DE69110854T2 - Antivirusderivate von (Phosphonmethoxy)Methoxy Purin/Pyrimidin. - Google Patents

Antivirusderivate von (Phosphonmethoxy)Methoxy Purin/Pyrimidin.

Info

Publication number
DE69110854T2
DE69110854T2 DE69110854T DE69110854T DE69110854T2 DE 69110854 T2 DE69110854 T2 DE 69110854T2 DE 69110854 T DE69110854 T DE 69110854T DE 69110854 T DE69110854 T DE 69110854T DE 69110854 T2 DE69110854 T2 DE 69110854T2
Authority
DE
Germany
Prior art keywords
phosphonomethoxy
pyrimidine
derivatives
antivirus
purine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69110854T
Other languages
English (en)
Other versions
DE69110854D1 (de
Inventor
Choung Un Kim
John C Martin
Bing Yu Luh
Peter F Misco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stichting Rega VZW
Czech Academy of Sciences CAS
Original Assignee
Stichting Rega VZW
Czech Academy of Sciences CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Rega VZW, Czech Academy of Sciences CAS filed Critical Stichting Rega VZW
Publication of DE69110854D1 publication Critical patent/DE69110854D1/de
Application granted granted Critical
Publication of DE69110854T2 publication Critical patent/DE69110854T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
DE69110854T 1990-11-29 1991-11-27 Antivirusderivate von (Phosphonmethoxy)Methoxy Purin/Pyrimidin. Expired - Lifetime DE69110854T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/619,856 US5208221A (en) 1990-11-29 1990-11-29 Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives

Publications (2)

Publication Number Publication Date
DE69110854D1 DE69110854D1 (de) 1995-08-03
DE69110854T2 true DE69110854T2 (de) 1995-12-07

Family

ID=24483605

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69110854T Expired - Lifetime DE69110854T2 (de) 1990-11-29 1991-11-27 Antivirusderivate von (Phosphonmethoxy)Methoxy Purin/Pyrimidin.

Country Status (8)

Country Link
US (2) US5208221A (de)
EP (1) EP0494370B1 (de)
JP (1) JP3172803B2 (de)
AT (1) ATE124412T1 (de)
CA (1) CA2054870C (de)
DE (1) DE69110854T2 (de)
DK (1) DK0494370T3 (de)
ES (1) ES2074637T3 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208221A (en) * 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
US5656745A (en) * 1993-09-17 1997-08-12 Gilead Sciences, Inc. Nucleotide analogs
US5798340A (en) * 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
AU690587B2 (en) * 1993-09-17 1998-04-30 Gilead Sciences, Inc. Method for dosing therapeutic compounds
US5502177A (en) * 1993-09-17 1996-03-26 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US5977061A (en) * 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
US5969135A (en) * 1995-11-02 1999-10-19 Icn Pharmaceuticals, Inc. Oligonucleotide analogs with an amino acid or a modified amino alcohol residue
US6093816A (en) 1996-06-27 2000-07-25 Isis Pharmaceuticals, Inc. Cationic lipids
US5922695A (en) * 1996-07-26 1999-07-13 Gilead Sciences, Inc. Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
US6765019B1 (en) 1999-05-06 2004-07-20 University Of Kentucky Research Foundation Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids
US20030187261A1 (en) * 2000-01-07 2003-10-02 Libor Havlicek Purine derivatives, process for their preparation and use thereof
HRP20160074B1 (hr) 2000-07-21 2021-09-03 Gilead Sciences, Inc. Prolijekovi koji su fosfonatni analozi nukleotida i metode njihovog odabira te njihova priprava
KR100891366B1 (ko) * 2001-06-29 2009-04-02 인스티튜트 오브 오르가닉 케미스트리 앤드 바이오케미스트리, 어케더미 오브 사이언시스 오브 더 체크 리퍼블릭 항 바이러스 활성을 갖는 6-'2-(포스포노메톡시)알콕시 피리미딘 유도체
US20040023928A1 (en) * 2001-10-31 2004-02-05 Colacino Joseph Matthew Phosphonate nucleotide and thiadiazole compounds for the treatment of smallpox
US7247621B2 (en) * 2002-04-30 2007-07-24 Valeant Research & Development Antiviral phosphonate compounds and methods therefor
EP3025718A1 (de) 2003-01-14 2016-06-01 Gilead Sciences, Inc. Zusammensetzungen und verfahren für antivirale kombinationstherapie
DE602004031115D1 (de) * 2003-06-16 2011-03-03 Acad Of Science Czech Republic Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
CA2616314A1 (en) * 2005-07-27 2007-02-01 Gilead Sciences, Inc. Antiviral phosphonate conjugates for inhibition of hiv
TWI444384B (zh) 2008-02-20 2014-07-11 Gilead Sciences Inc 核苷酸類似物及其在治療惡性腫瘤上的用途
CN114588161A (zh) * 2020-12-07 2022-06-07 四川大学华西医院 具有防治肺炎作用的次黄碱衍生物

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868187A (en) * 1980-09-16 1989-09-19 Syntex (U.S.A.) Inc. Anti-viral N-substituted pyrimidines
GB2133767B (en) * 1982-08-06 1986-02-26 Engineering Ind Inc Emulsion package and method of mixing the emulsion
CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
EP0272446B1 (de) * 1983-05-24 1992-11-11 Sri International Antivirales Mittel
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
WO1987003446A1 (en) * 1985-11-25 1987-06-04 Alcatel N.V. A telemetry terminal
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
AU613592B2 (en) * 1986-11-18 1991-08-08 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosophonomethoxy-alkyene purine and pyrimide derivatives
EP0309491A1 (de) * 1987-01-20 1989-04-05 Sri International Antivirales mittel
DE3721959A1 (de) * 1987-07-03 1989-01-19 Mannesmann Kienzle Gmbh Geber fuer den betriebszustand von bremsen
PL158762B1 (en) * 1987-11-30 1992-10-30 Beecham Group Plc Method for manufacturing new derivatives of purine
EP0338168A1 (de) * 1988-04-19 1989-10-25 Merrell Dow Pharmaceuticals Inc. Phosphonoalkylpurin-Derivate
SE8801729D0 (sv) * 1988-05-06 1988-05-06 Astra Ab Purine derivatives for use in therapy
US4952707A (en) * 1988-06-30 1990-08-28 Tropix, Inc. Enzymatically-cleavable chemiluminescent fused polycyclic ring-containing 1,2-dioxetanes
EP0353955A3 (de) * 1988-08-02 1991-08-14 Beecham Group Plc Chemische Verbindungen
GB8907173D0 (en) * 1989-03-30 1989-05-10 Beecham Group Plc Novel compounds
US4988703A (en) * 1989-05-22 1991-01-29 Abbott Laboratories Carbocyclic nucleoside analogs with antiviral activity
GB8912043D0 (en) * 1989-05-25 1989-07-12 Beecham Group Plc Novel compounds
US5208221A (en) * 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives

Also Published As

Publication number Publication date
DK0494370T3 (da) 1995-08-28
CA2054870C (en) 1995-08-29
ES2074637T3 (es) 1995-09-16
EP0494370A1 (de) 1992-07-15
US5386030A (en) 1995-01-31
DE69110854D1 (de) 1995-08-03
ATE124412T1 (de) 1995-07-15
EP0494370B1 (de) 1995-06-28
CA2054870A1 (en) 1992-05-30
JPH04266893A (ja) 1992-09-22
JP3172803B2 (ja) 2001-06-04
US5208221A (en) 1993-05-04

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