ATE86997T1 - Verfahren zur herstellung von 7-oxabicycloheptanaminoalkohol-zwischenprodukten zur verwendung in der herstellung von thromboxan-a2-antagonisten und zwischenprodukte in diesem verfahren. - Google Patents
Verfahren zur herstellung von 7-oxabicycloheptanaminoalkohol-zwischenprodukten zur verwendung in der herstellung von thromboxan-a2-antagonisten und zwischenprodukte in diesem verfahren.Info
- Publication number
- ATE86997T1 ATE86997T1 AT87108128T AT87108128T ATE86997T1 AT E86997 T1 ATE86997 T1 AT E86997T1 AT 87108128 T AT87108128 T AT 87108128T AT 87108128 T AT87108128 T AT 87108128T AT E86997 T1 ATE86997 T1 AT E86997T1
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- intermediate products
- hydroxymethyl
- treating
- oxabicyclo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/870,564 US4687865A (en) | 1986-06-04 | 1986-06-04 | Process for preparing 7-oxabicycloheptane amino-alcohol intermediates useful in making thromboxane A2 receptor antagonists |
| HU872539A HU201941B (en) | 1986-06-04 | 1987-06-03 | Process for producing 7-oxabicycloheptane aminoalcohol |
| EP87108128A EP0248435B1 (de) | 1986-06-04 | 1987-06-04 | Verfahren zur Herstellung von 7-Oxabicycloheptan-Aminoalkohol-Zwischenprodukten zur Verwendung in der Herstellung von Thromboxan-A2-Antagonisten und Zwischenprodukte in diesem Verfahren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE86997T1 true ATE86997T1 (de) | 1993-04-15 |
Family
ID=26317529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87108128T ATE86997T1 (de) | 1986-06-04 | 1987-06-04 | Verfahren zur herstellung von 7-oxabicycloheptanaminoalkohol-zwischenprodukten zur verwendung in der herstellung von thromboxan-a2-antagonisten und zwischenprodukte in diesem verfahren. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4687865A (de) |
| EP (1) | EP0248435B1 (de) |
| JP (1) | JP2525411B2 (de) |
| AT (1) | ATE86997T1 (de) |
| AU (1) | AU597373B2 (de) |
| CA (1) | CA1305713C (de) |
| DE (1) | DE3784772T2 (de) |
| DK (1) | DK284587A (de) |
| ES (1) | ES2053466T3 (de) |
| HU (1) | HU201941B (de) |
| IE (1) | IE60657B1 (de) |
| NZ (1) | NZ220228A (de) |
| ZA (1) | ZA873282B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU593316B2 (en) * | 1986-02-14 | 1990-02-08 | E.R. Squibb & Sons, Inc. | Hydroxamic acids of 7-oxabicycloheptane substituted ethers |
| US4749715A (en) * | 1987-03-02 | 1988-06-07 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane substituted amino prostaglandin analogs |
| US4900723A (en) * | 1988-04-29 | 1990-02-13 | E. R. Squibb & Sons, Inc. | Method of preventing or reducing venous thrombosis using a thromboxane A2 receptor antagonist in conjunction with heparin and combination |
| CA2006086A1 (en) * | 1989-01-17 | 1990-07-17 | A. K. Gunnar Aberg | Method of preventing or treating atherosclerosis using a thromboxane a receptor antagonist |
| NZ233600A (en) * | 1989-06-12 | 1992-10-28 | Squibb & Sons Inc | 7-oxabicyclo(2.2.1)heptane imidazole prostaglandin analogs and pharmaceutical compositions |
| US4978762A (en) * | 1990-02-26 | 1990-12-18 | E. R. Squibb & Sons, Inc. | Process for preparing [1S-[1α,2α)Z),3α,4α]]-7-[3-[[[[[1-oxoheptyl]-amino]acetyl]amino]methyl]-7-oxabicyclo-[2,2,1]hept-2-yl]-5-heptenoic acid |
| US5081266A (en) * | 1990-02-26 | 1992-01-14 | E. R. Squibb & Sons, Inc. | Process for preparing [1S-[1α,2α(Z),3α,4α]]-7-[3-[[[[(1-oxoheptyl)-amino]acetyl]amino]methyl]-7-oxabicyclo-[2.2.1]hept-2-yl]-5-heptenoic acid |
| KR950704235A (ko) * | 1993-08-30 | 1995-11-17 | 오오쓰까 아끼히꼬 | 벤질아민 유도체(benzylamine derivatives) |
| KR102375396B1 (ko) | 2014-05-13 | 2022-03-18 | 노파르티스 아게 | 연골형성을 유도하기 위한 화합물 및 조성물 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB760686A (en) * | 1953-03-25 | 1956-11-07 | Pennsylvania Salt Mfg Co | Oxygen-bridged hydrogenated derivatives of phthalamic acid |
| US4187236A (en) * | 1977-11-04 | 1980-02-05 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane compounds |
| US4143054A (en) * | 1977-11-04 | 1979-03-06 | E. R. Squibb & Sons, Inc. | 7-oxabicycloheptane- and 7-oxabicycloheptene compounds |
| US4220594A (en) * | 1977-11-04 | 1980-09-02 | E. R. Squibb & Sons, Inc. | Hexa- and octahydro-4,7-epoxyisobenzofuran-1-ol and hexa- and octahydro-5,8-epoxy-1H-2-benzopyran-3-ol |
| US4254044A (en) * | 1977-11-04 | 1981-03-03 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane- and 7-oxabicycloheptene compounds |
| EP0045118B1 (de) * | 1979-01-05 | 1984-04-04 | National Research Development Corporation | Zwischenprodukte für die Synthese von Bizyklo(2,2,1)heptanen und Bizyklo(2,2,1)hept-2Z-enen |
| US4228180A (en) * | 1979-11-01 | 1980-10-14 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs |
| ZA829068B (en) * | 1980-07-01 | 1983-02-23 | Nat Res Dev | Prostaglandins |
| EP0082646B1 (de) * | 1981-12-23 | 1989-11-15 | National Research Development Corporation | Prostaglandine |
| US4416896A (en) * | 1982-05-17 | 1983-11-22 | E. R. Squibb & Sons, Inc. | 7-Oxabicyclopheptane substituted amino prostaglandin analogs useful in the treatment of thrombolytic disease |
| US4456615A (en) * | 1982-10-25 | 1984-06-26 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction |
| US4456617A (en) * | 1983-01-12 | 1984-06-26 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction |
| US4474972A (en) * | 1983-03-14 | 1984-10-02 | E. R. Squibb & Sons, Inc. | 7-Oxabicycloheptane prostaglandin intermediates and method for preparing same |
-
1986
- 1986-06-04 US US06/870,564 patent/US4687865A/en not_active Expired - Lifetime
-
1987
- 1987-05-07 ZA ZA873282A patent/ZA873282B/xx unknown
- 1987-05-07 CA CA000536604A patent/CA1305713C/en not_active Expired - Lifetime
- 1987-05-07 NZ NZ220228A patent/NZ220228A/xx unknown
- 1987-05-28 AU AU73488/87A patent/AU597373B2/en not_active Ceased
- 1987-05-29 IE IE141987A patent/IE60657B1/en not_active IP Right Cessation
- 1987-06-02 JP JP62139650A patent/JP2525411B2/ja not_active Expired - Fee Related
- 1987-06-03 DK DK284587A patent/DK284587A/da not_active Application Discontinuation
- 1987-06-03 HU HU872539A patent/HU201941B/hu not_active IP Right Cessation
- 1987-06-04 DE DE8787108128T patent/DE3784772T2/de not_active Expired - Lifetime
- 1987-06-04 ES ES87108128T patent/ES2053466T3/es not_active Expired - Lifetime
- 1987-06-04 EP EP87108128A patent/EP0248435B1/de not_active Expired - Lifetime
- 1987-06-04 AT AT87108128T patent/ATE86997T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK284587D0 (da) | 1987-06-03 |
| EP0248435A1 (de) | 1987-12-09 |
| US4687865A (en) | 1987-08-18 |
| HUT52776A (en) | 1990-08-28 |
| HU201941B (en) | 1991-01-28 |
| DE3784772T2 (de) | 1993-06-24 |
| NZ220228A (en) | 1989-07-27 |
| DK284587A (da) | 1987-12-05 |
| CA1305713C (en) | 1992-07-28 |
| AU7348887A (en) | 1987-12-10 |
| JP2525411B2 (ja) | 1996-08-21 |
| ZA873282B (en) | 1987-12-30 |
| EP0248435B1 (de) | 1993-03-17 |
| IE871419L (en) | 1987-12-04 |
| IE60657B1 (en) | 1994-08-10 |
| DE3784772D1 (de) | 1993-04-22 |
| AU597373B2 (en) | 1990-05-31 |
| ES2053466T3 (es) | 1994-08-01 |
| JPS62292786A (ja) | 1987-12-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |