ES2083363T3 - Multimeros de acidos nucleicos y ensayos de hibridacion de acidos nucleicos amplificados utilizando los mismos. - Google Patents
Multimeros de acidos nucleicos y ensayos de hibridacion de acidos nucleicos amplificados utilizando los mismos.Info
- Publication number
- ES2083363T3 ES2083363T3 ES88309697T ES88309697T ES2083363T3 ES 2083363 T3 ES2083363 T3 ES 2083363T3 ES 88309697 T ES88309697 T ES 88309697T ES 88309697 T ES88309697 T ES 88309697T ES 2083363 T3 ES2083363 T3 ES 2083363T3
- Authority
- ES
- Spain
- Prior art keywords
- nucleic acid
- multimers
- oligonucleotide
- hybridization tests
- acid hybridization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/682—Signal amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/706—Specific hybridization probes for hepatitis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
- G01N2333/03—Herpetoviridae, e.g. pseudorabies virus
- G01N2333/04—Varicella-zoster virus
- G01N2333/045—Cytomegalovirus
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
MULTIMEROS DE OLIGONUCLEOTIDOS LINEALES O RAMIFICADOS UTILES COMO AMPLIFICADORES EN ENSAYOS BIOQUIMICOS QUE COMPRENDEN (1) AL MENOS UNA UNIDAD DE OLIGONUCLEOTIDO DE CORDON UNICO QUE ES COMPLEMENTARIA DE UNA SECUENCIA DE OLIGONUCLEOTIDO DE UNICO CORDON DE INTERES, Y (2) UNA MULTIPLICIDAD DE UNIDADES DE CORDON UNICO QUE SON COMPLEMENTARIAS DE UN OLIGONUCLEOTIDO MARCADO DE CORDON UNICO. SE MUESTRAN EJEMPLOS DE HIBRIDACION DE ACIDO NUCLEICO DE ESTRUCTURA SANDURIDA AMPLIFICADA E INMUNOENSAYOS QUE UTILIZAN LOS MULTINUMEROS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10928287A | 1987-10-15 | 1987-10-15 | |
US18520188A | 1988-04-22 | 1988-04-22 | |
US25263888A | 1988-09-30 | 1988-09-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2083363T3 true ES2083363T3 (es) | 1996-04-16 |
Family
ID=27380635
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88309697T Expired - Lifetime ES2083363T3 (es) | 1987-10-15 | 1988-10-17 | Multimeros de acidos nucleicos y ensayos de hibridacion de acidos nucleicos amplificados utilizando los mismos. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0317077B1 (es) |
AT (1) | ATE133713T1 (es) |
CA (1) | CA1339351C (es) |
DE (1) | DE3854956T2 (es) |
DK (1) | DK175932B1 (es) |
ES (1) | ES2083363T3 (es) |
GR (1) | GR3019046T3 (es) |
IE (1) | IE75211B1 (es) |
WO (1) | WO1989003891A1 (es) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5118605A (en) * | 1984-10-16 | 1992-06-02 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
US5430136A (en) * | 1984-10-16 | 1995-07-04 | Chiron Corporation | Oligonucleotides having selectably cleavable and/or abasic sites |
US5175270A (en) * | 1986-09-10 | 1992-12-29 | Polyprobe, Inc. | Reagents for detecting and assaying nucleic acid sequences |
US5656731A (en) * | 1987-10-15 | 1997-08-12 | Chiron Corporation | Nucleic acid-amplified immunoassay probes |
US5359100A (en) * | 1987-10-15 | 1994-10-25 | Chiron Corporation | Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers |
US5124246A (en) * | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
US5350671A (en) * | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
US5047523A (en) * | 1988-08-02 | 1991-09-10 | Ortho Diagnostic Systems Inc. | Nucleic acid probe for detection of neisseria gonorrhoea |
ES2121750T3 (es) * | 1988-12-09 | 1998-12-16 | Amrad Corp Ltd | Ensayo de adn amplificado. |
DE3925613A1 (de) * | 1989-06-22 | 1991-01-03 | Boehringer Mannheim Gmbh | Neisseria-spezifische dna-sonde |
CA2065287C (en) | 1989-09-15 | 1999-12-21 | Tatsuo Miyamura | New hcv isolates |
US5232829A (en) * | 1989-09-29 | 1993-08-03 | Hoffmann-La Roche Inc. | Detection of chlamydia trachomatis by polymerase chain reaction using biotin labelled lina primers and capture probes |
CA2025180A1 (en) * | 1989-10-12 | 1991-04-13 | William G. Weisburg | Nucleic acid probes and methods for detecting pathogenic candida yeasts |
CA2025179A1 (en) * | 1989-10-12 | 1991-04-13 | William G. Weisburg | Nucleic acid probes and methods for detecting cryptococcus neoformans |
GB8924989D0 (en) * | 1989-11-06 | 1989-12-28 | Scotgen Ltd | Method and device for the detection of antibiotic resistance |
US5629153A (en) * | 1990-01-10 | 1997-05-13 | Chiron Corporation | Use of DNA-dependent RNA polymerase transcripts as reporter molecules for signal amplification in nucleic acid hybridization assays |
DE69131596T2 (de) * | 1990-01-10 | 1999-12-23 | Chiron Diagnostics Corp | Dns-abhängige rns-polymerase-transkripte als reportermoleküle zur signalverstärkung in nukleinsäure-hybridisierungsuntersuchungen |
CA2037349C (en) | 1990-03-26 | 2008-06-17 | James G. Wetmur | Branch migration of nucleotides |
CA2039517C (en) * | 1990-04-03 | 2006-11-07 | David Segev | Dna probe signal amplification |
RO113496B1 (ro) * | 1990-05-04 | 1998-07-30 | Chiron Corp Emeryville | Proba moleculara hibrida polipeptida/polinucleotida si metoda de amplificare a unui semnal detectabil intr-o determinare imunologica |
US5849481A (en) * | 1990-07-27 | 1998-12-15 | Chiron Corporation | Nucleic acid hybridization assays employing large comb-type branched polynucleotides |
US5430138A (en) * | 1990-07-27 | 1995-07-04 | Chiron Corporation | Hydroxyl-protecting groups attached to cytidine nucleotide compounds which are orthogonally removable |
CA2087961A1 (en) * | 1990-07-27 | 1992-01-28 | Michael S. Urdea | Large comb-type branched polynucleotides |
US5420330A (en) * | 1990-09-07 | 1995-05-30 | Pharmacia P-L Biochemicals Inc. | Lipo-phosphoramidites |
EP0610215A1 (en) * | 1991-06-17 | 1994-08-17 | Chiron Corporation | Polynucleotide determination with selectable cleavage sites |
JPH07502657A (ja) * | 1991-12-23 | 1995-03-23 | バイエル コーポレイション | 溶液相サンドイッチハイブリダイゼーションアッセイに用いるためのhtlv−1プローブ |
US5747244A (en) * | 1991-12-23 | 1998-05-05 | Chiron Corporation | Nucleic acid probes immobilized on polystyrene surfaces |
JPH07502414A (ja) * | 1991-12-23 | 1995-03-16 | バイエル コーポレイション | 溶液相サンドイッチハイブリダイゼーションアッセイに用いるためのクラミジアプローブ |
JPH07502655A (ja) * | 1991-12-23 | 1995-03-23 | バイエル コーポレイション | 溶液相サンドイッチハイブリダイゼーションアッセイに用いるためのcmvプローブ |
EP0618924B1 (en) * | 1991-12-23 | 2001-02-14 | Bayer Corporation | Hbv amplifier probes for use in solution phase sandwich hybridization assays |
JP3907201B2 (ja) * | 1991-12-23 | 2007-04-18 | カイロン コーポレイション | 溶液相サンドイッチハイブリダイゼーションアッセイに用いるためのhivプローブ |
EP0672175A4 (en) * | 1991-12-23 | 1997-08-06 | Chiron Corp | HAV PROBES USED IN SOLUTION PHASE SANDWICH HYBRIDIZATION METHODS. |
AU4596893A (en) * | 1992-05-29 | 1993-12-30 | Gen Trak, Inc. | Signal amplification probe and methods of use |
US5985548A (en) * | 1993-02-04 | 1999-11-16 | E. I. Du Pont De Nemours And Company | Amplification of assay reporters by nucleic acid replication |
BE1007918A3 (fr) * | 1993-02-19 | 1995-11-21 | Wallone Region | Sondes d'acides nucleiques chimiquement modifiees en 5'(oh) et/ou en 3'(oh) en vue de l'introduction en ces positions d'un ou plusieurs elements de marquage non radioactif et procede de preparation. |
FR2710075B1 (fr) * | 1993-09-15 | 1995-10-27 | Bio Merieux | Réactif et procédé pour la détection d'une séquence nucléotidique avec amplification de signal. |
US5561043A (en) * | 1994-01-31 | 1996-10-01 | Trustees Of Boston University | Self-assembling multimeric nucleic acid constructs |
US5648213A (en) * | 1994-08-30 | 1997-07-15 | Beckman Instruments, Inc. | Compositions and methods for use in detection of analytes |
US5853974A (en) * | 1995-06-07 | 1998-12-29 | Chiron Corporation | Enhancement of alkaline phosphatase with SDS in chemiluminescent substrates |
US5780227A (en) * | 1995-06-07 | 1998-07-14 | Sheridan; Patrick J. | Oligonucleotide probe conjugated to a purified hydrophilic alkaline phosphatase and uses thereof |
US6632936B2 (en) | 1995-09-06 | 2003-10-14 | Icos Corp | Cell-cycle checkpoint genes |
CA2218440A1 (en) * | 1996-12-21 | 1998-06-21 | Boehringer Mannheim Gmbh | Method of analysis using signal amplification |
CA2307330A1 (en) | 1997-10-21 | 1999-04-29 | The University Court Of The University Of Glasgow | Jmy, a co-activator for p300/cbp, nucleic acid encoding jmy and uses thereof |
US5962273A (en) * | 1997-11-04 | 1999-10-05 | Becton Dickinson And Company | Detection of Neisseria gonorrhoeae by amplification and detection of its nucleic acid |
GB9806093D0 (en) | 1998-03-20 | 1998-05-20 | Taylor John Hermon | Diagnostics and vaccines for mycobacterial infections of animals and humans |
US5976805A (en) * | 1998-04-27 | 1999-11-02 | Becton Dickinson And Company | Neisseria gonorrhoeae specific DNA fragment--GC3 |
US6468743B1 (en) | 1998-05-18 | 2002-10-22 | Conagra Grocery Products Company | PCR techniques for detecting microbial contaminants in foodstuffs |
GB9811403D0 (en) * | 1998-05-27 | 1998-07-22 | Isis Innovation | Polynucleotide multimers and their use in hybridisation assays |
US6203989B1 (en) | 1998-09-30 | 2001-03-20 | Affymetrix, Inc. | Methods and compositions for amplifying detectable signals in specific binding assays |
GB9914943D0 (en) * | 1999-06-25 | 1999-08-25 | Imp College Innovations Ltd | Methods |
EP1268508A4 (en) * | 2000-03-29 | 2004-11-03 | Polyprobe Inc | REAGENTS FOR QUALITY CONTROL OF NUCLEIC ACID MICRO ARRANGEMENTS |
US7763421B2 (en) | 2000-06-05 | 2010-07-27 | Ventana Medical Systems, Inc. | Methods for producing nucleic acid hybridization probes that amplify hybridization signal by promoting network formation |
ATE510214T1 (de) | 2000-11-30 | 2011-06-15 | Crawford Healthcare Holdings Ltd | Krankheitsdiagnose |
JP2006516099A (ja) | 2002-12-23 | 2006-06-22 | ダイナバックス テクノロジーズ コーポレイション | 分枝状の免疫調節化合物及び該化合物の使用方法 |
US7229800B2 (en) | 2004-04-16 | 2007-06-12 | Becton, Dickinson And Company | Neisseria gonorrhoeae assay |
CA2638782C (en) * | 2006-04-07 | 2020-08-25 | Siemens Healthcare Diagnostics Inc. | Neisseria gonorrhoeae pivng gene specific oligonucleotide sequences |
JP2008043332A (ja) * | 2006-08-17 | 2008-02-28 | Panomics Inc | 組織スライドからの核酸定量 |
JP2010043063A (ja) | 2008-05-09 | 2010-02-25 | Agency For Science Technology & Research | 川崎病の診断及び治療 |
US20110081367A1 (en) | 2008-06-14 | 2011-04-07 | Veredus Laboratories Pte Ltd | Influenza sequences |
WO2010071610A1 (en) | 2008-12-19 | 2010-06-24 | Agency For Science, Technology And Research (A*Star) | Severe chikungunya biomarkers |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI71768C (fi) * | 1984-02-17 | 1987-02-09 | Orion Yhtymae Oy | Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning. |
GB8405437D0 (en) * | 1984-03-01 | 1984-04-04 | Amersham Int Plc | Detecting polynucleotide sequences |
DE3420925A1 (de) * | 1984-06-05 | 1985-12-05 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und reagenz zum nachweis einer nukleinsaeure-sequenz |
US4755458A (en) * | 1984-08-30 | 1988-07-05 | Enzo Biochem, Inc. | Composition and method for the detection of the presence of a polynucleotide sequence of interest |
US4883750A (en) * | 1984-12-13 | 1989-11-28 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
CA1272443A (en) * | 1985-02-22 | 1990-08-07 | Nanibhushan Dattagupta | Solution-phase dual hybridization assay for detecting polynucleotide sequences |
US5252760A (en) | 1985-03-28 | 1993-10-12 | Chiron Corporation | Method of using colored phosphorylating reagents |
DE3680156D1 (de) * | 1985-05-31 | 1991-08-14 | Amoco Corp | Verstaerkung von hybridisierungssignalen durch verwendung von komplementarischen dns-straengen. |
US4868105A (en) * | 1985-12-11 | 1989-09-19 | Chiron Corporation | Solution phase nucleic acid sandwich assay |
US4882269A (en) * | 1985-12-13 | 1989-11-21 | Princeton University | Amplified hybridization assay |
AU7015287A (en) * | 1986-03-19 | 1987-09-24 | Cetus Corporation | Detection of nucleic acid sequence using liquid hybridization method |
-
1988
- 1988-10-07 CA CA000579610A patent/CA1339351C/en not_active Expired - Fee Related
- 1988-10-14 IE IE313188A patent/IE75211B1/en not_active IP Right Cessation
- 1988-10-14 WO PCT/US1988/003644 patent/WO1989003891A1/en unknown
- 1988-10-17 DE DE3854956T patent/DE3854956T2/de not_active Expired - Fee Related
- 1988-10-17 AT AT88309697T patent/ATE133713T1/de not_active IP Right Cessation
- 1988-10-17 ES ES88309697T patent/ES2083363T3/es not_active Expired - Lifetime
- 1988-10-17 EP EP88309697A patent/EP0317077B1/en not_active Expired - Lifetime
-
1989
- 1989-06-15 DK DK198902945A patent/DK175932B1/da active
-
1996
- 1996-02-21 GR GR960400449T patent/GR3019046T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE3854956D1 (de) | 1996-03-14 |
CA1339351C (en) | 1997-08-26 |
EP0317077A1 (en) | 1989-05-14 |
IE75211B1 (en) | 1997-08-27 |
IE883131L (en) | 1989-04-15 |
DK294589D0 (da) | 1989-06-15 |
WO1989003891A1 (en) | 1989-05-05 |
EP0317077B1 (en) | 1996-01-31 |
ATE133713T1 (de) | 1996-02-15 |
DE3854956T2 (de) | 1996-06-13 |
DK175932B1 (da) | 2005-07-18 |
DK294589A (da) | 1989-08-15 |
GR3019046T3 (en) | 1996-05-31 |
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