ES2075881T3 - Un microorganismo para la produccion selectiva de un componente especifico de avermectina y metodo para esta produccion selectiva. - Google Patents

Un microorganismo para la produccion selectiva de un componente especifico de avermectina y metodo para esta produccion selectiva.

Info

Publication number
ES2075881T3
ES2075881T3 ES90308842T ES90308842T ES2075881T3 ES 2075881 T3 ES2075881 T3 ES 2075881T3 ES 90308842 T ES90308842 T ES 90308842T ES 90308842 T ES90308842 T ES 90308842T ES 2075881 T3 ES2075881 T3 ES 2075881T3
Authority
ES
Spain
Prior art keywords
selective production
avermectin
microorganism
specific
component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90308842T
Other languages
English (en)
Inventor
Satoshi Omura
Haruo Ikeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kitasato Institute
Original Assignee
Kitasato Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kitasato Institute filed Critical Kitasato Institute
Application granted granted Critical
Publication of ES2075881T3 publication Critical patent/ES2075881T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/02—Preparation of hybrid cells by fusion of two or more cells, e.g. protoplast fusion
    • C12N15/03—Bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

1. UN MICROORGANISMO DEL GENERO STREPTOMYCES QUE ES CAPAZ DE PRODUCIR SELECTIVAMENTE UN COMPONENTE EXPECIFICO DE AVERMECTINA, TENIENDO DICHO MICROORGANISMO UNA O MAS DE LAS PROPIEDADES SIGUIENTES: VERMECTINA, AVERMECTINA, Y NA O DE CETOACIDO DE LA MISMA (ACIDO 2-OXOISOVALERICO) EN UNA MOLECULA DE AVERMECTINA.
ES90308842T 1990-03-05 1990-08-10 Un microorganismo para la produccion selectiva de un componente especifico de avermectina y metodo para esta produccion selectiva. Expired - Lifetime ES2075881T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2053411A JP2888586B2 (ja) 1990-03-05 1990-03-05 エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法

Publications (1)

Publication Number Publication Date
ES2075881T3 true ES2075881T3 (es) 1995-10-16

Family

ID=12942087

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90308842T Expired - Lifetime ES2075881T3 (es) 1990-03-05 1990-08-10 Un microorganismo para la produccion selectiva de un componente especifico de avermectina y metodo para esta produccion selectiva.

Country Status (10)

Country Link
US (2) US5206155A (es)
EP (1) EP0445460B1 (es)
JP (1) JP2888586B2 (es)
AT (1) ATE123805T1 (es)
AU (1) AU629966B2 (es)
CA (1) CA2023114C (es)
DE (1) DE69020138T2 (es)
DK (1) DK0445460T3 (es)
ES (1) ES2075881T3 (es)
NZ (1) NZ234741A (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6103504A (en) * 1992-03-25 2000-08-15 Pfizer Inc. Process for production of avermectins and cultures therefor
IT1255135B (it) * 1992-05-05 1995-10-20 Principio attivo a base di avermectine, ceppo e procedimento per la sua preparazione e composizione veterinaria che lo contiene.
US5292647A (en) * 1992-11-30 1994-03-08 Eli Lilly And Company Strain of streptomyces for producing avermectins and processes therewith
CA2167186C (en) * 1993-07-23 1999-01-26 Abdullah R. Ali Method for precipitating natural avermectins
SK11722000A3 (sk) * 1998-02-13 2001-04-09 Pfizer Products Inc. Gén streptomyces avermitilis riadici pomer b2 : b1 avermektínov
ATE556083T1 (de) 1999-02-09 2012-05-15 Kitasato Inst Avermectin derivate
JP2000245457A (ja) * 1999-02-24 2000-09-12 Kitasato Inst:The エバーメクチンアグリコン合成酵素遺伝子
JPWO2002012248A1 (ja) 2000-08-09 2004-01-15 社団法人北里研究所 エバーメクチン誘導体
AU2001277712A1 (en) 2000-08-09 2002-02-18 The Kitasato Institute Avermectin derivatives
CN101429536B (zh) * 2008-12-15 2011-09-14 浙江升华拜克生物股份有限公司 一种采用全孢子接种工艺生产阿维菌素的方法
UA116835C2 (uk) * 2014-03-10 2018-05-10 Чжецзян Хісун Фармасьютикал Ко., Лтд. Рекомбінантний мікроорганізм streptomyces avermitilis, який експресує тенвермектини, його застосування, спосіб конструювання та спосіб отримання тенвермектинів

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4429042A (en) * 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
IN167980B (es) * 1987-01-23 1991-01-19 Pfizer
DE3881147T2 (de) * 1987-10-23 1993-09-02 Pfizer Verfahren zur herstellung von aglykonen von avermectin und sie enthaltende kulturen.

Also Published As

Publication number Publication date
EP0445460B1 (en) 1995-06-14
CA2023114A1 (en) 1991-09-06
JP2888586B2 (ja) 1999-05-10
DK0445460T3 (da) 1995-08-14
AU629966B2 (en) 1992-10-15
JPH03254678A (ja) 1991-11-13
US5206155A (en) 1993-04-27
DE69020138T2 (de) 1995-12-14
ATE123805T1 (de) 1995-06-15
NZ234741A (en) 1992-03-26
US5369021A (en) 1994-11-29
EP0445460A1 (en) 1991-09-11
CA2023114C (en) 1996-12-17
AU6020190A (en) 1991-09-05
DE69020138D1 (de) 1995-07-20

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