IT1186766B - Metodo per la preparazione di immunoglobuline per uso endovenoso - Google Patents

Metodo per la preparazione di immunoglobuline per uso endovenoso

Info

Publication number
IT1186766B
IT1186766B IT22766/85A IT2276685A IT1186766B IT 1186766 B IT1186766 B IT 1186766B IT 22766/85 A IT22766/85 A IT 22766/85A IT 2276685 A IT2276685 A IT 2276685A IT 1186766 B IT1186766 B IT 1186766B
Authority
IT
Italy
Prior art keywords
preparation
immunoglobulins
chem
pepsin
intravenous use
Prior art date
Application number
IT22766/85A
Other languages
English (en)
Other versions
IT8522766A0 (it
Inventor
Guido Gazzei
Aldo Giannozzi
Andrea Valeri
Original Assignee
Sclavo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sclavo Spa filed Critical Sclavo Spa
Publication of IT8522766A0 publication Critical patent/IT8522766A0/it
Priority to IT22766/85A priority Critical patent/IT1186766B/it
Priority to AU64278/86A priority patent/AU6427886A/en
Priority to CA000521255A priority patent/CA1306964C/en
Priority to EP86115016A priority patent/EP0221505B1/en
Priority to AT86115016T priority patent/ATE66151T1/de
Priority to ES198686115016T priority patent/ES2033231T3/es
Priority to DE8686115016T priority patent/DE3680860D1/de
Priority to ZA868271A priority patent/ZA868271B/xx
Priority to JP61264125A priority patent/JPH07121876B2/ja
Priority to IL80547A priority patent/IL80547A0/xx
Application granted granted Critical
Publication of IT1186766B publication Critical patent/IT1186766B/it
Priority to GR91401562T priority patent/GR3002931T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/14—Enzymes or microbial cells immobilised on or in an inorganic carrier
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/091—Phenol resins; Amino resins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/098—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer formed in the presence of the enzymes or microbial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
IT22766/85A 1985-11-08 1985-11-08 Metodo per la preparazione di immunoglobuline per uso endovenoso IT1186766B (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IT22766/85A IT1186766B (it) 1985-11-08 1985-11-08 Metodo per la preparazione di immunoglobuline per uso endovenoso
AU64278/86A AU6427886A (en) 1985-11-08 1986-10-22 Preparation of immunoglobulins suitable for intravenous administration
CA000521255A CA1306964C (en) 1985-11-08 1986-10-23 Method for the preparation of immunoglobulins suitable for intravenous administration
AT86115016T ATE66151T1 (de) 1985-11-08 1986-10-29 Verfahren zur herstellung von intravenoes geeigneten immunoglobulinen.
EP86115016A EP0221505B1 (en) 1985-11-08 1986-10-29 Method for the preparation of immunoglobulins suitable for intravenous administration
ES198686115016T ES2033231T3 (es) 1985-11-08 1986-10-29 Metodo para la preparacion de inmunoglubulinas apropiadas para administracion intravenosa.
DE8686115016T DE3680860D1 (de) 1985-11-08 1986-10-29 Verfahren zur herstellung von intravenoes geeigneten immunoglobulinen.
ZA868271A ZA868271B (en) 1985-11-08 1986-10-30 Method for the preparation of immunoglobulins suitable for intravenous administration
JP61264125A JPH07121876B2 (ja) 1985-11-08 1986-11-07 静注用免疫グロブリンの製法
IL80547A IL80547A0 (en) 1985-11-08 1986-11-07 Method for the preparation of immunoglobulins suitable for intravenous administration
GR91401562T GR3002931T3 (en) 1985-11-08 1991-10-17 Method for the preparation of immunoglobulins suitable for intravenous administration

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22766/85A IT1186766B (it) 1985-11-08 1985-11-08 Metodo per la preparazione di immunoglobuline per uso endovenoso

Publications (2)

Publication Number Publication Date
IT8522766A0 IT8522766A0 (it) 1985-11-08
IT1186766B true IT1186766B (it) 1987-12-16

Family

ID=11200219

Family Applications (1)

Application Number Title Priority Date Filing Date
IT22766/85A IT1186766B (it) 1985-11-08 1985-11-08 Metodo per la preparazione di immunoglobuline per uso endovenoso

Country Status (11)

Country Link
EP (1) EP0221505B1 (it)
JP (1) JPH07121876B2 (it)
AT (1) ATE66151T1 (it)
AU (1) AU6427886A (it)
CA (1) CA1306964C (it)
DE (1) DE3680860D1 (it)
ES (1) ES2033231T3 (it)
GR (1) GR3002931T3 (it)
IL (1) IL80547A0 (it)
IT (1) IT1186766B (it)
ZA (1) ZA868271B (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE465950B (sv) * 1989-10-23 1991-11-25 Medinvent Sa Kombination av ett aggregat partikelformat, kristallint eller frystorkat laekemedel med en pseudoplastisk gel foer beredning av ett injicerbart preparat samt foerfarande foer dess framstaellning
CA2061519C (en) * 1991-02-20 2004-05-18 Naoki Asakawa Packings combining protein to a support via a spacer
US5354461A (en) * 1991-02-20 1994-10-11 Eisai Co., Ltd. Packings combining protein to a support via a spacer
EP0835880A1 (de) * 1996-10-14 1998-04-15 Rotkreuzstiftung Zentrallaboratorium Blutspendedienst Srk Verfahren zur Herstellung eines IgM Präparates für die intravenöse Applikation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5615215A (en) * 1979-07-14 1981-02-14 Nippon Sekijiyuujishiya Preparation of human immunoglobulin for intravenous injection with immobilized pepsin gel
WO1983004180A1 (en) * 1982-05-31 1983-12-08 Mochida Pharmaceutical Co., Ltd. Immobilized pepsin for removing blood immune complex and method for removing blood immune complex using immobilized pepsin

Also Published As

Publication number Publication date
JPS62114919A (ja) 1987-05-26
IT8522766A0 (it) 1985-11-08
EP0221505A2 (en) 1987-05-13
AU6427886A (en) 1987-05-14
DE3680860D1 (de) 1991-09-19
EP0221505B1 (en) 1991-08-14
ZA868271B (en) 1987-06-24
IL80547A0 (en) 1987-02-27
EP0221505A3 (en) 1988-05-04
JPH07121876B2 (ja) 1995-12-25
GR3002931T3 (en) 1993-01-25
ES2033231T3 (es) 1993-03-16
CA1306964C (en) 1992-09-01
ATE66151T1 (de) 1991-08-15

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