DK0494370T3 - Antivirale (phosphonomethoxy)methoxypurin/pyrimidinderivater - Google Patents

Antivirale (phosphonomethoxy)methoxypurin/pyrimidinderivater

Info

Publication number
DK0494370T3
DK0494370T3 DK91120288.5T DK91120288T DK0494370T3 DK 0494370 T3 DK0494370 T3 DK 0494370T3 DK 91120288 T DK91120288 T DK 91120288T DK 0494370 T3 DK0494370 T3 DK 0494370T3
Authority
DK
Denmark
Prior art keywords
phosphonomethoxy
pyrimidine derivatives
methoxypurine
antiviral
compositions
Prior art date
Application number
DK91120288.5T
Other languages
English (en)
Inventor
John C Martin
Choung Un Kim
Bing Yu Luh
Peter F Misco
Original Assignee
Rega Stichting
Acad Of Science Czech Republic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rega Stichting, Acad Of Science Czech Republic filed Critical Rega Stichting
Application granted granted Critical
Publication of DK0494370T3 publication Critical patent/DK0494370T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DK91120288.5T 1990-11-29 1991-11-27 Antivirale (phosphonomethoxy)methoxypurin/pyrimidinderivater DK0494370T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/619,856 US5208221A (en) 1990-11-29 1990-11-29 Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives

Publications (1)

Publication Number Publication Date
DK0494370T3 true DK0494370T3 (da) 1995-08-28

Family

ID=24483605

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91120288.5T DK0494370T3 (da) 1990-11-29 1991-11-27 Antivirale (phosphonomethoxy)methoxypurin/pyrimidinderivater

Country Status (8)

Country Link
US (2) US5208221A (da)
EP (1) EP0494370B1 (da)
JP (1) JP3172803B2 (da)
AT (1) ATE124412T1 (da)
CA (1) CA2054870C (da)
DE (1) DE69110854T2 (da)
DK (1) DK0494370T3 (da)
ES (1) ES2074637T3 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208221A (en) * 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
CA2171868A1 (en) * 1993-09-17 1995-03-23 Petr Alexander Method for dosing therapeutic compounds
US5502177A (en) 1993-09-17 1996-03-26 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US5798340A (en) * 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
US5656745A (en) * 1993-09-17 1997-08-12 Gilead Sciences, Inc. Nucleotide analogs
US5977061A (en) * 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
US5969135A (en) * 1995-11-02 1999-10-19 Icn Pharmaceuticals, Inc. Oligonucleotide analogs with an amino acid or a modified amino alcohol residue
US6093816A (en) 1996-06-27 2000-07-25 Isis Pharmaceuticals, Inc. Cationic lipids
US5922695A (en) * 1996-07-26 1999-07-13 Gilead Sciences, Inc. Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
US6765019B1 (en) 1999-05-06 2004-07-20 University Of Kentucky Research Foundation Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
EP1244668B1 (en) * 2000-01-07 2006-04-05 Universitaire Instelling Antwerpen Purine derivatives, process for their preparation and use thereof
JP4651264B2 (ja) 2000-07-21 2011-03-16 ギリアード サイエンシーズ， インコーポレイテッド ホスホネートヌクレオチドアナログのプロドラッグならびにこれを選択および作製するための方法。
TR200302288T2 (tr) 2001-06-29 2004-12-21 Institute Of Organic Chemistry And Biochemistry Academy Of Terapi için yeni bileşikler ve metotlar.
US20040023928A1 (en) * 2001-10-31 2004-02-05 Colacino Joseph Matthew Phosphonate nucleotide and thiadiazole compounds for the treatment of smallpox
US7247621B2 (en) * 2002-04-30 2007-07-24 Valeant Research & Development Antiviral phosphonate compounds and methods therefor
US20040224917A1 (en) 2003-01-14 2004-11-11 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
ATE496056T1 (de) 2003-06-16 2011-02-15 Acad Of Science Czech Republic Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
CA2616314A1 (en) * 2005-07-27 2007-02-01 Gilead Sciences, Inc. Antiviral phosphonate conjugates for inhibition of hiv
TWI444384B (zh) 2008-02-20 2014-07-11 Gilead Sciences Inc 核苷酸類似物及其在治療惡性腫瘤上的用途
CN114588161A (zh) * 2020-12-07 2022-06-07 四川大学华西医院 具有防治肺炎作用的次黄碱衍生物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868187A (en) * 1980-09-16 1989-09-19 Syntex (U.S.A.) Inc. Anti-viral N-substituted pyrimidines
DE3277837D1 (en) * 1982-08-06 1988-01-28 Engineering Ind Inc Emulsion package and method of mixing the emulsion
CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
US4850010A (en) * 1985-11-25 1989-07-18 Alcatel N.V. Telemetry terminal
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
AU613592B2 (en) * 1986-11-18 1991-08-08 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosophonomethoxy-alkyene purine and pyrimide derivatives
DE3790883T1 (da) * 1987-01-20 1988-12-08
DE3721959A1 (de) * 1987-07-03 1989-01-19 Mannesmann Kienzle Gmbh Geber fuer den betriebszustand von bremsen
NZ227104A (en) * 1987-11-30 1991-11-26 Beecham Group Plc Phosphorus-substituted purine derivatives and pharmaceutical compositions
EP0338168A1 (en) * 1988-04-19 1989-10-25 Merrell Dow Pharmaceuticals Inc. Phosphonoalkylpurine derivatives
SE8801729D0 (sv) * 1988-05-06 1988-05-06 Astra Ab Purine derivatives for use in therapy
US4952707A (en) * 1988-06-30 1990-08-28 Tropix, Inc. Enzymatically-cleavable chemiluminescent fused polycyclic ring-containing 1,2-dioxetanes
EP0353955A3 (en) * 1988-08-02 1991-08-14 Beecham Group Plc Novel compounds
GB8907173D0 (en) * 1989-03-30 1989-05-10 Beecham Group Plc Novel compounds
US4988703A (en) * 1989-05-22 1991-01-29 Abbott Laboratories Carbocyclic nucleoside analogs with antiviral activity
GB8912043D0 (en) * 1989-05-25 1989-07-12 Beecham Group Plc Novel compounds
US5208221A (en) * 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives

Also Published As

Publication number Publication date
CA2054870C (en) 1995-08-29
US5386030A (en) 1995-01-31
JP3172803B2 (ja) 2001-06-04
DE69110854D1 (de) 1995-08-03
EP0494370B1 (en) 1995-06-28
ES2074637T3 (es) 1995-09-16
JPH04266893A (ja) 1992-09-22
US5208221A (en) 1993-05-04
CA2054870A1 (en) 1992-05-30
EP0494370A1 (en) 1992-07-15
DE69110854T2 (de) 1995-12-07
ATE124412T1 (de) 1995-07-15

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