ES2033678T3 - Procedimiento para la preparacion de una proteina de fusion. - Google Patents
Procedimiento para la preparacion de una proteina de fusion.Info
- Publication number
- ES2033678T3 ES2033678T3 ES198686117481T ES86117481T ES2033678T3 ES 2033678 T3 ES2033678 T3 ES 2033678T3 ES 198686117481 T ES198686117481 T ES 198686117481T ES 86117481 T ES86117481 T ES 86117481T ES 2033678 T3 ES2033678 T3 ES 2033678T3
- Authority
- ES
- Spain
- Prior art keywords
- fusion protein
- procedure
- preparation
- interleukin
- advantagely
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108020001507 fusion proteins Proteins 0.000 title abstract 3
- 108010002350 Interleukin-2 Proteins 0.000 abstract 3
- 102000000588 Interleukin-2 Human genes 0.000 abstract 2
- 150000001413 amino acids Chemical group 0.000 abstract 2
- 102000037865 fusion proteins Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
COMO "PORCION DE LASTRE" PARA PROTEINAS DE FUSION ES APROPIADA UNA PARTE DE LA SECUENCIA DE AMINOACIDOS DE LA INTERLEUCINA-2(IL-2), QUE COMPRENDE ESENCIALMENTE MENOS DE 100 AMINOACIDOS. VENTAJOSAMENTE, SE PARTE DE UN GEN DE INTERLEUCINA-2, QUE ESTA DIVIDIDO EN SEIS SEGMENTOS MEDIANTE PUNTOS DE INTERSECCION SINGULARES, DE ENTRE LOS QUE PUEDEN COMBINARSE HASTA TRES, EN CUALQUIER ORDEN DE SUCESION, SEGUN EL PRINCIPIO DE LAS CAJAS DE CONSTRUCCIONES. LA INVENCION PERMITE CONSTRUCCIONES PREFIJADAS CON LAS QUE PUEDE VARIARSE LA SOLUBILIDAD DE LA PROTEINA DE FUSION.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3545565 | 1985-12-21 | ||
| DE19863636903 DE3636903A1 (de) | 1985-12-21 | 1986-10-30 | Fusionsproteine mit eukaryotischem ballastanteil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2033678T3 true ES2033678T3 (es) | 1993-04-01 |
Family
ID=25839208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES198686117481T Expired - Lifetime ES2033678T3 (es) | 1985-12-21 | 1986-12-16 | Procedimiento para la preparacion de una proteina de fusion. |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0229998B1 (es) |
| JP (2) | JP2553058B2 (es) |
| KR (1) | KR950000301B1 (es) |
| AT (1) | ATE78296T1 (es) |
| AU (1) | AU599943B2 (es) |
| CA (1) | CA1339894C (es) |
| DE (1) | DE3636903A1 (es) |
| DK (1) | DK168823B1 (es) |
| ES (1) | ES2033678T3 (es) |
| FI (1) | FI93734C (es) |
| GR (1) | GR3005985T3 (es) |
| HU (1) | HU209747B (es) |
| IE (1) | IE58935B1 (es) |
| IL (1) | IL81018A (es) |
| NO (1) | NO175003C (es) |
| PT (1) | PT83973B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3545568A1 (de) * | 1985-12-21 | 1987-07-16 | Hoechst Ag | Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung |
| DE3844211A1 (de) * | 1988-12-29 | 1990-07-05 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| FR2643646B1 (fr) * | 1989-02-27 | 1993-09-17 | Pasteur Institut | Expression de sequences de nucleotides codant pour des vesicules a gaz |
| CU22222A1 (es) * | 1989-08-03 | 1995-01-31 | Cigb | Procedimiento para la expresion de proteinas heterologicas producidas de forma fusionada en escherichia coli, su uso, vectores de expresion y cepas recombinantes |
| DE3942580A1 (de) * | 1989-12-22 | 1991-06-27 | Basf Ag | Verfahren zur herstellung von hirudin |
| DE4105480A1 (de) * | 1991-02-21 | 1992-08-27 | Boehringer Mannheim Gmbh | Verbesserte aktivierung von rekombinanten proteinen |
| DK0821006T3 (da) | 1996-07-26 | 2004-08-16 | Aventis Pharma Gmbh | Insulinderivater med öget zinkbinding |
| DE19825447A1 (de) | 1998-06-06 | 1999-12-09 | Hoechst Marion Roussel De Gmbh | Neue Insulinanaloga mit erhöhter Zinkbildung |
| DE102006031955A1 (de) | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende |
| DE102006031962A1 (de) | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Amidiertes Insulin Glargin |
| EP3228320B1 (de) | 2008-10-17 | 2019-12-18 | Sanofi-Aventis Deutschland GmbH | Kombination von einem insulin und einem glp-1-agonisten |
| EP3202394A1 (de) | 2009-07-06 | 2017-08-09 | Sanofi-Aventis Deutschland GmbH | Wässrige insulinzubereitungen enthaltend methionin |
| PE20121316A1 (es) | 2009-11-13 | 2012-10-05 | Sanofi Aventis Deutschland | Composicion farmaceutica que comprende un agonista de glp-1 y metionina |
| PT2554183T (pt) | 2009-11-13 | 2018-07-09 | Sanofi Aventis Deutschland | Composição farmacêutica que compreende um agonista de glp-1, uma insulina e metionina |
| US20140148384A1 (en) | 2010-08-30 | 2014-05-29 | Sanofi-Aventis Deutschland Gmbh | Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| CN108079281A (zh) | 2011-08-29 | 2018-05-29 | 赛诺菲-安万特德国有限公司 | 用于2型糖尿病患者中的血糖控制的药物组合 |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| TWI758239B (zh) | 2014-12-12 | 2022-03-21 | 德商賽諾菲阿凡提斯德意志有限公司 | 甘精胰島素/利司那肽固定比率配製劑 |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| KR20200080748A (ko) | 2018-12-27 | 2020-07-07 | 주식회사 폴루스 | 음이온 교환 크로마토그래피를 이용한 인슐린 전구체의 정제방법 |
| KR20200080747A (ko) | 2018-12-27 | 2020-07-07 | 주식회사 폴루스 | 인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK108685A (da) * | 1984-03-19 | 1985-09-20 | Fujisawa Pharmaceutical Co | Vaekstfaktor i |
| EP0158198A1 (en) * | 1984-03-29 | 1985-10-16 | Takeda Chemical Industries, Ltd. | DNA and use thereof |
| GB8412517D0 (en) * | 1984-05-16 | 1984-06-20 | Nagai K | Recombinant fusion proteins |
-
1986
- 1986-10-30 DE DE19863636903 patent/DE3636903A1/de not_active Withdrawn
- 1986-12-16 ES ES198686117481T patent/ES2033678T3/es not_active Expired - Lifetime
- 1986-12-16 EP EP86117481A patent/EP0229998B1/de not_active Expired - Lifetime
- 1986-12-16 AT AT86117481T patent/ATE78296T1/de not_active IP Right Cessation
- 1986-12-18 IL IL81018A patent/IL81018A/xx not_active IP Right Cessation
- 1986-12-18 FI FI865187A patent/FI93734C/fi not_active IP Right Cessation
- 1986-12-19 HU HU865354A patent/HU209747B/hu unknown
- 1986-12-19 DK DK619186A patent/DK168823B1/da not_active IP Right Cessation
- 1986-12-19 PT PT83973A patent/PT83973B/pt unknown
- 1986-12-19 NO NO865192A patent/NO175003C/no not_active IP Right Cessation
- 1986-12-19 AU AU66760/86A patent/AU599943B2/en not_active Expired
- 1986-12-19 CA CA000525858A patent/CA1339894C/en not_active Expired - Lifetime
- 1986-12-19 IE IE333486A patent/IE58935B1/en not_active IP Right Cessation
- 1986-12-20 KR KR1019860011010A patent/KR950000301B1/ko not_active Expired - Lifetime
- 1986-12-22 JP JP61306185A patent/JP2553058B2/ja not_active Expired - Lifetime
-
1992
- 1992-10-15 GR GR920402187T patent/GR3005985T3/el unknown
-
1995
- 1995-10-11 JP JP7263310A patent/JP2774260B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NO175003C (no) | 1994-08-17 |
| HUT44614A (en) | 1988-03-28 |
| KR870006187A (ko) | 1987-07-09 |
| KR950000301B1 (ko) | 1995-01-13 |
| DK168823B1 (da) | 1994-06-20 |
| NO175003B (no) | 1994-05-09 |
| FI865187L (fi) | 1987-06-22 |
| DK619186A (da) | 1987-06-22 |
| NO865192D0 (no) | 1986-12-19 |
| ATE78296T1 (de) | 1992-08-15 |
| DK619186D0 (da) | 1986-12-19 |
| JP2774260B2 (ja) | 1998-07-09 |
| EP0229998A2 (de) | 1987-07-29 |
| JPH08187089A (ja) | 1996-07-23 |
| IL81018A0 (en) | 1987-03-31 |
| FI93734C (fi) | 1995-05-26 |
| JP2553058B2 (ja) | 1996-11-13 |
| EP0229998B1 (de) | 1992-07-15 |
| JPS62167799A (ja) | 1987-07-24 |
| HU209747B (en) | 1994-10-28 |
| IL81018A (en) | 1992-03-29 |
| FI93734B (fi) | 1995-02-15 |
| FI865187A0 (fi) | 1986-12-18 |
| IE863334L (en) | 1987-06-21 |
| DE3636903A1 (de) | 1987-07-02 |
| CA1339894C (en) | 1998-06-02 |
| AU6676086A (en) | 1987-06-25 |
| EP0229998A3 (en) | 1988-08-03 |
| GR3005985T3 (es) | 1993-06-07 |
| AU599943B2 (en) | 1990-08-02 |
| IE58935B1 (en) | 1993-12-01 |
| NO865192L (no) | 1987-06-22 |
| PT83973B (pt) | 1989-07-31 |
| PT83973A (de) | 1987-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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