親指抜き装置 |
JP2506415B2 (ja) * | 1988-07-29 | 1996-06-12 | 富士写真フイルム株式会社 | カメラ一体型vtrおよびビデオカメラ |
EP0408782A1 (en) * | 1989-07-18 | 1991-01-23 | Nauchnoissledovatelski Chimikopharmatzevtichen Institut | Antihypoxic agent |
-
1990
- 1990-02-28 US US07/486,542 patent/US5087627A/en not_active Expired - Fee Related
- 1990-03-07 JP JP2057661A patent/JPH082875B2/ja not_active Expired - Lifetime
- 1990-03-08 EP EP90302479A patent/EP0388081B1/en not_active Expired - Lifetime
- 1990-03-08 DK DK90302479.2T patent/DK0388081T3/da active
- 1990-03-08 AT AT90302479T patent/ATE132038T1/de not_active IP Right Cessation
- 1990-03-08 ES ES90302479T patent/ES2084657T3/es not_active Expired - Lifetime
- 1990-03-08 DE DE69024385T patent/DE69024385T2/de not_active Expired - Fee Related
- 1990-03-15 KR KR1019900003504A patent/KR900014345A/ko active IP Right Grant
-
1995
- 1995-12-29 GR GR950403702T patent/GR3018565T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69024385D1 (de) | 1996-02-08 |
KR900014345A (ko) | 1990-10-23 |
JPH082875B2 (ja) | 1996-01-17 |
DE69024385T2 (de) | 1996-05-30 |
EP0388081B1 (en) | 1995-12-27 |
US5087627A (en) | 1992-02-11 |
GR3018565T3 (en) | 1996-03-31 |
EP0388081A3 (en) | 1992-03-04 |
EP0388081A2 (en) | 1990-09-19 |
ATE132038T1 (de) | 1996-01-15 |
JPH037229A (ja) | 1991-01-14 |
DK0388081T3 (da) | 1996-01-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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