ES2045098T3 - Procedimiento para la preparacion de tiazolobencimidazoles y productos intermedios utilizados en el. - Google Patents

Procedimiento para la preparacion de tiazolobencimidazoles y productos intermedios utilizados en el.

Info

Publication number
ES2045098T3
ES2045098T3 ES88300432T ES88300432T ES2045098T3 ES 2045098 T3 ES2045098 T3 ES 2045098T3 ES 88300432 T ES88300432 T ES 88300432T ES 88300432 T ES88300432 T ES 88300432T ES 2045098 T3 ES2045098 T3 ES 2045098T3
Authority
ES
Spain
Prior art keywords
acid
formula
thiazolobencimidazoles
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88300432T
Other languages
English (en)
Inventor
Robin Gerald Shepherd
Sie-Yearl Chai
Maynard Emanuel Lichty
Arnold Stephen Milowsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Wyeth LLC
Original Assignee
John Wyeth and Brother Ltd
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John Wyeth and Brother Ltd, American Home Products Corp filed Critical John Wyeth and Brother Ltd
Application granted granted Critical
Publication of ES2045098T3 publication Critical patent/ES2045098T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO PARA OBTENER UN TIAZOLO[3,2-A] BENZIMIDAZOL DE FORMULA (I) EN LA QUE N ES 1 O 2, Y R1 ES HIDROGENO, ALQUILO INFERIOR, ALCOXI INFERIOR, TRIFLUOROMETILO O HALO O UNA DE SUS SALES, QUE COMPRENDE LA DESHIDRATACION DE UN COMPUESTO DE FORMULA (II), O UNA DE SUS SALES, EN LA QUE N Y R1 SON COMO SE DEFINIERON NATES Y COOR ES UNA FUNCION ACIDO O ESTER, EN PRESENCIA DE UN ACIDO ELEGIDO ENTRE ACIDO SULFURICO, SULFONICO Y FOSFORICO O SUS MEZCLAS, Y SI SE DESEA O REQUIERE, UN DISOLVENTE INERTE, PREVIENDO QUE SI HAY AGUA, ENTONCES LA CANTIDAD DE AGUA ES MENOR QUE 15 % EN VOLUMEN APROXIMADAMENTE DEL ACIDO, LLEVANDOSE A CABO LA REACCION CON CALENTAMIENTO SI ES NECESARIO.
ES88300432T 1987-01-21 1988-01-20 Procedimiento para la preparacion de tiazolobencimidazoles y productos intermedios utilizados en el. Expired - Lifetime ES2045098T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878701228A GB8701228D0 (en) 1987-01-21 1987-01-21 Thiazolobenzimidazoles

Publications (1)

Publication Number Publication Date
ES2045098T3 true ES2045098T3 (es) 1994-01-16

Family

ID=10610964

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88300432T Expired - Lifetime ES2045098T3 (es) 1987-01-21 1988-01-20 Procedimiento para la preparacion de tiazolobencimidazoles y productos intermedios utilizados en el.

Country Status (16)

Country Link
US (2) US4812574A (es)
EP (1) EP0276133B1 (es)
JP (1) JP2555397B2 (es)
KR (1) KR960004536B1 (es)
AT (1) ATE86257T1 (es)
AU (1) AU602045B2 (es)
CA (1) CA1327042C (es)
DE (1) DE3878700T2 (es)
DK (1) DK169819B1 (es)
ES (1) ES2045098T3 (es)
GB (2) GB8701228D0 (es)
HU (1) HU201081B (es)
IE (1) IE61348B1 (es)
IL (1) IL85135A (es)
PT (1) PT86567B (es)
ZA (1) ZA88378B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1243362B (it) * 1990-07-25 1994-06-10 Pietro Monforte Sintesi di attivita' anti-hiv di 1h, 3h-tiazolo 3,4-a benzimidazoli 1-sostituiti
WO2010077295A1 (en) * 2008-12-09 2010-07-08 King Faisal Specialist Hospital & Research Centre Substituted tricyclic heterocycles and uses to treat tumors and proliferative disorders
CN111116613B (zh) * 2019-12-13 2021-04-23 湘潭大学 一种多取代苯并咪唑并噻唑及衍生物及其合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1380507A (fr) * 1963-08-28 1964-12-04 Emballages Transparents Soc D Procédé et dispositif pour la fabrication d'emballages se présentant sous forme de sachets multiples accolés ou superposés
US4214089A (en) * 1978-07-18 1980-07-22 American Home Products Corporation Thiazolo[3,2-a]benzimidazoles, imidazo [2,1-b]thiazoles, and related compounds as antineoplastic agents, and enhancers of the immune response
US4361574A (en) * 1981-10-02 1982-11-30 American Home Products Corporation Inhibitors of mammalian collagenase
US4466957A (en) * 1982-02-25 1984-08-21 American Home Products Corporation Vaccine adjuvants

Also Published As

Publication number Publication date
JP2555397B2 (ja) 1996-11-20
EP0276133A3 (en) 1990-03-21
AU602045B2 (en) 1990-09-27
HU201081B (en) 1990-09-28
DK169819B1 (da) 1995-03-06
PT86567A (en) 1988-02-01
CA1327042C (en) 1994-02-15
IE61348B1 (en) 1994-11-02
EP0276133A2 (en) 1988-07-27
US4812574A (en) 1989-03-14
HUT50835A (en) 1990-03-28
DE3878700T2 (de) 1993-06-09
AU1037988A (en) 1988-07-28
US4889936A (en) 1989-12-26
KR960004536B1 (ko) 1996-04-06
ZA88378B (en) 1989-09-27
GB8701228D0 (en) 1987-02-25
GB2200116B (en) 1991-06-12
IL85135A (en) 1992-07-15
IL85135A0 (en) 1988-06-30
KR880009031A (ko) 1988-09-13
ATE86257T1 (de) 1993-03-15
GB8801219D0 (en) 1988-02-17
EP0276133B1 (en) 1993-03-03
IE880143L (en) 1988-07-21
DK24088A (da) 1988-07-06
GB2200116A (en) 1988-07-27
JPS63198689A (ja) 1988-08-17
PT86567B (pt) 1991-12-31
DK24088D0 (da) 1988-01-20
DE3878700D1 (de) 1993-04-08

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