KR880002536A - 옥시란 슈도올리고삭카라이드, 이의 제조방법 및 이의 용도 및 약제학적 제제 - Google Patents

옥시란 슈도올리고삭카라이드, 이의 제조방법 및 이의 용도 및 약제학적 제제 Download PDF

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Publication number
KR880002536A
KR880002536A KR1019870008816A KR870008816A KR880002536A KR 880002536 A KR880002536 A KR 880002536A KR 1019870008816 A KR1019870008816 A KR 1019870008816A KR 870008816 A KR870008816 A KR 870008816A KR 880002536 A KR880002536 A KR 880002536A
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KR
South Korea
Prior art keywords
pseudooligosaccharide
oxirane
formula
physiologically acceptable
preparation
Prior art date
Application number
KR1019870008816A
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English (en)
Inventor
베르테시 라스쯜로
베쯔 요아힘
펠하버 한스-볼프람
가이젠 칼
Original Assignee
하인리히 벡커, 베른하르트 벡크
훽스트 아크티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 하인리히 벡커, 베른하르트 벡크, 훽스트 아크티엔게젤샤프트 filed Critical 하인리히 벡커, 베른하르트 벡크
Publication of KR880002536A publication Critical patent/KR880002536A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

내용 없음

Description

옥시란 슈도올리고삭카라이드, 이의 제조방법, 및 이의 용도 및 약제학적 제재
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 하기 일반식(Ⅰ)의 옥시란-슈도올리고삭카라이드 및 이의 생리학적으로 허용되는 산과의 염.
    상기식에서, Z는 0 또는 1이다.
  2. a)하기 일반식(Ⅱ)의 α-글루코시다제 억제제 또는 이들 억제제의 혼합물로부터 화학적 또는 생화학적 방법으로 당을 제거하여 일반식(Ⅰ)의 화합물을 형성시키거나, b) 일반식(Ⅰ)의 슈도올리고삭카라이드를 생산하는 스트랩토마이세트 (Streptomycete)를 적합한 액침방법을 사용하여 발효배지에서 배양한 후, 균사체 또는 배양 여액으로 부터 슈도올리고 삭카라이드를 분리 및 정제하고, 경우에 따라, 수득된 일반식(Ⅰ)의 화합물을 생리학적으로 허용되는 염으로 전환시킴을 특징으로 하여, 일반식(Ⅰ)의 옥시란-슈도올리고삭카라이드 및 이의 생리학적으로 허용되는 산과의 염을 제조하는 방법.
    상기식에서, z는 0또는 1이며, m은 2 또는 3이고, n은 1 내지 20의 정수이다.
  3. 제1항에 따르는 옥시란-슈도올리고삭카라이드를 함유하는 약제학적 제제.
  4. 제1항에 따르는 옥시란-슈도올리고삭카라이드를 적절한 투여형태로 전환시킴을 특징으로 하여, 약제학적 제제를 제조하는 방법.
  5. α-글루코시다제를 억제하기 위한, 제1항에 따르는 옥시란-슈도올리고삭카라이드의 용도.
  6. 당뇨병, 당뇨병 전기 및 지방증 치료를 위한, 제1항에 따르는 옥시란-슈도올리고삭카라이드의 용도.
  7. 진단용 약물, 시약 또는 충치 예방약으로서의, 제1항에 따르는 옥시란-슈도올리고삭카라이드의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870008816A 1986-08-13 1987-08-12 옥시란 슈도올리고삭카라이드, 이의 제조방법 및 이의 용도 및 약제학적 제제 KR880002536A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3627421.6 1986-08-13
DE3627421 1986-08-13

Publications (1)

Publication Number Publication Date
KR880002536A true KR880002536A (ko) 1988-05-09

Family

ID=6307284

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870008816A KR880002536A (ko) 1986-08-13 1987-08-12 옥시란 슈도올리고삭카라이드, 이의 제조방법 및 이의 용도 및 약제학적 제제

Country Status (15)

Country Link
US (1) US4990500A (ko)
EP (1) EP0257418B1 (ko)
JP (1) JPS6348302A (ko)
KR (1) KR880002536A (ko)
AT (1) ATE89563T1 (ko)
AU (1) AU7680187A (ko)
DE (1) DE3785895D1 (ko)
DK (1) DK420187A (ko)
ES (1) ES2056801T3 (ko)
FI (1) FI873483A (ko)
HU (1) HUT44802A (ko)
IL (1) IL83495A0 (ko)
NO (1) NO873385L (ko)
PT (1) PT85524B (ko)
ZA (1) ZA875954B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960022566A (ko) * 1994-12-30 1996-07-18 김충환 신규한 아미노올리고당 유도체 및 그의 제조방법
DE19631288A1 (de) * 1996-08-02 1998-02-05 Hoechst Ag Neue Inhibitoren der ß-Glucuronidase
NZ541455A (en) * 2003-01-30 2007-08-31 Sankyo Co Oligosaccharide derivative

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013510A (en) * 1970-12-28 1977-03-22 Farbenfabriken Bayer Aktiengesellschaft Glycoside-hydrolase enzyme inhibitors
DE2064092C2 (de) * 1970-12-28 1983-06-01 Bayer Ag, 5090 Leverkusen Inhibitoren für Glykosidhydrolasen aus Actinomyceten
DE2719912C3 (de) * 1977-05-04 1979-12-06 Bayer Ag, 5090 Leverkusen Verfahren zur Isolierung von 0- |4,6-Dideoxy-4- [JJl S-O,4,6/5)-4,5,6-trihydroxy-3-hydroxymethyl-2cyclohexen-1-yl] -amino] - a -D-glucopyranosyl} -(I Pfeil nach rechts 4)-0- a D-glucopyranosyl-(l Pfeil nach rechts 4)-D-glucopyranose aus Kulturbrühen
CH648326A5 (en) * 1981-11-03 1985-03-15 Byk Gulden Lomberg Chem Fab Maltotriose derivatives, processes for their preparation
US4595678A (en) * 1982-03-19 1986-06-17 Takeda Chemical Industries, Ltd. N-substituted pseudo-aminosugars and pharmaceutical compositions containing same
JPS58172400A (ja) * 1982-04-05 1983-10-11 Tokyo Tanabe Co Ltd 新規なアミノオリゴ糖誘導体
EP0173950A3 (de) * 1984-09-04 1987-10-28 Hoechst Aktiengesellschaft Neuer alpha-Glukosidase Inhibitor, Verfahren zur seiner Herstellung, seine Verwendung und pharmazeutische Präparate
EP0173948A3 (de) * 1984-09-04 1987-11-04 Hoechst Aktiengesellschaft Neue Pseudooligosaccharide mit alpha-Glukosidase-hemmender Wirkung, Verfahren zur deren Herstellung, deren Verwendung und pharmazeutische Präparate

Also Published As

Publication number Publication date
PT85524A (de) 1987-09-01
PT85524B (pt) 1990-06-29
AU7680187A (en) 1988-02-18
HUT44802A (en) 1988-04-28
EP0257418B1 (de) 1993-05-19
EP0257418A2 (de) 1988-03-02
EP0257418A3 (en) 1989-12-20
ATE89563T1 (de) 1993-06-15
JPS6348302A (ja) 1988-03-01
NO873385D0 (no) 1987-08-12
DK420187D0 (da) 1987-08-12
ES2056801T3 (es) 1994-10-16
FI873483A0 (fi) 1987-08-11
DK420187A (da) 1988-02-14
ZA875954B (en) 1988-03-30
FI873483A (fi) 1988-02-14
NO873385L (no) 1988-02-15
IL83495A0 (en) 1988-01-31
US4990500A (en) 1991-02-05
DE3785895D1 (de) 1993-06-24

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