ES2074179T3 - Haptenos marcados mejorados, procedimiento para su preparacion, asi como empleo de estos haptenos marcados en inmunoensayos. - Google Patents

Haptenos marcados mejorados, procedimiento para su preparacion, asi como empleo de estos haptenos marcados en inmunoensayos.

Info

Publication number
ES2074179T3
ES2074179T3 ES91101656T ES91101656T ES2074179T3 ES 2074179 T3 ES2074179 T3 ES 2074179T3 ES 91101656 T ES91101656 T ES 91101656T ES 91101656 T ES91101656 T ES 91101656T ES 2074179 T3 ES2074179 T3 ES 2074179T3
Authority
ES
Spain
Prior art keywords
hapten
marked
preparation
procedure
well
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91101656T
Other languages
English (en)
Inventor
Tonio Dr Kinkel
Andreas Dr Mayer
Stephan Dr Neuenhofer
Raymond Dr Oekonomopulos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2074179T3 publication Critical patent/ES2074179T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA LA FABRICACION DE UN HAPTENO CON FORMULA I EN LA QUE SON: HAPTENO UNA SUSTANCIA CON ACTIVIDAD BIOLOGICA, PEG POLIETILENGLICOL, P PROTEINA, OLIGOPEPTIDO O POLIPEPTIDO, N 1 A 4, M 1 A 4. LOS HAPTENOS DESCRITOS NO POSEEN UNA REDUCCION DE SU CAPACIDAD DE REACCION, CUANDO SE UNEN AL "LABEL" CORRESPONDIENTE POR MEDIO DE "SPACER".
ES91101656T 1990-02-13 1991-02-07 Haptenos marcados mejorados, procedimiento para su preparacion, asi como empleo de estos haptenos marcados en inmunoensayos. Expired - Lifetime ES2074179T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4004296A DE4004296A1 (de) 1990-02-13 1990-02-13 Verbesserte markierte haptene, verfahren zu deren herstellung sowie verwendung dieser markierten haptene in immunoassays

Publications (1)

Publication Number Publication Date
ES2074179T3 true ES2074179T3 (es) 1995-09-01

Family

ID=6399985

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91101656T Expired - Lifetime ES2074179T3 (es) 1990-02-13 1991-02-07 Haptenos marcados mejorados, procedimiento para su preparacion, asi como empleo de estos haptenos marcados en inmunoensayos.

Country Status (5)

Country Link
EP (1) EP0442372B1 (es)
AT (1) ATE122149T1 (es)
DE (2) DE4004296A1 (es)
DK (1) DK0442372T3 (es)
ES (1) ES2074179T3 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU689920B2 (en) * 1994-06-24 1998-04-09 Dade Behring Marburg Gmbh Method of stabilizing molecules, or parts of molecules, which are sensitive to hydrolysis
DE4444002A1 (de) * 1994-12-10 1996-06-13 Behringwerke Ag Immunoassays für Haptene und hierfür verwendbare Haptentracer-Antikörper-Komplexe sowie Verfahren zur Herstellung derselben
US6544797B1 (en) * 1997-04-09 2003-04-08 Biosite Diagnostics, Inc. Compositions and methods for inhibiting light-induced inactivation of biological reagents
DE19748489A1 (de) 1997-11-03 1999-05-06 Roche Diagnostics Gmbh Polyethylenglykol-derivatisierte Biomoleküle und deren Verwendung in heterogenen Nachweisverfahren
ATE322255T1 (de) * 1997-12-23 2006-04-15 Inex Pharmaceuticals Corp Polyamid-oligomere
US6320017B1 (en) 1997-12-23 2001-11-20 Inex Pharmaceuticals Corp. Polyamide oligomers
US6664043B2 (en) * 2001-07-03 2003-12-16 Bayer Corporation Acridinium ester labels having hydrophilic modifiers
EP1539702B1 (en) * 2002-08-20 2012-04-11 Quest Diagnostics Investments Incorporated Hydrophilic chemiluminescent acridinium labeling reagents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0134307B1 (de) * 1983-07-29 1989-04-19 Henning Berlin GmbH Chemie und Pharmawerk Voraktivierte Kunststoffoberflächen zur Immobilisierung von organisch-chemischen und biologischen Materialien, Verfahren zur Herstellung und Verwendung derselben
US4732863A (en) * 1984-12-31 1988-03-22 University Of New Mexico PEG-modified antibody with reduced affinity for cell surface Fc receptors
US4810638A (en) * 1986-07-24 1989-03-07 Miles Inc. Enzyme-labeled antibody reagent with polyalkyleneglycol linking group
DE3628795A1 (de) * 1986-08-25 1988-03-03 Hoechst Ag Neue thyroninderivate

Also Published As

Publication number Publication date
EP0442372B1 (de) 1995-05-03
DE4004296A1 (de) 1991-08-14
EP0442372A1 (de) 1991-08-21
ATE122149T1 (de) 1995-05-15
DE59105344D1 (de) 1995-06-08
DK0442372T3 (da) 1995-09-25

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