ES2064618T3 - Agonistas de serotonina de tetrahidrobenz(c,d)indol. - Google Patents

Agonistas de serotonina de tetrahidrobenz(c,d)indol.

Info

Publication number
ES2064618T3
ES2064618T3 ES90303775T ES90303775T ES2064618T3 ES 2064618 T3 ES2064618 T3 ES 2064618T3 ES 90303775 T ES90303775 T ES 90303775T ES 90303775 T ES90303775 T ES 90303775T ES 2064618 T3 ES2064618 T3 ES 2064618T3
Authority
ES
Spain
Prior art keywords
hydrogen
alkyl
tetrahidrobenz
indol
serotonin agonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90303775T
Other languages
English (en)
Inventor
Michael Edward Flaugh
Mark Mortensen Foreman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2064618T3 publication Critical patent/ES2064618T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

ESTE INVENTO PROPORCIONA AGONISTAS DE LA SEROTONINA 6-SUSTITUIDO-4-(AMINO O AMINO SUSTITUIDO) TETRAHIDROBENCENO (C,D), DE LA FORMULA: EN DONDE: R1 ES HIDROGENO, C1-C4 ALQUIL, ALIL O....R2 ES HIDROGENO, C1-C4 ALQUIL O ALIL; R3 ES HIDROGENO, C1-C3 ALCOXI, -NR5R6 O C1-C3 ALQUILTIO. R4 ES HIDROGENO, METIL, ETIL O VINIL. R5 Y R6 SON, INDEPENDIENTEMENTE, UN ALQUIL C1-C4, UN ALQUIL SUSTITUIDO C1-C4 CON UN GRUPO FENIL, O UN GRUPO FENIL, O R5 Y R6 JUNTOS FORMAN UN ANILLO HETEROCICLICO C3-C5. R5 ES HIDROGENO ADICIONAL. X ES O O S.
ES90303775T 1989-04-11 1990-04-09 Agonistas de serotonina de tetrahidrobenz(c,d)indol. Expired - Lifetime ES2064618T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33640989A 1989-04-11 1989-04-11

Publications (1)

Publication Number Publication Date
ES2064618T3 true ES2064618T3 (es) 1995-02-01

Family

ID=23315961

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90303775T Expired - Lifetime ES2064618T3 (es) 1989-04-11 1990-04-09 Agonistas de serotonina de tetrahidrobenz(c,d)indol.

Country Status (18)

Country Link
US (2) US5204340A (es)
EP (1) EP0392768B1 (es)
JP (1) JP2944140B2 (es)
KR (1) KR900016196A (es)
CN (1) CN1024626C (es)
AT (1) ATE115129T1 (es)
AU (1) AU631863B2 (es)
CA (1) CA2013893C (es)
DE (1) DE69014697T2 (es)
ES (1) ES2064618T3 (es)
HU (1) HUT53869A (es)
IL (1) IL94014A (es)
MX (1) MX20222A (es)
NZ (1) NZ233239A (es)
PT (1) PT93687A (es)
RU (1) RU2007393C1 (es)
TW (1) TW219895B (es)
ZA (1) ZA902668B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204340A (en) * 1989-04-11 1993-04-20 Eli Lilly And Company Tetrahydrobenz(c,d)indole serotonin agonists
US5302612A (en) * 1990-02-26 1994-04-12 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
TW219933B (es) * 1990-02-26 1994-02-01 Lilly Co Eli
IL97308A (en) * 1990-02-26 1996-10-31 Lilly Co Eli Xahydrobenz [DC] Induced indoles in position 6, their preparation process and pharmaceutical preparations containing them
US5039820A (en) * 1990-02-26 1991-08-13 Eli Lilly And Company 4-amino-6-iodo-hexahydrobenz(cd)indoles
US5340838A (en) * 1990-05-04 1994-08-23 Eli Lilly And Company Method of inhibiting gastric acid secretion with 2-phenylcyclopropylamines
US5229409A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-tetrahydrobenz[cd]indoles
US5633273A (en) * 1991-03-28 1997-05-27 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd] indoles
US5347013A (en) * 1991-03-28 1994-09-13 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles
US5364856A (en) * 1991-03-28 1994-11-15 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
TW248556B (es) * 1993-01-18 1995-06-01 Takeda Pharm Industry Co
NZ314570A (en) * 1993-06-10 2000-11-24 Lilly Co Eli Treatment of emesis using tetrahydrobenz[cd]indole-6-carboxamides
US5385928A (en) * 1994-05-18 1995-01-31 Eli Lilly And Company Tetrahydrobenz [CD] indazoles, compositions and use
US5498727A (en) * 1994-07-19 1996-03-12 Agouron Pharmaceuticals, Inc. Preparation of benzindole compounds from naphthalene compounds
US6193993B1 (en) * 1998-03-03 2001-02-27 Eisai Co., Ltd. Suppository containing an antidementia medicament
US6218421B1 (en) * 1999-07-01 2001-04-17 Smithkline Beecham P.L.C. Method of promoting smoking cessation
US20040018959A1 (en) * 2002-05-02 2004-01-29 Randall S. Hickle System and methods of lipid removal from the body
US8609162B2 (en) 2012-10-04 2013-12-17 Invivo Beverages Llc Integrated neuromodulation system for mood enhancement of a living human subject

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110339A (en) * 1977-11-25 1978-08-29 Eli Lilly And Company 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
US4282240A (en) * 1979-11-23 1981-08-04 Merck & Co., Inc. Amino substituted tetrahydrobenzindoles
DE3346573A1 (de) * 1983-12-23 1985-07-04 Troponwerke GmbH & Co KG, 5000 Köln 1,3,4,5-tetrahydrobenz(c,d)indole, ein verfahren zu ihrer herstellung und ihre verwendung
IL74222A (en) * 1984-02-06 1988-07-31 Lilly Co Eli 6-substituted-4-dialkylamino tetrahydrobenz(c,d)indoles,their preparation and pharmaceutical compositions comprising them
US4983622A (en) * 1984-02-06 1991-01-08 Eli Lilly And Company 6-substituted-4-dialkylaminotetrahydrobenz(c,d)indoles
US4576959A (en) * 1984-02-06 1986-03-18 Eli Lilly And Company 6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles
CA1266482A1 (en) * 1984-05-24 1990-03-06 Carl Kaiser 6-oxygenated-1,3,4,5-tetrahydrobenz(cd)indol-4-amines
US4640921A (en) * 1986-02-04 1987-02-03 Bristol-Myers Treatment of sexual dysfunction with buspirone
US4745126A (en) * 1987-03-12 1988-05-17 Eli Lilly And Company Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
DE3809155A1 (de) * 1988-03-18 1989-09-28 Bayer Ag 1,3,4,5-tetrahydrobenz-(c,d)-indole
DE3826371A1 (de) * 1988-08-03 1990-02-08 Bayer Ag Tetrahydro-1-benz-(c,d)-indolpropionsaeure-sulfonamide
US5204340A (en) * 1989-04-11 1993-04-20 Eli Lilly And Company Tetrahydrobenz(c,d)indole serotonin agonists
US5302612A (en) * 1990-02-26 1994-04-12 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
US5229409A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-tetrahydrobenz[cd]indoles
US5229410A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles

Also Published As

Publication number Publication date
TW219895B (es) 1994-02-01
KR900016196A (ko) 1990-11-12
AU5304790A (en) 1990-10-18
JPH02290849A (ja) 1990-11-30
CA2013893C (en) 2001-06-19
EP0392768B1 (en) 1994-12-07
EP0392768A1 (en) 1990-10-17
IL94014A (en) 1994-10-21
PT93687A (pt) 1990-11-20
HU902129D0 (en) 1990-07-28
RU2007393C1 (ru) 1994-02-15
AU631863B2 (en) 1992-12-10
US5204340A (en) 1993-04-20
ZA902668B (en) 1991-12-24
CN1046330A (zh) 1990-10-24
NZ233239A (en) 1991-09-25
DE69014697D1 (de) 1995-01-19
CA2013893A1 (en) 1990-10-11
JP2944140B2 (ja) 1999-08-30
MX20222A (es) 1994-01-31
ATE115129T1 (de) 1994-12-15
CN1024626C (zh) 1994-05-25
US5462962A (en) 1995-10-31
DE69014697T2 (de) 1995-05-11
HUT53869A (en) 1990-12-28
IL94014A0 (en) 1991-01-31

Similar Documents

Publication Publication Date Title
ES2064618T3 (es) Agonistas de serotonina de tetrahidrobenz(c,d)indol.
PT918776E (pt) Sintese total de acilfulvenos antitumorais
ATE125808T1 (de) Indolederivate und ihre verwendung als serotonin- antagoniste.
AU586337B2 (en) Antiallergy and antiinflammatory agents
ATE87921T1 (de) Cycloalkylamide von (8beta)-1-alkyl-6(substituierten) ergolinen.
MY130817A (en) Herbicides
ATE212356T1 (de) Carbamoylmethylharnstoffderivate
AR017500A1 (es) Derivados de naftilpiperacin-ftalacinonas
EP1325913A3 (en) Piperidinecarboxylic acid amide derivatives
EP0878475A3 (en) 5-(4-Piperidinyl)dibenzothiazepine derivatives and 5-(4-piperidinyl)dibenzoxazepine derivatives, and antiarrhythmic agents
ES2077697T3 (es) Derivados de 1-fenoxicarbonil-2-pirrolidinona y agentes nootropicos.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 392768

Country of ref document: ES