ES2057024T3 - Antagonistas de la neuroquinina a. - Google Patents

Antagonistas de la neuroquinina a.

Info

Publication number
ES2057024T3
ES2057024T3 ES89111108T ES89111108T ES2057024T3 ES 2057024 T3 ES2057024 T3 ES 2057024T3 ES 89111108 T ES89111108 T ES 89111108T ES 89111108 T ES89111108 T ES 89111108T ES 2057024 T3 ES2057024 T3 ES 2057024T3
Authority
ES
Spain
Prior art keywords
neuroquinine
antagonists
derivatives
neurokinine
antagonist
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89111108T
Other languages
English (en)
Inventor
Stephen H Buck
John L Krstenansky
James R Mccarthy
Scott L Harbeson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2057024T3 publication Critical patent/ES2057024T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

SE DESCRIBEN ANTAGONISTAS DE NEUROQUININA A TALES COMO DERIVADOS DE NEUROQUININA A OBTENIDA NATURALMENTE EN LOS CUALES LA UNION DE LA AMINA QUE CONECTA LOS DOS AMINOACIDOS SOBRE EL RADICAL TERMINAL CARBOXILO ESTA MODIFICADA. EL ANTAGONISTA SE CONFIRMA USANDO LIGANTES COMPETITIVOS CONVENCIONALES Y ENSAYOS BIOQUIMICOS ASI COMO MUESTRAS FISIOLOGICAS CONVENCIONALES Y EL USO DE ESTOS DERIVADOS EN UNA VARIEDAD DE CONDICIONES EN LAS CUALES LA NEUROQUININA A IMPLICADA TAMBIEN ESTA DESCRITA.
ES89111108T 1988-06-20 1989-06-19 Antagonistas de la neuroquinina a. Expired - Lifetime ES2057024T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20892688A 1988-06-20 1988-06-20

Publications (1)

Publication Number Publication Date
ES2057024T3 true ES2057024T3 (es) 1994-10-16

Family

ID=22776618

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89111108T Expired - Lifetime ES2057024T3 (es) 1988-06-20 1989-06-19 Antagonistas de la neuroquinina a.

Country Status (19)

Country Link
EP (1) EP0347802B1 (es)
JP (1) JP2711720B2 (es)
KR (1) KR0136605B1 (es)
CN (1) CN1030703C (es)
AR (1) AR246085A1 (es)
AT (1) ATE107312T1 (es)
AU (1) AU619857B2 (es)
CA (1) CA1340824C (es)
DE (1) DE68916113T2 (es)
DK (1) DK174964B1 (es)
ES (1) ES2057024T3 (es)
FI (1) FI94351C (es)
HU (1) HU204850B (es)
IE (1) IE61362B1 (es)
IL (1) IL90637A (es)
NO (1) NO176105C (es)
NZ (1) NZ229552A (es)
PT (1) PT90902B (es)
ZA (1) ZA894533B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877277A (en) 1987-09-24 1999-03-02 Biomeasure, Inc. Octapeptide bombesin analogs
ZA906188B (en) * 1989-08-10 1991-06-26 Merrell Dow Pharma Cyclic neurokinin a antagonists
IE77033B1 (en) * 1989-08-16 1997-11-19 Univ Tulane Substance P antagonists
FR2666335B1 (fr) 1990-09-05 1992-12-11 Sanofi Sa Arylalkylamines, procede pour leur preparation et compositions pharmaceutiques les contenant.
WO1992018536A2 (en) * 1991-04-22 1992-10-29 Mallinckrodt Medical, Inc. Method for detecting an localizing tissues having neurokinine 1 receptors
US5625060A (en) * 1991-05-03 1997-04-29 Elf Sanofi Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions on which they are present
FR2676055B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
AU659659B2 (en) * 1991-05-23 1995-05-25 Merrell Dow Pharmaceuticals Inc. Bombesin analogs
GB9727123D0 (en) * 1997-12-22 1998-02-25 Int Centre Genetic Eng & Bio Synthesis of diamines
JP2000021345A (ja) 1998-07-06 2000-01-21 Hitachi Ltd 走査型電子顕微鏡

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1302926C (en) * 1986-03-04 1992-06-09 Hideo Sugawara Antibiotic f-0769, process for its production, and its use as a growthaccelerating and feed efficiency increasing agent and as an antitumour agent
IT1233696B (it) * 1989-05-29 1992-04-14 Menarini Farma Ind Peptidi di sintesi antagonisti della neurochinina a. loro sali e relativi procedimenti di fabbricazione
ZA906188B (en) * 1989-08-10 1991-06-26 Merrell Dow Pharma Cyclic neurokinin a antagonists

Also Published As

Publication number Publication date
KR0136605B1 (ko) 1998-04-25
FI893002A (fi) 1989-12-21
HUT50196A (en) 1989-12-28
NO892542L (no) 1989-12-21
KR910000791A (ko) 1991-01-30
AR246085A1 (es) 1994-03-30
DK301889A (da) 1989-12-21
FI94351B (fi) 1995-05-15
CA1340824C (en) 1999-11-16
JP2711720B2 (ja) 1998-02-10
DE68916113D1 (de) 1994-07-21
EP0347802A3 (en) 1991-07-17
FI893002A0 (fi) 1989-06-19
NO892542D0 (no) 1989-06-19
ATE107312T1 (de) 1994-07-15
ZA894533B (en) 1990-03-28
IE61362B1 (en) 1994-11-02
DK174964B1 (da) 2004-04-05
FI94351C (fi) 1995-08-25
EP0347802B1 (en) 1994-06-15
JPH0245497A (ja) 1990-02-15
IE891987L (en) 1989-12-20
DK301889D0 (da) 1989-06-19
EP0347802A2 (en) 1989-12-27
NO176105B (no) 1994-10-24
IL90637A0 (en) 1990-01-18
CN1030703C (zh) 1996-01-17
CN1039597A (zh) 1990-02-14
PT90902A (pt) 1989-12-29
AU3652389A (en) 1989-12-21
PT90902B (pt) 1994-12-30
IL90637A (en) 1993-07-08
DE68916113T2 (de) 1994-09-22
NO176105C (no) 1995-02-01
NZ229552A (en) 1992-06-25
HU204850B (en) 1992-02-28
AU619857B2 (en) 1992-02-06

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