ES2000743A6 - Estuche y procedimiento para preparar una unidad de dosificacion de activador de plasminogeno de tejidos humanos. - Google Patents
Estuche y procedimiento para preparar una unidad de dosificacion de activador de plasminogeno de tejidos humanos.Info
- Publication number
- ES2000743A6 ES2000743A6 ES8600558A ES8600558A ES2000743A6 ES 2000743 A6 ES2000743 A6 ES 2000743A6 ES 8600558 A ES8600558 A ES 8600558A ES 8600558 A ES8600558 A ES 8600558A ES 2000743 A6 ES2000743 A6 ES 2000743A6
- Authority
- ES
- Spain
- Prior art keywords
- dosage unit
- pharmaceutical dosage
- tpa
- plasminogen activator
- human tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21068—Tissue plasminogen activator (3.4.21.68), i.e. tPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
Abstract
EL ESTUCHE DESCRITO COMPRENDE UNO O MAS RECIPIENTES ESTERILES DE TPA (ACTIVADOR DE PLASMINOGENO DE TEJIDOS HUMANOS) EN FORMA LIOFILIZADA Y UNO O MAS RECIPIENTES ESTERILES DISTINTOS DE SOLUCION PARA RECONSTITUCION, HABIENDO UN TAMPON EN UNO O AMBOS RECIPIENTES Y SELECCIONANDOSE EL TAMPON, LA SOLUCION PARA RECONSTITUCION Y LAS CANTIDADES DE TPA Y DE SOLUCION DE MANERA QUE PROPORCIONEN UNA UNIDAD DE DOSIFICACION FARMACEUTICA QUE COMPRENDE 0,1-15 MG/ML DE TPA A PH 3,5-5,5. POR SU PARTE, EL PROCEDIMIENTO COMPRENDE DISOLVER TPA EN UN DISOLVENTE ACUOSO AL PH CITADO HASTA ALCANZAR LA CONCENTRACION DEL TPA MENCIONADA. LA UNIDAD DE DOSIFICACION OBTENIDA ES UTIL PARA ADMINISTRACION PARENTERAL, PARTICULARMENTE EN TERAPIA TROMBOLITICA.-
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75978585A | 1985-07-29 | 1985-07-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2000743A6 true ES2000743A6 (es) | 1988-03-16 |
Family
ID=25056946
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8600558A Expired ES2000743A6 (es) | 1985-07-29 | 1986-07-24 | Estuche y procedimiento para preparar una unidad de dosificacion de activador de plasminogeno de tejidos humanos. |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0211592A3 (es) |
JP (1) | JPS6236332A (es) |
KR (1) | KR870000918A (es) |
CN (1) | CN86105526A (es) |
AU (1) | AU593566B2 (es) |
DK (1) | DK352686A (es) |
ES (1) | ES2000743A6 (es) |
FI (1) | FI863077A (es) |
GR (1) | GR861961B (es) |
HU (1) | HU198264B (es) |
NO (1) | NO863029L (es) |
PH (1) | PH22989A (es) |
PT (1) | PT83075B (es) |
ZA (1) | ZA865652B (es) |
ZW (1) | ZW14486A1 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4929444A (en) * | 1985-05-28 | 1990-05-29 | Burroughs Wellcome Co. | Low pH pharmaceutical formulation containing t-PA |
BE904831A (fr) * | 1985-05-28 | 1986-11-27 | Wellcome Found | Composition d'activateur tissulaire du plasminogene. |
US4777043A (en) * | 1985-12-17 | 1988-10-11 | Genentech, Inc. | Stabilized human tissue plasminogen activator compositions |
US5034225A (en) * | 1985-12-17 | 1991-07-23 | Genentech Inc. | Stabilized human tissue plasminogen activator compositions |
DE3845000C2 (de) * | 1987-07-10 | 1998-11-19 | Novartis Ag | Anwendung von Octreotid zur Behandlung von Brustkrebs |
US4929560A (en) * | 1988-02-03 | 1990-05-29 | Damon Biotech, Inc. | Recovery of tissue plasminogen activator |
DE3806562A1 (de) * | 1988-03-01 | 1989-09-14 | Alpha Therapeutic Gmbh | Zweikammerspritze mit einer fuellung aus aktivitaetsempfindlichem humanen protein als wirkstoff |
US5270198A (en) * | 1988-05-20 | 1993-12-14 | Genentech, Inc. | DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells |
US5342616A (en) * | 1988-06-20 | 1994-08-30 | The Wellcome Foundation Limited | Method of administering tissue plasminogen activator |
GB8814604D0 (en) * | 1988-06-20 | 1988-07-27 | Wellcome Found | Medicaments |
US5262170A (en) * | 1988-09-02 | 1993-11-16 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells |
US5714145A (en) * | 1988-09-02 | 1998-02-03 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
DE3835350A1 (de) * | 1988-10-17 | 1990-04-19 | Boehringer Mannheim Gmbh | Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern |
US4980165A (en) * | 1989-01-27 | 1990-12-25 | Genetics Institute, Inc. | Pharmaceutical formulations of plasminogen activator proteins |
AU6470590A (en) | 1989-10-23 | 1991-04-26 | Smithkline Beecham Corporation | Cyclic anti-aggregatory peptides |
DE3942145A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | T-pa-solubilisierung |
DE3942143A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | T-pa pro stabilisierung |
DE3942141A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | K2p pro-stabilisierung |
DE3942142A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | Stabilisierung von glykosyliertem t-pa |
US5366730A (en) * | 1989-12-20 | 1994-11-22 | Boehringer Mannheim Gmbh | Stabilized compositions having human tissue type plasminogen activator enzymatic activity |
DE3942144A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | Stabilisierung von k1k2p pro |
ATE132373T1 (de) * | 1991-04-16 | 1996-01-15 | Boehringer Mannheim Gmbh | Pharmazeutische verpackungseinheit enthaltend plasminogenaktivatoren zur mehrfachbolusgabe |
US5272076A (en) * | 1991-06-13 | 1993-12-21 | Eli Lilly And Company | Compounds and methods for treatment of thromboembolic disorders using an adduct of t-PA |
US5747447A (en) * | 1992-04-30 | 1998-05-05 | Cor Therapeutics | Stable polypeptide composition |
DE10199044I2 (de) * | 1992-06-03 | 2006-02-09 | Genentech Inc | Varianten des Gewebeplasminogenaktivators mit verbesserter Therapeutischer wirkung |
US7879341B2 (en) | 2004-07-26 | 2011-02-01 | Merz Pharma Gmbh & Co. Kgaa | Therapeutic composition with a botulinum neurotoxin |
KR102194891B1 (ko) | 2020-07-08 | 2020-12-28 | 대상 주식회사 | 계란프라이 조리장치 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8003402A (nl) * | 1980-06-11 | 1982-01-04 | Leuven Res & Dev Vzw | Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking. |
JPS59196824A (ja) * | 1983-04-21 | 1984-11-08 | Kowa Co | 吸着防止剤 |
BE904831A (fr) * | 1985-05-28 | 1986-11-27 | Wellcome Found | Composition d'activateur tissulaire du plasminogene. |
US4929444A (en) * | 1985-05-28 | 1990-05-29 | Burroughs Wellcome Co. | Low pH pharmaceutical formulation containing t-PA |
JPH0672105B2 (ja) * | 1985-10-02 | 1994-09-14 | 持田製薬株式会社 | 血栓溶解剤及びその製法 |
-
1986
- 1986-07-23 ZW ZW144/86A patent/ZW14486A1/xx unknown
- 1986-07-24 DK DK352686A patent/DK352686A/da not_active Application Discontinuation
- 1986-07-24 ES ES8600558A patent/ES2000743A6/es not_active Expired
- 1986-07-25 GR GR861961A patent/GR861961B/el unknown
- 1986-07-28 CN CN198686105526A patent/CN86105526A/zh active Pending
- 1986-07-28 PT PT83075A patent/PT83075B/pt unknown
- 1986-07-28 NO NO863029A patent/NO863029L/no unknown
- 1986-07-28 EP EP86305794A patent/EP0211592A3/en not_active Withdrawn
- 1986-07-28 HU HU863218A patent/HU198264B/hu not_active IP Right Cessation
- 1986-07-28 FI FI863077A patent/FI863077A/fi not_active Application Discontinuation
- 1986-07-28 PH PH34074A patent/PH22989A/en unknown
- 1986-07-28 KR KR1019860006133A patent/KR870000918A/ko not_active Application Discontinuation
- 1986-07-29 ZA ZA865652A patent/ZA865652B/xx unknown
- 1986-07-29 AU AU60647/86A patent/AU593566B2/en not_active Ceased
- 1986-07-29 JP JP61179812A patent/JPS6236332A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
NO863029L (no) | 1987-01-30 |
AU6064786A (en) | 1987-02-05 |
DK352686D0 (da) | 1986-07-24 |
ZW14486A1 (en) | 1986-10-22 |
FI863077A0 (fi) | 1986-07-28 |
GR861961B (en) | 1986-11-26 |
PT83075B (en) | 1988-07-13 |
EP0211592A2 (en) | 1987-02-25 |
PT83075A (en) | 1986-08-01 |
ZA865652B (en) | 1987-11-25 |
EP0211592A3 (en) | 1988-03-02 |
AU593566B2 (en) | 1990-02-15 |
CN86105526A (zh) | 1987-02-04 |
JPS6236332A (ja) | 1987-02-17 |
FI863077A (fi) | 1987-01-30 |
HUT42953A (en) | 1987-09-28 |
DK352686A (da) | 1987-01-30 |
PH22989A (en) | 1989-02-24 |
NO863029D0 (no) | 1986-07-28 |
HU198264B (en) | 1989-09-28 |
KR870000918A (ko) | 1987-03-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20000503 |