ES2084657T3 - AGENT FOR THE TREATMENT OF DISORDERS OF THE BRAIN-NEURAL TRANSMISSION SYSTEM. - Google Patents
AGENT FOR THE TREATMENT OF DISORDERS OF THE BRAIN-NEURAL TRANSMISSION SYSTEM.Info
- Publication number
- ES2084657T3 ES2084657T3 ES90302479T ES90302479T ES2084657T3 ES 2084657 T3 ES2084657 T3 ES 2084657T3 ES 90302479 T ES90302479 T ES 90302479T ES 90302479 T ES90302479 T ES 90302479T ES 2084657 T3 ES2084657 T3 ES 2084657T3
- Authority
- ES
- Spain
- Prior art keywords
- agent
- disorders
- brain
- treatment
- reduced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- External Artificial Organs (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
DICHO AGENTE CONTIENE UN COMPUESTO DE FORMLA (I) O SUS SALES COMO INGREDIENTES ACTIVOS, DONDE AR Y AR'' SON FENIL O PIRIDIL QUE PUEDEN SER SUSTITUIDOS POR UN ALQUIL REBAJADO, UN ALCOXI REBAJADO, HALOGENO O ALQUILENIDIOXI REBAJADO, R ES HIDROGENO, ALQUIL REBAJADO, ALCOXI REBAJADO, HALOGENO O ALQUILENODIOXI REBAJADO; A ES UN ALQULENO DIRECTO O RAMIFICADO QUE TIENE 1 A 6 ATOMOS DE CARBONO; Y N ES 0 O 1; Y UN METODO PARA PREPARAR EL MISMO.SUCH AGENT CONTAINS A COMPOUND OF FORMLA (I) OR ITS SALTS AS ACTIVE INGREDIENTS, WHERE AR AND AR '' ARE PHENYL OR PIRIDILE THAT MAY BE REPLACED BY A REDUCED RENT, AN ALKYLENE, ALKYLENIDIOXI, OR ALKYLENIDIOXI. REDUCED, REDUCED ALCOXY, HALOGEN OR ALKYLENEDIOXI REDUCED; A IS A DIRECT OR BRANCHED ALKYLENE THAT HAS 1 TO 6 ATOMS OF CARBON; Y N IS 0 O 1; AND A METHOD TO PREPARE THE SAME.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6414889 | 1989-03-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2084657T3 true ES2084657T3 (en) | 1996-05-16 |
Family
ID=13249705
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90302479T Expired - Lifetime ES2084657T3 (en) | 1989-03-15 | 1990-03-08 | AGENT FOR THE TREATMENT OF DISORDERS OF THE BRAIN-NEURAL TRANSMISSION SYSTEM. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5087627A (en) |
EP (1) | EP0388081B1 (en) |
JP (1) | JPH082875B2 (en) |
KR (1) | KR900014345A (en) |
AT (1) | ATE132038T1 (en) |
DE (1) | DE69024385T2 (en) |
DK (1) | DK0388081T3 (en) |
ES (1) | ES2084657T3 (en) |
GR (1) | GR3018565T3 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3831993A1 (en) * | 1988-09-21 | 1990-03-29 | Basf Ag | 2-HYDROXY-3-PHENOXY-PROPYL-SUBSTITUTED PIPERAZINE AND HOMO-PIPERAZINE, THEIR PRODUCTION AND USE |
US5314885A (en) * | 1992-09-11 | 1994-05-24 | Mcneilab, Inc. | Cyclic benzylamino, benzylamido, and benzylimido antipsychotic agents |
GB9305282D0 (en) * | 1993-03-15 | 1993-05-05 | Ucb Sa | Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine |
WO1994024115A1 (en) * | 1993-04-16 | 1994-10-27 | Santen Pharmaceutical Co., Ltd. | Novel piperazine derivative |
ES2210450T3 (en) * | 1996-02-13 | 2004-07-01 | Pfizer Inc. | PROFARMS OF 5- (2- (4- (1,2-BENZOISOTIAZOL-3-IL) -1-PIPERAZINIL) ETIL) -6-CHLORINE-1,3-DIHYDRO-2H-INDOL-2-ONA. |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB863180A (en) * | 1957-12-17 | 1961-03-15 | Scient Res I For Practical Lif | Laevo-1:2-diphenyl-1-dimethylaminoethane and acid addition salts thereof |
JPS5247514B2 (en) * | 1972-10-07 | 1977-12-02 | ||
US3957788A (en) * | 1974-01-23 | 1976-05-18 | Dainippon Pharmaceutical Co., Ltd. | 1-substituted-4-(1,2-diphenylethyl)piperazine derivatives and their salts and the preparation thereof |
GB1545094A (en) * | 1976-12-14 | 1979-05-02 | Gist Brocades Nv | Piperazine derivatives |
US4624953A (en) * | 1981-12-02 | 1986-11-25 | Bjoerk Anders K | 1-piperazinocarboxylates and pharmaceutical compositions containing them |
GB8320701D0 (en) * | 1983-08-01 | 1983-09-01 | Wellcome Found | Chemotherapeutic agent |
JPH0745471B2 (en) * | 1986-12-04 | 1995-05-17 | 参天製薬株式会社 | Piperazine derivative |
JP2683670B2 (en) * | 1988-06-28 | 1997-12-03 | 雅春 吐前 | Bowling ball thumb punch |
JP2506415B2 (en) * | 1988-07-29 | 1996-06-12 | 富士写真フイルム株式会社 | Camera integrated VTR and video camera |
EP0408782A1 (en) * | 1989-07-18 | 1991-01-23 | Nauchnoissledovatelski Chimikopharmatzevtichen Institut | Antihypoxic agent |
-
1990
- 1990-02-28 US US07/486,542 patent/US5087627A/en not_active Expired - Fee Related
- 1990-03-07 JP JP2057661A patent/JPH082875B2/en not_active Expired - Lifetime
- 1990-03-08 EP EP90302479A patent/EP0388081B1/en not_active Expired - Lifetime
- 1990-03-08 DK DK90302479.2T patent/DK0388081T3/en active
- 1990-03-08 DE DE69024385T patent/DE69024385T2/en not_active Expired - Fee Related
- 1990-03-08 AT AT90302479T patent/ATE132038T1/en not_active IP Right Cessation
- 1990-03-08 ES ES90302479T patent/ES2084657T3/en not_active Expired - Lifetime
- 1990-03-15 KR KR1019900003504A patent/KR900014345A/en active IP Right Grant
-
1995
- 1995-12-29 GR GR950403702T patent/GR3018565T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
ATE132038T1 (en) | 1996-01-15 |
DE69024385T2 (en) | 1996-05-30 |
DE69024385D1 (en) | 1996-02-08 |
DK0388081T3 (en) | 1996-01-29 |
EP0388081A3 (en) | 1992-03-04 |
GR3018565T3 (en) | 1996-03-31 |
KR900014345A (en) | 1990-10-23 |
EP0388081A2 (en) | 1990-09-19 |
JPH037229A (en) | 1991-01-14 |
JPH082875B2 (en) | 1996-01-17 |
EP0388081B1 (en) | 1995-12-27 |
US5087627A (en) | 1992-02-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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