DE3688188D1 - Verfahren zur herstellung einer formulierung mit verzoegerter freisetzung. - Google Patents
Verfahren zur herstellung einer formulierung mit verzoegerter freisetzung.Info
- Publication number
- DE3688188D1 DE3688188D1 DE8686117946T DE3688188T DE3688188D1 DE 3688188 D1 DE3688188 D1 DE 3688188D1 DE 8686117946 T DE8686117946 T DE 8686117946T DE 3688188 T DE3688188 T DE 3688188T DE 3688188 D1 DE3688188 D1 DE 3688188D1
- Authority
- DE
- Germany
- Prior art keywords
- mixture
- gelatin
- collagen
- release formulation
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2063—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Peptides Or Proteins (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP29459785A JPS62152816A (ja) | 1985-12-27 | 1985-12-27 | ゲル状高分子の成形方法 |
JP29459685 | 1985-12-27 | ||
JP29129886A JPH0759522B2 (ja) | 1985-12-27 | 1986-12-05 | 徐放性製剤の製造法 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3688188D1 true DE3688188D1 (de) | 1993-05-06 |
DE3688188T2 DE3688188T2 (de) | 1993-10-14 |
Family
ID=27337645
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE86117946T Expired - Fee Related DE3688188T2 (de) | 1985-12-27 | 1986-12-23 | Verfahren zur Herstellung einer Formulierung mit verzögerter Freisetzung. |
Country Status (6)
Country | Link |
---|---|
US (1) | US4849141A (de) |
EP (1) | EP0230647B1 (de) |
AT (1) | ATE87469T1 (de) |
CA (1) | CA1277601C (de) |
DE (1) | DE3688188T2 (de) |
ES (1) | ES2054613T3 (de) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5556620A (en) * | 1985-02-05 | 1996-09-17 | Cetus Oncology Corporation | Use of recombinant colony stimulating factor-1 to enhance wound healing |
JPH0720483B2 (ja) * | 1987-05-29 | 1995-03-08 | 住友製薬株式会社 | 高粘度糊状組成物成形体の乾燥法 |
ATE90205T1 (de) * | 1987-09-08 | 1993-06-15 | Takeda Chemical Industries Ltd | Wasserunloesliche cytokine. |
DE68907066T2 (de) * | 1988-01-29 | 1993-12-16 | Koken Kk | Verbesserte Formulierungen mit kontrollierter Abgabe. |
US6919308B2 (en) | 1988-04-08 | 2005-07-19 | Stryker Corporation | Osteogenic devices |
US4975526A (en) * | 1989-02-23 | 1990-12-04 | Creative Biomolecules, Inc. | Bone collagen matrix for zenogenic implants |
US5162114A (en) * | 1989-02-23 | 1992-11-10 | Stryker Corporation | Bone collagen matrix for xenogenic implants |
US5266683A (en) * | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
US6586388B2 (en) | 1988-04-08 | 2003-07-01 | Stryker Corporation | Method of using recombinant osteogenic protein to repair bone or cartilage defects |
US5354557A (en) * | 1988-04-08 | 1994-10-11 | Stryker Corporation | Osteogenic devices |
US5023080A (en) * | 1988-06-17 | 1991-06-11 | Basic Bio Systems, Inc. | Time release protein |
US5447966A (en) * | 1988-07-19 | 1995-09-05 | United States Surgical Corporation | Treating bioabsorbable surgical articles by coating with glycerine, polalkyleneoxide block copolymer and gelatin |
US5298243A (en) * | 1988-10-20 | 1994-03-29 | Denki Kagaku Kogyo Kabushiki Kaisha | Colony stimulating factor-gelatin conjugate |
US4992220A (en) * | 1989-06-23 | 1991-02-12 | Neri Michael A | Method for producing biodegradable packaging material |
JP2719671B2 (ja) * | 1989-07-11 | 1998-02-25 | 日本ゼオン株式会社 | 創傷被覆材 |
JP3187410B2 (ja) * | 1989-08-10 | 2001-07-11 | 住友製薬株式会社 | 脳内投与用徐放性製剤 |
DK0448704T3 (da) * | 1989-10-17 | 1999-04-06 | Stryker Corp | Osteogene anordninger |
US5645591A (en) * | 1990-05-29 | 1997-07-08 | Stryker Corporation | Synthetic bone matrix |
US5081106A (en) * | 1990-07-16 | 1992-01-14 | The Oregon Health Sciences University | Wound dressing protocol utilizing collagen gelatin formed with iodine |
US5128136A (en) * | 1990-07-16 | 1992-07-07 | The Oregon Health Sciences University | Wound healing kit comprised of gelable collagen |
US5139152A (en) * | 1990-07-18 | 1992-08-18 | Rhone-Poulenc Ag Company | Water dispersible gel formulations |
AU1432292A (en) * | 1991-02-07 | 1992-09-07 | Lawrence Samuel Bass | Drug delivery composition and method of using the same |
US5496559A (en) * | 1991-04-08 | 1996-03-05 | Sumitomo Pharmaceuticals Company, Limited | Porous solid formulations containing proteinaceous physiologically active substances |
CA2071137A1 (en) * | 1991-07-10 | 1993-01-11 | Clarence C. Lee | Composition and method for revitalizing scar tissue |
FR2686250A1 (fr) * | 1992-01-16 | 1993-07-23 | Coletica | Compositions injectables contenant en suspension des microcapsules a base de collagene, leur utilisation biomedicale et des compositions pharmaceutiques. |
US5658593A (en) * | 1992-01-16 | 1997-08-19 | Coletica | Injectable compositions containing collagen microcapsules |
US5876754A (en) * | 1992-01-17 | 1999-03-02 | Alfatec-Pharma Gmbh | Solid bodies containing active substances and a structure consisting of hydrophilic macromolecules, plus a method of producing such bodies |
ES2108258T3 (es) * | 1992-01-17 | 1997-12-16 | Alfatec Pharma Gmbh | Granulos que contienen sustancias medicamentosas peptidicas y su preparacion asi como su empleo. |
WO1994008568A1 (en) * | 1992-10-16 | 1994-04-28 | Nippon Shinyaku Co., Ltd. | Method of manufacturing wax matrices |
CN1040840C (zh) * | 1993-02-22 | 1998-11-25 | 唐山市骨科医院 | 抗生素植入剂及生产方法 |
US6001895A (en) * | 1993-03-22 | 1999-12-14 | Johnson & Johnson Medical, Inc. | Composite surgical material |
GB2280850B (en) * | 1993-07-28 | 1997-07-30 | Johnson & Johnson Medical | Absorbable composite materials for use in the treatment of periodontal disease |
US6015844A (en) * | 1993-03-22 | 2000-01-18 | Johnson & Johnson Medical, Inc. | Composite surgical material |
GB2281861B (en) * | 1993-09-21 | 1997-08-20 | Johnson & Johnson Medical | Bioabsorbable wound implant materials containing microspheres |
DE69527141T2 (de) | 1994-04-29 | 2002-11-07 | Scimed Life Systems, Inc. | Stent mit kollagen |
US5582591A (en) * | 1994-09-02 | 1996-12-10 | Delab | Delivery of solid drug compositions |
US5595760A (en) * | 1994-09-02 | 1997-01-21 | Delab | Sustained release of peptides from pharmaceutical compositions |
US5837276A (en) * | 1994-09-02 | 1998-11-17 | Delab | Apparatus for the delivery of elongate solid drug compositions |
US6998268B2 (en) | 1995-07-03 | 2006-02-14 | Dainippon Sumitomo Pharma Co. Ltd. | Gene preparations |
US6090915A (en) * | 1996-10-18 | 2000-07-18 | Hormel Foods Corporation | Collagen or gelatin crumble composition and uses |
TW586934B (en) * | 1997-05-19 | 2004-05-11 | Sumitomo Pharma | Immunopotentiating composition |
DE19739031A1 (de) * | 1997-09-05 | 1999-03-11 | Suwelack Nachf Dr Otto | Mittel zur peroralen Verabreichung, seine Herstellung und Verwendung |
US6432442B1 (en) | 1998-02-23 | 2002-08-13 | Mcneil-Ppc, Inc. | Chewable product |
US20030007991A1 (en) * | 1998-09-25 | 2003-01-09 | Masters David B. | Devices including protein matrix materials and methods of making and using thereof |
US20050147690A1 (en) * | 1998-09-25 | 2005-07-07 | Masters David B. | Biocompatible protein particles, particle devices and methods thereof |
US7662409B2 (en) * | 1998-09-25 | 2010-02-16 | Gel-Del Technologies, Inc. | Protein matrix materials, devices and methods of making and using thereof |
US20010046968A1 (en) * | 2000-03-23 | 2001-11-29 | Zagon Ian S. | Opioid growth factor modulates angiogenesis |
US20030003157A1 (en) * | 2001-06-06 | 2003-01-02 | University Of Medicine & Dentistry Of New Jersey | Collagen compositions and methods for making and using the same |
JP2003119156A (ja) * | 2001-08-06 | 2003-04-23 | Kikuji Yamashita | コラーゲンを含有する口腔用剤、医薬品および医薬部外品 |
EP1480618B1 (de) * | 2002-03-04 | 2009-06-03 | Ipsen Pharma | Arzneimittelformulierungen mit verzögerter freisetzung mit einem trägerpeptid |
AU2003225212A1 (en) * | 2002-04-29 | 2003-11-17 | Gel-Del Technologies, Inc. | Biomatrix structural containment and fixation systems and methods of use thereof |
US8465537B2 (en) * | 2003-06-17 | 2013-06-18 | Gel-Del Technologies, Inc. | Encapsulated or coated stent systems |
US8153591B2 (en) * | 2003-08-26 | 2012-04-10 | Gel-Del Technologies, Inc. | Protein biomaterials and biocoacervates and methods of making and using thereof |
AU2004296851A1 (en) * | 2003-12-08 | 2005-06-23 | Gel-Del Technologies, Inc. | Mucoadhesive drug delivery devices and methods of making and using thereof |
US8283312B2 (en) | 2005-02-04 | 2012-10-09 | The Research Foundation Of State University Of New York | Compositions and methods for modulating body weight and treating obesity-related disorders |
DE102007051059B4 (de) * | 2007-10-18 | 2014-04-03 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen | Bioverbundmaterial für die kontrollierte Freisetzung von Wirkstoffen |
WO2009086483A2 (en) * | 2007-12-26 | 2009-07-09 | Gel-Del Technologies, Inc. | Biocompatible protein particles, particle devices and methods thereof |
US10016534B2 (en) | 2008-11-17 | 2018-07-10 | Gel-Del Technologies, Inc. | Protein biomaterial and biocoacervate vessel graft systems and methods of making and using thereof |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB642385A (en) * | 1947-06-03 | 1950-08-30 | Wyeth Corp | Improvements in therapeutic products |
US2518510A (en) * | 1947-08-25 | 1950-08-15 | Weich Henry | Stable injectable oil-pectin therapeutic compositions |
US3016895A (en) * | 1958-08-01 | 1962-01-16 | Pan American Lab Inc | Injector for subcutaneous implantation of solids |
US3143475A (en) * | 1961-01-23 | 1964-08-04 | Hoffmann La Roche | Vitamin-containing gelatin beadlets and the process of preparing them |
US3857932A (en) * | 1970-09-09 | 1974-12-31 | F Gould | Dry hydrophilic acrylate or methacrylate polymer prolonged release drug implants |
US4193813A (en) * | 1976-09-07 | 1980-03-18 | Medi-Coll, Inc. | Method for making collagen sponge |
US4181731A (en) * | 1976-09-07 | 1980-01-01 | Sumitomo Chemical Company, Limited | Novel therapeutic application of 4-carbamoyl-5-hydroxyimidazole |
US4294241A (en) * | 1977-06-09 | 1981-10-13 | Teruo Miyata | Collagen skin dressing |
US4164559A (en) * | 1977-09-21 | 1979-08-14 | Cornell Research Foundation, Inc. | Collagen drug delivery device |
DE2843963A1 (de) * | 1978-10-09 | 1980-04-24 | Merck Patent Gmbh | Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin |
US4245635A (en) * | 1979-01-29 | 1981-01-20 | Jelco Laboratories | Catheter assembly for intermittent intravenous use |
GB2042888B (en) * | 1979-03-05 | 1983-09-28 | Teijin Ltd | Preparation for administration to the mucosa of the oral or nasal cavity |
US4279812A (en) * | 1979-09-12 | 1981-07-21 | Seton Company | Process for preparing macromolecular biologically active collagen |
US4374121A (en) * | 1979-09-12 | 1983-02-15 | Seton Company | Macromolecular biologically active collagen articles |
US4412947A (en) * | 1979-09-12 | 1983-11-01 | Seton Company | Collagen sponge |
IN151913B (de) * | 1980-01-11 | 1983-09-03 | Boots Co Ltd | |
JPS56122317A (en) * | 1980-02-29 | 1981-09-25 | Koken:Kk | Drug transporting material and its preparation |
GB2075458B (en) * | 1980-04-21 | 1983-06-02 | Nicholas Pty Ltd | Encapsulation of indomethacin |
US4440680A (en) * | 1980-09-24 | 1984-04-03 | Seton Company | Macromolecular biologically active collagen articles |
GB2091554B (en) * | 1981-01-13 | 1984-09-12 | Mitsui Toatsu Chemicals | Rod like moulded drug |
US4483807A (en) * | 1981-01-27 | 1984-11-20 | Japan Atomic Energy Research Institute | Process for producing a slow release composite |
US4357312A (en) * | 1981-07-16 | 1982-11-02 | The Children's Hospital Medical Center | Method of making prolonged release body |
DE3134479C2 (de) * | 1981-09-01 | 1988-12-22 | Josef A. 7144 Asperg Blach | Vorrichtung zum kontinuierlichen Aufschmelzen und Mischen von Kunststoffen |
US4409332A (en) * | 1982-01-12 | 1983-10-11 | Jefferies Steven R | Collagen-enzyme conjugates that exhibit no inflammatory response and method for making the same |
DE3360633D1 (en) * | 1982-02-12 | 1985-10-03 | Unitika Ltd | Anti-cancer device |
DE3372705D1 (en) * | 1982-04-30 | 1987-09-03 | Takeda Chemical Industries Ltd | Pharmaceutical composition and its use |
DE3380726D1 (en) * | 1982-06-24 | 1989-11-23 | Japan Chem Res | Long-acting composition |
JPS597684A (ja) * | 1982-07-05 | 1984-01-14 | 株式会社日立製作所 | エスカレ−タ− |
JPS5919925A (ja) * | 1982-07-27 | 1984-02-01 | Stanley Electric Co Ltd | 2層式液晶セルの製造方法 |
ZA836030B (en) * | 1983-08-16 | 1985-02-27 | Verex Lab | Constant order release solid dosage indomethacin formulation and method of treating arthritis and other inflammatory conditions |
DE3484951D1 (de) * | 1983-10-14 | 1991-09-26 | Sumitomo Pharma | Verlaengerte praeparate mit verzoegerter abgabe. |
EP0138216B1 (de) * | 1983-10-14 | 1993-01-07 | Sumitomo Pharmaceuticals Company, Limited | IFN-Präparat mit verzögerter Abgabe für parentale Verabreichung |
US4774091A (en) * | 1983-10-14 | 1988-09-27 | Sumitomo Pharmaceuticals Company, Ltd. | Long-term sustained-release preparation |
DE3484584D1 (de) * | 1983-10-14 | 1991-06-20 | Sumitomo Pharma | Injektionen mit verzoegerter abgabe. |
DE3429038A1 (de) * | 1984-08-07 | 1986-02-20 | B. Braun Melsungen Ag, 3508 Melsungen | Wirkstoff-depot |
-
1986
- 1986-12-23 EP EP86117946A patent/EP0230647B1/de not_active Expired - Lifetime
- 1986-12-23 ES ES86117946T patent/ES2054613T3/es not_active Expired - Lifetime
- 1986-12-23 CA CA000526240A patent/CA1277601C/en not_active Expired - Fee Related
- 1986-12-23 DE DE86117946T patent/DE3688188T2/de not_active Expired - Fee Related
- 1986-12-23 AT AT86117946T patent/ATE87469T1/de not_active IP Right Cessation
- 1986-12-24 US US06/946,075 patent/US4849141A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE87469T1 (de) | 1993-04-15 |
EP0230647A2 (de) | 1987-08-05 |
US4849141A (en) | 1989-07-18 |
EP0230647A3 (en) | 1988-12-14 |
DE3688188T2 (de) | 1993-10-14 |
CA1277601C (en) | 1990-12-11 |
EP0230647B1 (de) | 1993-03-31 |
ES2054613T3 (es) | 1994-08-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |