ES2123790T3 - Procedimiento para la preparacion de biopolimeros yodados que tienen actividad desinfectante y cicatrizante, y los biopolimeros yodados obtenidos por dicho procedimiento. - Google Patents
Procedimiento para la preparacion de biopolimeros yodados que tienen actividad desinfectante y cicatrizante, y los biopolimeros yodados obtenidos por dicho procedimiento.Info
- Publication number
- ES2123790T3 ES2123790T3 ES94916383T ES94916383T ES2123790T3 ES 2123790 T3 ES2123790 T3 ES 2123790T3 ES 94916383 T ES94916383 T ES 94916383T ES 94916383 T ES94916383 T ES 94916383T ES 2123790 T3 ES2123790 T3 ES 2123790T3
- Authority
- ES
- Spain
- Prior art keywords
- iodine
- solutions
- complexes
- acid
- citosan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229920001222 biopolymer Polymers 0.000 title 2
- 230000000249 desinfective effect Effects 0.000 title 1
- 230000035876 healing Effects 0.000 title 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 6
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 5
- 229910052740 iodine Inorganic materials 0.000 abstract 5
- 239000011630 iodine Substances 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 3
- 239000000843 powder Substances 0.000 abstract 3
- 239000004094 surface-active agent Substances 0.000 abstract 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical class [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 2
- 235000013922 glutamic acid Nutrition 0.000 abstract 2
- 239000004220 glutamic acid Substances 0.000 abstract 2
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 238000013019 agitation Methods 0.000 abstract 1
- 239000003125 aqueous solvent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000002497 iodine compounds Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 230000007928 solubilization Effects 0.000 abstract 1
- 238000005063 solubilization Methods 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Organic Chemistry (AREA)
- Plant Pathology (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Agronomy & Crop Science (AREA)
- Molecular Biology (AREA)
- Pest Control & Pesticides (AREA)
- Medicinal Chemistry (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCESO PARA LA PREPARACION DE COMPLEJOS DE YODO CON CITOSANO O DERIVADOS DEL MISMO, Y LOS COMPUESTOS YODADOS ASI OBTENIDOS. TALES COMPUESTOS FORMAN PARTE DE POLVOS, QUE PUEDEN CONTENER POR ENCIMA DEL 60% DE YODO EN SU FORMA ELEMENTAL. EN UN ESTADO SECO, EL YODO, FIJADO AL CITOSANO O DERIVADOS DEL MISMO, NO SE SUBLIMA. SI EL CONTENIDO EN PORCENTAJE DEL YODO NO EXCEDE DEL 50% (POR PESO), TALES POLVOS PUEDEN DISOLVERSE EN DISOLVENTES ACUOSOS DEL TIPO ACIDO, POR EJEMPLO, ACIDO ACETICO DILUIDO O ACIDO GLUTAMICO. TALES SOLUCIONES SON COMPATIBLES CON SURFACTANTES, PREFERENTEMENTE DEL TIPO NO IONICO, QUE MEJORAN LA SOLUBILIDAD DEL COMPLEJO CITOSANO-YODO. PUEDEN PREPARARSE SOLUCIONES CON IDENTICAS CARACTERISTICAS ALTERNATIVAMENTE, MEDIANTE SOLUBILIZACION, CALENTANDO, SI ES NECESARIO, EL YODO EN UN SURFACTANTE ADECUADO, PREFERENTEMENTE NO IONICO, Y AÑADIENDO ESTA SOLUCION EN AGITACION RAPIDA A LOS MISMOS DERIVADOS DEL CITOSANO, DISUELTOS EN AGUA, OPCIONALMENTE EN PRESENCIA DE ACIDOS O SALES. ALTERNATIVAMENTE, PUEDEN AÑADIRSE EL CITOSANO O DERIVADOS DEL MISMO A LA SOLUCION DE YODO EN SURFACTANTE QUE RAPIDAMENTE SE ABSORBE SOBRE EL SOLIDO, FORMANDO LOS COMPLEJOS DE CITOSANO-YODO. ESTE PRODUCTO SUSPENDIDO EN AGUA O EN SOLUCIONES ACIDAS, PREFERENTEMENTE ACIDO ACETICO O ACIDO GLUTAMICO, SE SOLUBILIZA RAPIDAMENTE. LOS COMPLEJOS DE YODO CON CITOSANO O DERIVADOS DEL MISMO, EN FORMA DE POLVOS ASPERSABLES, SOLUCIONES O BALSAMOS, GRACIAS A SUS PROPIEDADES DESIFECTANTES Y CICATRIZANTES, PUEDEN USARSE EN EL CAMPO DEL TRATAMIENTO DE LA CIRUGIA POS-OPERATIVA, Y MAS GENERALMENTE HABLANDO, COMO PRODUCTOS DE USO TOPICO, PARA MEDICACION DE HERIDAS Y DESINFECTACION DE LA PIEL. OTRO CAMPO DE INTERES EN EL QUE PUEDEN USARSE LOS COMPLEJOS COMO PRINCIPIO ACTIVO ES EL DE LA COSMETICA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM930291A IT1261474B (it) | 1993-05-07 | 1993-05-07 | Procedimento per la preparazione di biopolimeri iodurati con attivita'disinfettante e cicatrizzante, e biopolimeri iodurati cosi' ottenuti. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2123790T3 true ES2123790T3 (es) | 1999-01-16 |
Family
ID=11401746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94916383T Expired - Lifetime ES2123790T3 (es) | 1993-05-07 | 1994-04-28 | Procedimiento para la preparacion de biopolimeros yodados que tienen actividad desinfectante y cicatrizante, y los biopolimeros yodados obtenidos por dicho procedimiento. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5538955A (es) |
| EP (1) | EP0649437B1 (es) |
| AT (1) | ATE173276T1 (es) |
| CA (1) | CA2139509C (es) |
| DE (1) | DE69414521T2 (es) |
| ES (1) | ES2123790T3 (es) |
| IT (1) | IT1261474B (es) |
| WO (1) | WO1994026788A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996019921A1 (en) * | 1994-12-23 | 1996-07-04 | Commonwealth Scientific And Industrial Research Organisation | Iodine biocidal material |
| JP2002088101A (ja) * | 2000-09-19 | 2002-03-27 | Tatsuaki Yamaguchi | アルキルアンモニウムキトサン−ヨウ素複合体、ヨードホール、ヨードホールの製造方法、殺菌性組成物 |
| US6521243B2 (en) * | 2000-12-22 | 2003-02-18 | Pharma C And D, Limited | Ionic chitosan -iodine complexes: antiseptic hydrogels and wound healing promoters |
| US6623761B2 (en) | 2000-12-22 | 2003-09-23 | Hassan Emadeldin M. | Method of making nanoparticles of substantially water insoluble materials |
| KR100505434B1 (ko) * | 2002-08-31 | 2005-08-05 | 한국과학기술연구원 | 생리활성물질을 효과적으로 전달하기 위한 요오드화 오일과 양이온성 고분자를 이용한 제제 및 이들의 제조방법 |
| GB0526505D0 (en) * | 2005-12-29 | 2006-02-08 | Medtrade Products Ltd | Hemostatic material |
| US8119780B2 (en) | 2006-06-02 | 2012-02-21 | Synedgen, Inc. | Chitosan-derivative compounds and methods of controlling microbial populations |
| US20080248508A1 (en) * | 2006-08-17 | 2008-10-09 | Shenda Baker | Methods of making a chitosan product having an ultra-low endotoxin concentration and the ultra-low endotoxin chitosan product derived therefrom and method of accurately determining inflammatory and anti-inflammatory cellular response to such materials |
| US20080152724A1 (en) * | 2006-12-21 | 2008-06-26 | Mark Hirsh | Treatment of periodontitis with an injectable slow release iodine |
| EP2550083A4 (en) * | 2010-03-22 | 2015-07-15 | Water Security Corp | FILTER COMPRISING A HALOGEN RELEASE SYSTEM AND CHITOSAN |
| WO2013119704A2 (en) * | 2012-02-06 | 2013-08-15 | Water Security Corporation | Methods of improving chitosan for water purification |
| CN103113492A (zh) * | 2012-12-20 | 2013-05-22 | 贵州扬生医用器材有限公司 | 一种制备壳聚糖碘的方法 |
| CN103933062B (zh) * | 2014-03-12 | 2015-10-28 | 贵州扬生医用器材有限公司 | 聚氨基多糖多肽络合碘复合体系溶液及其制法 |
| CN105418799B (zh) * | 2015-12-18 | 2018-08-17 | 黄河三角洲京博化工研究院有限公司 | 一种壳寡糖碘络合物及其制备方法和应用 |
| CN113768874B (zh) * | 2021-09-16 | 2023-04-11 | 四川省伊洁士医疗科技有限公司 | 一种复合碘消毒液及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4275194A (en) * | 1977-11-26 | 1981-06-23 | Nihon Tennen Gas Kogyo Co., Ltd. | Chitosan-iodine adduct |
| US4424346A (en) * | 1981-06-04 | 1984-01-03 | Canadian Patents And Development Ltd. | Derivatives of chitins, chitosans and other polysaccharides |
| US5051256A (en) * | 1988-02-16 | 1991-09-24 | Barnes Carl E | Biocidal complex and dressing formed therefrom |
| JPH04178329A (ja) * | 1990-11-09 | 1992-06-25 | Unitika Ltd | 抗菌性材料及び抗菌性創傷被覆保護材 |
| US5336415A (en) * | 1993-02-10 | 1994-08-09 | Vanson L.P. | Removing polyvalent metals from aqueous waste streams with chitosan and halogenating agents |
-
1993
- 1993-05-07 IT ITRM930291A patent/IT1261474B/it active IP Right Grant
-
1994
- 1994-04-28 US US08/362,568 patent/US5538955A/en not_active Expired - Lifetime
- 1994-04-28 AT AT94916383T patent/ATE173276T1/de not_active IP Right Cessation
- 1994-04-28 DE DE69414521T patent/DE69414521T2/de not_active Expired - Fee Related
- 1994-04-28 ES ES94916383T patent/ES2123790T3/es not_active Expired - Lifetime
- 1994-04-28 WO PCT/IT1994/000052 patent/WO1994026788A1/en active IP Right Grant
- 1994-04-28 EP EP94916383A patent/EP0649437B1/en not_active Expired - Lifetime
- 1994-04-28 CA CA002139509A patent/CA2139509C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0649437A1 (en) | 1995-04-26 |
| ITRM930291A1 (it) | 1994-11-07 |
| DE69414521D1 (de) | 1998-12-17 |
| CA2139509C (en) | 2005-06-14 |
| EP0649437B1 (en) | 1998-11-11 |
| DE69414521T2 (de) | 1999-05-06 |
| US5538955A (en) | 1996-07-23 |
| ITRM930291A0 (it) | 1993-05-07 |
| IT1261474B (it) | 1996-05-23 |
| CA2139509A1 (en) | 1994-11-24 |
| ATE173276T1 (de) | 1998-11-15 |
| WO1994026788A1 (en) | 1994-11-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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