ES2079530T3 - 1-(piridinilalquil)-1h-indoles, -indolinas y compuestos analogos relacionados. - Google Patents

1-(piridinilalquil)-1h-indoles, -indolinas y compuestos analogos relacionados.

Info

Publication number
ES2079530T3
ES2079530T3 ES91113333T ES91113333T ES2079530T3 ES 2079530 T3 ES2079530 T3 ES 2079530T3 ES 91113333 T ES91113333 T ES 91113333T ES 91113333 T ES91113333 T ES 91113333T ES 2079530 T3 ES2079530 T3 ES 2079530T3
Authority
ES
Spain
Prior art keywords
hydrogen
loweralkyl
compounds
piridinilalquil
indolines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91113333T
Other languages
English (en)
Inventor
Richard Charles Effland
Larry Davis
Gordon E Olsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Hoechst Roussel Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2079530T3 publication Critical patent/ES2079530T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Display Devices Of Pinball Game Machines (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS QUE TIENEN LA FORMULA EN DONDE R SUB 1 ES HIDROGENO, ALQUILO INFERIOR, ARILALQUILO INFERIOR, ALQUENILO INFERIOR O ALQUINILO INFERIOR; R SUB 2 ES HIDROGENO, ALQUILO INFERIOR, ALQUENILO INFERIOR, FORMILO O CIANO; X ES HIDROGENO, HALOGENO, NITRO, AMINO, ALQUILO INFERIOR, ALCOXI INFERIOR O HIDROXI; Y ES HIDROGENO, ALQUILO INFERIOR, ALCOXI INFERIOR, ARILALCOXI INFERIOR, HIDROXI, HALOGENO, NITRO O AMINO; LAS SALES DE ADICION ACIDAS FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS Y , CUANDO PROCEDA, LOS ISOMEROS GEOMETRICOS Y OPTICOS Y MEZCLAS RACEMICAS DE LOS MISMOS. LOS COMPUESTOS DE LA INVENCION SON UTILES PARA EL TRATAMIENTO DE VARIAS DISFUNCIONES DE LA MEMORIA CARACTERIZADAS POR UNA DISMINUCION DE LA FUNCION COLINERGICA, COMO POR EJEMPLO LA ENFERMEDAD DE ALZHEIMER.
ES91113333T 1990-08-13 1991-08-08 1-(piridinilalquil)-1h-indoles, -indolinas y compuestos analogos relacionados. Expired - Lifetime ES2079530T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56657590A 1990-08-13 1990-08-13

Publications (1)

Publication Number Publication Date
ES2079530T3 true ES2079530T3 (es) 1996-01-16

Family

ID=24263468

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91113333T Expired - Lifetime ES2079530T3 (es) 1990-08-13 1991-08-08 1-(piridinilalquil)-1h-indoles, -indolinas y compuestos analogos relacionados.

Country Status (20)

Country Link
EP (1) EP0471296B1 (es)
JP (1) JP3057828B2 (es)
KR (1) KR100223133B1 (es)
AT (1) ATE130002T1 (es)
AU (1) AU637249B2 (es)
CA (1) CA2048980C (es)
CS (1) CS249191A3 (es)
DE (1) DE69114404T2 (es)
DK (1) DK0471296T3 (es)
ES (1) ES2079530T3 (es)
FI (1) FI103341B (es)
GR (1) GR3018187T3 (es)
HU (1) HUT58722A (es)
IE (1) IE70596B1 (es)
IL (1) IL99168A (es)
MX (1) MX9100638A (es)
NO (1) NO179583C (es)
NZ (2) NZ260632A (es)
PL (1) PL291408A1 (es)
ZA (1) ZA916341B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5068234A (en) * 1990-02-26 1991-11-26 Sterling Drug Inc. 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
DK0471298T3 (da) * 1990-08-13 1996-03-04 Hoechst Roussel Pharma Carbamoyl-1-(pyridinylalkyl)-1H-indoler, -indoliner og belægtede forbindelser
FR2674522B1 (fr) * 1991-03-26 1993-07-16 Lipha Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.
WO2003087087A2 (en) * 2002-04-09 2003-10-23 Astex Technology Limited Heterocyclic compounds and their use as modulators of p38 map kinase

Also Published As

Publication number Publication date
NZ260632A (en) 1997-06-24
HUT58722A (en) 1992-03-30
PL291408A1 (en) 1992-12-28
NO913140D0 (no) 1991-08-12
KR920004379A (ko) 1992-03-27
CA2048980C (en) 2003-05-13
AU637249B2 (en) 1993-05-20
ATE130002T1 (de) 1995-11-15
HU912674D0 (en) 1992-01-28
NO179583B (no) 1996-07-29
CS249191A3 (en) 1992-03-18
DK0471296T3 (da) 1996-03-11
FI103341B1 (fi) 1999-06-15
NZ239328A (en) 1996-03-26
NO913140L (no) 1992-02-14
EP0471296B1 (en) 1995-11-08
CA2048980A1 (en) 1992-02-14
DE69114404T2 (de) 1996-05-02
IL99168A0 (en) 1992-07-15
EP0471296A1 (en) 1992-02-19
IL99168A (en) 1995-07-31
FI103341B (fi) 1999-06-15
AU8176791A (en) 1992-02-20
FI913799A (fi) 1992-02-14
FI913799A0 (fi) 1991-08-09
IE912850A1 (en) 1992-02-26
NO179583C (no) 1996-11-06
IE70596B1 (en) 1996-12-11
JP3057828B2 (ja) 2000-07-04
MX9100638A (es) 1992-04-01
GR3018187T3 (en) 1996-02-29
JPH05132481A (ja) 1993-05-28
ZA916341B (en) 1992-04-29
KR100223133B1 (ko) 1999-10-15
DE69114404D1 (de) 1995-12-14

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ES2079530T3 (es) 1-(piridinilalquil)-1h-indoles, -indolinas y compuestos analogos relacionados.
ES2079532T3 (es) Carbamoil-1-(piridinilalquil)-1h-indoles, indolinas y analogos relacionados.

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