DK0523183T3 - Microspheres, their preparation and use - Google Patents

Microspheres, their preparation and use

Info

Publication number
DK0523183T3
DK0523183T3 DK91908505T DK91908505T DK0523183T3 DK 0523183 T3 DK0523183 T3 DK 0523183T3 DK 91908505 T DK91908505 T DK 91908505T DK 91908505 T DK91908505 T DK 91908505T DK 0523183 T3 DK0523183 T3 DK 0523183T3
Authority
DK
Denmark
Prior art keywords
microspheres
preparation
Prior art date
Application number
DK91908505T
Other languages
Danish (da)
Inventor
Michel Veillard
Gilles Spenlehauer
Thierry Verrechia
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Application granted granted Critical
Publication of DK0523183T3 publication Critical patent/DK0523183T3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
DK91908505T 1990-04-06 1991-04-04 Microspheres, their preparation and use DK0523183T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9004471A FR2660556B1 (en) 1990-04-06 1990-04-06 MICROSPHERES, THEIR PREPARATION PROCESS AND THEIR USE.

Publications (1)

Publication Number Publication Date
DK0523183T3 true DK0523183T3 (en) 1994-05-09

Family

ID=9395533

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91908505T DK0523183T3 (en) 1990-04-06 1991-04-04 Microspheres, their preparation and use

Country Status (8)

Country Link
EP (1) EP0523183B1 (en)
JP (1) JP3244502B2 (en)
CA (1) CA2076010C (en)
DE (1) DE69101144T2 (en)
DK (1) DK0523183T3 (en)
ES (1) ES2062786T3 (en)
FR (1) FR2660556B1 (en)
WO (1) WO1991015193A1 (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
AU642066B2 (en) * 1991-01-25 1993-10-07 Nanosystems L.L.C. X-ray contrast compositions useful in medical imaging
ES2034891B1 (en) * 1991-08-08 1993-12-16 Cusi Lab CONTINUOUS ELABORATION PROCEDURE OF SCATTERED COLLOID SYSTEMS, IN THE FORM OF NANOCAPSULES OR NANOPARTICLES.
CA2078388A1 (en) * 1991-10-02 1993-04-03 Mridula Nair Biocompatible emulsion particles
DE4227752A1 (en) * 1992-08-21 1994-02-24 Basf Ag Process for the preparation of alkyl glycosides
US6537579B1 (en) 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US5916596A (en) 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
FR2721510B1 (en) * 1994-06-22 1996-07-26 Rhone Poulenc Rorer Sa Nanoparticles filterable under sterile conditions.
EP0805678B1 (en) * 1995-01-05 2003-10-29 THE BOARD OF REGENTS acting for and on behalf of THE UNIVERSITY OF MICHIGAN Surface-modified nanoparticles and method of making and using same
ES2177592T3 (en) * 1995-07-05 2002-12-16 Europ Economic Community BIOCOMPATIBLE AND BIODEGRADABLE NANOPARTICLES FOR THE ABSORPTION AND ADMINISTRATION OF PROTEINIC MEDICINES.
ATE386506T1 (en) * 1995-10-17 2008-03-15 Jagotec Ag ADMINISTRATION OF INSOLUBLE DRUGS
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
FR2742357B1 (en) * 1995-12-19 1998-01-09 Rhone Poulenc Rorer Sa STABILIZED AND FILTRABLE NANOPARTICLES UNDER STERILE CONDITIONS
US6143037A (en) * 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
US8137684B2 (en) 1996-10-01 2012-03-20 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
FR2757768B1 (en) * 1996-12-27 1999-04-02 Biovector Therapeutics Sa HOMEOCHARGE PARTICULATE VECTOR AND PHARMACEUTICAL OR COSMETIC COMPOSITION CONTAINING THE SAME
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
CN101579335B (en) 1997-06-27 2016-08-03 阿布拉科斯生物科学有限公司 The preparation of medicament and methods for making and using same thereof
IT1293088B1 (en) * 1997-07-10 1999-02-11 Isi Ist Sierovaccinogeno Ital MICROPARTICLES FOR THE CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE MOLECULES AND THEIR USE IN THERAPY, PROPHYLAXIS AND DIAGNOSTICS IN VITRO AND IN
CA2276066A1 (en) * 1999-03-11 2000-09-11 Zycos Inc. Microparticles for delivery of nucleic acid
WO2001012069A1 (en) 1999-08-13 2001-02-22 Point Biomedical Corporation Hollow microspheres with controlled fragility for medical use
EP1202671A4 (en) 1999-08-13 2004-11-10 Point Biomedical Corp Microparticles useful as ultrasonic contrast agents and for lymphatic system
US7147627B2 (en) 2002-08-21 2006-12-12 Hollister Incorporated Bowel management system
CN101410174B (en) 2003-04-10 2011-04-06 Pr药品有限公司 Method for the production of emulsion-based micro particles
US8871269B2 (en) 2003-07-15 2014-10-28 Evonik Corporation Method for the preparation of controlled release formulations
WO2005009357A2 (en) 2003-07-23 2005-02-03 Pr Pharmaceuticals, Inc. Controlled release compositions
PL1853250T3 (en) 2005-02-18 2012-03-30 Abraxis Bioscience Llc Combinations and modes of administration of therapeutic agents and combination therapy
US8735394B2 (en) 2005-02-18 2014-05-27 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
MX2012011155A (en) 2010-03-29 2012-12-05 Abraxis Bioscience Llc Methods of enhancing drug delivery and effectiveness of therapeutic agents.
MX364637B (en) 2010-03-29 2019-05-03 Abraxis Bioscience Llc Star Methods of treating cancer.
KR20180049180A (en) 2010-06-04 2018-05-10 아브락시스 바이오사이언스, 엘엘씨 Methods of treatment of pancreatic cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4330338A (en) * 1978-10-02 1982-05-18 Purdue Research Foundation Pharmaceutical coating composition, and preparation and dosages so coated
US4384975A (en) * 1980-06-13 1983-05-24 Sandoz, Inc. Process for preparation of microspheres
CA1196864A (en) * 1983-06-10 1985-11-19 Mattheus F.A. Goosen Controlled release of injectable and implantable insulin compositions
JPS63122620A (en) * 1986-11-12 1988-05-26 Sanraku Inc Polylactic acid microsphere and production thereof
GB2207693A (en) * 1987-08-06 1989-02-08 Costain Concrete Company Limit Concrete railway sleepers

Also Published As

Publication number Publication date
DE69101144D1 (en) 1994-03-17
FR2660556B1 (en) 1994-09-16
JP3244502B2 (en) 2002-01-07
DE69101144T2 (en) 1994-05-26
CA2076010C (en) 2004-05-18
EP0523183B1 (en) 1994-02-02
FR2660556A1 (en) 1991-10-11
WO1991015193A1 (en) 1991-10-17
EP0523183A1 (en) 1993-01-20
CA2076010A1 (en) 1991-10-07
ES2062786T3 (en) 1994-12-16
JPH05507063A (en) 1993-10-14

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