ES2054613T3 - Un metodo para preparar una formulacion de liberacion mantenida. - Google Patents

Un metodo para preparar una formulacion de liberacion mantenida.

Info

Publication number
ES2054613T3
ES2054613T3 ES86117946T ES86117946T ES2054613T3 ES 2054613 T3 ES2054613 T3 ES 2054613T3 ES 86117946 T ES86117946 T ES 86117946T ES 86117946 T ES86117946 T ES 86117946T ES 2054613 T3 ES2054613 T3 ES 2054613T3
Authority
ES
Spain
Prior art keywords
mixture
gelatin
collagen
preparing
release formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES86117946T
Other languages
English (en)
Inventor
Keiji Fujioka
Shigeji Sato
Yoshio Sasaki
Teruo Miyata
Masayasu Furuse
Hiromi Naito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koken Co Ltd
Sumitomo Pharmaceuticals Co Ltd
Original Assignee
Koken Co Ltd
Sumitomo Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP29459785A external-priority patent/JPS62152816A/ja
Priority claimed from JP29129886A external-priority patent/JPH0759522B2/ja
Application filed by Koken Co Ltd, Sumitomo Pharmaceuticals Co Ltd filed Critical Koken Co Ltd
Application granted granted Critical
Publication of ES2054613T3 publication Critical patent/ES2054613T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2063—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE DESCRIBE UN METODO PARA PREPARAR UNA FORMULACION DE LIBERACION CONTINUA QUE UTILIZA COLAGENO Y/O GELATINA COMO PORTADOR, QUE COMPRENDE LAS ETAPAS: (I) PREPARACION DE UNA MEZCLA UNIFORME Y MUY CONCENTRADA CON RESPECTO AL COLAGENO Y/O GELATINA, MEZCLANDO UN INGREDIENTE ACTIVO, DICHO COLAGENO Y/O GELATINA Y UNA MEZCLA QUE CONSTA DE AGUA Y UN DISOLVENTE ORGANICO HIDROFILO BAJO UNA DE LAS CONDICIONES ELEGIDAS DE: (A) EL PH DE LA MEZCLA SE MANTIENE POR DEBAJO DE 5 Y LA CONCENTRACION SALINA DE LA MEZCLA SE MANTIENE POR DEBAJO DE LA CONCENTRACION FORMADORA DE FIBRAS; (B) SE EMPLEA COLAGENO QUIMICAMENTE MODIFICADO Y/O GELATINA; Y (C) SE A/ADE GLUCOSA A LA MEZCLA; (II) MOLDEADO DE LA MEZCLA RESULTANTE; Y (III) ELIMINACION GRADUAL DEL DISOLVENTE DEL PRODUCTO MOLDEADO.
ES86117946T 1985-12-27 1986-12-23 Un metodo para preparar una formulacion de liberacion mantenida. Expired - Lifetime ES2054613T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP29459785A JPS62152816A (ja) 1985-12-27 1985-12-27 ゲル状高分子の成形方法
JP29459685 1985-12-27
JP29129886A JPH0759522B2 (ja) 1985-12-27 1986-12-05 徐放性製剤の製造法

Publications (1)

Publication Number Publication Date
ES2054613T3 true ES2054613T3 (es) 1994-08-16

Family

ID=27337645

Family Applications (1)

Application Number Title Priority Date Filing Date
ES86117946T Expired - Lifetime ES2054613T3 (es) 1985-12-27 1986-12-23 Un metodo para preparar una formulacion de liberacion mantenida.

Country Status (6)

Country Link
US (1) US4849141A (es)
EP (1) EP0230647B1 (es)
AT (1) ATE87469T1 (es)
CA (1) CA1277601C (es)
DE (1) DE3688188T2 (es)
ES (1) ES2054613T3 (es)

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AU1432292A (en) * 1991-02-07 1992-09-07 Lawrence Samuel Bass Drug delivery composition and method of using the same
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FR2686250A1 (fr) * 1992-01-16 1993-07-23 Coletica Compositions injectables contenant en suspension des microcapsules a base de collagene, leur utilisation biomedicale et des compositions pharmaceutiques.
US5658593A (en) * 1992-01-16 1997-08-19 Coletica Injectable compositions containing collagen microcapsules
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GB2280850B (en) * 1993-07-28 1997-07-30 Johnson & Johnson Medical Absorbable composite materials for use in the treatment of periodontal disease
GB2281861B (en) * 1993-09-21 1997-08-20 Johnson & Johnson Medical Bioabsorbable wound implant materials containing microspheres
EP1217101B8 (en) 1994-04-29 2006-02-01 Boston Scientific Scimed, Inc. Stent with collagen
US5595760A (en) * 1994-09-02 1997-01-21 Delab Sustained release of peptides from pharmaceutical compositions
US5582591A (en) * 1994-09-02 1996-12-10 Delab Delivery of solid drug compositions
US5837276A (en) * 1994-09-02 1998-11-17 Delab Apparatus for the delivery of elongate solid drug compositions
US6998268B2 (en) 1995-07-03 2006-02-14 Dainippon Sumitomo Pharma Co. Ltd. Gene preparations
US6090915A (en) * 1996-10-18 2000-07-18 Hormel Foods Corporation Collagen or gelatin crumble composition and uses
TW586934B (en) * 1997-05-19 2004-05-11 Sumitomo Pharma Immunopotentiating composition
DE19739031A1 (de) * 1997-09-05 1999-03-11 Suwelack Nachf Dr Otto Mittel zur peroralen Verabreichung, seine Herstellung und Verwendung
US6432442B1 (en) 1998-02-23 2002-08-13 Mcneil-Ppc, Inc. Chewable product
US20030007991A1 (en) * 1998-09-25 2003-01-09 Masters David B. Devices including protein matrix materials and methods of making and using thereof
US20050147690A1 (en) * 1998-09-25 2005-07-07 Masters David B. Biocompatible protein particles, particle devices and methods thereof
US7662409B2 (en) * 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
US20010046968A1 (en) * 2000-03-23 2001-11-29 Zagon Ian S. Opioid growth factor modulates angiogenesis
US20030003157A1 (en) * 2001-06-06 2003-01-02 University Of Medicine & Dentistry Of New Jersey Collagen compositions and methods for making and using the same
JP2003119156A (ja) * 2001-08-06 2003-04-23 Kikuji Yamashita コラーゲンを含有する口腔用剤、医薬品および医薬部外品
BR0308137A (pt) * 2002-03-04 2005-01-04 Sod Conseils Rech Applic Formulações de droga de liberação constante contendo um peptìdeo veìculo
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US8465537B2 (en) * 2003-06-17 2013-06-18 Gel-Del Technologies, Inc. Encapsulated or coated stent systems
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US8283312B2 (en) 2005-02-04 2012-10-09 The Research Foundation Of State University Of New York Compositions and methods for modulating body weight and treating obesity-related disorders
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Also Published As

Publication number Publication date
EP0230647A3 (en) 1988-12-14
EP0230647B1 (en) 1993-03-31
US4849141A (en) 1989-07-18
CA1277601C (en) 1990-12-11
EP0230647A2 (en) 1987-08-05
DE3688188D1 (de) 1993-05-06
ATE87469T1 (de) 1993-04-15
DE3688188T2 (de) 1993-10-14

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