ES2045098T3 - Procedimiento para la preparacion de tiazolobencimidazoles y productos intermedios utilizados en el. - Google Patents
Procedimiento para la preparacion de tiazolobencimidazoles y productos intermedios utilizados en el.Info
- Publication number
- ES2045098T3 ES2045098T3 ES88300432T ES88300432T ES2045098T3 ES 2045098 T3 ES2045098 T3 ES 2045098T3 ES 88300432 T ES88300432 T ES 88300432T ES 88300432 T ES88300432 T ES 88300432T ES 2045098 T3 ES2045098 T3 ES 2045098T3
- Authority
- ES
- Spain
- Prior art keywords
- acid
- formula
- thiazolobencimidazoles
- procedure
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A UN PROCEDIMIENTO PARA OBTENER UN TIAZOLO[3,2-A] BENZIMIDAZOL DE FORMULA (I) EN LA QUE N ES 1 O 2, Y R1 ES HIDROGENO, ALQUILO INFERIOR, ALCOXI INFERIOR, TRIFLUOROMETILO O HALO O UNA DE SUS SALES, QUE COMPRENDE LA DESHIDRATACION DE UN COMPUESTO DE FORMULA (II), O UNA DE SUS SALES, EN LA QUE N Y R1 SON COMO SE DEFINIERON NATES Y COOR ES UNA FUNCION ACIDO O ESTER, EN PRESENCIA DE UN ACIDO ELEGIDO ENTRE ACIDO SULFURICO, SULFONICO Y FOSFORICO O SUS MEZCLAS, Y SI SE DESEA O REQUIERE, UN DISOLVENTE INERTE, PREVIENDO QUE SI HAY AGUA, ENTONCES LA CANTIDAD DE AGUA ES MENOR QUE 15 % EN VOLUMEN APROXIMADAMENTE DEL ACIDO, LLEVANDOSE A CABO LA REACCION CON CALENTAMIENTO SI ES NECESARIO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB878701228A GB8701228D0 (en) | 1987-01-21 | 1987-01-21 | Thiazolobenzimidazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2045098T3 true ES2045098T3 (es) | 1994-01-16 |
Family
ID=10610964
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88300432T Expired - Lifetime ES2045098T3 (es) | 1987-01-21 | 1988-01-20 | Procedimiento para la preparacion de tiazolobencimidazoles y productos intermedios utilizados en el. |
Country Status (16)
Country | Link |
---|---|
US (2) | US4812574A (es) |
EP (1) | EP0276133B1 (es) |
JP (1) | JP2555397B2 (es) |
KR (1) | KR960004536B1 (es) |
AT (1) | ATE86257T1 (es) |
AU (1) | AU602045B2 (es) |
CA (1) | CA1327042C (es) |
DE (1) | DE3878700T2 (es) |
DK (1) | DK169819B1 (es) |
ES (1) | ES2045098T3 (es) |
GB (2) | GB8701228D0 (es) |
HU (1) | HU201081B (es) |
IE (1) | IE61348B1 (es) |
IL (1) | IL85135A (es) |
PT (1) | PT86567B (es) |
ZA (1) | ZA88378B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1243362B (it) * | 1990-07-25 | 1994-06-10 | Pietro Monforte | Sintesi di attivita' anti-hiv di 1h, 3h-tiazolo 3,4-a benzimidazoli 1-sostituiti |
WO2010077295A1 (en) * | 2008-12-09 | 2010-07-08 | King Faisal Specialist Hospital & Research Centre | Substituted tricyclic heterocycles and uses to treat tumors and proliferative disorders |
CN111116613B (zh) * | 2019-12-13 | 2021-04-23 | 湘潭大学 | 一种多取代苯并咪唑并噻唑及衍生物及其合成方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1380507A (fr) * | 1963-08-28 | 1964-12-04 | Emballages Transparents Soc D | Procédé et dispositif pour la fabrication d'emballages se présentant sous forme de sachets multiples accolés ou superposés |
US4214089A (en) * | 1978-07-18 | 1980-07-22 | American Home Products Corporation | Thiazolo[3,2-a]benzimidazoles, imidazo [2,1-b]thiazoles, and related compounds as antineoplastic agents, and enhancers of the immune response |
US4361574A (en) * | 1981-10-02 | 1982-11-30 | American Home Products Corporation | Inhibitors of mammalian collagenase |
US4466957A (en) * | 1982-02-25 | 1984-08-21 | American Home Products Corporation | Vaccine adjuvants |
-
1987
- 1987-01-21 GB GB878701228A patent/GB8701228D0/en active Pending
- 1987-12-23 US US07/133,823 patent/US4812574A/en not_active Expired - Fee Related
-
1988
- 1988-01-19 PT PT86567A patent/PT86567B/pt not_active IP Right Cessation
- 1988-01-19 AU AU10379/88A patent/AU602045B2/en not_active Ceased
- 1988-01-19 IL IL85135A patent/IL85135A/xx not_active IP Right Cessation
- 1988-01-20 DK DK024088A patent/DK169819B1/da not_active IP Right Cessation
- 1988-01-20 AT AT88300432T patent/ATE86257T1/de not_active IP Right Cessation
- 1988-01-20 IE IE14388A patent/IE61348B1/en not_active IP Right Cessation
- 1988-01-20 JP JP63010569A patent/JP2555397B2/ja not_active Expired - Lifetime
- 1988-01-20 ES ES88300432T patent/ES2045098T3/es not_active Expired - Lifetime
- 1988-01-20 GB GB8801219A patent/GB2200116B/en not_active Expired - Fee Related
- 1988-01-20 ZA ZA88378A patent/ZA88378B/xx unknown
- 1988-01-20 CA CA000556943A patent/CA1327042C/en not_active Expired - Fee Related
- 1988-01-20 HU HU88216A patent/HU201081B/hu not_active IP Right Cessation
- 1988-01-20 EP EP88300432A patent/EP0276133B1/en not_active Expired - Lifetime
- 1988-01-20 DE DE8888300432T patent/DE3878700T2/de not_active Expired - Fee Related
- 1988-01-21 KR KR1019880000433A patent/KR960004536B1/ko not_active IP Right Cessation
-
1989
- 1989-01-10 US US07/295,410 patent/US4889936A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2555397B2 (ja) | 1996-11-20 |
EP0276133A3 (en) | 1990-03-21 |
AU602045B2 (en) | 1990-09-27 |
HU201081B (en) | 1990-09-28 |
DK169819B1 (da) | 1995-03-06 |
PT86567A (en) | 1988-02-01 |
CA1327042C (en) | 1994-02-15 |
IE61348B1 (en) | 1994-11-02 |
EP0276133A2 (en) | 1988-07-27 |
US4812574A (en) | 1989-03-14 |
HUT50835A (en) | 1990-03-28 |
DE3878700T2 (de) | 1993-06-09 |
AU1037988A (en) | 1988-07-28 |
US4889936A (en) | 1989-12-26 |
KR960004536B1 (ko) | 1996-04-06 |
ZA88378B (en) | 1989-09-27 |
GB8701228D0 (en) | 1987-02-25 |
GB2200116B (en) | 1991-06-12 |
IL85135A (en) | 1992-07-15 |
IL85135A0 (en) | 1988-06-30 |
KR880009031A (ko) | 1988-09-13 |
ATE86257T1 (de) | 1993-03-15 |
GB8801219D0 (en) | 1988-02-17 |
EP0276133B1 (en) | 1993-03-03 |
IE880143L (en) | 1988-07-21 |
DK24088A (da) | 1988-07-06 |
GB2200116A (en) | 1988-07-27 |
JPS63198689A (ja) | 1988-08-17 |
PT86567B (pt) | 1991-12-31 |
DK24088D0 (da) | 1988-01-20 |
DE3878700D1 (de) | 1993-04-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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