ES2053466T3 - Procedimiento para preparar compuestos intermedios de 7-oxabicicloheptano-amino-alcohol utiles para la preparacion de antagonistas de los receptores de tromboxano a2 y nuevos compuestos intermedios producidos con el. - Google Patents

Procedimiento para preparar compuestos intermedios de 7-oxabicicloheptano-amino-alcohol utiles para la preparacion de antagonistas de los receptores de tromboxano a2 y nuevos compuestos intermedios producidos con el.

Info

Publication number
ES2053466T3
ES2053466T3 ES87108128T ES87108128T ES2053466T3 ES 2053466 T3 ES2053466 T3 ES 2053466T3 ES 87108128 T ES87108128 T ES 87108128T ES 87108128 T ES87108128 T ES 87108128T ES 2053466 T3 ES2053466 T3 ES 2053466T3
Authority
ES
Spain
Prior art keywords
intermediate compounds
amino
oxabicicloheptano
thromboxan
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87108128T
Other languages
English (en)
Inventor
John Kurian Thottathill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Application granted granted Critical
Publication of ES2053466T3 publication Critical patent/ES2053466T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA INVENCION DESCRIBE UN PROCEDIMIENTO PARA PREPARAR COMPUESTOS INTERMEDIOS DE ESTRUCTURA GENERAL (IB) O (I) QUE REPRESENTAN LOS ISOMEROS D O L, UTILES PARA PREPARAR ANTAGONISTAS DE RECEPTORES DE TROMBOXANO A2. LOS COMPUESTOS SE PREPARAN HACIENDO REACCIONAR MESOANHIDRIDO CON UNA ARILAMINA (C), EN LA QUE R ES ALQUILO, CH2OH, CO2H O CO2-ALQUILO PARA FORMAR UN ACIDO QUE EN UNA SERIE DE PASOS SUCESIVOS DA LUGAR AL AMINOALCOHOL INTERMEDIO. TODOS LOS COMPUESTOS DE 7-OXABICICLOHEPTANO QUE SE FORMAN EN LA PRESENTE INVENCION SON NUEVOS Y QUEDAN PROTEGIDOS EN LA PATENTE.
ES87108128T 1986-06-04 1987-06-04 Procedimiento para preparar compuestos intermedios de 7-oxabicicloheptano-amino-alcohol utiles para la preparacion de antagonistas de los receptores de tromboxano a2 y nuevos compuestos intermedios producidos con el. Expired - Lifetime ES2053466T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/870,564 US4687865A (en) 1986-06-04 1986-06-04 Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists
HU872539A HU201941B (en) 1986-06-04 1987-06-03 Process for producing 7-oxabicycloheptane aminoalcohol

Publications (1)

Publication Number Publication Date
ES2053466T3 true ES2053466T3 (es) 1994-08-01

Family

ID=26317529

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87108128T Expired - Lifetime ES2053466T3 (es) 1986-06-04 1987-06-04 Procedimiento para preparar compuestos intermedios de 7-oxabicicloheptano-amino-alcohol utiles para la preparacion de antagonistas de los receptores de tromboxano a2 y nuevos compuestos intermedios producidos con el.

Country Status (13)

Country Link
US (1) US4687865A (es)
EP (1) EP0248435B1 (es)
JP (1) JP2525411B2 (es)
AT (1) ATE86997T1 (es)
AU (1) AU597373B2 (es)
CA (1) CA1305713C (es)
DE (1) DE3784772T2 (es)
DK (1) DK284587A (es)
ES (1) ES2053466T3 (es)
HU (1) HU201941B (es)
IE (1) IE60657B1 (es)
NZ (1) NZ220228A (es)
ZA (1) ZA873282B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU593316B2 (en) * 1986-02-14 1990-02-08 E.R. Squibb & Sons, Inc. Hydroxamic acids of 7-oxabicycloheptane substituted ethers
US4749715A (en) * 1987-03-02 1988-06-07 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted amino prostaglandin analogs
US4900723A (en) * 1988-04-29 1990-02-13 E. R. Squibb & Sons, Inc. Method of preventing or reducing venous thrombosis using a thromboxane A2 receptor antagonist in conjunction with heparin and combination
CA2006086A1 (en) * 1989-01-17 1990-07-17 A. K. Gunnar Aberg Method of preventing or treating atherosclerosis using a thromboxane a receptor antagonist
NZ233600A (en) * 1989-06-12 1992-10-28 Squibb & Sons Inc 7-oxabicyclo(2.2.1)heptane imidazole prostaglandin analogs and pharmaceutical compositions
US5081266A (en) * 1990-02-26 1992-01-14 E. R. Squibb & Sons, Inc. Process for preparing [1S-[1α,2α(Z),3α,4α]]-7-[3-[[[[(1-oxoheptyl)-amino]acetyl]amino]methyl]-7-oxabicyclo-[2.2.1]hept-2-yl]-5-heptenoic acid
US4978762A (en) * 1990-02-26 1990-12-18 E. R. Squibb & Sons, Inc. Process for preparing [1S-[1α,2α)Z),3α,4α]]-7-[3-[[[[[1-oxoheptyl]-amino]acetyl]amino]methyl]-7-oxabicyclo-[2,2,1]hept-2-yl]-5-heptenoic acid
AU667280B2 (en) * 1993-08-30 1996-03-14 Otsuka Pharmaceutical Co., Ltd. Benzylamine derivatives
KR102375396B1 (ko) 2014-05-13 2022-03-18 노파르티스 아게 연골형성을 유도하기 위한 화합물 및 조성물

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB760686A (en) * 1953-03-25 1956-11-07 Pennsylvania Salt Mfg Co Oxygen-bridged hydrogenated derivatives of phthalamic acid
US4254044A (en) * 1977-11-04 1981-03-03 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane- and 7-oxabicycloheptene compounds
US4220594A (en) * 1977-11-04 1980-09-02 E. R. Squibb & Sons, Inc. Hexa- and octahydro-4,7-epoxyisobenzofuran-1-ol and hexa- and octahydro-5,8-epoxy-1H-2-benzopyran-3-ol
US4187236A (en) * 1977-11-04 1980-02-05 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane compounds
US4143054A (en) * 1977-11-04 1979-03-06 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane- and 7-oxabicycloheptene compounds
EP0013607B1 (en) * 1979-01-05 1983-03-23 National Research Development Corporation Substituted bicyclo (2,2,1)heptanes and bicyclo (2,2,1) hept-2-enes and their pharmaceutical compositions
US4228180A (en) * 1979-11-01 1980-10-14 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs
ZA814307B (en) * 1980-07-01 1983-02-23 Nat Res Dev Prostaglandins
GB2113678B (en) * 1981-12-23 1985-06-19 Nat Res Dev Prostaglandins
US4416896A (en) * 1982-05-17 1983-11-22 E. R. Squibb & Sons, Inc. 7-Oxabicyclopheptane substituted amino prostaglandin analogs useful in the treatment of thrombolytic disease
US4456615A (en) * 1982-10-25 1984-06-26 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4456617A (en) * 1983-01-12 1984-06-26 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4474972A (en) * 1983-03-14 1984-10-02 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane prostaglandin intermediates and method for preparing same

Also Published As

Publication number Publication date
ATE86997T1 (de) 1993-04-15
AU7348887A (en) 1987-12-10
DE3784772D1 (de) 1993-04-22
JPS62292786A (ja) 1987-12-19
DK284587D0 (da) 1987-06-03
CA1305713C (en) 1992-07-28
HU201941B (en) 1991-01-28
DE3784772T2 (de) 1993-06-24
NZ220228A (en) 1989-07-27
HUT52776A (en) 1990-08-28
EP0248435B1 (en) 1993-03-17
JP2525411B2 (ja) 1996-08-21
IE60657B1 (en) 1994-08-10
AU597373B2 (en) 1990-05-31
DK284587A (da) 1987-12-05
US4687865A (en) 1987-08-18
EP0248435A1 (en) 1987-12-09
ZA873282B (en) 1987-12-30
IE871419L (en) 1987-12-04

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