ES2079531T3 - 3-(1,2-bencisoxazol-3-il)-4-piridinaminas y derivados. - Google Patents

3-(1,2-bencisoxazol-3-il)-4-piridinaminas y derivados.

Info

Publication number
ES2079531T3
ES2079531T3 ES91113335T ES91113335T ES2079531T3 ES 2079531 T3 ES2079531 T3 ES 2079531T3 ES 91113335 T ES91113335 T ES 91113335T ES 91113335 T ES91113335 T ES 91113335T ES 2079531 T3 ES2079531 T3 ES 2079531T3
Authority
ES
Spain
Prior art keywords
hydrogen
derivatives
pyridinamines
benzisoxazol
loweralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91113335T
Other languages
English (en)
Inventor
Joseph Thomas Klein
Richard Charles Effland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2079531T3 publication Critical patent/ES2079531T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

3-(1, 2-BENZISOXAZOL-3-IL)-4-PIRIDINAMINAS Y DERIVADOS LA INVENCION SE REFIERE A 3-(1, 2-BENZISOXAZOL-3-IL)-4-PIRIDINAMINAS QUE TIENEN LA FORMULA DONDE R SUB 1 ES HIDROGENO, ALQUILO INFERIOR, ARILALQUILO O ACILO; R SUB 2 ES HIDROGENO, ALQUILO INFERIOR O ARILALQUILO, X ES HIDROGENO, HALOGENO, NITRO O AMINO; O LAS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES DE LAS MISMAS Y, CUANDO PROCEDA, LOS ISOMEROS GEOMETRICOS Y OPTICOS Y MEZCLAS RACEMICAS DE LAS MISMAS. LOS COMPUESTOS DE LA INVENCION SON UTILES COMO ANALGESICOS, PARA ALIVIAR VARIAS DISFUNCIONES DE LA MEMORIA CARACTERIZADAS POR UNA DISMINUCION DE LA FUNCION COLINESPICA, COMO INTERSIFICADORES DE LA COGNICION EN EL TRATAMIENTO DE LA DEMENCIA SENIL COMO POR EJEMPLO LA ENFERMEDAD DE ALZHEIMER Y COMO AGENTES ANTIINFLAMATORIOS TOPICOS PARA EL TRATAMIENTO DE VARIAS DERMATOSIS.
ES91113335T 1990-08-13 1991-08-08 3-(1,2-bencisoxazol-3-il)-4-piridinaminas y derivados. Expired - Lifetime ES2079531T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/566,932 US5055476A (en) 1990-08-13 1990-08-13 3-(1,2-benzisoxazol-3-yl)-4-pyridinamines and derivatives

Publications (1)

Publication Number Publication Date
ES2079531T3 true ES2079531T3 (es) 1996-01-16

Family

ID=24265033

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91113335T Expired - Lifetime ES2079531T3 (es) 1990-08-13 1991-08-08 3-(1,2-bencisoxazol-3-il)-4-piridinaminas y derivados.

Country Status (24)

Country Link
US (1) US5055476A (es)
EP (1) EP0471297B1 (es)
JP (1) JP3057829B2 (es)
KR (1) KR100191386B1 (es)
AT (1) ATE130004T1 (es)
AU (1) AU633791B2 (es)
CA (1) CA2048959C (es)
CZ (1) CZ280568B6 (es)
DE (1) DE69114405T2 (es)
DK (1) DK0471297T3 (es)
ES (1) ES2079531T3 (es)
FI (1) FI103970B (es)
GR (1) GR3018184T3 (es)
HU (1) HU213201B (es)
IE (1) IE70597B1 (es)
IL (1) IL99166A (es)
MX (1) MX9100639A (es)
NO (1) NO179519C (es)
NZ (1) NZ239326A (es)
PT (1) PT98645B (es)
RU (1) RU2012561C1 (es)
TW (1) TW202446B (es)
YU (1) YU140991A (es)
ZA (1) ZA916342B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5308826A (en) * 1993-04-22 1994-05-03 Zeneca Limited Herbicidal 4-substituted pyridyl-3-carbinols
BR9507595A (pt) * 1994-05-02 1997-09-16 Zeneca Ltd Composto composição herbicida processo para controlar vegetação indesejável
US5595958A (en) * 1994-05-02 1997-01-21 Zeneca Limited 3-substituted pyridine compounds and derivatives thereof
EA031153B1 (ru) 2011-06-10 2018-11-30 Мерк Патент Гмбх Применение пиримидиновых соединений с btk ингибирующей активностью
RU2626650C2 (ru) * 2015-08-31 2017-07-31 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" 2-Арил-2,4-дигидрокси-2,5-дигидро-3-гетерил-5-оксо-1Н-пиррол-1-ил-4-метилбелзолсульфаниламиды, обладающие анальгетической активностью
WO2023083445A1 (en) 2021-11-10 2023-05-19 Symrise Ag Compositions comprising trpm8 agonistic cooling agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
IL66866A (en) * 1982-04-09 1987-08-31 Hoechst Roussel Pharma 1-(3-(6-fluoro-1,2-benzisoxazol-3-yl)propyl)-4-(substituted)-piperazines and-piperidines,a process for the preparation thereof,and pharmaceutical compositions containing them
CA1335289C (en) * 1987-10-26 1995-04-18 Fujio Antoku Piperidinyl benzisoxazole derivatives, their production and pharmaceutical use
MY107955A (en) * 1990-07-27 1996-07-15 Ici Plc Fungicides.

Also Published As

Publication number Publication date
ZA916342B (en) 1992-04-29
FI103970B1 (fi) 1999-10-29
ATE130004T1 (de) 1995-11-15
NO913142L (no) 1992-02-14
CA2048959C (en) 2003-07-29
CZ280568B6 (cs) 1996-02-14
IL99166A0 (en) 1992-07-15
PT98645A (pt) 1992-06-30
CA2048959A1 (en) 1992-02-14
HU912673D0 (en) 1992-01-28
DE69114405D1 (de) 1995-12-14
FI913800A (fi) 1992-02-14
EP0471297B1 (en) 1995-11-08
NO913142D0 (no) 1991-08-12
RU2012561C1 (ru) 1994-05-15
DE69114405T2 (de) 1996-05-02
HUT61755A (en) 1993-03-01
CS248991A3 (en) 1992-03-18
IE70597B1 (en) 1996-12-11
JP3057829B2 (ja) 2000-07-04
JPH05112562A (ja) 1993-05-07
NZ239326A (en) 1994-04-27
PT98645B (pt) 1999-01-29
HU213201B (en) 1997-03-28
DK0471297T3 (da) 1996-03-04
MX9100639A (es) 1992-04-01
US5055476A (en) 1991-10-08
NO179519B (no) 1996-07-15
FI913800A0 (fi) 1991-08-09
KR920004383A (ko) 1992-03-27
IE912851A1 (en) 1992-02-26
FI103970B (fi) 1999-10-29
KR100191386B1 (ko) 1999-06-15
TW202446B (es) 1993-03-21
AU633791B2 (en) 1993-02-04
YU140991A (sh) 1995-01-31
AU8176591A (en) 1992-02-20
NO179519C (no) 1996-10-23
IL99166A (en) 1995-12-08
EP0471297A1 (en) 1992-02-19
GR3018184T3 (en) 1996-02-29

Similar Documents

Publication Publication Date Title
GR3030798T3 (en) 2-(Piperidin-4-yl, pyridin-4-yl and tetrahydropyridin-4-yl)benzofuran-7-ol and carbamate derivatives, their preparation and their use as acetylcholinesterase inhibitors.
ES2079531T3 (es) 3-(1,2-bencisoxazol-3-il)-4-piridinaminas y derivados.
AU640590B2 (en) 3-(1h-indazol-3-yl)-4-pyridinamines
FI920566A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten 9-aminotetrahydroakridiinien ja niiden johdannaisten valmistamiseksi
ES2079530T3 (es) 1-(piridinilalquil)-1h-indoles, -indolinas y compuestos analogos relacionados.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 471297

Country of ref document: ES