ES2084627T3 - Antagonistas de neuroquinina ciclica. - Google Patents
Antagonistas de neuroquinina ciclica.Info
- Publication number
- ES2084627T3 ES2084627T3 ES90115309T ES90115309T ES2084627T3 ES 2084627 T3 ES2084627 T3 ES 2084627T3 ES 90115309 T ES90115309 T ES 90115309T ES 90115309 T ES90115309 T ES 90115309T ES 2084627 T3 ES2084627 T3 ES 2084627T3
- Authority
- ES
- Spain
- Prior art keywords
- cyclic
- neurokinin
- antagonists
- link
- neuroquinine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
UNOS ANTAGONISTAS DE NEUROKININ A QUE SON DERIVADOS DE NEUROKININ A EXTRAIDO NATURALMENTE, EN EL CUAL, EL ENLACE AMIDA SE CONECTA A LOS DOS AMINO ACIDOS SOBRE EL EXTREMO TERMINAL DEL CARBOXIL. EL ANTAGONISMO SE CONFIRMA SUTILIZANDO UN ENLACE CONVENCIONAL Y ENSAYOS BIOQUIMICOS, ASI COMO TESTS PSICOLOGICOS CONVENCIONALES. IGUALMENTE, SE DESCRIBE EL USO DE ESTOS DERIVADOS EN UNA VARIEDAD DE CONDICIONES EN LAS QUE SE IMPLICA EL NEUROKININ A
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39223689A | 1989-08-10 | 1989-08-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2084627T3 true ES2084627T3 (es) | 1996-05-16 |
Family
ID=23549831
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90115309T Expired - Lifetime ES2084627T3 (es) | 1989-08-10 | 1990-08-09 | Antagonistas de neuroquinina ciclica. |
Country Status (22)
Country | Link |
---|---|
US (1) | US5731286A (es) |
EP (1) | EP0412542B1 (es) |
JP (1) | JP2829779B2 (es) |
KR (1) | KR0169123B1 (es) |
CN (1) | CN1035056C (es) |
AR (1) | AR246087A1 (es) |
AT (1) | ATE132503T1 (es) |
AU (1) | AU638264B2 (es) |
CA (1) | CA2022740C (es) |
DD (1) | DD297168A5 (es) |
DE (1) | DE69024555T2 (es) |
DK (1) | DK0412542T3 (es) |
ES (1) | ES2084627T3 (es) |
FI (1) | FI95913C (es) |
GR (1) | GR3018984T3 (es) |
HU (1) | HU206729B (es) |
IE (1) | IE69382B1 (es) |
IL (1) | IL95309A (es) |
NO (1) | NO177715C (es) |
NZ (1) | NZ234814A (es) |
PT (1) | PT94952B (es) |
ZA (1) | ZA906188B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA894533B (en) * | 1988-06-20 | 1990-03-28 | Merrell Dow Pharma | Neurokinin a antogonists |
DE4034829A1 (de) * | 1990-11-02 | 1992-05-07 | Merck Patent Gmbh | Cyclopeptide |
FR2676055B1 (fr) * | 1991-05-03 | 1993-09-03 | Sanofi Elf | Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
US5625060A (en) * | 1991-05-03 | 1997-04-29 | Elf Sanofi | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions on which they are present |
JPH06509571A (ja) * | 1991-08-08 | 1994-10-27 | エイ・メナリニ・インダストリー・ファーマシューティケ・リウニテ・エスアールエル | タキキニン拮抗薬としての環状ヘキサペプチドの製法およびその薬学的化合物 |
US5731285A (en) * | 1992-04-15 | 1998-03-24 | A. Menatini Industrie Farmaceutiche | Tachiquinine antagonist tricyclic compounds, preparation of same and pharmaceutical compositions containing such compounds |
CA2756804C (en) * | 2009-03-16 | 2020-12-22 | The Governing Council Of The University Of Toronto | Cyclic amino acid molecules and methods of preparing the same |
US11046695B2 (en) | 2015-11-11 | 2021-06-29 | Zealand Pharma A/S | Fragment synthesis of substituted cyclic peptides |
US11111273B2 (en) | 2016-11-11 | 2021-09-07 | Zealand Pharma A/S | Cyclic peptides multimers targeting alpha-4-beta-7 integrin |
WO2018205008A1 (en) | 2017-05-10 | 2018-11-15 | Encycle Therapeutics, Inc. | HOMODETIC CYCLIC PEPTIDES TARGETING α4β7 1NTEGRIN |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4742156A (en) * | 1985-09-30 | 1988-05-03 | Mcneilab, Inc. | Peptide antagonists of neurokinin B and opthalmic solutions containing them |
US4665157A (en) * | 1985-09-30 | 1987-05-12 | Mcneilab, Inc. | Peptide antagonists of neurokinin B |
DE3711335A1 (de) * | 1987-04-03 | 1988-10-20 | Merck Patent Gmbh | Aminosaeurederivate |
GB8807246D0 (en) * | 1988-03-25 | 1988-04-27 | Merck Sharp & Dohme | Therapeutic agents |
ZA894533B (en) * | 1988-06-20 | 1990-03-28 | Merrell Dow Pharma | Neurokinin a antogonists |
FI97540C (fi) * | 1989-11-06 | 1997-01-10 | Sanofi Sa | Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi |
IL99320A (en) * | 1990-09-05 | 1995-07-31 | Sanofi Sa | Arylalkylamines, their preparation and pharmaceutical preparations containing them |
FR2677361A1 (fr) * | 1991-06-04 | 1992-12-11 | Adir | Nouveaux peptides et pseudopeptides, derives de tachykinines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
-
1990
- 1990-08-06 ZA ZA906188A patent/ZA906188B/xx unknown
- 1990-08-06 AU AU60222/90A patent/AU638264B2/en not_active Expired
- 1990-08-07 AR AR90317547A patent/AR246087A1/es active
- 1990-08-07 CA CA002022740A patent/CA2022740C/en not_active Expired - Lifetime
- 1990-08-07 IL IL9530990A patent/IL95309A/en not_active IP Right Cessation
- 1990-08-08 NZ NZ234814A patent/NZ234814A/en unknown
- 1990-08-08 FI FI903922A patent/FI95913C/fi active IP Right Grant
- 1990-08-09 PT PT94952A patent/PT94952B/pt not_active IP Right Cessation
- 1990-08-09 HU HU904952A patent/HU206729B/hu not_active IP Right Cessation
- 1990-08-09 CN CN90106972A patent/CN1035056C/zh not_active Expired - Fee Related
- 1990-08-09 EP EP90115309A patent/EP0412542B1/en not_active Expired - Lifetime
- 1990-08-09 NO NO903513A patent/NO177715C/no unknown
- 1990-08-09 KR KR1019900012226A patent/KR0169123B1/ko not_active IP Right Cessation
- 1990-08-09 AT AT90115309T patent/ATE132503T1/de not_active IP Right Cessation
- 1990-08-09 DE DE69024555T patent/DE69024555T2/de not_active Expired - Lifetime
- 1990-08-09 IE IE288690A patent/IE69382B1/en not_active IP Right Cessation
- 1990-08-09 ES ES90115309T patent/ES2084627T3/es not_active Expired - Lifetime
- 1990-08-09 JP JP2209390A patent/JP2829779B2/ja not_active Expired - Lifetime
- 1990-08-09 DK DK90115309.8T patent/DK0412542T3/da active
- 1990-08-10 DD DD90343398A patent/DD297168A5/de unknown
-
1996
- 1996-02-14 GR GR960400385T patent/GR3018984T3/el unknown
-
1997
- 1997-03-05 US US08/811,913 patent/US5731286A/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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