ES2072267T3 - Forma de liberacion prolongada del diltiazem y su medicamento asi obtenido. - Google Patents
Forma de liberacion prolongada del diltiazem y su medicamento asi obtenido.Info
- Publication number
- ES2072267T3 ES2072267T3 ES88402981T ES88402981T ES2072267T3 ES 2072267 T3 ES2072267 T3 ES 2072267T3 ES 88402981 T ES88402981 T ES 88402981T ES 88402981 T ES88402981 T ES 88402981T ES 2072267 T3 ES2072267 T3 ES 2072267T3
- Authority
- ES
- Spain
- Prior art keywords
- diltiazem
- medication
- release form
- prolonged release
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 title abstract 2
- 229960004166 diltiazem Drugs 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 230000002035 prolonged effect Effects 0.000 title 1
- 239000001856 Ethyl cellulose Substances 0.000 abstract 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 abstract 2
- 229920001249 ethyl cellulose Polymers 0.000 abstract 2
- 235000019325 ethyl cellulose Nutrition 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000037406 food intake Effects 0.000 abstract 1
- 239000004014 plasticizer Substances 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
- B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
- H01L21/00—Processes or apparatus adapted for the manufacture or treatment of semiconductor or solid state devices or of parts thereof
- H01L21/02—Manufacture or treatment of semiconductor devices or of parts thereof
- H01L21/027—Making masks on semiconductor bodies for further photolithographic processing not provided for in group H01L21/18 or H01L21/34
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Manufacturing & Machinery (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Computer Hardware Design (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Power Engineering (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
MICROGRANULOS CON UN NUCLEO PROTEGGRAL DE CAPAS CON DILTIAZEM Y UNA MEMBRANA EXTERIOR. ESTA MEMBRANA ESTA FORMADA POR UNA MEZCLA DE GOMA LACA Y DE ETILCELULOSA O POR UNA MEZCLA DE ETILCELULOSA CON UN PLASTIFICANTE DE LA FORMA RETARAL OBTENIDA POR EL PROCEDIMIENTO DE LA INVENCION PERMITE DISMINUIR EL NUMERO DE TOMAS COTIDIANAS, TENER PUNTOS DE CONCENTRACION MENOS ELEVADOS EN LAS HORAS QUE SIGUEN A LA INGESTION Y UNA CONCENTRACION QUE QUEDA MAS ELEVADA CON EL TIEMPO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8716425A FR2623714B1 (fr) | 1987-11-26 | 1987-11-26 | Forme a liberation prolongee du diltiazem, et son medicament ainsi obtenu |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2072267T3 true ES2072267T3 (es) | 1995-07-16 |
Family
ID=9357210
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88402981T Expired - Lifetime ES2072267T3 (es) | 1987-11-26 | 1988-11-25 | Forma de liberacion prolongada del diltiazem y su medicamento asi obtenido. |
Country Status (13)
Country | Link |
---|---|
US (2) | US4960596A (es) |
EP (1) | EP0318398B1 (es) |
JP (1) | JP2881442B2 (es) |
KR (1) | KR890007743A (es) |
AU (1) | AU610951B2 (es) |
CA (1) | CA1331740C (es) |
DE (1) | DE3853341T2 (es) |
DK (1) | DK171155B1 (es) |
ES (1) | ES2072267T3 (es) |
FR (1) | FR2623714B1 (es) |
IL (1) | IL88426A (es) |
NZ (1) | NZ227072A (es) |
ZA (1) | ZA888757B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL92484A0 (en) * | 1988-11-30 | 1990-08-31 | Schering Corp | Sustained release diltiazem formulation |
SE8902699D0 (sv) * | 1989-08-09 | 1989-08-09 | Lejus Medical Ab | Diltiazem containing pharmaceutical compositios |
FR2677886B1 (fr) * | 1991-06-18 | 1995-03-31 | Adir | Comprime matriciel permettant la liberation prolongee d'indapamide apres administration par voie orale. |
US5252337A (en) * | 1991-06-25 | 1993-10-12 | Eurand America, Inc. | Controlled release calcium channel blocker microcapsules |
US5288505A (en) * | 1991-06-26 | 1994-02-22 | Galephar P.R., Inc., Ltd. | Extended release form of diltiazem |
KR100221695B1 (ko) * | 1991-08-12 | 1999-09-15 | 그린 마틴, 브라이언 쥐 테슬리 | 약학적 구상 제형 |
US5229135A (en) * | 1991-11-22 | 1993-07-20 | Prographarm Laboratories | Sustained release diltiazem formulation |
DE69313775T2 (de) * | 1992-10-23 | 1998-01-22 | Tanabe Seiyaku Co | Mittel zur Verbesserung der peripheren Durchblutung |
US5637582A (en) * | 1992-10-23 | 1997-06-10 | Tanabe Seiyaku Co., Ltd. | Peripheral circulation improving agent |
US5834024A (en) * | 1995-01-05 | 1998-11-10 | Fh Faulding & Co. Limited | Controlled absorption diltiazem pharmaceutical formulation |
FR2742660B1 (fr) | 1995-12-22 | 1998-04-03 | Ethypharm Lab Prod Ethiques | Nouvelles formes de microgranules a liberation prolongee contenant du diltiazem comme principe actif |
FR2754710B1 (fr) * | 1996-10-22 | 1998-12-31 | Prographarm Lab | Procede de preparation d'une forme pharmaceutique multiparticulaire a liberation controlee plurisequentielle |
US5914134A (en) * | 1997-01-27 | 1999-06-22 | Wockhardt Europe Limited | Process for the pulsatile delivery of diltiazem HCL and product produced thereby |
US6524620B2 (en) * | 1998-07-20 | 2003-02-25 | Andrx Pharmaceuticals, Inc. | Diltiazem controlled release formulation and method of manufacture |
FR2790668B1 (fr) * | 1999-03-12 | 2002-07-26 | D B F | Granules contenant une substance vegetale et leur procede de preparation |
US6555139B2 (en) | 1999-06-28 | 2003-04-29 | Wockhardt Europe Limited | Preparation of micron-size pharmaceutical particles by microfluidization |
US20060153914A1 (en) * | 1999-12-10 | 2006-07-13 | Biovail Laboratories International S.R.L. | Chronotherapeutic diltiazem formulations and the administration thereof |
US7108866B1 (en) | 1999-12-10 | 2006-09-19 | Biovall Laboratories International Srl | Chronotherapeutic diltiazem formulations and the administration thereof |
US6635277B2 (en) | 2000-04-12 | 2003-10-21 | Wockhardt Limited | Composition for pulsatile delivery of diltiazem and process of manufacture |
US7348028B2 (en) * | 2002-09-09 | 2008-03-25 | Kenneth Stephen Albert | Chronotherapeutic diltiazem formulations and the administration thereof |
KR101148734B1 (ko) * | 2003-10-10 | 2012-07-05 | 에띠빠흠 | 징코 빌로바 추출물을 포함하는 서방형 미세과립 및 이것을 제조하는 방법 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5867616A (ja) * | 1981-10-15 | 1983-04-22 | Tanabe Seiyaku Co Ltd | 腸溶性マイクロカプセル |
IE56999B1 (en) * | 1983-12-22 | 1992-03-11 | Elan Corp Plc | Pharmaceutical formulation |
IT1175814B (it) * | 1984-03-09 | 1987-07-15 | Luso Farmaco Inst | Resine solfoniche ad attivita' terapeutica,loro preparazione e composizioni farmaceutiche che le contengono |
CA1268710A (en) * | 1984-11-06 | 1990-05-08 | Nagin K. Patel | Drug in bead form and process for preparing same |
-
1987
- 1987-11-26 FR FR8716425A patent/FR2623714B1/fr not_active Expired - Lifetime
-
1988
- 1988-11-21 IL IL88426A patent/IL88426A/xx not_active IP Right Cessation
- 1988-11-23 ZA ZA888757A patent/ZA888757B/xx unknown
- 1988-11-23 US US07/275,354 patent/US4960596A/en not_active Ceased
- 1988-11-24 NZ NZ227072A patent/NZ227072A/xx unknown
- 1988-11-24 AU AU25909/88A patent/AU610951B2/en not_active Expired
- 1988-11-25 CA CA000584196A patent/CA1331740C/en not_active Expired - Lifetime
- 1988-11-25 EP EP88402981A patent/EP0318398B1/fr not_active Expired - Lifetime
- 1988-11-25 ES ES88402981T patent/ES2072267T3/es not_active Expired - Lifetime
- 1988-11-25 DE DE3853341T patent/DE3853341T2/de not_active Expired - Lifetime
- 1988-11-25 JP JP63296431A patent/JP2881442B2/ja not_active Expired - Lifetime
- 1988-11-25 DK DK658888A patent/DK171155B1/da not_active IP Right Cessation
- 1988-11-26 KR KR1019880015635A patent/KR890007743A/ko not_active Application Discontinuation
-
1992
- 1992-06-23 US US07/903,247 patent/USRE35903E/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2881442B2 (ja) | 1999-04-12 |
CA1331740C (en) | 1994-08-30 |
ZA888757B (en) | 1989-08-30 |
FR2623714A1 (fr) | 1989-06-02 |
JPH01168617A (ja) | 1989-07-04 |
AU2590988A (en) | 1989-06-01 |
KR890007743A (ko) | 1989-07-05 |
DK658888A (da) | 1989-05-27 |
NZ227072A (en) | 1990-07-26 |
DE3853341T2 (de) | 1995-11-09 |
EP0318398A1 (fr) | 1989-05-31 |
USRE35903E (en) | 1998-09-22 |
IL88426A (en) | 1993-06-10 |
IL88426A0 (en) | 1989-06-30 |
FR2623714B1 (fr) | 1990-04-20 |
AU610951B2 (en) | 1991-05-30 |
EP0318398B1 (fr) | 1995-03-15 |
DE3853341D1 (de) | 1995-04-20 |
DK658888D0 (da) | 1988-11-25 |
US4960596A (en) | 1990-10-02 |
DK171155B1 (da) | 1996-07-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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