ES2077998T3 - Derivados de 2-aminopirimidina-4-carboxamida, su preparacion y su aplicacion terapeutica. - Google Patents

Derivados de 2-aminopirimidina-4-carboxamida, su preparacion y su aplicacion terapeutica.

Info

Publication number
ES2077998T3
ES2077998T3 ES92401773T ES92401773T ES2077998T3 ES 2077998 T3 ES2077998 T3 ES 2077998T3 ES 92401773 T ES92401773 T ES 92401773T ES 92401773 T ES92401773 T ES 92401773T ES 2077998 T3 ES2077998 T3 ES 2077998T3
Authority
ES
Spain
Prior art keywords
aminopyrimidine
carboxamide
derivatives
preparation
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92401773T
Other languages
English (en)
Inventor
Pascal George
Philippe Manoury
Benoit Marabout
Jacques Froissant
Jean-Pierre Merly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Application granted granted Critical
Publication of ES2077998T3 publication Critical patent/ES2077998T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

COMPUESTO QUE RESPONDE A LA FORMULA GENERAL (I) EN LA QUE N = 2 O 3, X = H, CL O OCH3, R = H O CH3, R1 = H O CH3, R2 = ALKILO, HIDROXIALKILO, (HIDROXI) (METOXI)ALKILO, DIMETOXIALKILO, 2-(AMINOSULFONIL)ETILO, 2-(METILSULFONIL)ETILO, 2-(METILSULFONILAMINO)ETILO, AMINOCARBONILMETILO EVENTUALMENTE SUSTITUIDO POR NITROGENO, FENILETILO EVENTUALMENTE SUSTITUIDO, PIRIMIDINILAMINOALKILO O ARILCARBONILAMINOALKILO, O BIEN R1 Y R2 FORMAN, CON EL NITROGENO QUE LOS LLEVA, UN CICLO DE PIPERIDINA, MORFOLINA, TIOMORFOLINA O PIPERAZINA EVENTUALMENTE SUTITUIDO POR NITROGENO. APLICACION EN TERAPIA.
ES92401773T 1991-06-27 1992-06-24 Derivados de 2-aminopirimidina-4-carboxamida, su preparacion y su aplicacion terapeutica. Expired - Lifetime ES2077998T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9107939A FR2678272B1 (fr) 1991-06-27 1991-06-27 Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.

Publications (1)

Publication Number Publication Date
ES2077998T3 true ES2077998T3 (es) 1995-12-01

Family

ID=9414359

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92401773T Expired - Lifetime ES2077998T3 (es) 1991-06-27 1992-06-24 Derivados de 2-aminopirimidina-4-carboxamida, su preparacion y su aplicacion terapeutica.

Country Status (23)

Country Link
US (1) US5244894A (es)
EP (1) EP0520883B1 (es)
JP (1) JP3159526B2 (es)
KR (1) KR930000508A (es)
CN (1) CN1067885A (es)
AT (1) ATE124935T1 (es)
AU (1) AU644295B2 (es)
CA (1) CA2072433A1 (es)
CZ (1) CZ9202003A3 (es)
DE (1) DE69203402T2 (es)
DK (1) DK0520883T3 (es)
ES (1) ES2077998T3 (es)
FI (1) FI922982A (es)
FR (1) FR2678272B1 (es)
GR (1) GR3017249T3 (es)
HU (1) HUT61749A (es)
IE (1) IE922094A1 (es)
IL (1) IL102332A0 (es)
MX (1) MX9203333A (es)
NO (1) NO922525L (es)
NZ (1) NZ243340A (es)
PL (1) PL295045A1 (es)
ZA (1) ZA924785B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0598046T3 (da) * 1991-08-14 1999-05-25 Procter & Gamble Pharma Hidtil ukendte urinstoffer egnede som antiarrytmi- og antifibrilleringsmidler
DK0577470T3 (da) * 1992-07-03 1995-10-02 Synthelabo 2-amino-N(((4-(aminocarbonyl)pyrimidin-2-yl)amino)alkyl) pyrimidin-4-carboxamid-derivater, deres fremstilling og deres anvendelse i terapi
FR2703355B1 (fr) * 1993-03-29 1995-05-05 Synthelabo Dérivés de 2-aminopyrimidine-4-carboxamide, leur préparation et leur application en thérapeutique.
DE4425143A1 (de) * 1994-07-15 1996-01-18 Basf Ag Substituierte Pyrimidinverbindungen und deren Verwendung
US5688795A (en) * 1994-11-08 1997-11-18 Syntex (U.S.A.) Inc. 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists
FR2744722B1 (fr) * 1996-02-14 1998-03-13 Synthelabo Devires de 2-((3-(piperazin-1-yl)propyl)amino)pyrimidine-4- carboxamide et leur application en therapeutique
WO1999057131A1 (en) 1998-05-06 1999-11-11 Duke University Method of treating bladder and lower urinary tract syndromes
US7064211B2 (en) * 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
JP2008504279A (ja) * 2004-06-24 2008-02-14 インサイト・コーポレイション アミド化合物およびその医薬としての使用
AU2005258248A1 (en) * 2004-06-24 2006-01-05 Incyte Corporation Amido compounds and their use as pharmaceuticals
US7687665B2 (en) * 2004-06-24 2010-03-30 Incyte Corporation 2-methylprop anamides and their use as pharmaceuticals
EA200700117A1 (ru) 2004-06-24 2007-06-29 Инсайт Корпорейшн N-замещенные пиперидины и их применение в качестве фармацевтических препаратов
MX2007001540A (es) * 2004-08-10 2007-04-23 Incyte Corp Compuestos amido y sus usos como farmaceuticos.
CA2872883A1 (en) * 2012-05-09 2013-11-14 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2143730A1 (de) * 1971-09-01 1973-03-08 Byk Gulden Lomberg Chem Fab Substituierte pyridine, verfahren zu deren herstellung und sie enthaltende arzneimittel
FR2656609B1 (fr) * 1989-12-28 1992-03-27 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
FR2678271B1 (fr) * 1991-06-27 1995-01-13 Synthelabo Derives de pyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
MX9203333A (es) 1993-02-01
CZ9202003A3 (en) 1993-01-13
HUT61749A (en) 1993-03-01
FI922982A (fi) 1992-12-28
FR2678272B1 (fr) 1994-01-14
HU9202143D0 (en) 1992-10-28
IL102332A0 (en) 1993-01-14
IE922094A1 (en) 1992-12-30
NO922525L (no) 1992-12-28
CN1067885A (zh) 1993-01-13
FR2678272A1 (fr) 1992-12-31
DK0520883T3 (da) 1995-12-11
AU1858892A (en) 1993-01-07
ATE124935T1 (de) 1995-07-15
JP3159526B2 (ja) 2001-04-23
DE69203402D1 (de) 1995-08-17
NO922525D0 (no) 1992-06-26
FI922982A0 (fi) 1992-06-26
EP0520883B1 (fr) 1995-07-12
JPH05186435A (ja) 1993-07-27
ZA924785B (en) 1993-03-31
PL295045A1 (en) 1993-03-08
EP0520883A1 (fr) 1992-12-30
CA2072433A1 (en) 1992-12-28
GR3017249T3 (en) 1995-11-30
DE69203402T2 (de) 1996-03-07
AU644295B2 (en) 1993-12-02
US5244894A (en) 1993-09-14
KR930000508A (ko) 1993-01-15
NZ243340A (en) 1994-02-25

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