DE3784772D1 - Verfahren zur herstellung von 7-oxabicycloheptan-aminoalkohol-zwischenprodukten zur verwendung in der herstellung von thromboxan-a2-antagonisten und zwischenprodukte in diesem verfahren. - Google Patents

Verfahren zur herstellung von 7-oxabicycloheptan-aminoalkohol-zwischenprodukten zur verwendung in der herstellung von thromboxan-a2-antagonisten und zwischenprodukte in diesem verfahren.

Info

Publication number
DE3784772D1
DE3784772D1 DE8787108128T DE3784772T DE3784772D1 DE 3784772 D1 DE3784772 D1 DE 3784772D1 DE 8787108128 T DE8787108128 T DE 8787108128T DE 3784772 T DE3784772 T DE 3784772T DE 3784772 D1 DE3784772 D1 DE 3784772D1
Authority
DE
Germany
Prior art keywords
intermediate products
hydroxymethyl
treating
oxabicycloheptan
thromboxan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8787108128T
Other languages
English (en)
Other versions
DE3784772T2 (de
Inventor
John Kurian Thottathill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of DE3784772D1 publication Critical patent/DE3784772D1/de
Application granted granted Critical
Publication of DE3784772T2 publication Critical patent/DE3784772T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE8787108128T 1986-06-04 1987-06-04 Verfahren zur herstellung von 7-oxabicycloheptan-aminoalkohol-zwischenprodukten zur verwendung in der herstellung von thromboxan-a2-antagonisten und zwischenprodukte in diesem verfahren. Expired - Lifetime DE3784772T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/870,564 US4687865A (en) 1986-06-04 1986-06-04 Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists
HU872539A HU201941B (en) 1986-06-04 1987-06-03 Process for producing 7-oxabicycloheptane aminoalcohol

Publications (2)

Publication Number Publication Date
DE3784772D1 true DE3784772D1 (de) 1993-04-22
DE3784772T2 DE3784772T2 (de) 1993-06-24

Family

ID=26317529

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787108128T Expired - Lifetime DE3784772T2 (de) 1986-06-04 1987-06-04 Verfahren zur herstellung von 7-oxabicycloheptan-aminoalkohol-zwischenprodukten zur verwendung in der herstellung von thromboxan-a2-antagonisten und zwischenprodukte in diesem verfahren.

Country Status (13)

Country Link
US (1) US4687865A (de)
EP (1) EP0248435B1 (de)
JP (1) JP2525411B2 (de)
AT (1) ATE86997T1 (de)
AU (1) AU597373B2 (de)
CA (1) CA1305713C (de)
DE (1) DE3784772T2 (de)
DK (1) DK284587A (de)
ES (1) ES2053466T3 (de)
HU (1) HU201941B (de)
IE (1) IE60657B1 (de)
NZ (1) NZ220228A (de)
ZA (1) ZA873282B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU593316B2 (en) * 1986-02-14 1990-02-08 E.R. Squibb & Sons, Inc. Hydroxamic acids of 7-oxabicycloheptane substituted ethers
US4749715A (en) * 1987-03-02 1988-06-07 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted amino prostaglandin analogs
US4900723A (en) * 1988-04-29 1990-02-13 E. R. Squibb & Sons, Inc. Method of preventing or reducing venous thrombosis using a thromboxane A2 receptor antagonist in conjunction with heparin and combination
CA2006086A1 (en) * 1989-01-17 1990-07-17 A. K. Gunnar Aberg Method of preventing or treating atherosclerosis using a thromboxane a receptor antagonist
NZ233600A (en) * 1989-06-12 1992-10-28 Squibb & Sons Inc 7-oxabicyclo(2.2.1)heptane imidazole prostaglandin analogs and pharmaceutical compositions
US5081266A (en) * 1990-02-26 1992-01-14 E. R. Squibb & Sons, Inc. Process for preparing [1S-[1α,2α(Z),3α,4α]]-7-[3-[[[[(1-oxoheptyl)-amino]acetyl]amino]methyl]-7-oxabicyclo-[2.2.1]hept-2-yl]-5-heptenoic acid
US4978762A (en) * 1990-02-26 1990-12-18 E. R. Squibb & Sons, Inc. Process for preparing [1S-[1α,2α)Z),3α,4α]]-7-[3-[[[[[1-oxoheptyl]-amino]acetyl]amino]methyl]-7-oxabicyclo-[2,2,1]hept-2-yl]-5-heptenoic acid
AU667280B2 (en) * 1993-08-30 1996-03-14 Otsuka Pharmaceutical Co., Ltd. Benzylamine derivatives
WO2015175487A1 (en) 2014-05-13 2015-11-19 Novartis Ag Compounds and compositions for inducing chondrogenesis

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB760686A (en) * 1953-03-25 1956-11-07 Pennsylvania Salt Mfg Co Oxygen-bridged hydrogenated derivatives of phthalamic acid
US4187236A (en) * 1977-11-04 1980-02-05 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane compounds
US4254044A (en) * 1977-11-04 1981-03-03 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane- and 7-oxabicycloheptene compounds
US4220594A (en) * 1977-11-04 1980-09-02 E. R. Squibb & Sons, Inc. Hexa- and octahydro-4,7-epoxyisobenzofuran-1-ol and hexa- and octahydro-5,8-epoxy-1H-2-benzopyran-3-ol
US4143054A (en) * 1977-11-04 1979-03-06 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane- and 7-oxabicycloheptene compounds
JPH025739B2 (de) * 1979-01-05 1990-02-05 Nat Res Dev
US4228180A (en) * 1979-11-01 1980-10-14 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs
ZA829068B (en) * 1980-07-01 1983-02-23 Nat Res Dev Prostaglandins
AU561739B2 (en) * 1981-12-23 1987-05-14 British Technology Group Limited Prostaglandins
US4416896A (en) * 1982-05-17 1983-11-22 E. R. Squibb & Sons, Inc. 7-Oxabicyclopheptane substituted amino prostaglandin analogs useful in the treatment of thrombolytic disease
US4456615A (en) * 1982-10-25 1984-06-26 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4456617A (en) * 1983-01-12 1984-06-26 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4474972A (en) * 1983-03-14 1984-10-02 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane prostaglandin intermediates and method for preparing same

Also Published As

Publication number Publication date
NZ220228A (en) 1989-07-27
AU7348887A (en) 1987-12-10
ZA873282B (en) 1987-12-30
IE60657B1 (en) 1994-08-10
CA1305713C (en) 1992-07-28
ES2053466T3 (es) 1994-08-01
ATE86997T1 (de) 1993-04-15
EP0248435B1 (de) 1993-03-17
IE871419L (en) 1987-12-04
DE3784772T2 (de) 1993-06-24
EP0248435A1 (de) 1987-12-09
AU597373B2 (en) 1990-05-31
DK284587D0 (da) 1987-06-03
JPS62292786A (ja) 1987-12-19
US4687865A (en) 1987-08-18
HU201941B (en) 1991-01-28
JP2525411B2 (ja) 1996-08-21
DK284587A (da) 1987-12-05
HUT52776A (en) 1990-08-28

Similar Documents

Publication Publication Date Title
DE69020794D1 (de) Enzymatische Entfernung einer aminoterminalen Proteinsequenz.
DE3586773D1 (de) Verfahren zur beseitigung von n-endaminosaeureresten aus eukaryotpolypeptidanlagen und so erzeugte polypeptide.
DE3784772T2 (de) Verfahren zur herstellung von 7-oxabicycloheptan-aminoalkohol-zwischenprodukten zur verwendung in der herstellung von thromboxan-a2-antagonisten und zwischenprodukte in diesem verfahren.
ATE108777T1 (de) Substituierte (chinolin-2-yl-methoxy)phenyl-acyl- sulfonamide und -cyanamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln.
DE69011880D1 (de) Verfahren zur Herstellung von L-Aminosäuren durch Fermentation.
ATE196458T1 (de) Verfahren zur herstellung von xylitol
DE59407251D1 (de) Verfahren zur Herstellung von Ketonen
ATE178316T1 (de) Verfahren zur herstellung von aminoalkylguanidinen
ATE154393T1 (de) Verfahren zur herstellung von trans-l-hydroxy- prolin
ATE100801T1 (de) Verfahren zur herstellung von 5-methyltetrazol.
DE59000702D1 (de) Verfahren zur fermentativen herstellung von 2-(4-hydroxiphenoxi-)propionsaeure.
ATE113986T1 (de) Verfahren zur herstellung von aprotinin und aprotinin-homologen in hefe.
ATE196927T1 (de) Verfahren zur herstellung von proteaseinhibitoren
DE69024999T2 (de) Verfahren zur Herstellung von 2-Oxindol-1-carboxamiden
DE59803194D1 (de) Verfahren zur herstellung von 1,3-disubstituierten 2-nitroguanidinen
DE69321767D1 (de) Verfahren zur Herstellung von N-Alkyl oder N-Cycloalkyl-2-Benzolthiazolesulfenimiden
DE69407789T2 (de) Verfahren zur herstellung von (s)-4-aminohepta-5,6-diencarbon-säure und intermediate
DE69015499T2 (de) Verfahren zur Herstellung von Castanosperminestern.
DE68919531D1 (de) Verfahren zur Herstellung von 5-Amino-7(substituierte amino)-chinolin-3-carbonsäure.
ATE301637T1 (de) Verfahren zur herstellung von n-geschützten azetidin-2-carbonsäuren
DE58909692D1 (de) Verfahren zur selektiven Spaltung von Fusionsproteinen
DE3584528D1 (de) Katalytisches verfahren zur herstellung von amiden.
ATE10623T1 (de) Verfahren zur herstellung von l-prolin.
DE58909308D1 (de) Verfahren zur Herstellung von Tripeptiden.
ATE159516T1 (de) Verfahren zur herstellung von isocyansäure aus cyanursäure