ES2036179T3 - Procedimiento para preparar monohidrato de hidrocloruro de (s)-(-)-1-propil-2',6'-pipecoloxilidida. - Google Patents

Procedimiento para preparar monohidrato de hidrocloruro de (s)-(-)-1-propil-2',6'-pipecoloxilidida.

Info

Publication number
ES2036179T3
ES2036179T3 ES198686850440T ES86850440T ES2036179T3 ES 2036179 T3 ES2036179 T3 ES 2036179T3 ES 198686850440 T ES198686850440 T ES 198686850440T ES 86850440 T ES86850440 T ES 86850440T ES 2036179 T3 ES2036179 T3 ES 2036179T3
Authority
ES
Spain
Prior art keywords
pipecoloxilidida
propil
preparing
procedure
hydrochloride monohydrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198686850440T
Other languages
English (en)
Inventor
Rune Verner Sandberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astra Lakemedel AB
Original Assignee
Astra Lakemedel AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20363001&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2036179(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astra Lakemedel AB filed Critical Astra Lakemedel AB
Application granted granted Critical
Publication of ES2036179T3 publication Critical patent/ES2036179T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Un procedimiento para preparar monohidrato de hidrocoluro de (S)-(-)-1-propil-2'',6''- pipecoloxilidida, sustancial y ópticamente puro, caracterizado porque se disuelve en agua hidrocloruro de A (S)-(-)-1-propil-2'',6''-pipecoloxilidida que contiene elenantiómero (R)-(+), a continuación se añade acetona calentada a una temperatura comprendida entre 45º C y su punto de ebullición y se aisla el monohidrato de hidrocloruro de (S)-(-)-1-propil-2'',6''-pipecoloxilidida.
ES198686850440T 1986-01-03 1986-12-15 Procedimiento para preparar monohidrato de hidrocloruro de (s)-(-)-1-propil-2',6'-pipecoloxilidida. Expired - Lifetime ES2036179T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8600017A SE451840B (sv) 1986-01-03 1986-01-03 Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning

Publications (1)

Publication Number Publication Date
ES2036179T3 true ES2036179T3 (es) 1993-05-16

Family

ID=20363001

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198686850440T Expired - Lifetime ES2036179T3 (es) 1986-01-03 1986-12-15 Procedimiento para preparar monohidrato de hidrocloruro de (s)-(-)-1-propil-2',6'-pipecoloxilidida.

Country Status (29)

Country Link
US (1) US4870086A (es)
EP (1) EP0239710B1 (es)
JP (1) JPH07598B2 (es)
KR (1) KR940008302B1 (es)
AR (1) AR242561A1 (es)
AT (1) ATE56956T1 (es)
AU (1) AU592392B2 (es)
BG (1) BG62066B2 (es)
CA (1) CA1276154C (es)
CY (1) CY1680A (es)
DE (1) DE3674582D1 (es)
DK (1) DK171378B1 (es)
EG (1) EG17867A (es)
ES (1) ES2036179T3 (es)
FI (1) FI83075C (es)
GR (1) GR3002516T3 (es)
HK (1) HK5493A (es)
IE (1) IE59061B1 (es)
LU (1) LU88843I2 (es)
LV (1) LV5765B4 (es)
MY (1) MY101132A (es)
NL (1) NL960005I2 (es)
NO (2) NO170330C (es)
NZ (1) NZ218615A (es)
PH (1) PH22924A (es)
PT (1) PT84041B (es)
SE (1) SE451840B (es)
SG (1) SG117292G (es)
ZA (1) ZA868600B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MC2210A1 (fr) * 1990-06-07 1992-11-26 Wellcome Found Composes heterocycliques therapeutiques,leur utilisation et procede pour les preparer
ES2082703B1 (es) * 1993-11-04 1996-12-16 Inst Investigacion Desarrollo Nuevos derivados de ciclopropilo, procedimientos para su preparacion y aplicaciones.
US5834490A (en) * 1993-11-04 1998-11-10 Instituto De Investigacion Y Desarrolo Quimico Biologico, S.A. Cyclopropyl derivatives, preparation method there-of and applications
KR100393133B1 (ko) * 1994-09-23 2003-11-17 다윈 디스커버리 리미티드 레보부피바카인및그의유사체의제조에사용하는라세미화및비대칭변환방법
SE9501808D0 (sv) * 1995-05-16 1995-05-16 Astra Ab New process
US7799337B2 (en) 1997-07-21 2010-09-21 Levin Bruce H Method for directed intranasal administration of a composition
SE9800139D0 (sv) 1998-01-21 1998-01-21 Astra Ab New use
BRPI0104491B8 (pt) * 2001-10-10 2021-05-25 Cristalia Produtos Quim Farmaceuticos Ltda n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica.
US20060270708A1 (en) * 2005-05-25 2006-11-30 Navinta Llc Novel process for preparation of isotonic aqueous injection of ropivacaine
US7683175B2 (en) * 2005-06-06 2010-03-23 Navinta, Llc Process of making optically pure L-pipecolic acid and process of making anesthetics and intermediates therefrom
WO2007123405A1 (en) * 2006-04-25 2007-11-01 Dishman Pharmaceuticals And Chemicals Ltd. Ropivacaine hydrochloride anhydrate and the preparation thereof
DK2234974T3 (da) * 2008-01-15 2012-06-25 Pharmathen Sa Fremgangsmåde til fremstilling af (S)-1-alkyl-2',6'-pipecoloxylidid-forbindelse
US8473062B2 (en) 2008-05-01 2013-06-25 Autonomic Technologies, Inc. Method and device for the treatment of headache
US8412336B2 (en) 2008-12-29 2013-04-02 Autonomic Technologies, Inc. Integrated delivery and visualization tool for a neuromodulation system
US8494641B2 (en) 2009-04-22 2013-07-23 Autonomic Technologies, Inc. Implantable neurostimulator with integral hermetic electronic enclosure, circuit substrate, monolithic feed-through, lead assembly and anchoring mechanism
US9320908B2 (en) 2009-01-15 2016-04-26 Autonomic Technologies, Inc. Approval per use implanted neurostimulator
CN102093284B (zh) * 2010-12-29 2013-05-08 宜昌人福药业有限责任公司 富集哌啶-2-甲酰苯胺类旋光化合物的方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2248018A (en) * 1939-03-30 1941-07-01 Winthrop Chem Co Inc 4-aryl-piperidine-ketones and a process of preparing them
GB775749A (en) * 1955-04-06 1957-05-29 Bofors Ab Method of preparing amides of n-alkyl piperidine monocarboxylic acid and n-alkyl pyrrolidine -a-monocarboxylic acid
US2799679A (en) * 1955-04-28 1957-07-16 Bofors Ab Process of preparing amides of heterocyclic carboxylic acids
GB775750A (en) * 1955-04-28 1957-05-29 Bofors Ab Method of preparing amides of n-alkyl piperidine mono-carboxylic acid and n-alkyl pyrrolidine -a-monocarboxylic acid
GB800565A (en) * 1956-01-23 1958-08-27 Bofors Ab Method of producing n-alkyl-piperidine-ª‡-monocarboxylic acid amides and n-alkyl-pyrrolidine-ª‡-monocarboxylic acid amides
GB824542A (en) * 1957-05-15 1959-12-02 Bofors Ab Method of producing n-alkyl-piperidine-alpha-monocarboxylic acid amides
GB869978A (en) * 1958-03-13 1961-06-07 Bofors Ab Method of producing n-alkyl-and-cycloalkyl-piperidine carboxylic acid amides
GB949729A (en) * 1960-11-15 1964-02-19 Bofors Ab Substituted-piperidine carboxylic acid amide salts and their preparation
SE341404B (es) * 1967-05-18 1971-12-27 Sterling Drug Inc
CH491915A (de) * 1967-06-28 1970-06-15 Geigy Ag J R Verfahren zur Herstellung von neuen Piperidinderivaten
US3879382A (en) * 1971-08-27 1975-04-22 Teijin Ltd Process for the recovery of D- or L-{60 -amino-{68 -caprolactam hydrochloride of enhanced optical purity from mixtures of D- and L-{60 -amino-{68 -caprolactam hydrochloride
SE7607114L (sv) * 1976-06-22 1977-12-23 Bofors Ab Sett att framstella hydrokloriden av n-metylpiperidin-2-karbonsyra-2,6-xyllidid
SE431092B (sv) * 1979-07-10 1984-01-16 Thuresson Af Ekenstam Bo Terapeutiskt aktiva, substituerade piperidinkarboxianilider
ATE40994T1 (de) * 1983-08-01 1989-03-15 Astra Laekemedel Ab L-n-n-propylpipekolsaeure-2,6-xylidid und dessen herstellung.

Also Published As

Publication number Publication date
MY101132A (en) 1991-07-31
CA1276154C (en) 1990-11-13
EP0239710A1 (en) 1987-10-07
SE8600017L (sv) 1987-07-04
DE3674582D1 (de) 1990-10-31
JPH07598B2 (ja) 1995-01-11
FI83075B (fi) 1991-02-15
NL960005I1 (nl) 1996-09-02
CY1680A (en) 1993-10-10
DK171378B1 (da) 1996-10-07
FI870003A (fi) 1987-07-04
NL960005I2 (nl) 1997-10-01
SG117292G (en) 1993-01-29
NZ218615A (en) 1989-07-27
NO170330B (no) 1992-06-29
DK287A (da) 1987-07-04
EG17867A (en) 1991-03-30
SE8600017D0 (sv) 1986-01-03
NO864858D0 (no) 1986-12-03
DK287D0 (da) 1987-01-02
FI870003A0 (fi) 1987-01-02
IE59061B1 (en) 1993-12-15
NO1997009I1 (no) 1997-08-18
LV5765A4 (lv) 1996-12-20
BG62066B2 (bg) 1999-01-29
KR870007118A (ko) 1987-08-14
EP0239710B1 (en) 1990-09-26
AU6644986A (en) 1987-07-09
NO864858L (no) 1987-07-06
JPS62158251A (ja) 1987-07-14
NO170330C (no) 1992-10-07
ATE56956T1 (de) 1990-10-15
SE451840B (sv) 1987-11-02
GR3002516T3 (en) 1993-01-25
PT84041A (en) 1987-01-01
PH22924A (en) 1989-01-24
US4870086A (en) 1989-09-26
IE870004L (en) 1987-07-03
LU88843I2 (fr) 1997-03-14
KR940008302B1 (ko) 1994-09-12
FI83075C (fi) 1991-05-27
HK5493A (en) 1993-01-29
PT84041B (pt) 1989-09-14
ZA868600B (en) 1987-08-26
LV5765B4 (lv) 1997-06-20
AU592392B2 (en) 1990-01-11
AR242561A1 (es) 1993-04-30

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