DK168823B1 - Fusionsproteiner, hvor ballastandelen består af peptider af interleukin 2, fremgangsmåde til deres fremstilling, deres anvendelse, genstruktur, der koder for et sådant fusionsprotein, vektor indeholdende en sådan genstruktur, og E. coli-celle indeholdende en sådan vektor. - Google Patents
Fusionsproteiner, hvor ballastandelen består af peptider af interleukin 2, fremgangsmåde til deres fremstilling, deres anvendelse, genstruktur, der koder for et sådant fusionsprotein, vektor indeholdende en sådan genstruktur, og E. coli-celle indeholdende en sådan vektor. Download PDFInfo
- Publication number
- DK168823B1 DK168823B1 DK619186A DK619186A DK168823B1 DK 168823 B1 DK168823 B1 DK 168823B1 DK 619186 A DK619186 A DK 619186A DK 619186 A DK619186 A DK 619186A DK 168823 B1 DK168823 B1 DK 168823B1
- Authority
- DK
- Denmark
- Prior art keywords
- plasmid
- amino acid
- fusion proteins
- acid sequence
- protein
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3545565 | 1985-12-21 | ||
| DE3545565 | 1985-12-21 | ||
| DE19863636903 DE3636903A1 (de) | 1985-12-21 | 1986-10-30 | Fusionsproteine mit eukaryotischem ballastanteil |
| DE3636903 | 1986-10-30 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK619186D0 DK619186D0 (da) | 1986-12-19 |
| DK619186A DK619186A (da) | 1987-06-22 |
| DK168823B1 true DK168823B1 (da) | 1994-06-20 |
Family
ID=25839208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK619186A DK168823B1 (da) | 1985-12-21 | 1986-12-19 | Fusionsproteiner, hvor ballastandelen består af peptider af interleukin 2, fremgangsmåde til deres fremstilling, deres anvendelse, genstruktur, der koder for et sådant fusionsprotein, vektor indeholdende en sådan genstruktur, og E. coli-celle indeholdende en sådan vektor. |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0229998B1 (es) |
| JP (2) | JP2553058B2 (es) |
| KR (1) | KR950000301B1 (es) |
| AT (1) | ATE78296T1 (es) |
| AU (1) | AU599943B2 (es) |
| CA (1) | CA1339894C (es) |
| DE (1) | DE3636903A1 (es) |
| DK (1) | DK168823B1 (es) |
| ES (1) | ES2033678T3 (es) |
| FI (1) | FI93734C (es) |
| GR (1) | GR3005985T3 (es) |
| HU (1) | HU209747B (es) |
| IE (1) | IE58935B1 (es) |
| IL (1) | IL81018A (es) |
| NO (1) | NO175003C (es) |
| PT (1) | PT83973B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3545568A1 (de) * | 1985-12-21 | 1987-07-16 | Hoechst Ag | Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung |
| DE3844211A1 (de) * | 1988-12-29 | 1990-07-05 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
| FR2643646B1 (fr) * | 1989-02-27 | 1993-09-17 | Pasteur Institut | Expression de sequences de nucleotides codant pour des vesicules a gaz |
| CU22222A1 (es) * | 1989-08-03 | 1995-01-31 | Cigb | Procedimiento para la expresion de proteinas heterologicas producidas de forma fusionada en escherichia coli, su uso, vectores de expresion y cepas recombinantes |
| DE3942580A1 (de) * | 1989-12-22 | 1991-06-27 | Basf Ag | Verfahren zur herstellung von hirudin |
| DE4105480A1 (de) * | 1991-02-21 | 1992-08-27 | Boehringer Mannheim Gmbh | Verbesserte aktivierung von rekombinanten proteinen |
| DE59711533D1 (de) | 1996-07-26 | 2004-05-27 | Aventis Pharma Gmbh | Insulinderivate mit erhöhter Zinkbindung |
| DE19825447A1 (de) | 1998-06-06 | 1999-12-09 | Hoechst Marion Roussel De Gmbh | Neue Insulinanaloga mit erhöhter Zinkbildung |
| DE102006031955A1 (de) | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende |
| DE102006031962A1 (de) | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Amidiertes Insulin Glargin |
| EP3228320B1 (de) | 2008-10-17 | 2019-12-18 | Sanofi-Aventis Deutschland GmbH | Kombination von einem insulin und einem glp-1-agonisten |
| AR080669A1 (es) | 2009-11-13 | 2012-05-02 | Sanofi Aventis Deutschland | Composicion farmaceutica que comprende un agonista de glp-1, una insulina y metionina |
| UY33025A (es) | 2009-11-13 | 2011-06-30 | Sanofi Aventis Deustschland Gmbh | Composicion farmaceutica que comprende un agonista de glp-1 metionina |
| MX339614B (es) | 2010-08-30 | 2016-06-02 | Sanofi - Aventis Deutschland GmbH | Uso de ave0010 para la fabricacion de un medicamento para el tratamiento de la diabetes mellitus tipo 2. |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| RU2650616C2 (ru) | 2011-08-29 | 2018-04-16 | Санофи-Авентис Дойчланд Гмбх | Фармацевтическая комбинация для применения при гликемическом контроле у пациентов с сахарным диабетом 2 типа |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| CN107206058A (zh) | 2014-12-12 | 2017-09-26 | 赛诺菲-安万特德国有限公司 | 甘精胰岛素/利西拉来固定比率配制剂 |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
| KR20200080748A (ko) | 2018-12-27 | 2020-07-07 | 주식회사 폴루스 | 음이온 교환 크로마토그래피를 이용한 인슐린 전구체의 정제방법 |
| KR20200080747A (ko) | 2018-12-27 | 2020-07-07 | 주식회사 폴루스 | 인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK108685A (da) * | 1984-03-19 | 1985-09-20 | Fujisawa Pharmaceutical Co | Vaekstfaktor i |
| EP0158198A1 (en) * | 1984-03-29 | 1985-10-16 | Takeda Chemical Industries, Ltd. | DNA and use thereof |
| GB8412517D0 (en) * | 1984-05-16 | 1984-06-20 | Nagai K | Recombinant fusion proteins |
-
1986
- 1986-10-30 DE DE19863636903 patent/DE3636903A1/de not_active Withdrawn
- 1986-12-16 AT AT86117481T patent/ATE78296T1/de not_active IP Right Cessation
- 1986-12-16 ES ES198686117481T patent/ES2033678T3/es not_active Expired - Lifetime
- 1986-12-16 EP EP86117481A patent/EP0229998B1/de not_active Expired - Lifetime
- 1986-12-18 FI FI865187A patent/FI93734C/fi not_active IP Right Cessation
- 1986-12-18 IL IL81018A patent/IL81018A/xx not_active IP Right Cessation
- 1986-12-19 IE IE333486A patent/IE58935B1/en not_active IP Right Cessation
- 1986-12-19 HU HU865354A patent/HU209747B/hu unknown
- 1986-12-19 CA CA000525858A patent/CA1339894C/en not_active Expired - Lifetime
- 1986-12-19 DK DK619186A patent/DK168823B1/da not_active IP Right Cessation
- 1986-12-19 AU AU66760/86A patent/AU599943B2/en not_active Expired
- 1986-12-19 NO NO865192A patent/NO175003C/no not_active IP Right Cessation
- 1986-12-19 PT PT83973A patent/PT83973B/pt unknown
- 1986-12-20 KR KR1019860011010A patent/KR950000301B1/ko not_active IP Right Cessation
- 1986-12-22 JP JP61306185A patent/JP2553058B2/ja not_active Expired - Lifetime
-
1992
- 1992-10-15 GR GR920402187T patent/GR3005985T3/el unknown
-
1995
- 1995-10-11 JP JP7263310A patent/JP2774260B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU599943B2 (en) | 1990-08-02 |
| IL81018A0 (en) | 1987-03-31 |
| KR950000301B1 (ko) | 1995-01-13 |
| ATE78296T1 (de) | 1992-08-15 |
| EP0229998A2 (de) | 1987-07-29 |
| FI93734C (fi) | 1995-05-26 |
| NO865192D0 (no) | 1986-12-19 |
| FI865187A0 (fi) | 1986-12-18 |
| JPS62167799A (ja) | 1987-07-24 |
| HU209747B (en) | 1994-10-28 |
| NO865192L (no) | 1987-06-22 |
| NO175003B (no) | 1994-05-09 |
| JPH08187089A (ja) | 1996-07-23 |
| NO175003C (no) | 1994-08-17 |
| DK619186A (da) | 1987-06-22 |
| PT83973A (de) | 1987-01-01 |
| KR870006187A (ko) | 1987-07-09 |
| EP0229998B1 (de) | 1992-07-15 |
| EP0229998A3 (en) | 1988-08-03 |
| JP2774260B2 (ja) | 1998-07-09 |
| HUT44614A (en) | 1988-03-28 |
| FI865187A (fi) | 1987-06-22 |
| GR3005985T3 (es) | 1993-06-07 |
| CA1339894C (en) | 1998-06-02 |
| DK619186D0 (da) | 1986-12-19 |
| FI93734B (fi) | 1995-02-15 |
| AU6676086A (en) | 1987-06-25 |
| IE863334L (en) | 1987-06-21 |
| IL81018A (en) | 1992-03-29 |
| IE58935B1 (en) | 1993-12-01 |
| PT83973B (pt) | 1989-07-31 |
| DE3636903A1 (de) | 1987-07-02 |
| JP2553058B2 (ja) | 1996-11-13 |
| ES2033678T3 (es) | 1993-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PUP | Patent expired |