ZA873282B - Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane a2 receptor antagonists and novel intermediates produced therein - Google Patents

Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane a2 receptor antagonists and novel intermediates produced therein

Info

Publication number
ZA873282B
ZA873282B ZA873282A ZA873282A ZA873282B ZA 873282 B ZA873282 B ZA 873282B ZA 873282 A ZA873282 A ZA 873282A ZA 873282 A ZA873282 A ZA 873282A ZA 873282 B ZA873282 B ZA 873282B
Authority
ZA
South Africa
Prior art keywords
amino
oxabicycloheptane
thromboxane
preparing
making
Prior art date
Application number
ZA873282A
Other languages
English (en)
Inventor
John Kurian Thottathil
Kurian Thottathil John
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of ZA873282B publication Critical patent/ZA873282B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA873282A 1986-06-04 1987-05-07 Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane a2 receptor antagonists and novel intermediates produced therein ZA873282B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/870,564 US4687865A (en) 1986-06-04 1986-06-04 Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists
HU872539A HU201941B (en) 1986-06-04 1987-06-03 Process for producing 7-oxabicycloheptane aminoalcohol

Publications (1)

Publication Number Publication Date
ZA873282B true ZA873282B (en) 1987-12-30

Family

ID=26317529

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA873282A ZA873282B (en) 1986-06-04 1987-05-07 Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane a2 receptor antagonists and novel intermediates produced therein

Country Status (13)

Country Link
US (1) US4687865A (xx)
EP (1) EP0248435B1 (xx)
JP (1) JP2525411B2 (xx)
AT (1) ATE86997T1 (xx)
AU (1) AU597373B2 (xx)
CA (1) CA1305713C (xx)
DE (1) DE3784772T2 (xx)
DK (1) DK284587A (xx)
ES (1) ES2053466T3 (xx)
HU (1) HU201941B (xx)
IE (1) IE60657B1 (xx)
NZ (1) NZ220228A (xx)
ZA (1) ZA873282B (xx)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU593316B2 (en) * 1986-02-14 1990-02-08 E.R. Squibb & Sons, Inc. Hydroxamic acids of 7-oxabicycloheptane substituted ethers
US4749715A (en) * 1987-03-02 1988-06-07 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted amino prostaglandin analogs
US4900723A (en) * 1988-04-29 1990-02-13 E. R. Squibb & Sons, Inc. Method of preventing or reducing venous thrombosis using a thromboxane A2 receptor antagonist in conjunction with heparin and combination
CA2006086A1 (en) * 1989-01-17 1990-07-17 A. K. Gunnar Aberg Method of preventing or treating atherosclerosis using a thromboxane a receptor antagonist
NZ233600A (en) * 1989-06-12 1992-10-28 Squibb & Sons Inc 7-oxabicyclo(2.2.1)heptane imidazole prostaglandin analogs and pharmaceutical compositions
US5081266A (en) * 1990-02-26 1992-01-14 E. R. Squibb & Sons, Inc. Process for preparing [1S-[1α,2α(Z),3α,4α]]-7-[3-[[[[(1-oxoheptyl)-amino]acetyl]amino]methyl]-7-oxabicyclo-[2.2.1]hept-2-yl]-5-heptenoic acid
US4978762A (en) * 1990-02-26 1990-12-18 E. R. Squibb & Sons, Inc. Process for preparing [1S-[1α,2α)Z),3α,4α]]-7-[3-[[[[[1-oxoheptyl]-amino]acetyl]amino]methyl]-7-oxabicyclo-[2,2,1]hept-2-yl]-5-heptenoic acid
AU667280B2 (en) * 1993-08-30 1996-03-14 Otsuka Pharmaceutical Co., Ltd. Benzylamine derivatives
JO3563B1 (ar) 2014-05-13 2020-07-05 Novartis Ag مركبات وتركيبات لتحفيز تكوين الغضاريف

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB760686A (en) * 1953-03-25 1956-11-07 Pennsylvania Salt Mfg Co Oxygen-bridged hydrogenated derivatives of phthalamic acid
US4220594A (en) * 1977-11-04 1980-09-02 E. R. Squibb & Sons, Inc. Hexa- and octahydro-4,7-epoxyisobenzofuran-1-ol and hexa- and octahydro-5,8-epoxy-1H-2-benzopyran-3-ol
US4187236A (en) * 1977-11-04 1980-02-05 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane compounds
US4254044A (en) * 1977-11-04 1981-03-03 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane- and 7-oxabicycloheptene compounds
US4143054A (en) * 1977-11-04 1979-03-06 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane- and 7-oxabicycloheptene compounds
WO1980001381A1 (en) * 1979-01-05 1980-07-10 R Jones Substituted bicyclo (2,2,1) heptanes and hept-2-enes
US4228180A (en) * 1979-11-01 1980-10-14 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs
ZA814307B (en) * 1980-07-01 1983-02-23 Nat Res Dev Prostaglandins
EP0082646B1 (en) * 1981-12-23 1989-11-15 National Research Development Corporation Prostaglandins
US4416896A (en) * 1982-05-17 1983-11-22 E. R. Squibb & Sons, Inc. 7-Oxabicyclopheptane substituted amino prostaglandin analogs useful in the treatment of thrombolytic disease
US4456615A (en) * 1982-10-25 1984-06-26 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4456617A (en) * 1983-01-12 1984-06-26 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4474972A (en) * 1983-03-14 1984-10-02 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane prostaglandin intermediates and method for preparing same

Also Published As

Publication number Publication date
ES2053466T3 (es) 1994-08-01
JP2525411B2 (ja) 1996-08-21
ATE86997T1 (de) 1993-04-15
IE871419L (en) 1987-12-04
JPS62292786A (ja) 1987-12-19
NZ220228A (en) 1989-07-27
AU597373B2 (en) 1990-05-31
EP0248435B1 (en) 1993-03-17
DK284587A (da) 1987-12-05
DE3784772D1 (de) 1993-04-22
US4687865A (en) 1987-08-18
HU201941B (en) 1991-01-28
AU7348887A (en) 1987-12-10
DE3784772T2 (de) 1993-06-24
IE60657B1 (en) 1994-08-10
HUT52776A (en) 1990-08-28
CA1305713C (en) 1992-07-28
EP0248435A1 (en) 1987-12-09
DK284587D0 (da) 1987-06-03

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