ES2064310T3 - Procedimiento para preparar compuestos de imidazopiridina. - Google Patents
Procedimiento para preparar compuestos de imidazopiridina.Info
- Publication number
- ES2064310T3 ES2064310T3 ES87117018T ES87117018T ES2064310T3 ES 2064310 T3 ES2064310 T3 ES 2064310T3 ES 87117018 T ES87117018 T ES 87117018T ES 87117018 T ES87117018 T ES 87117018T ES 2064310 T3 ES2064310 T3 ES 2064310T3
- Authority
- ES
- Spain
- Prior art keywords
- amino
- protected
- short
- aquile
- protegido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000005232 imidazopyridines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 AMINO Chemical class 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003973 alkyl amines Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868628262A GB8628262D0 (en) | 1986-11-26 | 1986-11-26 | Imidazopyridine compounds |
| GB878723439A GB8723439D0 (en) | 1987-10-06 | 1987-10-06 | Imidazopyridine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2064310T3 true ES2064310T3 (es) | 1995-02-01 |
Family
ID=26291587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES87117018T Expired - Lifetime ES2064310T3 (es) | 1986-11-26 | 1987-11-18 | Procedimiento para preparar compuestos de imidazopiridina. |
Country Status (13)
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4725601A (en) * | 1985-06-04 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers |
| US4791117A (en) * | 1986-09-22 | 1988-12-13 | Ortho Pharmaceutical Corporation | 2- or 3-aryl substituted imidazo[1,2-a]pyridines and their use as calcium channel blockers |
| KR890701585A (ko) * | 1987-07-16 | 1989-12-21 | 헤르베르크 슈키·울리히 볼프 | 새로운 디아졸 |
| GB8722488D0 (en) * | 1987-09-24 | 1987-10-28 | Fujisawa Pharmaceutical Co | Imidazopyridine compound |
| CA2048110C (en) * | 1990-07-30 | 2002-06-25 | Muneo Takatani | Imidazopyridine derivatives and their use |
| MY110439A (en) * | 1991-02-07 | 1998-05-30 | Ishihara Sangyo Kaisha | N-phenylcarbamate compound, process for preparing the same and biocidal composition for control of harmful organisms |
| GB9201693D0 (en) * | 1992-01-27 | 1992-03-11 | Smithkline Beecham Intercredit | Compounds |
| US5574042A (en) * | 1992-11-02 | 1996-11-12 | Fujisawa Pharmaceutical Co., Ltd | Imidazo [1,2-a] pyridines and their pharmaceutical use |
| IL108520A (en) * | 1993-02-15 | 1997-09-30 | Byk Gulden Lomberg Chem Fab | 2, 3, 8-TRISUBSTITUTED IMIDAZO £1, 2-a| PYRIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| UA48122C2 (uk) * | 1993-10-11 | 2002-08-15 | Бік Гульден Ломберг Хеміше Фабрік Гмбх | АЛКОКСІАЛКІЛКАРБАМАТИ ІМІДАЗО[1,2-а]ПІРИДИНІВ, СПОСІБ ЇХ ОДЕРЖАННЯ ТА ЛІКАРСЬКИЙ ЗАСІБ НА ЇХ ОСНОВІ |
| CZ22697A3 (en) * | 1994-07-28 | 1997-07-16 | Byk Gulden Lomberg Chem Fab | Imidazopyridine-azolidinone derivatives, process of their preparation and pharmaceutical composition containing thereof |
| CA2196077A1 (en) * | 1994-07-28 | 1996-02-08 | Georg Rainer | Benzyl-imidazopyridines |
| WO1996003402A1 (de) * | 1994-07-28 | 1996-02-08 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Halogenimidazopyridine |
| WO1997027193A1 (de) * | 1996-01-26 | 1997-07-31 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Halogenimidazopyridine |
| US6096758A (en) * | 1996-01-26 | 2000-08-01 | Byk Gulden Lomberg Chemische Fabrik Gmbh | 3-methylimidazopyridines |
| UA80393C2 (uk) | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
| DE10145457A1 (de) | 2001-09-14 | 2003-04-03 | Basf Ag | Substituierte Imidazo[1,2-a]-5,6,7,8-tetrahydropyridin-8-one, Verfahren zu ihrer Herstellung, sowie deren Verwendung zur Herstellung von Imidazo[1,2,-a]pyridinen |
| MY140561A (en) * | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| AU2004220357B2 (en) | 2003-03-10 | 2010-09-30 | Astrazeneca Ab | Novel process for the preparation of roflumilast |
| EP1861074B1 (en) * | 2005-03-16 | 2013-04-24 | Takeda GmbH | Taste masked dosage form containing roflumilast |
| US9012450B2 (en) | 2011-12-28 | 2015-04-21 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
| BR112014016165B1 (pt) | 2011-12-28 | 2019-06-11 | Global Blood Therapeutics, Inc. | Benzaldeído substituído, seus usos, e composição farmacêutica |
| US10266551B2 (en) | 2013-03-15 | 2019-04-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| CN105246477A (zh) | 2013-03-15 | 2016-01-13 | 全球血液疗法股份有限公司 | 化合物及其用于调节血红蛋白的用途 |
| US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
| AP2015008722A0 (en) | 2013-03-15 | 2015-09-30 | Global Blood Therapeutics Inc | Compounds and uses thereof for the modulation of hemoglobin |
| US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| ES2852054T3 (es) | 2013-03-15 | 2021-09-10 | Global Blood Therapeutics Inc | Compuestos y usos de los mismos para la modulación de hemoglobina |
| WO2014145040A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation |
| US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| RS61653B2 (sr) | 2014-02-07 | 2024-10-31 | Global Blood Therapeutics Inc | Kristalni polimorfni oblik slobodne baze 2-hidroksi-6-((2-(1-izopropil-1h-pirazol-5-il)piridin-3-il)metoksi)benzaldehid |
| MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
| MA43373A (fr) | 2015-12-04 | 2018-10-10 | Global Blood Therapeutics Inc | Régimes posologiques pour 2-hydroxy-6-((2- (1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)méthoxy)benzaldéhyde |
| TWI752307B (zh) | 2016-05-12 | 2022-01-11 | 美商全球血液治療公司 | 新穎化合物及製造化合物之方法 |
| TW202332423A (zh) | 2016-10-12 | 2023-08-16 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
| EP3860975B1 (en) | 2018-10-01 | 2023-10-18 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin for the treatment of sickle cell disease |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA81219B (en) * | 1980-01-23 | 1982-01-27 | Schering Corp | Imidazo (1,2-a) pyridines ,process for their preparation and pharmaceutical compositions containing them |
| EP0068378B1 (en) * | 1981-06-26 | 1986-03-05 | Schering Corporation | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them |
| US4725601A (en) * | 1985-06-04 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers |
| EP0228006A1 (en) * | 1985-12-16 | 1987-07-08 | Fujisawa Pharmaceutical Co., Ltd. | Imidazopyridine compounds and processes for preparation thereof |
-
1987
- 1987-11-12 US US07/119,577 patent/US4831041A/en not_active Expired - Fee Related
- 1987-11-18 DE DE8787117018T patent/DE3780263T2/de not_active Expired - Lifetime
- 1987-11-18 EP EP87117018A patent/EP0268989B1/en not_active Expired - Lifetime
- 1987-11-18 ES ES87117018T patent/ES2064310T3/es not_active Expired - Lifetime
- 1987-11-18 IL IL84522A patent/IL84522A0/xx unknown
- 1987-11-19 DK DK608887A patent/DK608887A/da not_active Application Discontinuation
- 1987-11-23 FI FI875157A patent/FI875157A7/fi not_active Application Discontinuation
- 1987-11-25 KR KR1019870013343A patent/KR880006237A/ko not_active Ceased
- 1987-11-25 AU AU81693/87A patent/AU8169387A/en not_active Abandoned
- 1987-11-25 HU HU875302A patent/HUT45526A/hu unknown
- 1987-11-25 NO NO874904A patent/NO874904L/no unknown
- 1987-11-26 CN CN198787108027A patent/CN87108027A/zh active Pending
-
1992
- 1992-09-10 GR GR920402014T patent/GR3005685T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE3780263T2 (de) | 1992-12-24 |
| EP0268989A1 (en) | 1988-06-01 |
| GR3005685T3 (enrdf_load_stackoverflow) | 1993-06-07 |
| HUT45526A (en) | 1988-07-28 |
| FI875157A7 (fi) | 1988-05-27 |
| AU8169387A (en) | 1988-06-02 |
| DE3780263D1 (de) | 1992-08-13 |
| KR880006237A (ko) | 1988-07-22 |
| FI875157A0 (fi) | 1987-11-23 |
| CN87108027A (zh) | 1988-06-08 |
| EP0268989B1 (en) | 1992-07-08 |
| DK608887A (da) | 1988-05-27 |
| US4831041A (en) | 1989-05-16 |
| NO874904L (no) | 1988-05-27 |
| IL84522A0 (en) | 1988-04-29 |
| DK608887D0 (da) | 1987-11-19 |
| NO874904D0 (no) | 1987-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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