ES2084347T3 - Derivados de 5-heteroil-indol. - Google Patents
Derivados de 5-heteroil-indol.Info
- Publication number
- ES2084347T3 ES2084347T3 ES92904837T ES92904837T ES2084347T3 ES 2084347 T3 ES2084347 T3 ES 2084347T3 ES 92904837 T ES92904837 T ES 92904837T ES 92904837 T ES92904837 T ES 92904837T ES 2084347 T3 ES2084347 T3 ES 2084347T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- hydrogen
- heteroil
- indol
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Luminescent Compositions (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65471291A | 1991-02-12 | 1991-02-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2084347T3 true ES2084347T3 (es) | 1996-05-01 |
Family
ID=24625959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92904837T Expired - Lifetime ES2084347T3 (es) | 1991-02-12 | 1992-02-03 | Derivados de 5-heteroil-indol. |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0571471B1 (OSRAM) |
| JP (1) | JPH07121942B2 (OSRAM) |
| KR (1) | KR930703305A (OSRAM) |
| AT (1) | ATE135005T1 (OSRAM) |
| AU (1) | AU655456B2 (OSRAM) |
| CA (1) | CA2101521A1 (OSRAM) |
| CZ (1) | CZ165693A3 (OSRAM) |
| DE (1) | DE69208868T2 (OSRAM) |
| DK (1) | DK0571471T3 (OSRAM) |
| ES (1) | ES2084347T3 (OSRAM) |
| FI (1) | FI933551A7 (OSRAM) |
| GR (1) | GR3019778T3 (OSRAM) |
| HU (1) | HUT65766A (OSRAM) |
| IE (1) | IE920442A1 (OSRAM) |
| IL (1) | IL100888A0 (OSRAM) |
| MX (1) | MX9200569A (OSRAM) |
| MY (1) | MY131298A (OSRAM) |
| NO (1) | NO932859D0 (OSRAM) |
| NZ (1) | NZ241584A (OSRAM) |
| PT (1) | PT100114A (OSRAM) |
| TW (1) | TW263508B (OSRAM) |
| WO (1) | WO1992013856A1 (OSRAM) |
| YU (1) | YU13792A (OSRAM) |
| ZA (1) | ZA92969B (OSRAM) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW288010B (OSRAM) * | 1992-03-05 | 1996-10-11 | Pfizer | |
| NZ251086A (en) * | 1992-04-07 | 1996-09-25 | Pfizer | Substituted indole derivatives and medicaments |
| GB9211277D0 (en) | 1992-05-28 | 1992-07-15 | Glaxo Group Inc | Pharmaceutical compositions |
| GB9226537D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| GB9226532D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| ES2070087B1 (es) * | 1993-08-13 | 1996-02-16 | Pfizer | Derivados de indol |
| US6423731B2 (en) | 1994-01-06 | 2002-07-23 | Zeneca Limited | Indole derivatives as prodrugs of 5-HT1-like receptor agonists |
| US5468768A (en) * | 1994-01-06 | 1995-11-21 | Bristol-Myers Squibb Company | Antimigraine derivatives of indolylcycloalkanylamines |
| US5807857A (en) * | 1994-05-19 | 1998-09-15 | Merck Sharp & Dohme Ltd. | Piperazine, piperidine and tetrahydropyridine derivative of indol-3-alkyl as 5-HT1D-α agonists |
| JP3262800B2 (ja) * | 1994-06-01 | 2002-03-04 | ゼネカ・リミテッド | 療用複素環化合物 |
| US5521196A (en) * | 1994-10-05 | 1996-05-28 | Eli Lilly And Company | 5-HT1F agonists for the treatment of migraine |
| US5521197A (en) * | 1994-12-01 | 1996-05-28 | Eli Lilly And Company | 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists |
| GB9501865D0 (en) * | 1995-01-31 | 1995-03-22 | Merck Sharp & Dohme | Therapeutic agents |
| EA001113B1 (ru) * | 1995-03-20 | 2000-10-30 | Эли Лилли Энд Компани | 5-замещенные-3-(1,2,3,6-тетрагидропиридин-4-ил)- и 3-(пиперидин-4-ил)-1н-индолы и их фармацевтически приемлемые соли и сольваты, фармацевтическая композиция на их основе, способ активации рецепторов 5-нт1 и способ ингибирования нейронной белковой транссудации |
| US5942536A (en) * | 1995-10-10 | 1999-08-24 | Eli Lilly And Company | N- 2-substituted-3-(2-aminoethyl)-1H-indol-5-YL!-Amides: new 5-HT1F agonists |
| GB9523583D0 (en) * | 1995-11-17 | 1996-01-17 | Merck Sharp & Dohme | Therapeutic agents |
| FR2754709B1 (fr) | 1996-10-23 | 1999-03-05 | Sanofi Sa | Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition |
| FR2763243A1 (fr) * | 1997-05-14 | 1998-11-20 | Pf Medicament | Utilisation d'amines indoliques comme medicaments antithrombotiques |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| DK1068198T3 (da) * | 1998-03-09 | 2003-09-22 | Lundbeck & Co As H | 5-Heteroarylsubstituerede indoler |
| AU4831899A (en) * | 1998-06-30 | 2000-01-17 | Eli Lilly And Company | 5-HT1F agonists |
| DE69937372T2 (de) * | 1999-04-21 | 2008-06-26 | Nps Allelix Corp., Mississauga | Piperidin-indol derivate mit 5-ht6 affinität |
| WO2001034146A1 (en) * | 1999-11-08 | 2001-05-17 | Smithkline Beecham Corporation | Novel anti-infectives |
| WO2002032863A1 (en) | 2000-10-20 | 2002-04-25 | Biovitrum Ab | 2-, 3-, 4-, or 5-substituted-n1-(benzensulfonyl)indoles and their use in therapy |
| DE10121217A1 (de) | 2001-04-30 | 2002-10-31 | Merck Patent Gmbh | 6H-Oxazolo[4,5-e]indol-Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden |
| AU2003239508A1 (en) | 2002-05-21 | 2003-12-12 | Bristol-Myers Squibb Company | Indole compounds useful as impdh inhibitors |
| CA2509982C (en) * | 2002-11-28 | 2011-11-08 | Suven Life Sciences Limited | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them |
| US7332508B2 (en) | 2002-12-18 | 2008-02-19 | Novo Nordisk A/S | Substituted homopiperidine, piperidine or pyrrolidine derivatives |
| WO2005005439A1 (en) * | 2003-07-09 | 2005-01-20 | Suven Life Sciences Limited | Benzothiazino indoles |
| US20050245540A1 (en) * | 2003-12-09 | 2005-11-03 | Fujisawa Pharmaceutical Co., Ltd. | New methods |
| WO2005121132A1 (ja) * | 2004-06-11 | 2005-12-22 | Shionogi & Co., Ltd. | 抗ｈｃｖ作用を有する縮合ヘテロ環化合物 |
| TWI466879B (zh) | 2005-04-13 | 2015-01-01 | Neuraxon Inc | 具有一氧化氮合成酶抑制活性之取代的吲哚化合物 |
| JP2009502816A (ja) * | 2005-07-29 | 2009-01-29 | ４エスツェー アクチェンゲゼルシャフト | 新規ヘテロ環状ＮＦ−κＢ阻害剤 |
| WO2007098418A1 (en) * | 2006-02-17 | 2007-08-30 | Memory Pharmaceuticals Corporation | Compounds having 5-ht6 receptor affinity |
| JP5350219B2 (ja) | 2006-04-13 | 2013-11-27 | ニューラクソン，インコーポレーテッド | Ｎｏｓ阻害活性を有する１，５および３，６−置換インドール化合物 |
| JP2010500372A (ja) * | 2006-08-09 | 2010-01-07 | スミスクライン ビーチャム コーポレーション | オピオイド受容体に対するアンタゴニストまたはインバースアゴニストとしての新規化合物 |
| TW200848021A (en) | 2007-03-06 | 2008-12-16 | Wyeth Corp | Sulfonylated heterocycles useful for modulation of the progesterone receptor |
| US8673909B2 (en) | 2007-11-16 | 2014-03-18 | Neuraxon, Inc. | Indole compounds and methods for treating visceral pain |
| WO2012064744A2 (en) * | 2010-11-08 | 2012-05-18 | Lycera Corporation | Tetrahydroquinoline and related bicyclic compounds for inhibition of rorϒ activity and the treatment of disease |
| MX367341B (es) | 2012-05-08 | 2019-08-14 | Merck Sharp & Dohme | Tetrahidronaftiridina y compuestos biciclicos relacionados para la inhibicion de la actividad de rorgamma y el tratamiento de enfermedades. |
| WO2013169864A2 (en) | 2012-05-08 | 2013-11-14 | Lycera Corporation | TETRAHYDRO[1,8]NAPHTHYRIDINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORƴ AND THE TREATMENT OF DISEASE |
| WO2015095788A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | 2-ACYLAMIDOMETHYL AND SULFONYLAMIDOMETHYL BENZOXAZINE CARBAMATES FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE |
| WO2015095792A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Carbamate benzoxaxine propionic acids and acid derivatives for modulation of rorgamma activity and the treatment of disease |
| WO2015095795A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE, AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE |
| CA2939305A1 (en) | 2014-02-27 | 2015-09-03 | Lycera Corporation | Adoptive cellular therapy using an agonist of retinoic acid receptor-related orphan receptor gamma & related therapeutic methods |
| EP3140291A4 (en) | 2014-05-05 | 2018-01-10 | Lycera Corporation | Tetrahydroquinoline sulfonamide and related compounds for use as agonists of rory and the treatment of disease |
| EP3209641A4 (en) | 2014-05-05 | 2018-06-06 | Lycera Corporation | Benzenesulfonamido and related compounds for use as agonists of ror and the treatement of disease |
| WO2016130818A1 (en) | 2015-02-11 | 2016-08-18 | Merck Sharp & Dohme Corp. | SUBSTITUTED PYRAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF |
| JP2018515491A (ja) | 2015-05-05 | 2018-06-14 | リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ | ＲＯＲγの作動薬及び疾患の療法として使用するジヒドロ−２Ｈ−ベンゾ［ｂ］［１，４］オキサジンスルホンアミド及び関連化合物 |
| CA2987289A1 (en) | 2015-06-11 | 2016-12-15 | Lycera Corporation | Aryl dihydro-2h-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of ror.gamma. and the treatment of disease |
| JP2018535958A (ja) | 2015-10-27 | 2018-12-06 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | ＲＯＲγＴ阻害薬としての置換インダゾール化合物及びその使用 |
| JP2018531957A (ja) | 2015-10-27 | 2018-11-01 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | ＲＯＲγＴ阻害薬としての置換二環式ピラゾール化合物及びその使用 |
| EP3368535B1 (en) | 2015-10-27 | 2020-12-02 | Merck Sharp & Dohme Corp. | Heteroaryl substituted benzoic acids as rorgammat inhibitors and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8332437D0 (en) * | 1983-12-06 | 1984-01-11 | Glaxo Group Ltd | Chemical compounds |
| DE3678805D1 (de) * | 1985-11-08 | 1991-05-23 | Glaxo Group Ltd | Indolderivate. |
| GB8600398D0 (en) * | 1986-01-08 | 1986-02-12 | Glaxo Group Ltd | Chemical compounds |
| GB8719167D0 (en) * | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
| GB8724912D0 (en) * | 1987-10-23 | 1987-11-25 | Wellcome Found | Indole derivatives |
| CA2064815C (en) * | 1990-06-07 | 1999-11-16 | Alan Duncan Robertson | Therapeutic heterocyclic compounds |
-
1992
- 1992-01-28 TW TW081100627A patent/TW263508B/zh active
- 1992-02-03 KR KR1019930702398A patent/KR930703305A/ko not_active Ceased
- 1992-02-03 WO PCT/US1992/000556 patent/WO1992013856A1/en not_active Ceased
- 1992-02-03 EP EP92904837A patent/EP0571471B1/en not_active Expired - Lifetime
- 1992-02-03 HU HU9302328A patent/HUT65766A/hu unknown
- 1992-02-03 ES ES92904837T patent/ES2084347T3/es not_active Expired - Lifetime
- 1992-02-03 AT AT92904837T patent/ATE135005T1/de not_active IP Right Cessation
- 1992-02-03 CZ CS931656A patent/CZ165693A3/cs unknown
- 1992-02-03 JP JP4505422A patent/JPH07121942B2/ja not_active Expired - Lifetime
- 1992-02-03 DK DK92904837.9T patent/DK0571471T3/da active
- 1992-02-03 DE DE69208868T patent/DE69208868T2/de not_active Expired - Fee Related
- 1992-02-03 FI FI933551A patent/FI933551A7/fi not_active Application Discontinuation
- 1992-02-03 AU AU12637/92A patent/AU655456B2/en not_active Ceased
- 1992-02-03 CA CA002101521A patent/CA2101521A1/en not_active Abandoned
- 1992-02-06 IL IL100888A patent/IL100888A0/xx unknown
- 1992-02-10 MX MX9200569A patent/MX9200569A/es unknown
- 1992-02-10 PT PT100114A patent/PT100114A/pt not_active Application Discontinuation
- 1992-02-11 IE IE044292A patent/IE920442A1/en not_active Application Discontinuation
- 1992-02-11 ZA ZA92969A patent/ZA92969B/xx unknown
- 1992-02-11 NZ NZ241584A patent/NZ241584A/en unknown
- 1992-02-11 MY MYPI92000204A patent/MY131298A/en unknown
- 1992-02-11 YU YU13792A patent/YU13792A/sh unknown
-
1993
- 1993-08-11 NO NO932859A patent/NO932859D0/no unknown
-
1996
- 1996-04-29 GR GR960401158T patent/GR3019778T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA92969B (en) | 1993-08-11 |
| MX9200569A (es) | 1992-08-01 |
| JPH07121942B2 (ja) | 1995-12-25 |
| CZ165693A3 (en) | 1994-05-18 |
| IL100888A0 (en) | 1992-11-15 |
| EP0571471B1 (en) | 1996-03-06 |
| KR930703305A (ko) | 1993-11-29 |
| NO932859L (no) | 1993-08-11 |
| GR3019778T3 (en) | 1996-07-31 |
| FI933551A0 (fi) | 1993-08-11 |
| DE69208868D1 (de) | 1996-04-11 |
| EP0571471A1 (en) | 1993-12-01 |
| CA2101521A1 (en) | 1992-08-13 |
| NZ241584A (en) | 1994-12-22 |
| FI933551L (fi) | 1993-08-11 |
| YU13792A (sh) | 1994-11-15 |
| AU1263792A (en) | 1992-09-07 |
| WO1992013856A1 (en) | 1992-08-20 |
| TW263508B (OSRAM) | 1995-11-21 |
| IE920442A1 (en) | 1992-08-12 |
| PT100114A (pt) | 1993-05-31 |
| NO932859D0 (no) | 1993-08-11 |
| FI933551A7 (fi) | 1993-08-11 |
| HUT65766A (en) | 1994-07-28 |
| DK0571471T3 (da) | 1996-04-01 |
| HU9302328D0 (en) | 1993-10-28 |
| DE69208868T2 (de) | 1996-10-17 |
| AU655456B2 (en) | 1994-12-22 |
| JPH06500122A (ja) | 1994-01-06 |
| ATE135005T1 (de) | 1996-03-15 |
| MY131298A (en) | 2007-08-30 |
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| ECSP951529A (es) | Compuestos farmaceuticos |
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