ES2063829T3 - Compuestos. - Google Patents

Compuestos.

Info

Publication number
ES2063829T3
ES2063829T3 ES89312898T ES89312898T ES2063829T3 ES 2063829 T3 ES2063829 T3 ES 2063829T3 ES 89312898 T ES89312898 T ES 89312898T ES 89312898 T ES89312898 T ES 89312898T ES 2063829 T3 ES2063829 T3 ES 2063829T3
Authority
ES
Spain
Prior art keywords
compounds
unit
2alkyl
4alkyl
aralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89312898T
Other languages
English (en)
Inventor
Deirdre Mary Bernadette Hickey
Albert Andrzej Jaxa-Chamiec
David Alston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Application granted granted Critical
Publication of ES2063829T3 publication Critical patent/ES2063829T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F265/00—Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group C08F20/00
    • C08F265/04—Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group C08F20/00 on to polymers of esters
    • C08F265/06—Polymerisation of acrylate or methacrylate esters on to polymers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids
    • C07C69/653—Acrylic acid esters; Methacrylic acid esters; Haloacrylic acid esters; Halomethacrylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/44—Preparation of metal salts or ammonium salts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Piezo-Electric Or Mechanical Vibrators, Or Delay Or Filter Circuits (AREA)
  • Liquid Crystal (AREA)
  • Electrically Driven Valve-Operating Means (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

POLIMEROS DE ESTRUCTURA (I) EN LA CUAL X ES UNA UNIDAD DE ENLACE EN CRUZ, X1 ES UNA UNIDAD CONOMERICA; R1 ES HIDROGENO O ALQUIL C 1-4, Y R1 Y R2 SON IGUALES O DIFERENTES Y SON CADA UNO ALQUIL C 1-2 O ARALQUIL, O R1 Y R3 JUNTOS, FORMAN UN ANILLO, LA COMPOSICION LOS CONTIENE Y SU USO ES LA TERAPIA PARA DISMINUIR LOS NIVELES DE SERUM DE COLESTEROL.
ES89312898T 1988-12-13 1989-12-11 Compuestos. Expired - Lifetime ES2063829T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888829088A GB8829088D0 (en) 1988-12-13 1988-12-13 Compounds

Publications (1)

Publication Number Publication Date
ES2063829T3 true ES2063829T3 (es) 1995-01-16

Family

ID=10648421

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89312898T Expired - Lifetime ES2063829T3 (es) 1988-12-13 1989-12-11 Compuestos.

Country Status (21)

Country Link
US (1) US5441731A (es)
EP (1) EP0373852B1 (es)
JP (1) JPH02212505A (es)
KR (1) KR900009725A (es)
CN (1) CN1044105A (es)
AT (1) ATE113299T1 (es)
AU (1) AU620183B2 (es)
CA (1) CA2004706A1 (es)
DE (1) DE68919061T2 (es)
DK (1) DK621289A (es)
ES (1) ES2063829T3 (es)
FI (1) FI895936A0 (es)
GB (1) GB8829088D0 (es)
HU (1) HU209397B (es)
IE (1) IE893966L (es)
MY (1) MY105079A (es)
NO (1) NO894995L (es)
NZ (1) NZ231728A (es)
PT (1) PT92531B (es)
ZA (1) ZA899467B (es)
ZW (1) ZW16589A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0622078B1 (en) * 1992-01-14 1999-09-01 Hisamitsu Pharmaceutical Co., Inc. Cholesterol level depressant
US5556619A (en) * 1992-08-20 1996-09-17 The Du Pont Merck Pharmaceutical Company Crosslinked polymeric ammonium salts
US5703188A (en) * 1993-06-02 1997-12-30 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5618530A (en) * 1994-06-10 1997-04-08 Geltex Pharmaceuticals, Inc. Hydrophobic amine polymer sequestrant and method of cholesterol depletion
US5624963A (en) * 1993-06-02 1997-04-29 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5607669A (en) * 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
US5900475A (en) * 1994-06-10 1999-05-04 Geltex Pharmaceuticals, Inc. Hydrophobic sequestrant for cholesterol depletion
EP0706399A4 (en) * 1993-06-02 1998-08-12 Geltex Pharma Inc PREPARATIONS AND METHOD FOR REMOVING BILE SALTS
US6129910A (en) * 1993-06-02 2000-10-10 Geltex Pharmaceuticals, Inc. Water-insoluble noncrosslinked bile acid sequestrants
US5929184A (en) * 1993-06-02 1999-07-27 Geltex Pharmaceuticals, Inc. Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants
ZA95390B (en) * 1994-01-18 1996-07-18 Du Pont Crosslinked polymeric ammonium salts
US5585115A (en) 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
IL139728A (en) * 1995-01-09 2003-06-24 Penwest Pharmaceuticals Compan Aqueous slurry composition containing microcrystalline cellulose for preparing a pharmaceutical excipient
US6471994B1 (en) 1995-01-09 2002-10-29 Edward Mendell Co., Inc. Pharmaceutical excipient having improved compressibility
US6395303B1 (en) * 1996-06-10 2002-05-28 Edward Mendell Co., Inc. Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose
US6936277B2 (en) * 1995-01-09 2005-08-30 J. Rettenmaier & Soehne Gmbh & Co. Kg Pharmaceutical excipient having improved compressibility
US5948438A (en) * 1995-01-09 1999-09-07 Edward Mendell Co., Inc. Pharmaceutical formulations having improved disintegration and/or absorptivity
US6203785B1 (en) 1996-12-30 2001-03-20 Geltex Pharmaceuticals, Inc. Poly(diallylamine)-based bile acid sequestrants
US5936003A (en) * 1997-03-03 1999-08-10 Dionex Corporation Hydrolytically stable resins for use in anion-exchange chromatography
US6423754B1 (en) 1997-06-18 2002-07-23 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with polyallylamine polymers
US6726905B1 (en) 1997-11-05 2004-04-27 Genzyme Corporation Poly (diallylamines)-based phosphate binders
KR100381512B1 (ko) * 2000-09-21 2003-04-26 굿젠 주식회사 유전자 및 생물학적 활성 약물 전달용 양이온성 지질과이의 용도
US7767768B2 (en) 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7335795B2 (en) 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7385012B2 (en) 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
US7449605B2 (en) 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
US7459502B2 (en) 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
US7608674B2 (en) 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
PL3219312T3 (pl) 2004-03-30 2019-07-31 Relypsa, Inc. Polimery wiążące jon i ich zastosowania
KR101228233B1 (ko) 2004-03-30 2013-01-31 리립사, 인크. 이온 결합 중합체 및 이의 용도
BRPI0616604A2 (pt) 2005-09-30 2012-12-25 Ilypsa Inc mÉtodo para remover e composiÇço para seletivamente remover Íon de potÁssio do trato gastrintestinal de um mamÍfero, mÉtodo para seletivamente remover Íon de potÁssio de um meio-ambiente, composiÇço farmacÊutica, partÍcula de nécleo-envoltàrio, e, usos de uma partÍcula de nécleo-envoltàrio e de uma composiÇço farmacÊutica
GB2446076B (en) 2005-09-30 2010-11-24 Ilypsa Inc Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom
GB2475657B (en) † 2008-08-22 2013-05-29 Relypsa Inc Crosslinked cation exchange polymers, compositions and use in treating hyperkalemia

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2843573A (en) * 1955-03-21 1958-07-15 Rohm & Haas New quaternary ammonium compounds in which the nitrogen atom carries an alkoxymethyl group
DE1065180B (de) * 1956-11-28 1959-09-10 Rohm &. Haas Company, Philadelphia, Pa. (V. St. A.) Verfahren zum Aminieren von Anionenaustauschharzen
DE1233604B (de) * 1961-09-08 1967-02-02 Du Pont Verfahren zur Herstellung Aminoxydgruppen enthaltender Mischpolymerisate
BE756035A (fr) * 1969-09-12 1971-03-11 Inveresk Res Int Polymeres pontes
GB1309496A (en) * 1970-05-20 1973-03-14 Mitsubishi Gas Chemical Co Process for producing cationic synthetic latex
CS171962B1 (es) * 1974-02-01 1976-11-29
JPS50110482A (es) * 1974-02-13 1975-08-30
JPS52127995A (en) * 1976-04-19 1977-10-27 Johnson & Johnson Hydrophilic random copolymers composition and process for producing same
US4393145A (en) * 1979-05-01 1983-07-12 Etablissement Texcontor Anionic ion exchange resins with cholesterol-decreasing properties
JPS58154709A (ja) * 1982-03-09 1983-09-14 Kyoritsu Yuki Kogyo Kenkyusho:Kk カチオン性高吸水性樹脂の製法
DE3587419T2 (de) * 1985-01-07 1993-12-16 Rhone Poulenc Spec Chim Karboxylgruppenhaltige Polymere, Verfahren zu deren Herstellung und ihre Verwendung.
US4621120A (en) * 1985-04-01 1986-11-04 Eastman Kodak Company Polymeric antibacterial compositions
JPH075683B2 (ja) * 1986-09-09 1995-01-25 三菱レイヨン株式会社 帯電防止性に優れたメタクリル樹脂キヤスト板の製造方法
US4981936A (en) * 1989-04-14 1991-01-01 Polypure, Inc. Terpolymer of oxyalkyene acrylates, acrylamides and quaternary monomers

Also Published As

Publication number Publication date
HU209397B (en) 1994-05-30
ATE113299T1 (de) 1994-11-15
PT92531A (pt) 1990-06-29
AU620183B2 (en) 1992-02-13
HU896510D0 (en) 1990-02-28
ZW16589A1 (en) 1990-10-10
DE68919061T2 (de) 1995-04-06
CA2004706A1 (en) 1990-06-13
JPH02212505A (ja) 1990-08-23
NO894995D0 (no) 1989-12-12
CN1044105A (zh) 1990-07-25
HUT53135A (en) 1990-09-28
EP0373852B1 (en) 1994-10-26
DK621289A (da) 1990-06-14
NZ231728A (en) 1992-03-26
EP0373852A3 (en) 1991-12-27
MY105079A (en) 1994-07-30
DK621289D0 (da) 1989-12-08
FI895936A0 (fi) 1989-12-12
IE893966L (en) 1990-06-13
US5441731A (en) 1995-08-15
EP0373852A2 (en) 1990-06-20
GB8829088D0 (en) 1989-01-25
DE68919061D1 (de) 1994-12-01
ZA899467B (en) 1991-07-31
PT92531B (pt) 1995-08-09
AU4608089A (en) 1990-06-21
NO894995L (no) 1990-06-14
KR900009725A (ko) 1990-07-05

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