IT1261474B - Procedimento per la preparazione di biopolimeri iodurati con attivita'disinfettante e cicatrizzante, e biopolimeri iodurati cosi' ottenuti. - Google Patents
Procedimento per la preparazione di biopolimeri iodurati con attivita'disinfettante e cicatrizzante, e biopolimeri iodurati cosi' ottenuti.Info
- Publication number
- IT1261474B IT1261474B ITRM930291A ITRM930291A IT1261474B IT 1261474 B IT1261474 B IT 1261474B IT RM930291 A ITRM930291 A IT RM930291A IT RM930291 A ITRM930291 A IT RM930291A IT 1261474 B IT1261474 B IT 1261474B
- Authority
- IT
- Italy
- Prior art keywords
- iodine
- chitosan
- solutions
- derivatives
- complexes
- Prior art date
Links
- 239000000645 desinfectant Substances 0.000 title abstract 4
- 229920001222 biopolymer Polymers 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000000243 solution Substances 0.000 abstract 9
- 229920001661 Chitosan Polymers 0.000 abstract 8
- 229910052740 iodine Inorganic materials 0.000 abstract 8
- 239000011630 iodine Substances 0.000 abstract 8
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 6
- 239000000843 powder Substances 0.000 abstract 4
- 150000002496 iodine Chemical class 0.000 abstract 3
- 239000004094 surface-active agent Substances 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 239000002781 deodorant agent Substances 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 230000002980 postoperative effect Effects 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011343 solid material Substances 0.000 abstract 1
- 230000003381 solubilizing effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000010186 staining Methods 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 235000012222 talc Nutrition 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dentistry (AREA)
- Materials Engineering (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Oggetto dell'invenzione sono procedimenti per la preparazione di complessi dello iodio con il chitosano o suoi derivati, e i complessi iodurati così ottenuti. Detti complessi, si presentano come polveri, contenenti anche più del 60% di iodio allo stato elementare. Allo stato secco lo iodio legato al chitosano o ai suoi derivati non sublima, può pertanto essere conservato indefinitamente a temperatura ambiente, anche in contenitori non chiusi e, messo a contatto con la pelle, non macchia.Dette polveri, quando il contenuto percentuale di iodio non supera il 50% (p/p), possono essere sciolte in solventi acquosi a carattere acido, come ad esempio l'acido acetico diluito, originando soluzioni viscose di colore bruno che non macchiano la pelle, in cui lo iodio rimane stabile sotto forma di complesso solubile con il chitosano. Dette soluzioni sono compatibili con l'aggiunta di tensioattivi, di preferenza di tipo non ionico, che migliorano la solubilità del complesso chitosano-iodio, facendone virare il colore su tonalità giallo-arancio.Soluzioni con caratteristiche identiche possono, in alternativa, essere preparate solubilizzando, eventualmente a caldo, lo iodio in un idoneo tensioattivo, di preferenza non ionico, ed aggiungendo sotto energica agitazione questa soluzione al chitosano o suoi derivati sciolti in acqua, eventualmente in presenza di acidi o sali.In alternativa il chitosano o suoi derivati allo stato secco possono essere aggiunti alla soluzione dello iodio nel tensioattivo, che rapidamente si adsorbe sul materiale solido, formando il complesso chitosano-iodio. Questo materiale sospeso in acqua o in soluzioni di acidi, di preferenza acido acetico, si solubilizza rapidamente dando soluzioni giallo-arancio, la cui viscosità dipende dal peso molecolare e dalla quantità del chitosano impiegato.I complessi dello iodio con il chitosano o i suoi derivati, in forma di polveri aspersorie, soluzioni e pomate, per il loro potere disinfettante e cicatrizzante, possono trovare impiego in campo medico chirurgico nel trattamento postoperatorio e più in generale come prodotti di uso topico per la medicazione delle ferite e la disinfezione della cute. In particolare le forme solubili, quando vengono applicate sulla pelle, per l'eccezionale potere filmogeno dei complessi dello iodio con il chitosano o suoi derivati, danno origine ad un film di biopolimero iodurato che, in maniera uniforme e prolungata, garantisce un'efficace azione disinfettante senza macchiare o danneggiare la pelle.Altro settore di interesse, in cui i complessi dell'invenzione possono trovare impiego come principio attivo, è quello cosmetico, ad esempio per la preparazione di talchi innovativi, polveri deodoranti, soluzioni detergenti e disinfettanti.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM930291A IT1261474B (it) | 1993-05-07 | 1993-05-07 | Procedimento per la preparazione di biopolimeri iodurati con attivita'disinfettante e cicatrizzante, e biopolimeri iodurati cosi' ottenuti. |
| PCT/IT1994/000052 WO1994026788A1 (en) | 1993-05-07 | 1994-04-28 | Process for the preparation of iodinated biopolymers having disinfectant and cicatrizing activity, and the iodinated biopolymers obtainable thereby |
| EP94916383A EP0649437B1 (en) | 1993-05-07 | 1994-04-28 | Process for the preparation of iodinated biopolymers having disinfectant and cicatrizing activity, and the iodinated biopolymers obtainable thereby |
| CA002139509A CA2139509C (en) | 1993-05-07 | 1994-04-28 | Process for the preparation of iodinated biopolymers having disinfectant and cicatrizing activity, and the iodinated biopolymers obtainable thereby |
| US08/362,568 US5538955A (en) | 1993-05-07 | 1994-04-28 | Process for the preparation of iodinated biopolymers having disinfectant and cicatrizing activity, and the iodinated biopolymers obtainable thereby |
| DE69414521T DE69414521T2 (de) | 1993-05-07 | 1994-04-28 | Verfahren zur herstellung von iodierten biopolymeren mit desinfizierender und vernarbungsfördernder wirkung und darnach hergestellte iodierte biopolymeren |
| ES94916383T ES2123790T3 (es) | 1993-05-07 | 1994-04-28 | Procedimiento para la preparacion de biopolimeros yodados que tienen actividad desinfectante y cicatrizante, y los biopolimeros yodados obtenidos por dicho procedimiento. |
| AT94916383T ATE173276T1 (de) | 1993-05-07 | 1994-04-28 | Verfahren zur herstellung von iodierten biopolymeren mit desinfizierender und vernarbungsfördernder wirkung und darnach hergestellte iodierte biopolymeren |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM930291A IT1261474B (it) | 1993-05-07 | 1993-05-07 | Procedimento per la preparazione di biopolimeri iodurati con attivita'disinfettante e cicatrizzante, e biopolimeri iodurati cosi' ottenuti. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM930291A0 ITRM930291A0 (it) | 1993-05-07 |
| ITRM930291A1 ITRM930291A1 (it) | 1994-11-07 |
| IT1261474B true IT1261474B (it) | 1996-05-23 |
Family
ID=11401746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITRM930291A IT1261474B (it) | 1993-05-07 | 1993-05-07 | Procedimento per la preparazione di biopolimeri iodurati con attivita'disinfettante e cicatrizzante, e biopolimeri iodurati cosi' ottenuti. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5538955A (it) |
| EP (1) | EP0649437B1 (it) |
| AT (1) | ATE173276T1 (it) |
| CA (1) | CA2139509C (it) |
| DE (1) | DE69414521T2 (it) |
| ES (1) | ES2123790T3 (it) |
| IT (1) | IT1261474B (it) |
| WO (1) | WO1994026788A1 (it) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996019921A1 (en) * | 1994-12-23 | 1996-07-04 | Commonwealth Scientific And Industrial Research Organisation | Iodine biocidal material |
| JP2002088101A (ja) * | 2000-09-19 | 2002-03-27 | Tatsuaki Yamaguchi | アルキルアンモニウムキトサン−ヨウ素複合体、ヨードホール、ヨードホールの製造方法、殺菌性組成物 |
| US6521243B2 (en) * | 2000-12-22 | 2003-02-18 | Pharma C And D, Limited | Ionic chitosan -iodine complexes: antiseptic hydrogels and wound healing promoters |
| US6623761B2 (en) | 2000-12-22 | 2003-09-23 | Hassan Emadeldin M. | Method of making nanoparticles of substantially water insoluble materials |
| KR100505434B1 (ko) * | 2002-08-31 | 2005-08-05 | 한국과학기술연구원 | 생리활성물질을 효과적으로 전달하기 위한 요오드화 오일과 양이온성 고분자를 이용한 제제 및 이들의 제조방법 |
| GB0526505D0 (en) * | 2005-12-29 | 2006-02-08 | Medtrade Products Ltd | Hemostatic material |
| CA2848648C (en) | 2006-06-02 | 2017-10-10 | Synedgen, Inc. | Chitosan-derivative compounds and methods of controlling microbial populations |
| US20080248508A1 (en) * | 2006-08-17 | 2008-10-09 | Shenda Baker | Methods of making a chitosan product having an ultra-low endotoxin concentration and the ultra-low endotoxin chitosan product derived therefrom and method of accurately determining inflammatory and anti-inflammatory cellular response to such materials |
| US20080152724A1 (en) * | 2006-12-21 | 2008-06-26 | Mark Hirsh | Treatment of periodontitis with an injectable slow release iodine |
| AP2012006497A0 (en) * | 2010-03-22 | 2012-10-31 | Water Security Corp | Filter comprising a halogen release system and chitosan |
| WO2013119704A2 (en) * | 2012-02-06 | 2013-08-15 | Water Security Corporation | Methods of improving chitosan for water purification |
| CN103113492A (zh) * | 2012-12-20 | 2013-05-22 | 贵州扬生医用器材有限公司 | 一种制备壳聚糖碘的方法 |
| CN103933062B (zh) * | 2014-03-12 | 2015-10-28 | 贵州扬生医用器材有限公司 | 聚氨基多糖多肽络合碘复合体系溶液及其制法 |
| CN105418799B (zh) * | 2015-12-18 | 2018-08-17 | 黄河三角洲京博化工研究院有限公司 | 一种壳寡糖碘络合物及其制备方法和应用 |
| CN113768874B (zh) * | 2021-09-16 | 2023-04-11 | 四川省伊洁士医疗科技有限公司 | 一种复合碘消毒液及其制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4275194A (en) * | 1977-11-26 | 1981-06-23 | Nihon Tennen Gas Kogyo Co., Ltd. | Chitosan-iodine adduct |
| US4424346A (en) * | 1981-06-04 | 1984-01-03 | Canadian Patents And Development Ltd. | Derivatives of chitins, chitosans and other polysaccharides |
| US5051256A (en) * | 1988-02-16 | 1991-09-24 | Barnes Carl E | Biocidal complex and dressing formed therefrom |
| JPH04178329A (ja) * | 1990-11-09 | 1992-06-25 | Unitika Ltd | 抗菌性材料及び抗菌性創傷被覆保護材 |
| US5336415A (en) * | 1993-02-10 | 1994-08-09 | Vanson L.P. | Removing polyvalent metals from aqueous waste streams with chitosan and halogenating agents |
-
1993
- 1993-05-07 IT ITRM930291A patent/IT1261474B/it active IP Right Grant
-
1994
- 1994-04-28 ES ES94916383T patent/ES2123790T3/es not_active Expired - Lifetime
- 1994-04-28 EP EP94916383A patent/EP0649437B1/en not_active Expired - Lifetime
- 1994-04-28 WO PCT/IT1994/000052 patent/WO1994026788A1/en active IP Right Grant
- 1994-04-28 DE DE69414521T patent/DE69414521T2/de not_active Expired - Fee Related
- 1994-04-28 AT AT94916383T patent/ATE173276T1/de not_active IP Right Cessation
- 1994-04-28 CA CA002139509A patent/CA2139509C/en not_active Expired - Fee Related
- 1994-04-28 US US08/362,568 patent/US5538955A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ITRM930291A1 (it) | 1994-11-07 |
| CA2139509C (en) | 2005-06-14 |
| ITRM930291A0 (it) | 1993-05-07 |
| WO1994026788A1 (en) | 1994-11-24 |
| DE69414521T2 (de) | 1999-05-06 |
| DE69414521D1 (de) | 1998-12-17 |
| ES2123790T3 (es) | 1999-01-16 |
| US5538955A (en) | 1996-07-23 |
| EP0649437B1 (en) | 1998-11-11 |
| EP0649437A1 (en) | 1995-04-26 |
| ATE173276T1 (de) | 1998-11-15 |
| CA2139509A1 (en) | 1994-11-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970328 |