DK0388081T3 - Middel til behandling af sygdomme i det cerebrale neurotransmissionssystem - Google Patents

Middel til behandling af sygdomme i det cerebrale neurotransmissionssystem

Info

Publication number
DK0388081T3
DK0388081T3 DK90302479.2T DK90302479T DK0388081T3 DK 0388081 T3 DK0388081 T3 DK 0388081T3 DK 90302479 T DK90302479 T DK 90302479T DK 0388081 T3 DK0388081 T3 DK 0388081T3
Authority
DK
Denmark
Prior art keywords
diseases
agent
treatment
halogen
neurotransmission system
Prior art date
Application number
DK90302479.2T
Other languages
English (en)
Inventor
Takakazu Morita
Tadashi Iso
Hideyasu Yamauchi
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DK0388081T3 publication Critical patent/DK0388081T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • External Artificial Organs (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK90302479.2T 1989-03-15 1990-03-08 Middel til behandling af sygdomme i det cerebrale neurotransmissionssystem DK0388081T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6414889 1989-03-15

Publications (1)

Publication Number Publication Date
DK0388081T3 true DK0388081T3 (da) 1996-01-29

Family

ID=13249705

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90302479.2T DK0388081T3 (da) 1989-03-15 1990-03-08 Middel til behandling af sygdomme i det cerebrale neurotransmissionssystem

Country Status (9)

Country Link
US (1) US5087627A (da)
EP (1) EP0388081B1 (da)
JP (1) JPH082875B2 (da)
KR (1) KR900014345A (da)
AT (1) ATE132038T1 (da)
DE (1) DE69024385T2 (da)
DK (1) DK0388081T3 (da)
ES (1) ES2084657T3 (da)
GR (1) GR3018565T3 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3831993A1 (de) * 1988-09-21 1990-03-29 Basf Ag 2-hydroxy-3-phenoxy-propyl-substituierte piperazine und homo-piperazine, ihre herstellung und verwendung
US5314885A (en) * 1992-09-11 1994-05-24 Mcneilab, Inc. Cyclic benzylamino, benzylamido, and benzylimido antipsychotic agents
GB9305282D0 (en) * 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
WO1994024115A1 (en) * 1993-04-16 1994-10-27 Santen Pharmaceutical Co., Ltd. Novel piperazine derivative
DE69726206T2 (de) * 1996-02-13 2004-04-15 Pfizer Inc. Prodrogen von 5-(2-(4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2h-indol-2-on

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB863180A (en) * 1957-12-17 1961-03-15 Scient Res I For Practical Lif Laevo-1:2-diphenyl-1-dimethylaminoethane and acid addition salts thereof
JPS5247514B2 (da) * 1972-10-07 1977-12-02
US3957788A (en) * 1974-01-23 1976-05-18 Dainippon Pharmaceutical Co., Ltd. 1-substituted-4-(1,2-diphenylethyl)piperazine derivatives and their salts and the preparation thereof
GB1545094A (en) * 1976-12-14 1979-05-02 Gist Brocades Nv Piperazine derivatives
IL67372A (en) * 1981-12-02 1986-04-29 Ferrosan Ab Pharmaceutical compositions comprising 4-(4,4-bis(p-fluorophenyl)butyl)-1-piperazinocarboxylates,certain such novel compounds and their preparation
GB8320701D0 (en) * 1983-08-01 1983-09-01 Wellcome Found Chemotherapeutic agent
JPH0745471B2 (ja) * 1986-12-04 1995-05-17 参天製薬株式会社 ピペラジン誘導体
JP2683670B2 (ja) * 1988-06-28 1997-12-03 雅春 吐前 ボウリング球の親指抜き装置
JP2506415B2 (ja) * 1988-07-29 1996-06-12 富士写真フイルム株式会社 カメラ一体型ｖｔｒおよびビデオカメラ
EP0408782A1 (en) * 1989-07-18 1991-01-23 Nauchnoissledovatelski Chimikopharmatzevtichen Institut Antihypoxic agent

Also Published As

Publication number Publication date
KR900014345A (ko) 1990-10-23
JPH037229A (ja) 1991-01-14
DE69024385T2 (de) 1996-05-30
EP0388081B1 (en) 1995-12-27
ATE132038T1 (de) 1996-01-15
ES2084657T3 (es) 1996-05-16
US5087627A (en) 1992-02-11
EP0388081A3 (en) 1992-03-04
JPH082875B2 (ja) 1996-01-17
DE69024385D1 (de) 1996-02-08
GR3018565T3 (en) 1996-03-31
EP0388081A2 (en) 1990-09-19

Similar Documents

Publication Publication Date Title
ES2059069T3 (es) Nuevos derivados de 1-alcoxi-(2-acilamino-etil)-naftalenos y su procedimiento de preparacion.
EP0256503A3 (en) Pyridinecarboxamide derivatives and their use as fungicide
ES541709A0 (es) Un procedimiento para la preparacion de derivados de fenoxi-c3-c7-alquiloxi-3,4-dihidro-2h-1-benzopirano
PT87163A (pt) Process for preparing 1-phenyl-3-naphthalenyloxipropanamines
NO163568C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolonkarboksylsyrederivater.
NO161564C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive beta-carbolin-3-oxadiazolylderivater.
ES2039221T3 (es) Procedimiento para producir derivados de piridazinona.
DK0388081T3 (da) Middel til behandling af sygdomme i det cerebrale neurotransmissionssystem
DE3572480D1 (de) 2-(3,5-dialkyl-4-hydroxyphenyl)indole derivatives
DE69828197D1 (de) Amidderivate zur behandlung neurodegenerativer erkrankungen der netzhaut
NO171362C (no) Analogifremgangsmaate for fremstilling av nye aralkylaminforbindelser og deres salter
ES552782A0 (es) Un procedimiento para preparar un compuesto de n-fenil-trans-4-guanidincometilciclohexanocarboxamida.
DK0420224T3 (da) Anthihepatopatisk middel
SE8901060D0 (sv) New compounds
DK0784973T3 (da) Quinoxalinderivater til behandling af tinnitus
HK1048594A1 (zh) 用於青光眼治療的2-氨基1，2，3，4-四氫化萘衍生物
DE3782229D1 (de) Verwendung von 2-oxo-imidazolidin-derivaten zur behandlung von nierenkrankheiten.
DE69327077D1 (de) Carbamoylpyrrolidon-Derivate zur Behandlung von Depressionen und cerebrovasculären Störungen
EP0919233B8 (en) Therapeutic agent for kidney diseases
DE3782235D1 (de) Verwendung von 2-oxo-imidazolidin-derivaten zur prophylaxe und zur behandlung von herzinsuffizienz.
DK0501442T3 (da) 8-Chlor-benzothiazepin-forbindelse til forebyggelse og behandling af følgerne af cerebral nekrose af nerveceller
DE69424677D1 (de) Präparat zur behandlung der drogenabhängigkeit