DK0704445T3 - Fremstilling af N-9-substituerede guaninforbindelser - Google Patents

Fremstilling af N-9-substituerede guaninforbindelser

Info

Publication number
DK0704445T3
DK0704445T3 DK95111473T DK95111473T DK0704445T3 DK 0704445 T3 DK0704445 T3 DK 0704445T3 DK 95111473 T DK95111473 T DK 95111473T DK 95111473 T DK95111473 T DK 95111473T DK 0704445 T3 DK0704445 T3 DK 0704445T3
Authority
DK
Denmark
Prior art keywords
preparation
substituted guanine
guanine compounds
compounds
substituted
Prior art date
Application number
DK95111473T
Other languages
English (en)
Inventor
Eric Lodewijk
Yeun-Kwei Han
George Charles Schloemer
Sam Linh Nguyen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK0704445T3 publication Critical patent/DK0704445T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
DK95111473T 1994-08-04 1995-07-21 Fremstilling af N-9-substituerede guaninforbindelser DK0704445T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/286,045 US5565565A (en) 1994-08-04 1994-08-04 Preparation of N-9 substituted guanine compounds

Publications (1)

Publication Number Publication Date
DK0704445T3 true DK0704445T3 (da) 1999-10-25

Family

ID=23096824

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95111473T DK0704445T3 (da) 1994-08-04 1995-07-21 Fremstilling af N-9-substituerede guaninforbindelser

Country Status (9)

Country Link
US (1) US5565565A (da)
EP (1) EP0704445B1 (da)
JP (1) JP2944474B2 (da)
KR (1) KR100218610B1 (da)
CN (2) CN1051084C (da)
AT (1) ATE179174T1 (da)
DE (1) DE69509182T2 (da)
DK (1) DK0704445T3 (da)
ES (1) ES2131730T3 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997024357A1 (en) * 1995-12-28 1997-07-10 Mallinckrodt Chemical, Inc. Process for synthesis and purification of a compound useful in the preparation of acyclovir
US6040446A (en) * 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
EP0976751A1 (en) * 1996-04-09 2000-02-02 Lupin Laboratories Limited A process for the isomerisation of an N-7 isomer into an N-9 isomer useful in the synthesis of acyclic nucleosides
JPH11192744A (ja) 1997-12-29 1999-07-21 Canon Inc Ｌｅｄアレイ駆動装置および方法
CN1091445C (zh) * 1999-12-29 2002-09-25 湖北省医药工业研究院 抗病毒药物中间体、它们的制备及应用
US20050176956A1 (en) * 2001-10-15 2005-08-11 Babu Jayachandra S. Process for the preparation of ganciclovir intermediate n2-acetyl-9-(1,3-diacetoxy-2-propoxymethyl) guanine
US7078524B2 (en) * 2002-11-22 2006-07-18 Ranbaxy Laboratories Limited Process for the synthesis of ganciclovir
ZA200702234B (en) * 2006-03-21 2008-07-30 Cipla Ltd Preparation of ester of purine derivatives
US7497521B2 (en) * 2006-08-30 2009-03-03 Honda Motor Co., Ltd Seat belt retractor mounting system
EP2170191B1 (en) * 2007-06-28 2015-12-09 Spinal Elements, Inc. Spinal stabilization device
CA2697710A1 (en) * 2007-08-24 2009-03-05 Spinal Elements, Inc. Loop rod spinal stabilization device
CN108503668A (zh) * 2018-05-11 2018-09-07 浙江华贝药业有限责任公司 一种三甲基苯氧基硅烷的合成方法
CN114047262A (zh) * 2021-10-14 2022-02-15 湖北省宏源药业科技股份有限公司 一种分离测定易水解大极性化合物的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
KR880002276B1 (ko) * 1981-08-11 1988-10-21 더 웰컴 화운데이션 리미티드 항비루스성 화합물의 제조방법
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4621140A (en) * 1984-02-23 1986-11-04 Syntex (U.S.A.) Inc. Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives
DE3627024A1 (de) * 1985-09-24 1987-04-02 Hoechst Ag In 6- und 9-stellung substituierte 2-aminopurine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
DE3631562A1 (de) * 1986-09-17 1988-03-31 Hoechst Ag In 9-stellung substituierte 2-amino-6-alkoxy-purine, ihre verwendung, diese purine enthaltende arzneimittel und verfahren zur herstellung der purine
JPS63107982A (ja) * 1986-10-27 1988-05-12 Minofuaagen Seiyaku Honpo:Goushi ９−〔（２−ハイドロキシエトキシ）メチル〕−グアニンの製造方法
JP3225545B2 (ja) * 1991-09-18 2001-11-05 味の素株式会社 非環状ヌクレオシド類の製造法
JPH05213903A (ja) * 1991-12-09 1993-08-24 Mitsubishi Kasei Corp アシクロヌクレオシド誘導体の製造方法

Also Published As

Publication number Publication date
CN1137892C (zh) 2004-02-11
KR100218610B1 (ko) 1999-09-01
US5565565A (en) 1996-10-15
DE69509182D1 (de) 1999-05-27
ATE179174T1 (de) 1999-05-15
JP2944474B2 (ja) 1999-09-06
CN1051084C (zh) 2000-04-05
CN1120044A (zh) 1996-04-10
EP0704445B1 (en) 1999-04-21
EP0704445A1 (en) 1996-04-03
JPH0859662A (ja) 1996-03-05
CN1246477A (zh) 2000-03-08
DE69509182T2 (de) 1999-10-21
ES2131730T3 (es) 1999-08-01

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