ES2076146T3 - Derivados de desaza-purina-nucleosidos, procedimiento para su preparacion asi como su utilizacion en el secuenciamiento de acidos nucleicos y en calidad de agentes antiviricos. - Google Patents

Derivados de desaza-purina-nucleosidos, procedimiento para su preparacion asi como su utilizacion en el secuenciamiento de acidos nucleicos y en calidad de agentes antiviricos.

Info

Publication number
ES2076146T3
ES2076146T3 ES88105277T ES88105277T ES2076146T3 ES 2076146 T3 ES2076146 T3 ES 2076146T3 ES 88105277 T ES88105277 T ES 88105277T ES 88105277 T ES88105277 T ES 88105277T ES 2076146 T3 ES2076146 T3 ES 2076146T3
Authority
ES
Spain
Prior art keywords
group
denotes
nucleic acids
hydrogen
sequencing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88105277T
Other languages
English (en)
Inventor
Frank Seela
Heinz-Peter Muth
Klaus Kaiser
Werner Bourgeois
Klaus Muehlegger
Herbert Von Der Eltz
Hans-Georg Batz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of ES2076146T3 publication Critical patent/ES2076146T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Abstract

NUEVOS DESAZA-PURIN-NUCLEOSIDOS DE FORMULA (I) X, W, R1, R2, R3, R4, R5, R6 Y R7 TIENEN EL SIGNIFICADO QUE SE DETALLA EN LA INVENCION. SE PREENTAN TAMBIEN LOS POSIBLES TAUTOMEROS, SALES Y ACIDOS NUCLEICOS QUE CONTIENEN UNO O MAS COMPUESTOS DE FORMULA (I) COMO PIEZA ESTRUCTURAL. TAMBIEN SE REIVINDICAN PROCEDIMIENTOS PARA LA OBTENCION DE ESTOS COMPUESTOS, LAS SALES PRESENTAN PROPIEDADES ANTIVIRIASICAS Y SE PUEDEN EMPLEAR ADEMAS PARA LA SECUENCIACION DE ADN EN LA QUE DAN LUGAR A LA RUPTURA DE CADENA Y/O A LA COMPRESION DE BANDAS.
ES88105277T 1987-04-10 1988-03-31 Derivados de desaza-purina-nucleosidos, procedimiento para su preparacion asi como su utilizacion en el secuenciamiento de acidos nucleicos y en calidad de agentes antiviricos. Expired - Lifetime ES2076146T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3712280 1987-04-10
DE19873739366 DE3739366A1 (de) 1987-04-10 1987-11-20 Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel

Publications (1)

Publication Number Publication Date
ES2076146T3 true ES2076146T3 (es) 1995-11-01

Family

ID=25854556

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88105277T Expired - Lifetime ES2076146T3 (es) 1987-04-10 1988-03-31 Derivados de desaza-purina-nucleosidos, procedimiento para su preparacion asi como su utilizacion en el secuenciamiento de acidos nucleicos y en calidad de agentes antiviricos.

Country Status (11)

Country Link
EP (1) EP0286028B1 (es)
JP (2) JPH0662663B2 (es)
KR (1) KR880012631A (es)
CN (1) CN88102038A (es)
AT (1) ATE124415T1 (es)
AU (1) AU597483B2 (es)
CA (1) CA1311201C (es)
DE (2) DE3739366A1 (es)
DK (1) DK194688A (es)
ES (1) ES2076146T3 (es)
HU (1) HU199871B (es)

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US5661148A (en) * 1989-09-19 1997-08-26 Teijin Limited Pyrrolo[2,3-d]pyrimidine derivatives, process for producing the same and pharmaceutical preparation comprising the same as active ingredient
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AU6485996A (en) * 1995-07-06 1997-02-05 Board Of Regents, The University Of Texas System Methods and compositions for modulation and inhibition of teomerase
US6004939A (en) * 1995-07-06 1999-12-21 Ctrc Research Foundation Board Of Regents Methods for modulation and inhibition of telomerase
US6291164B1 (en) 1996-11-22 2001-09-18 Invitrogen Corporation Methods for preventing inhibition of nucleic acid synthesis by pyrophosphate
GB2323357B (en) * 1997-03-20 1999-09-29 Amersham Pharm Biotech Inc Derivatives of 7-deaza-2-deoxy-guanosine-5'-triphosphate, preparation and use thereof
US6143206A (en) * 1998-06-24 2000-11-07 Tdk Corporation Organic positive temperature coefficient thermistor and manufacturing method therefor
JP3619017B2 (ja) * 1998-06-24 2005-02-09 日本臓器製薬株式会社 新規アラビノシルアデニン誘導体
US6452476B1 (en) 1999-01-28 2002-09-17 Tdk Corporation Organic positive temperature coefficient thermistor
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US6660845B1 (en) 1999-11-23 2003-12-09 Epoch Biosciences, Inc. Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof
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Also Published As

Publication number Publication date
KR880012631A (ko) 1988-11-28
JPH0748396A (ja) 1995-02-21
DE3739366A1 (de) 1988-10-27
DE3854060D1 (de) 1995-08-03
HUT46703A (en) 1988-11-28
EP0286028A2 (de) 1988-10-12
DK194688A (da) 1988-10-11
ATE124415T1 (de) 1995-07-15
HU199871B (en) 1990-03-28
DK194688D0 (da) 1988-04-08
AU597483B2 (en) 1990-05-31
AU1439888A (en) 1988-10-13
EP0286028B1 (de) 1995-06-28
JPS63275598A (ja) 1988-11-14
JP2675749B2 (ja) 1997-11-12
CN88102038A (zh) 1988-10-26
EP0286028A3 (en) 1990-05-30
JPH0662663B2 (ja) 1994-08-17
CA1311201C (en) 1992-12-08

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