ES2033231T3 - Metodo para la preparacion de inmunoglubulinas apropiadas para administracion intravenosa. - Google Patents
Metodo para la preparacion de inmunoglubulinas apropiadas para administracion intravenosa.Info
- Publication number
- ES2033231T3 ES2033231T3 ES198686115016T ES86115016T ES2033231T3 ES 2033231 T3 ES2033231 T3 ES 2033231T3 ES 198686115016 T ES198686115016 T ES 198686115016T ES 86115016 T ES86115016 T ES 86115016T ES 2033231 T3 ES2033231 T3 ES 2033231T3
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- intravenous administration
- immunoglubulins
- proper
- aroid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- 238000001990 intravenous administration Methods 0.000 title abstract 2
- 108060003951 Immunoglobulin Proteins 0.000 abstract 2
- 102000018358 immunoglobulin Human genes 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 102000057297 Pepsin A Human genes 0.000 abstract 1
- 108090000284 Pepsin A Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000027326 copulation Effects 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 229940072221 immunoglobulins Drugs 0.000 abstract 1
- 238000011534 incubation Methods 0.000 abstract 1
- 229940111202 pepsin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/14—Enzymes or microbial cells immobilised on or in an inorganic carrier
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
- C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
- C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C12N11/091—Phenol resins; Amino resins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
- C12N11/098—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer formed in the presence of the enzymes or microbial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
UN PROCEDIMIENTO PARA LA PREPARACION DE INMUNOGLOBULINAS ADECUADAS PARA ADMINISTRACION INTRAVENOSA POR INCUBACION CON PEPSINA INMOVILIZADA EN UN GEL HIDROFILICO QUE CONTIENE GRUPOS AMINOS CARACTERIZADO PORQUE UN ESTER DISUCCINIMIDILICO DEL ACIDO DICARBOXILICO DE LA FORMULA GENERAL (I) FIGXX DONDE R ES UN RADICAL ALKILENO RECTO O RAMIFICADO QUE CONTIENE DE 1 A 20 ATOMOS DE CARBONO UN FIGXX GRUPO, SE USA COMO AGENTE DE COPULACION, LAS PREPARACIONES INMUNOGLOBULINAS LIOFILIZADAS SE OBTIENEN POR LIOFILIZACION Y PROCEDIMIENTO PARA INMOVILIZAR LA PEPSINA USANDO UN COMPUESTO DE FORMULA (I).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT22766/85A IT1186766B (it) | 1985-11-08 | 1985-11-08 | Metodo per la preparazione di immunoglobuline per uso endovenoso |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2033231T3 true ES2033231T3 (es) | 1993-03-16 |
Family
ID=11200219
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198686115016T Expired - Lifetime ES2033231T3 (es) | 1985-11-08 | 1986-10-29 | Metodo para la preparacion de inmunoglubulinas apropiadas para administracion intravenosa. |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0221505B1 (es) |
JP (1) | JPH07121876B2 (es) |
AT (1) | ATE66151T1 (es) |
AU (1) | AU6427886A (es) |
CA (1) | CA1306964C (es) |
DE (1) | DE3680860D1 (es) |
ES (1) | ES2033231T3 (es) |
GR (1) | GR3002931T3 (es) |
IL (1) | IL80547A0 (es) |
IT (1) | IT1186766B (es) |
ZA (1) | ZA868271B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE465950B (sv) * | 1989-10-23 | 1991-11-25 | Medinvent Sa | Kombination av ett aggregat partikelformat, kristallint eller frystorkat laekemedel med en pseudoplastisk gel foer beredning av ett injicerbart preparat samt foerfarande foer dess framstaellning |
CA2061519C (en) * | 1991-02-20 | 2004-05-18 | Naoki Asakawa | Packings combining protein to a support via a spacer |
US5354461A (en) * | 1991-02-20 | 1994-10-11 | Eisai Co., Ltd. | Packings combining protein to a support via a spacer |
EP0835880A1 (de) * | 1996-10-14 | 1998-04-15 | Rotkreuzstiftung Zentrallaboratorium Blutspendedienst Srk | Verfahren zur Herstellung eines IgM Präparates für die intravenöse Applikation |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5615215A (en) * | 1979-07-14 | 1981-02-14 | Nippon Sekijiyuujishiya | Preparation of human immunoglobulin for intravenous injection with immobilized pepsin gel |
NL8220181A (nl) * | 1982-05-31 | 1984-04-02 | Mochida Pharm Co Ltd | Geimmobiliseerd pepsine voor gebruik in de verwijdering van immuuncomplex uit bloed, en een werkwijze voor het verwijderen van immuuncomplex uit bloed door gebruik van het geimmobiliseerde pepsine. |
-
1985
- 1985-11-08 IT IT22766/85A patent/IT1186766B/it active
-
1986
- 1986-10-22 AU AU64278/86A patent/AU6427886A/en not_active Withdrawn
- 1986-10-23 CA CA000521255A patent/CA1306964C/en not_active Expired - Fee Related
- 1986-10-29 DE DE8686115016T patent/DE3680860D1/de not_active Expired - Fee Related
- 1986-10-29 EP EP86115016A patent/EP0221505B1/en not_active Expired - Lifetime
- 1986-10-29 AT AT86115016T patent/ATE66151T1/de not_active IP Right Cessation
- 1986-10-29 ES ES198686115016T patent/ES2033231T3/es not_active Expired - Lifetime
- 1986-10-30 ZA ZA868271A patent/ZA868271B/xx unknown
- 1986-11-07 JP JP61264125A patent/JPH07121876B2/ja not_active Expired - Lifetime
- 1986-11-07 IL IL80547A patent/IL80547A0/xx unknown
-
1991
- 1991-10-17 GR GR91401562T patent/GR3002931T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ZA868271B (en) | 1987-06-24 |
JPS62114919A (ja) | 1987-05-26 |
IL80547A0 (en) | 1987-02-27 |
IT1186766B (it) | 1987-12-16 |
EP0221505A2 (en) | 1987-05-13 |
CA1306964C (en) | 1992-09-01 |
AU6427886A (en) | 1987-05-14 |
ATE66151T1 (de) | 1991-08-15 |
JPH07121876B2 (ja) | 1995-12-25 |
DE3680860D1 (de) | 1991-09-19 |
IT8522766A0 (it) | 1985-11-08 |
EP0221505A3 (en) | 1988-05-04 |
EP0221505B1 (en) | 1991-08-14 |
GR3002931T3 (en) | 1993-01-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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