DK0523183T3 - Mikrosfærer, deres fremstilling og anvendelse - Google Patents

Mikrosfærer, deres fremstilling og anvendelse

Info

Publication number
DK0523183T3
DK0523183T3 DK91908505T DK91908505T DK0523183T3 DK 0523183 T3 DK0523183 T3 DK 0523183T3 DK 91908505 T DK91908505 T DK 91908505T DK 91908505 T DK91908505 T DK 91908505T DK 0523183 T3 DK0523183 T3 DK 0523183T3
Authority
DK
Denmark
Prior art keywords
microspheres
preparation
Prior art date
Application number
DK91908505T
Other languages
English (en)
Inventor
Michel Veillard
Gilles Spenlehauer
Thierry Verrechia
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Application granted granted Critical
Publication of DK0523183T3 publication Critical patent/DK0523183T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
DK91908505T 1990-04-06 1991-04-04 Mikrosfærer, deres fremstilling og anvendelse DK0523183T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9004471A FR2660556B1 (fr) 1990-04-06 1990-04-06 Microspheres, leur procede de preparation et leur utilisation.

Publications (1)

Publication Number Publication Date
DK0523183T3 true DK0523183T3 (da) 1994-05-09

Family

ID=9395533

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91908505T DK0523183T3 (da) 1990-04-06 1991-04-04 Mikrosfærer, deres fremstilling og anvendelse

Country Status (8)

Country Link
EP (1) EP0523183B1 (da)
JP (1) JP3244502B2 (da)
CA (1) CA2076010C (da)
DE (1) DE69101144T2 (da)
DK (1) DK0523183T3 (da)
ES (1) ES2062786T3 (da)
FR (1) FR2660556B1 (da)
WO (1) WO1991015193A1 (da)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
AU642066B2 (en) * 1991-01-25 1993-10-07 Nanosystems L.L.C. X-ray contrast compositions useful in medical imaging
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
ES2034891B1 (es) * 1991-08-08 1993-12-16 Cusi Lab Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas.
CA2078388A1 (en) * 1991-10-02 1993-04-03 Mridula Nair Biocompatible emulsion particles
DE4227752A1 (de) * 1992-08-21 1994-02-24 Basf Ag Verfahren zur Herstellung von Alkylglykosiden
US5916596A (en) * 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US6537579B1 (en) 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
FR2721510B1 (fr) * 1994-06-22 1996-07-26 Rhone Poulenc Rorer Sa Nanoparticules filtrables dans des conditions stériles.
DE69630514D1 (de) * 1995-01-05 2003-12-04 Univ Michigan Oberflächen-modifizierte nanopartikel und verfahren für ihre herstellung und verwendung
DE69526787T2 (de) * 1995-07-05 2002-12-05 Europ Community Luxemburg Luxe Biokompatibele und biodegradierbare Nanokapseln zur Absorption und Verabreichung von proteinischen Arzneimitteln
EP0855906B1 (en) * 1995-10-17 2008-02-20 Jagotec AG Insoluble drug delivery
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
FR2742357B1 (fr) * 1995-12-19 1998-01-09 Rhone Poulenc Rorer Sa Nanoparticules stabilisees et filtrables dans des conditions steriles
US6143037A (en) * 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
US20070092563A1 (en) 1996-10-01 2007-04-26 Abraxis Bioscience, Inc. Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
FR2757768B1 (fr) * 1996-12-27 1999-04-02 Biovector Therapeutics Sa Vecteur particulaire homeocharge et composition pharmaceutique ou cosmetique le contenant
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
SG165156A1 (en) 1997-06-27 2010-10-28 Abraxis Bioscience Llc Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
IT1293088B1 (it) * 1997-07-10 1999-02-11 Isi Ist Sierovaccinogeno Ital Microparticelle per il rilascio controllato di molecole biologicamente attive e loro uso in terapia, profilassi e diagnostica in vitro e in
CA2276066A1 (en) * 1999-03-11 2000-09-11 Zycos Inc. Microparticles for delivery of nucleic acid
EP1202671A4 (en) 1999-08-13 2004-11-10 Point Biomedical Corp MICROPARTICLES USEFUL AS ULTRASONIC CONTRAST AGENTS FOR THE LYMPHATIC SYSTEM
AU6636000A (en) 1999-08-13 2001-03-13 Point Biomedical Corporation Hollow microspheres with controlled fragility for medical use
US7147627B2 (en) 2002-08-21 2006-12-12 Hollister Incorporated Bowel management system
JP2007515392A (ja) 2003-04-10 2007-06-14 ピーアール ファーマシューティカルズ，インコーポレイテッド エマルジョンベースの微粒子の製造のための方法
JP5165239B2 (ja) * 2003-07-15 2013-03-21 ピーアール ファーマシューティカルズ， インコーポレイテッド 制御放出処方物の調製のための方法
CN100588423C (zh) 2003-07-23 2010-02-10 Pr药品有限公司 控释组合物
US8735394B2 (en) 2005-02-18 2014-05-27 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
MX2007009960A (es) 2005-02-18 2008-03-11 Abraxis Bioscience Inc Combinaciones y metodos de administracion de agentes terapeuticos y terapia de combinacion.
SG10201906075VA (en) 2010-03-29 2019-08-27 Abraxis Bioscience Llc Methods of treating cancer
CN107158389A (zh) 2010-03-29 2017-09-15 阿布拉科斯生物科学有限公司 增强药物递送和治疗剂有效性的方法
MY162903A (en) 2010-06-04 2017-07-31 Abraxis Bioscience Llc Methods of treatment of pancreatic cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4330338A (en) * 1978-10-02 1982-05-18 Purdue Research Foundation Pharmaceutical coating composition, and preparation and dosages so coated
US4384975A (en) * 1980-06-13 1983-05-24 Sandoz, Inc. Process for preparation of microspheres
CA1196864A (en) * 1983-06-10 1985-11-19 Mattheus F.A. Goosen Controlled release of injectable and implantable insulin compositions
JPS63122620A (ja) * 1986-11-12 1988-05-26 Sanraku Inc ポリ乳酸マイクロスフエア及びその製造方法
GB2207693A (en) * 1987-08-06 1989-02-08 Costain Concrete Company Limit Concrete railway sleepers

Also Published As

Publication number Publication date
FR2660556B1 (fr) 1994-09-16
DE69101144T2 (de) 1994-05-26
CA2076010A1 (fr) 1991-10-07
CA2076010C (fr) 2004-05-18
JP3244502B2 (ja) 2002-01-07
ES2062786T3 (es) 1994-12-16
EP0523183A1 (fr) 1993-01-20
EP0523183B1 (fr) 1994-02-02
FR2660556A1 (fr) 1991-10-11
WO1991015193A1 (fr) 1991-10-17
JPH05507063A (ja) 1993-10-14
DE69101144D1 (de) 1994-03-17

Similar Documents

Publication Publication Date Title
DK0523183T3 (da) Mikrosfærer, deres fremstilling og anvendelse
DK374389A (da) Arylbenzenoxazolidinoner, deres fremstilling og anvendelse
NO912058L (no) Bioforlikelige membraner, deres fremstilling og anvendelse
NO933434D0 (no) Piperidinderivater, deres fremstilling og anvendelse
NO912960D0 (no) Polylaktider, deres fremstilling og anvendelse.
DK609489A (da) Imidazolderivater, deres fremstilling og anvendelse
NO177751C (no) Piperidinsubstituerte polysiloksanforbindelser, deres fremstilling og anvendelse
DK0426476T3 (da) Pyrimidinderivater, deres fremstilling og anvendelse
NO940989L (no) Triazolkinoksalin-1,4-dioner og deres fremstilling og anvendelse
DK388989A (da) Acylcyanoguanidiner, deres fremstilling og anvendelse
DK435289A (da) Piperazindioner, deres fremstilling og anvendelse
NO903096D0 (no) Termotrope semialifatiske kopolyesteramider og deres fremstilling.
NO903978L (no) Pyridinyl-kinolonforbindelser, deres fremstilling og bruk.
NO933435D0 (no) Piperidinderivater, deres fremstilling og anvendelse
DK225089D0 (da) 2-adamantyl-4-isothiazolin-3-oner, deres fremstilling og anvendelse
DK73091D0 (da) Quinoxalinforbindelser, deres fremstilling og anvendelse
DK469389A (da) Piperidinyl-imidazol-derivater, deres fremstilling og anvendelse
NO922992L (no) Imid-terminerte polynitrogenforbindelser, deres fremstilling og anvendelse
DK592389A (da) Penemderivater, deres fremstilling og anvendelse
DK455189D0 (da) 2,3,4,5-tetrahydro-1-benzoxepiner, deres fremstilling og anvendelse
NO920228D0 (no) Polylaktider, deres fremstilling og anvendelse
NO923194D0 (no) Substituerte urea-forbindelser, deres fremstilling og anvendelse
DK82589A (da) Piperidinforbindelser, deres fremstilling og anvendelse
DK625988D0 (da) Imidazoquinoxalinforbindelser, deres fremstilling og anvendelse
DK639889D0 (da) Quinoxalinforbindelser, deres fremstilling og anvendelse