ES2084657T3 - Agente para el tratamiento de los trastornos del sistema de transmision cerebro-neural. - Google Patents

Agente para el tratamiento de los trastornos del sistema de transmision cerebro-neural.

Info

Publication number
ES2084657T3
ES2084657T3 ES90302479T ES90302479T ES2084657T3 ES 2084657 T3 ES2084657 T3 ES 2084657T3 ES 90302479 T ES90302479 T ES 90302479T ES 90302479 T ES90302479 T ES 90302479T ES 2084657 T3 ES2084657 T3 ES 2084657T3
Authority
ES
Spain
Prior art keywords
agent
disorders
brain
treatment
reduced
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90302479T
Other languages
English (en)
Inventor
Takakazu Kitasakurazuka Morita
Tadashi Iso
Hideyasu Yamauchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2084657T3 publication Critical patent/ES2084657T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • External Artificial Organs (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)

Abstract

DICHO AGENTE CONTIENE UN COMPUESTO DE FORMLA (I) O SUS SALES COMO INGREDIENTES ACTIVOS, DONDE AR Y AR'' SON FENIL O PIRIDIL QUE PUEDEN SER SUSTITUIDOS POR UN ALQUIL REBAJADO, UN ALCOXI REBAJADO, HALOGENO O ALQUILENIDIOXI REBAJADO, R ES HIDROGENO, ALQUIL REBAJADO, ALCOXI REBAJADO, HALOGENO O ALQUILENODIOXI REBAJADO; A ES UN ALQULENO DIRECTO O RAMIFICADO QUE TIENE 1 A 6 ATOMOS DE CARBONO; Y N ES 0 O 1; Y UN METODO PARA PREPARAR EL MISMO.
ES90302479T 1989-03-15 1990-03-08 Agente para el tratamiento de los trastornos del sistema de transmision cerebro-neural. Expired - Lifetime ES2084657T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6414889 1989-03-15

Publications (1)

Publication Number Publication Date
ES2084657T3 true ES2084657T3 (es) 1996-05-16

Family

ID=13249705

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90302479T Expired - Lifetime ES2084657T3 (es) 1989-03-15 1990-03-08 Agente para el tratamiento de los trastornos del sistema de transmision cerebro-neural.

Country Status (9)

Country Link
US (1) US5087627A (es)
EP (1) EP0388081B1 (es)
JP (1) JPH082875B2 (es)
KR (1) KR900014345A (es)
AT (1) ATE132038T1 (es)
DE (1) DE69024385T2 (es)
DK (1) DK0388081T3 (es)
ES (1) ES2084657T3 (es)
GR (1) GR3018565T3 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3831993A1 (de) * 1988-09-21 1990-03-29 Basf Ag 2-hydroxy-3-phenoxy-propyl-substituierte piperazine und homo-piperazine, ihre herstellung und verwendung
US5314885A (en) * 1992-09-11 1994-05-24 Mcneilab, Inc. Cyclic benzylamino, benzylamido, and benzylimido antipsychotic agents
GB9305282D0 (en) 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
JP3077047B2 (ja) * 1993-04-16 2000-08-14 参天製薬株式会社 新規ピペラジン誘導体
ES2210450T3 (es) * 1996-02-13 2004-07-01 Pfizer Inc. Profarmacos de 5-(2-(4-(1,2-benzoisotiazol-3-il)-1-piperazinil)etil)-6-cloro-1,3-dihidro-2h-indol-2-ona.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB863180A (en) * 1957-12-17 1961-03-15 Scient Res I For Practical Lif Laevo-1:2-diphenyl-1-dimethylaminoethane and acid addition salts thereof
JPS5247514B2 (es) * 1972-10-07 1977-12-02
US3957788A (en) * 1974-01-23 1976-05-18 Dainippon Pharmaceutical Co., Ltd. 1-substituted-4-(1,2-diphenylethyl)piperazine derivatives and their salts and the preparation thereof
GB1545094A (en) * 1976-12-14 1979-05-02 Gist Brocades Nv Piperazine derivatives
NZ202665A (en) * 1981-12-02 1986-04-11 Ferrosan Ab Diphenylbutyl-1-piperazinocarboxylate derivatives and pharmaceutical compositions
GB8320701D0 (en) * 1983-08-01 1983-09-01 Wellcome Found Chemotherapeutic agent
JPH0745471B2 (ja) * 1986-12-04 1995-05-17 参天製薬株式会社 ピペラジン誘導体
JP2683670B2 (ja) * 1988-06-28 1997-12-03 雅春 吐前 ボウリング球の親指抜き装置
JP2506415B2 (ja) * 1988-07-29 1996-06-12 富士写真フイルム株式会社 カメラ一体型ｖｔｒおよびビデオカメラ
EP0408782A1 (en) * 1989-07-18 1991-01-23 Nauchnoissledovatelski Chimikopharmatzevtichen Institut Antihypoxic agent

Also Published As

Publication number Publication date
JPH082875B2 (ja) 1996-01-17
DE69024385D1 (de) 1996-02-08
EP0388081A3 (en) 1992-03-04
GR3018565T3 (en) 1996-03-31
DE69024385T2 (de) 1996-05-30
JPH037229A (ja) 1991-01-14
US5087627A (en) 1992-02-11
EP0388081A2 (en) 1990-09-19
DK0388081T3 (da) 1996-01-29
ATE132038T1 (de) 1996-01-15
KR900014345A (ko) 1990-10-23
EP0388081B1 (en) 1995-12-27

Similar Documents

Publication Publication Date Title
ES2160237T3 (es) O-carbamoil-fenilalaninol que tiene sustituyente en anillo de benceno, sus sales farmaceuticamente utiles, y metodo para la preparacion de los mismos.
ES2170141T3 (es) 4-aminoderivados del acido micofenolico con actividad inmunosupresora.
ECSP941096A (es) Procedimiento para la preparacion de un derivado indol
ES2031513T3 (es) Quinazolindionas y piridopirimidinadionas.
ES2124373T3 (es) Procedimiento para la preparacion de derivados del acido n-acil-n,n',n'-etilendiamintriacetico.
ES2167377T3 (es) Derivados de piridina farmacologicamente activos y procedimientos para la preparacion de los mismos.
ES2113652T3 (es) Pamoato de risperidona.
JPS6470457A (en) Local remedy for skin damaged by beam
NO305281B1 (no) FremgangsmÕte for Õ lagringsstabilisere pereddiksyrel°sninger, samt stabiliserte pereddiksyrel°sninger
ES8507534A1 (es) Procedimiento para la preparacion de derivados benzopiranicos
ES2168359T3 (es) Acido micofenolico 6-sustituido y derivados con actividad inmunosupresora.
ES2055587T3 (es) El uso de agonistas selectivos de gaba-b como agentes antitusivos.
NO900251L (no) Fremgangsmaate for behandling eller hindring av intrinsik aldret hud med retinoider.
ATE169445T1 (de) Verwendung von gelformulierungen als beizmittel
ES2108717T3 (es) Derivados de la tetrahidropirrolo(1,2-a)pirazina-4-espiro-3'-pirrolidina, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.
TNSN90021A1 (fr) Procede de preparation de tetrahydroimidazo (1,4) benzodiazepin -2- thiones antivirales
DE69333413D1 (de) 5-ht2-antagonisten in der behandlung venöser zustände
ES2084657T3 (es) Agente para el tratamiento de los trastornos del sistema de transmision cerebro-neural.
ES2177811T3 (es) Uso de nitroflavonoides para el tratamiento de la ansiedad.
ES2116612T3 (es) Nuevas bis-naftalimidas para el tratamiento del cancer.
ES2090012T3 (es) Derivados de propoxibenceno y procedimiento para la preparacion de los mismos.
ES2059931T3 (es) Procedimiento para el tratamiento de la hipertrofia e hiperplasia cardiaca asi como vascular.
ES2053039T3 (es) Procedimiento para impedir el cambio de color de los alimentos.
ATE28794T1 (de) Arzneimittelzusammensetzungen mit antientz¨ndungswirkung auf die bauchspeicheldruese.
AR008860A1 (es) Empleo de 1-hidroxi-2-piridonas para el tratamiento de la dermatitis seborreica

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 388081

Country of ref document: ES