ES2084347T3 - Derivados de 5-heteroil-indol. - Google Patents
Derivados de 5-heteroil-indol.Info
- Publication number
- ES2084347T3 ES2084347T3 ES92904837T ES92904837T ES2084347T3 ES 2084347 T3 ES2084347 T3 ES 2084347T3 ES 92904837 T ES92904837 T ES 92904837T ES 92904837 T ES92904837 T ES 92904837T ES 2084347 T3 ES2084347 T3 ES 2084347T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- hydrogen
- heteroil
- indol
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Luminescent Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65471291A | 1991-02-12 | 1991-02-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2084347T3 true ES2084347T3 (es) | 1996-05-01 |
Family
ID=24625959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92904837T Expired - Lifetime ES2084347T3 (es) | 1991-02-12 | 1992-02-03 | Derivados de 5-heteroil-indol. |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0571471B1 (OSRAM) |
| JP (1) | JPH07121942B2 (OSRAM) |
| KR (1) | KR930703305A (OSRAM) |
| AT (1) | ATE135005T1 (OSRAM) |
| AU (1) | AU655456B2 (OSRAM) |
| CA (1) | CA2101521A1 (OSRAM) |
| CZ (1) | CZ165693A3 (OSRAM) |
| DE (1) | DE69208868T2 (OSRAM) |
| DK (1) | DK0571471T3 (OSRAM) |
| ES (1) | ES2084347T3 (OSRAM) |
| FI (1) | FI933551A0 (OSRAM) |
| GR (1) | GR3019778T3 (OSRAM) |
| HU (1) | HUT65766A (OSRAM) |
| IE (1) | IE920442A1 (OSRAM) |
| IL (1) | IL100888A0 (OSRAM) |
| MX (1) | MX9200569A (OSRAM) |
| MY (1) | MY131298A (OSRAM) |
| NO (1) | NO932859L (OSRAM) |
| NZ (1) | NZ241584A (OSRAM) |
| PT (1) | PT100114A (OSRAM) |
| TW (1) | TW263508B (OSRAM) |
| WO (1) | WO1992013856A1 (OSRAM) |
| YU (1) | YU13792A (OSRAM) |
| ZA (1) | ZA92969B (OSRAM) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW288010B (OSRAM) * | 1992-03-05 | 1996-10-11 | Pfizer | |
| UA27467C2 (uk) * | 1992-04-07 | 2000-09-15 | Пфайзер Інк. | ПОХІДНІ ІНДОЛУ ЯК 5-НТ<sub>1</sub> АГОНІСТИ ТА ПРОМІЖНІ СПОЛУКИ |
| GB9211277D0 (en) | 1992-05-28 | 1992-07-15 | Glaxo Group Inc | Pharmaceutical compositions |
| GB9226537D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| GB9226532D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| ES2070087B1 (es) * | 1993-08-13 | 1996-02-16 | Pfizer | Derivados de indol |
| US6423731B2 (en) | 1994-01-06 | 2002-07-23 | Zeneca Limited | Indole derivatives as prodrugs of 5-HT1-like receptor agonists |
| US5468768A (en) * | 1994-01-06 | 1995-11-21 | Bristol-Myers Squibb Company | Antimigraine derivatives of indolylcycloalkanylamines |
| EP0759918A1 (en) * | 1994-05-19 | 1997-03-05 | MERCK SHARP & DOHME LTD. | Piperazine, piperidine and tetrahydropyridine derivatives of indol-3-ylalkyl as 5-ht1d-alpha agonists |
| AU2621995A (en) * | 1994-06-01 | 1995-12-21 | Zeneca Limited | Indole derivatives as prodrugs of 5-ht1-like receptor agonists |
| US5521196A (en) * | 1994-10-05 | 1996-05-28 | Eli Lilly And Company | 5-HT1F agonists for the treatment of migraine |
| US5521197A (en) * | 1994-12-01 | 1996-05-28 | Eli Lilly And Company | 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists |
| GB9501865D0 (en) * | 1995-01-31 | 1995-03-22 | Merck Sharp & Dohme | Therapeutic agents |
| WO1996029075A1 (en) * | 1995-03-20 | 1996-09-26 | Eli Lilly And Company | 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles: new 5-ht1f agonists |
| AU7261196A (en) * | 1995-10-10 | 1997-04-30 | Eli Lilly And Company | N-{2-substituted-3-(2-aminoethyl)-1h-indol-5-yl}-amides: new 5-ht1f agonists |
| GB9523583D0 (en) * | 1995-11-17 | 1996-01-17 | Merck Sharp & Dohme | Therapeutic agents |
| FR2754709B1 (fr) | 1996-10-23 | 1999-03-05 | Sanofi Sa | Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition |
| FR2763243A1 (fr) * | 1997-05-14 | 1998-11-20 | Pf Medicament | Utilisation d'amines indoliques comme medicaments antithrombotiques |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| WO1999046259A1 (en) * | 1998-03-09 | 1999-09-16 | H. Lundbeck A/S | 5-heteroaryl substituted indoles |
| CA2336254A1 (en) * | 1998-06-30 | 2000-01-06 | Daniel James Koch | 5-ht1f agonists |
| ATE375990T1 (de) * | 1999-04-21 | 2007-11-15 | Nps Allelix Corp | Piperidin-indol derivate mit 5-ht6 affinität |
| WO2001034146A1 (en) * | 1999-11-08 | 2001-05-17 | Smithkline Beecham Corporation | Novel anti-infectives |
| EP1326830A1 (en) * | 2000-10-20 | 2003-07-16 | Biovitrum Ab | 2-, 3-, 4-, or 5-substituted-n1-(benzensulfonyl)indoles and their use in therapy |
| DE10121217A1 (de) * | 2001-04-30 | 2002-10-31 | Merck Patent Gmbh | 6H-Oxazolo[4,5-e]indol-Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden |
| US7008958B2 (en) | 2002-05-21 | 2006-03-07 | Bristol-Myers Squibb Company | 2-substituted 5-oxazolyl indole compounds useful as IMPDH inhibitors and pharmaceutical compositions comprising same |
| NZ540840A (en) * | 2002-11-28 | 2008-12-24 | Suven Life Sciences Ltd | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them |
| US7332508B2 (en) * | 2002-12-18 | 2008-02-19 | Novo Nordisk A/S | Substituted homopiperidine, piperidine or pyrrolidine derivatives |
| WO2005005439A1 (en) * | 2003-07-09 | 2005-01-20 | Suven Life Sciences Limited | Benzothiazino indoles |
| US20050245540A1 (en) * | 2003-12-09 | 2005-11-03 | Fujisawa Pharmaceutical Co., Ltd. | New methods |
| WO2005121132A1 (ja) * | 2004-06-11 | 2005-12-22 | Shionogi & Co., Ltd. | 抗ｈｃｖ作用を有する縮合ヘテロ環化合物 |
| KR20130136010A (ko) | 2005-04-13 | 2013-12-11 | 네우렉슨 인코포레이티드 | Ｎｏｓ 저해 활성을 갖는 치환된 인돌 화합물 |
| CA2617225A1 (en) * | 2005-07-29 | 2007-02-15 | 4Sc Ag | Novel heterocyclic nf-kb inhibitors |
| MX2008010481A (es) * | 2006-02-17 | 2008-12-19 | Memory Pharm Corp | Compuestos que tienen afinado para el receptor f-ht6. |
| JP5350219B2 (ja) | 2006-04-13 | 2013-11-27 | ニューラクソン，インコーポレーテッド | Ｎｏｓ阻害活性を有する１，５および３，６−置換インドール化合物 |
| WO2008021851A2 (en) * | 2006-08-09 | 2008-02-21 | Smithkline Beecham Corporation | Novel compounds as antagonists or inverse agonists for opioid receptors |
| TW200848021A (en) | 2007-03-06 | 2008-12-16 | Wyeth Corp | Sulfonylated heterocycles useful for modulation of the progesterone receptor |
| WO2009062319A1 (en) | 2007-11-16 | 2009-05-22 | Neuraxon, Inc. | Indole compounds and methods for treating visceral pain |
| EP2638014B1 (en) * | 2010-11-08 | 2017-01-04 | Lycera Corporation | N-sulfonylated tetrahydroquinolines and related bicyclic compounds for inhibition of ror-gamma activity and the treatment of diseases |
| RU2014149136A (ru) | 2012-05-08 | 2016-07-10 | Мерк Шарп И Доум Корп. | ТЕТРАГИДРОНАФТИРИДИНОВЫЕ И РОДСТВЕННЫЕ БИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ ДЛЯ ИНГИБИРОВАНИЯ RORγ АКТИВНОСТИ И ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ |
| JP6242868B2 (ja) | 2012-05-08 | 2017-12-06 | リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ | ＲＯＲγのアゴニストとしての使用のためおよび疾患の処置のためのテトラヒドロ［１，８］ナフチリジンスルホンアミドおよび関連化合物 |
| WO2015095792A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Carbamate benzoxaxine propionic acids and acid derivatives for modulation of rorgamma activity and the treatment of disease |
| WO2015095788A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | 2-ACYLAMIDOMETHYL AND SULFONYLAMIDOMETHYL BENZOXAZINE CARBAMATES FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE |
| WO2015095795A1 (en) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | TETRAHYDRONAPHTHYRIDINE, BENZOXAZINE, AZA-BENZOXAZINE, AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE |
| US10532088B2 (en) | 2014-02-27 | 2020-01-14 | Lycera Corporation | Adoptive cellular therapy using an agonist of retinoic acid receptor-related orphan receptor gamma and related therapeutic methods |
| US9896441B2 (en) | 2014-05-05 | 2018-02-20 | Lycera Corporation | Tetrahydroquinoline sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease |
| US10189777B2 (en) | 2014-05-05 | 2019-01-29 | Lycera Corporation | Benzenesulfonamido and related compounds for use as agonists of RORγ and the treatment of disease |
| CA2975997A1 (en) | 2015-02-11 | 2016-08-18 | Merck Sharp & Dohme Corp. | Substituted pyrazole compounds as rorgammat inhibitors and uses thereof |
| US10421751B2 (en) | 2015-05-05 | 2019-09-24 | Lycera Corporation | Dihydro-2H-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease |
| WO2016201225A1 (en) | 2015-06-11 | 2016-12-15 | Lycera Corporation | Aryl dihydro-2h-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of rory and the treatment of disease |
| US10287272B2 (en) | 2015-10-27 | 2019-05-14 | Merck Sharp & Dohme Corp. | Substituted indazole compounds as RORgammaT inhibitors and uses thereof |
| EP3368535B1 (en) | 2015-10-27 | 2020-12-02 | Merck Sharp & Dohme Corp. | Heteroaryl substituted benzoic acids as rorgammat inhibitors and uses thereof |
| WO2017075178A1 (en) | 2015-10-27 | 2017-05-04 | Merck Sharp & Dohme Corp. | SUBSTITUTED BICYCLIC PYRAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8332437D0 (en) * | 1983-12-06 | 1984-01-11 | Glaxo Group Ltd | Chemical compounds |
| DE3678805D1 (de) * | 1985-11-08 | 1991-05-23 | Glaxo Group Ltd | Indolderivate. |
| GB8600398D0 (en) * | 1986-01-08 | 1986-02-12 | Glaxo Group Ltd | Chemical compounds |
| GB8719167D0 (en) * | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
| GB8724912D0 (en) * | 1987-10-23 | 1987-11-25 | Wellcome Found | Indole derivatives |
| MC2210A1 (fr) * | 1990-06-07 | 1992-11-26 | Wellcome Found | Composes heterocycliques therapeutiques,leur utilisation et procede pour les preparer |
-
1992
- 1992-01-28 TW TW081100627A patent/TW263508B/zh active
- 1992-02-03 ES ES92904837T patent/ES2084347T3/es not_active Expired - Lifetime
- 1992-02-03 JP JP4505422A patent/JPH07121942B2/ja not_active Expired - Lifetime
- 1992-02-03 CA CA002101521A patent/CA2101521A1/en not_active Abandoned
- 1992-02-03 DE DE69208868T patent/DE69208868T2/de not_active Expired - Fee Related
- 1992-02-03 AT AT92904837T patent/ATE135005T1/de not_active IP Right Cessation
- 1992-02-03 HU HU9302328A patent/HUT65766A/hu unknown
- 1992-02-03 AU AU12637/92A patent/AU655456B2/en not_active Ceased
- 1992-02-03 CZ CS931656A patent/CZ165693A3/cs unknown
- 1992-02-03 FI FI933551A patent/FI933551A0/fi not_active Application Discontinuation
- 1992-02-03 EP EP92904837A patent/EP0571471B1/en not_active Expired - Lifetime
- 1992-02-03 KR KR1019930702398A patent/KR930703305A/ko not_active Ceased
- 1992-02-03 DK DK92904837.9T patent/DK0571471T3/da active
- 1992-02-03 WO PCT/US1992/000556 patent/WO1992013856A1/en not_active Ceased
- 1992-02-06 IL IL100888A patent/IL100888A0/xx unknown
- 1992-02-10 MX MX9200569A patent/MX9200569A/es unknown
- 1992-02-10 PT PT100114A patent/PT100114A/pt not_active Application Discontinuation
- 1992-02-11 IE IE044292A patent/IE920442A1/en not_active Application Discontinuation
- 1992-02-11 NZ NZ241584A patent/NZ241584A/en unknown
- 1992-02-11 YU YU13792A patent/YU13792A/sh unknown
- 1992-02-11 MY MYPI92000204A patent/MY131298A/en unknown
- 1992-02-11 ZA ZA92969A patent/ZA92969B/xx unknown
-
1993
- 1993-08-11 NO NO93932859A patent/NO932859L/no unknown
-
1996
- 1996-04-29 GR GR960401158T patent/GR3019778T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE920442A1 (en) | 1992-08-12 |
| EP0571471B1 (en) | 1996-03-06 |
| NO932859D0 (no) | 1993-08-11 |
| NO932859L (no) | 1993-08-11 |
| ZA92969B (en) | 1993-08-11 |
| CA2101521A1 (en) | 1992-08-13 |
| MY131298A (en) | 2007-08-30 |
| MX9200569A (es) | 1992-08-01 |
| WO1992013856A1 (en) | 1992-08-20 |
| DK0571471T3 (da) | 1996-04-01 |
| FI933551L (fi) | 1993-08-11 |
| AU655456B2 (en) | 1994-12-22 |
| AU1263792A (en) | 1992-09-07 |
| NZ241584A (en) | 1994-12-22 |
| ATE135005T1 (de) | 1996-03-15 |
| DE69208868T2 (de) | 1996-10-17 |
| HU9302328D0 (en) | 1993-10-28 |
| GR3019778T3 (en) | 1996-07-31 |
| FI933551A7 (fi) | 1993-08-11 |
| CZ165693A3 (en) | 1994-05-18 |
| JPH07121942B2 (ja) | 1995-12-25 |
| PT100114A (pt) | 1993-05-31 |
| JPH06500122A (ja) | 1994-01-06 |
| DE69208868D1 (de) | 1996-04-11 |
| HUT65766A (en) | 1994-07-28 |
| KR930703305A (ko) | 1993-11-29 |
| TW263508B (OSRAM) | 1995-11-21 |
| FI933551A0 (fi) | 1993-08-11 |
| IL100888A0 (en) | 1992-11-15 |
| YU13792A (sh) | 1994-11-15 |
| EP0571471A1 (en) | 1993-12-01 |
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| Date | Code | Title | Description |
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| FG2A | Definitive protection |
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