ES2062786T3 - Microesferas, su procedimiento de preparacion y su utilizacion. - Google Patents

Microesferas, su procedimiento de preparacion y su utilizacion.

Info

Publication number
ES2062786T3
ES2062786T3 ES91908505T ES91908505T ES2062786T3 ES 2062786 T3 ES2062786 T3 ES 2062786T3 ES 91908505 T ES91908505 T ES 91908505T ES 91908505 T ES91908505 T ES 91908505T ES 2062786 T3 ES2062786 T3 ES 2062786T3
Authority
ES
Spain
Prior art keywords
biodegradable
microspheres
preparation procedure
polymer
substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91908505T
Other languages
English (en)
Inventor
Gilles Spenlehauer
Michel Veillard
Thierry Verrechia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Application granted granted Critical
Publication of ES2062786T3 publication Critical patent/ES2062786T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A NUEVAS MICROESFERAS BIODEGRADABLES Y BIOCOMPATIBLES CONSTITUIDAS POR UNO O VARIOS PRINCIPIOS ACTIVOS Y POR UN POLIMERO BIODEGRADABLE Y BIOCOMPATIBLE Y POR UNA SUSTANCIA TENSIOACTIVA, ELLA TAMBIEN BIODEGRADABLE Y BIOCOMPATIBLE. EL PROCESO CONSISTE EN PREPARAR UNA SOLUCION DEL POLIMERO Y DEL PRINCIPIO ACTIVO EN UN SOLVENTE NO MISCIBLE EN AGUA QUE SE MEZCLA A CONTINUACION EN LA SOLUCION ACUOSA DE TENSIOACTIVO SEGUIDO DE UNA EVAPORACION DEL SOLVENTE.
ES91908505T 1990-04-06 1991-04-04 Microesferas, su procedimiento de preparacion y su utilizacion. Expired - Lifetime ES2062786T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9004471A FR2660556B1 (fr) 1990-04-06 1990-04-06 Microspheres, leur procede de preparation et leur utilisation.

Publications (1)

Publication Number Publication Date
ES2062786T3 true ES2062786T3 (es) 1994-12-16

Family

ID=9395533

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91908505T Expired - Lifetime ES2062786T3 (es) 1990-04-06 1991-04-04 Microesferas, su procedimiento de preparacion y su utilizacion.

Country Status (8)

Country Link
EP (1) EP0523183B1 (es)
JP (1) JP3244502B2 (es)
CA (1) CA2076010C (es)
DE (1) DE69101144T2 (es)
DK (1) DK0523183T3 (es)
ES (1) ES2062786T3 (es)
FR (1) FR2660556B1 (es)
WO (1) WO1991015193A1 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
AU642066B2 (en) * 1991-01-25 1993-10-07 Nanosystems L.L.C. X-ray contrast compositions useful in medical imaging
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
ES2034891B1 (es) * 1991-08-08 1993-12-16 Cusi Lab Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas.
CA2078388A1 (en) * 1991-10-02 1993-04-03 Mridula Nair Biocompatible emulsion particles
DE4227752A1 (de) * 1992-08-21 1994-02-24 Basf Ag Verfahren zur Herstellung von Alkylglykosiden
US6537579B1 (en) 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US5916596A (en) 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
FR2721510B1 (fr) * 1994-06-22 1996-07-26 Rhone Poulenc Rorer Sa Nanoparticules filtrables dans des conditions stériles.
DE69630514D1 (de) * 1995-01-05 2003-12-04 Univ Michigan Oberflächen-modifizierte nanopartikel und verfahren für ihre herstellung und verwendung
EP0752245B1 (en) * 1995-07-05 2002-05-22 European Community Biocompatible and biodegradable nanoparticles designed for proteinaceous drugs absorption and delivery
US6576264B1 (en) * 1995-10-17 2003-06-10 Skyepharma Canada Inc. Insoluble drug delivery
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
FR2742357B1 (fr) * 1995-12-19 1998-01-09 Rhone Poulenc Rorer Sa Nanoparticules stabilisees et filtrables dans des conditions steriles
US6143037A (en) * 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
US8137684B2 (en) 1996-10-01 2012-03-20 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
FR2757768B1 (fr) * 1996-12-27 1999-04-02 Biovector Therapeutics Sa Vecteur particulaire homeocharge et composition pharmaceutique ou cosmetique le contenant
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
SG165156A1 (en) 1997-06-27 2010-10-28 Abraxis Bioscience Llc Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
IT1293088B1 (it) * 1997-07-10 1999-02-11 Isi Ist Sierovaccinogeno Ital Microparticelle per il rilascio controllato di molecole biologicamente attive e loro uso in terapia, profilassi e diagnostica in vitro e in
CA2276066A1 (en) * 1999-03-11 2000-09-11 Zycos Inc. Microparticles for delivery of nucleic acid
EP1202671A4 (en) 1999-08-13 2004-11-10 Point Biomedical Corp MICROPARTICLES USEFUL AS ULTRASONIC CONTRAST AGENTS FOR THE LYMPHATIC SYSTEM
WO2001012069A1 (en) 1999-08-13 2001-02-22 Point Biomedical Corporation Hollow microspheres with controlled fragility for medical use
US7147627B2 (en) 2002-08-21 2006-12-12 Hollister Incorporated Bowel management system
BRPI0409032A (pt) 2003-04-10 2006-05-02 Pr Pharmaceuticals método para a produção de micropartìculas à base de emulsão
US8871269B2 (en) 2003-07-15 2014-10-28 Evonik Corporation Method for the preparation of controlled release formulations
WO2005009357A2 (en) * 2003-07-23 2005-02-03 Pr Pharmaceuticals, Inc. Controlled release compositions
US8735394B2 (en) 2005-02-18 2014-05-27 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
PL3248600T3 (pl) 2005-02-18 2020-09-07 Abraxis Bioscience, Llc Połączenia i sposoby podawania środków terapeutycznych i terapia skojarzona
BR112012024590A2 (pt) 2010-03-29 2016-05-31 Abraxis Bioscience Inc métodos de reforço da liberação de fármaco e da eficácia de agentes terapêuticos
MX364637B (es) 2010-03-29 2019-05-03 Abraxis Bioscience Llc Star Platino y nanopartículas que incluyen placlitaxel/albúmina para usarse en el trartamiento de nsclc.
WO2011153010A1 (en) 2010-06-04 2011-12-08 Abraxis Biosciences, Llc Methods of treatment of pancreatic cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4330338A (en) * 1978-10-02 1982-05-18 Purdue Research Foundation Pharmaceutical coating composition, and preparation and dosages so coated
US4384975A (en) * 1980-06-13 1983-05-24 Sandoz, Inc. Process for preparation of microspheres
CA1196864A (en) * 1983-06-10 1985-11-19 Mattheus F.A. Goosen Controlled release of injectable and implantable insulin compositions
JPS63122620A (ja) * 1986-11-12 1988-05-26 Sanraku Inc ポリ乳酸マイクロスフエア及びその製造方法
GB2207693A (en) * 1987-08-06 1989-02-08 Costain Concrete Company Limit Concrete railway sleepers

Also Published As

Publication number Publication date
JPH05507063A (ja) 1993-10-14
DE69101144T2 (de) 1994-05-26
CA2076010A1 (fr) 1991-10-07
FR2660556B1 (fr) 1994-09-16
DE69101144D1 (de) 1994-03-17
WO1991015193A1 (fr) 1991-10-17
EP0523183B1 (fr) 1994-02-02
FR2660556A1 (fr) 1991-10-11
EP0523183A1 (fr) 1993-01-20
JP3244502B2 (ja) 2002-01-07
CA2076010C (fr) 2004-05-18
DK0523183T3 (da) 1994-05-09

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