ES2053582T3 - Procedimiento para la obtencion de derivados del acido 5-amino-4-hidroxivalerianico. - Google Patents

Procedimiento para la obtencion de derivados del acido 5-amino-4-hidroxivalerianico.

Info

Publication number
ES2053582T3
ES2053582T3 ES87810450T ES87810450T ES2053582T3 ES 2053582 T3 ES2053582 T3 ES 2053582T3 ES 87810450 T ES87810450 T ES 87810450T ES 87810450 T ES87810450 T ES 87810450T ES 2053582 T3 ES2053582 T3 ES 2053582T3
Authority
ES
Spain
Prior art keywords
amino
cycloalkyl
aryl
lower alkyl
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87810450T
Other languages
English (en)
Inventor
Peter Dr Herold
Christof Dr Angst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of ES2053582T3 publication Critical patent/ES2053582T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03—Monocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/26—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS PROCEDIMIENTOS Y PRODUCTOS INTERMEDIOS PARA LA PREPARACION DE NUEVOS DERIVADOS DEL ACIDO 5-AMINO-4-HIDROXI-VALERIANICO DE FORMULA (I) EN LA QUE R1 ES H, EVENTUALMENTE ALQUILO SUSTITUIDO, CICLOALQUILO, CICLOALQUILO ALQUILO INFERIOR, ARILO, ARILALQUILO INFERIOR O EL RESTO DE UN AMINOACIDO NATURAL; R2 HIDROGENO, EVENTUALMENTE ALQUILO SUSTITUIDO, CICLOALQUILO-ALQUILO-INFERIOR, ARILO, ARILALQUILO (INFERIOR), AMINO, HIDROXI, MERCAPTO SULFINILO, SULFONILO O EL RESTO DE UN AMINOACIDO NATURAL Y R3 ES EVENTUALMENTE HIDROXI AMINO SUSTITUIDO. MEDIANTE TRANSPOSICION SIGMATROPICA DEL ESTER ALILICO ADECUADO, HALOLACTONIZACION DEL ACIDO GAMMA, DELTA- NO SATURADO OBTENIDO O DE UN DERIVADO ADECUADO, INTERCAMBIO DE HALOGENO MEDIANTE UN NUCLEOFILO QUE CONTENGA NITROGENO, APERTURA DEL ANILLO LACTONA Y LIBERACION DEL GRUPO AMINO. LOS COMPUESTOS DE LA FORMULA (I) SON MATERIALES DE PARTIDA PARA LA OBTENCION DE INHIBIDORES DE RENINA CON ACTIVIDAD ANTI-HIPERTENSORA.
ES87810450T 1986-08-13 1987-08-07 Procedimiento para la obtencion de derivados del acido 5-amino-4-hidroxivalerianico. Expired - Lifetime ES2053582T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH324886 1986-08-13

Publications (1)

Publication Number Publication Date
ES2053582T3 true ES2053582T3 (es) 1994-08-01

Family

ID=4251859

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87810450T Expired - Lifetime ES2053582T3 (es) 1986-08-13 1987-08-07 Procedimiento para la obtencion de derivados del acido 5-amino-4-hidroxivalerianico.

Country Status (14)

Country Link
US (2) US4898977A (es)
EP (1) EP0258183B1 (es)
JP (1) JP2571230B2 (es)
KR (1) KR950013635B1 (es)
AT (1) ATE86971T1 (es)
DD (1) DD269148A5 (es)
DE (1) DE3784812D1 (es)
DK (1) DK420887A (es)
ES (1) ES2053582T3 (es)
FI (1) FI90762C (es)
HU (3) HU202218B (es)
IL (1) IL83497A (es)
MX (1) MX7727A (es)
PT (1) PT85520B (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4992562A (en) * 1985-08-09 1991-02-12 Pfizer Inc. Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues
US5076973A (en) * 1988-10-24 1991-12-31 Arizona Board Of Regents Synthesis of dolastatin 3
AU629867B2 (en) * 1988-11-17 1992-10-15 Imperial Chemical Industries Plc Triazolo (4,3a) pyrazine derivatives
GB8912659D0 (en) * 1989-06-02 1989-07-19 Ici Plc Process
GB8927915D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Novel alcohols
DE4008403A1 (de) * 1990-03-16 1991-09-19 Merck Patent Gmbh Glykolsaeurederivate
US5436339A (en) * 1991-03-06 1995-07-25 Abbott Laboratories Process for the preparation of a substituted diaminoalcohol
EP0546230A1 (en) * 1991-12-10 1993-06-16 Merrell Dow Pharmaceuticals Inc. Novel process for preparing 4-amino-5-hexenoic acid
US5294737A (en) * 1992-02-27 1994-03-15 The Research Foundation State University Of New York Process for the production of chiral hydroxy-β-lactams and hydroxyamino acids derived therefrom
US5977278A (en) * 1993-11-03 1999-11-02 E. I. Du Pont De Nemours And Company Polymers formed from allylic chain transfer agents
AU688403B2 (en) * 1993-11-03 1998-03-12 Commonwealth Scientific And Industrial Research Organisation Allylic chain transfer agents
IL111484A (en) * 1993-11-03 2001-06-14 Commw Scient Ind Res Org Polymerization process using pendant chain transfer means to regulate the molecular weight, the polymers thus obtained and a number of new pesticide compounds
US5475138A (en) * 1994-07-07 1995-12-12 Pharm-Eco Laboratories Incorporated Method preparing amino acid-derived diaminopropanols
US5473104A (en) * 1994-09-13 1995-12-05 Neurocrine Biosciences, Inc. Process for the preparation of L-carnitine
US5760019A (en) * 1996-07-12 1998-06-02 The Research Foundation Of State University Of New York Silanol enzyme inhibitors
US6833460B2 (en) * 1999-06-18 2004-12-21 E. I. Du Pont De Nemours And Company Preparation and use of gamma-butyrolactones as cross-linking agents
US6423850B1 (en) 1999-06-18 2002-07-23 E.I. Du Pont De Nemours And Company Preparation and use of gamma-butyrolactones as cross-linking agents
US7842727B2 (en) * 2001-03-27 2010-11-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7312247B2 (en) 2001-03-27 2007-12-25 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US8026280B2 (en) * 2001-03-27 2011-09-27 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
WO2003099272A1 (en) * 2002-05-22 2003-12-04 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors based on alpha-ketoepoxide compounds
JP2006508986A (ja) * 2002-11-20 2006-03-16 エルラント ゲネ セラペウチクス エルエルシー ヒストンデアセチラーゼ阻害剤による肺細胞の治療方法
CA2587013A1 (en) * 2004-11-08 2006-05-18 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
CA2603129A1 (en) * 2005-04-06 2006-10-12 Teva Pharmaceutical Industries Ltd. Crystalline forms of pregabalin
CA2603215A1 (en) * 2005-04-11 2006-10-19 Teva Pharmaceutical Industries Ltd. Process for making (s)-pregabalin
US7488846B2 (en) * 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
ATE486841T1 (de) * 2005-05-10 2010-11-15 Teva Pharma Verfahren zur herstellung von pregabalin und salzen daraus
WO2006122255A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Pregabalin free of isobutylglutaric acid and a process for preparation thereof
MX2007014129A (es) * 2005-05-10 2008-01-11 Teva Pharma Resolucion optica del acido 3-carbamoilmetil-5-metil hexanoico.
KR20080034205A (ko) * 2005-09-19 2008-04-18 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ)-프레가발린의 신규한 합성을 위한 주요 중간체인 키랄3-카르바모일메틸-5-메틸 헥산산
TW200815323A (en) * 2006-05-24 2008-04-01 Teva Pharma Processes for the preparation of R-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid and salts thereof
EP1912931A2 (en) * 2006-05-31 2008-04-23 Teva Pharmaceutical Industries Ltd. Preparation of (s)-pregabalin-nitrile
WO2007143113A2 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. The use of enzymatic resolution for the preparation of intermediates of pregabalin
BRPI0803092A2 (pt) * 2007-03-22 2011-08-30 Teva Pharma sìntese de (s)-(+)-3-(aminometil)-5-metil ácido hexanóico, (s)-pregabalina
DE102007049039A1 (de) 2007-10-11 2009-04-16 Reuter Chemischer Apparatebau Kg Verfahren zur Herstellung von 8-Hydrazino-8-Aryl-Octanoylderivaten und deren Verwendung
US20100087525A1 (en) * 2008-06-23 2010-04-08 Lilach Hedvati Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
US8257462B2 (en) * 2009-10-15 2012-09-04 Federal-Mogul Corporation Iron-based sintered powder metal for wear resistant applications
JP5585172B2 (ja) * 2010-04-05 2014-09-10 三菱瓦斯化学株式会社 脂環式エステル化合物の製造方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB960005A (en) * 1961-01-18 1964-06-10 Distillers Co Yeast Ltd Production of acrylic and methacrylic esters
DE1914380A1 (de) * 1969-03-21 1970-10-01 Basf Ag Verfahren zur Herstellung von Buta-1,3-dien-1-carbonsaeurealkylestern
US4031115A (en) * 1976-03-29 1977-06-21 Chevron Research Company 4-Pentenoic acid conversion
CH634815A5 (fr) * 1978-08-30 1983-02-28 Firmenich & Cie Procede pour la preparation d'esters et acides gamma, delta-insatures.
US4372974A (en) * 1980-06-25 1983-02-08 New York University Anticonvulsive compositions and method of treating convulsive disorders
US4609643A (en) * 1980-08-06 1986-09-02 Aktiebolaget Hassle Renin inhibitors, treatments and dipeptide synthesis
US4487963A (en) * 1983-01-03 1984-12-11 Merck & Co., Inc. Enantioselective synthesis of 4-amino-3-hydroxy-2,4-(disubstituted)pentanoic acid
US4613676A (en) * 1983-11-23 1986-09-23 Ciba-Geigy Corporation Substituted 5-amino-4-hydroxyvaleryl derivatives
EP0173481A3 (en) * 1984-08-06 1988-12-21 The Upjohn Company Peptides
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
US4665055A (en) * 1985-06-17 1987-05-12 Merck & Co., Inc. Peptide renin inhibitors
WO1988003022A1 (en) * 1986-10-31 1988-05-05 Pfizer Inc. Relatively low molecular weight polypeptides as renin inhibitors

Also Published As

Publication number Publication date
HU198445B (en) 1989-10-30
EP0258183A3 (en) 1989-07-26
KR880002808A (ko) 1988-05-11
JPS6357561A (ja) 1988-03-12
DD269148A5 (de) 1989-06-21
DK420887D0 (da) 1987-08-12
FI873467A (fi) 1988-02-14
JP2571230B2 (ja) 1997-01-16
FI90762C (fi) 1994-03-25
EP0258183B1 (de) 1993-03-17
IL83497A0 (en) 1988-01-31
HU202218B (en) 1991-02-28
FI873467A0 (fi) 1987-08-10
PT85520A (en) 1987-09-01
FI90762B (fi) 1993-12-15
US4898977A (en) 1990-02-06
MX7727A (es) 1993-12-01
ATE86971T1 (de) 1993-04-15
EP0258183A2 (de) 1988-03-02
HU200981B (en) 1990-09-28
US5010189A (en) 1991-04-23
DK420887A (da) 1988-02-14
PT85520B (pt) 1990-06-29
DE3784812D1 (de) 1993-04-22
KR950013635B1 (ko) 1995-11-13
IL83497A (en) 1993-02-21
HUT44478A (en) 1988-03-28

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