EP4257202A3 - Particules de fibroïne injectables et leurs utilisations - Google Patents
Particules de fibroïne injectables et leurs utilisations Download PDFInfo
- Publication number
- EP4257202A3 EP4257202A3 EP23168344.2A EP23168344A EP4257202A3 EP 4257202 A3 EP4257202 A3 EP 4257202A3 EP 23168344 A EP23168344 A EP 23168344A EP 4257202 A3 EP4257202 A3 EP 4257202A3
- Authority
- EP
- European Patent Office
- Prior art keywords
- tissue
- compositions
- silk fibroin
- fibroin particles
- augmentation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010022355 Fibroins Proteins 0.000 title abstract 2
- 239000002245 particle Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 5
- 210000001519 tissue Anatomy 0.000 abstract 5
- 230000017423 tissue regeneration Effects 0.000 abstract 3
- 230000003416 augmentation Effects 0.000 abstract 2
- 239000011800 void material Substances 0.000 abstract 2
- 230000003190 augmentative effect Effects 0.000 abstract 1
- 239000000945 filler Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002324 minimally invasive surgery Methods 0.000 abstract 1
- 210000004872 soft tissue Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0059—Cosmetic or alloplastic implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Developmental Biology & Embryology (AREA)
- Composite Materials (AREA)
- Reproductive Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161557603P | 2011-11-09 | 2011-11-09 | |
EP12846915.2A EP2788040B1 (fr) | 2011-11-09 | 2012-11-09 | Particules de fibroïne injectables et leurs utilisations |
PCT/US2012/064450 WO2013071107A1 (fr) | 2011-11-09 | 2012-11-09 | Particules de fibroïne injectables et leurs utilisations |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP12846915.2A Division EP2788040B1 (fr) | 2011-11-09 | 2012-11-09 | Particules de fibroïne injectables et leurs utilisations |
EP12846915.2A Division-Into EP2788040B1 (fr) | 2011-11-09 | 2012-11-09 | Particules de fibroïne injectables et leurs utilisations |
Publications (2)
Publication Number | Publication Date |
---|---|
EP4257202A2 EP4257202A2 (fr) | 2023-10-11 |
EP4257202A3 true EP4257202A3 (fr) | 2023-12-20 |
Family
ID=48290608
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP12846915.2A Active EP2788040B1 (fr) | 2011-11-09 | 2012-11-09 | Particules de fibroïne injectables et leurs utilisations |
EP23168344.2A Pending EP4257202A3 (fr) | 2011-11-09 | 2012-11-09 | Particules de fibroïne injectables et leurs utilisations |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP12846915.2A Active EP2788040B1 (fr) | 2011-11-09 | 2012-11-09 | Particules de fibroïne injectables et leurs utilisations |
Country Status (12)
Country | Link |
---|---|
US (3) | US9931434B2 (fr) |
EP (2) | EP2788040B1 (fr) |
JP (2) | JP6362540B2 (fr) |
KR (3) | KR102138152B1 (fr) |
CN (1) | CN104363931A (fr) |
AU (2) | AU2012335106B2 (fr) |
BR (1) | BR112014011188B1 (fr) |
CA (1) | CA2890366A1 (fr) |
ES (1) | ES2953309T3 (fr) |
HK (1) | HK1207322A1 (fr) |
MX (1) | MX2014005702A (fr) |
WO (1) | WO2013071107A1 (fr) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112014011188B1 (pt) | 2011-11-09 | 2020-05-19 | Tufts College | composição injetável para utilização na reparação ou aumento de tecido em indivíduo e dispositivo de entrega compreendendo a referida composição |
WO2013152265A1 (fr) | 2012-04-06 | 2013-10-10 | Trustees Of Tufts College | Procédés de production et d'utilisation de microfibres de soie |
US11376329B2 (en) | 2013-03-15 | 2022-07-05 | Trustees Of Tufts College | Low molecular weight silk compositions and stabilizing silk compositions |
CN103357066B (zh) * | 2013-06-28 | 2015-07-29 | 陕西巨子生物技术有限公司 | 一种具有生物修复活性及优良降解性能的水凝胶及制备方法 |
US20150290248A1 (en) * | 2014-04-10 | 2015-10-15 | Nanofiber Health, Inc. | Fibrous component for health, performance, and aesthetic treatment |
AU2015301432B2 (en) | 2014-08-15 | 2019-11-21 | The Johns Hopkins University | Composite material for tissue restoration |
GB201415681D0 (en) | 2014-09-04 | 2014-10-22 | Cambridge Entpr Ltd And President And Fellows Of Harvard College | Protien Capsules |
CN113564927A (zh) | 2014-12-02 | 2021-10-29 | 丝绸医疗公司 | 丝性能服装和产品及其制备方法 |
KR20180072664A (ko) | 2015-07-14 | 2018-06-29 | 실크 테라퓨틱스, 인코퍼레이티드 | 실크 성능 의류와 제품들 및 이의 제조 방법 |
GB201514788D0 (en) * | 2015-08-20 | 2015-10-07 | Ecole Polytech | Malleable scaffold material and uses thereof |
KR101710639B1 (ko) * | 2016-06-07 | 2017-03-08 | 주식회사 파마리서치프로덕트 | 핵산, 키토산 및 히알루론산을 포함하는 조직 증강용 충전 조성물 및 이의 제조방법 |
WO2018081805A1 (fr) * | 2016-10-31 | 2018-05-03 | Sofregen Medical, Inc. | Compositions comprenant des fragments de fibroïne de soie à faible poids moléculaire et des plastifiants |
WO2018125829A1 (fr) | 2016-12-28 | 2018-07-05 | Sanbio, Inc. | Système d'administration de cellules et méthodes de fonctionnement de celui-ci |
CN106729982A (zh) * | 2016-12-29 | 2017-05-31 | 浙江大学 | 一种丝素蛋白纳米球的制备方法 |
JP6482604B2 (ja) * | 2017-06-22 | 2019-03-13 | 教裕 南郷 | 外皮内溶解型ニードル及びニードル装置 |
US11390988B2 (en) | 2017-09-27 | 2022-07-19 | Evolved By Nature, Inc. | Silk coated fabrics and products and methods of preparing the same |
US10821205B2 (en) * | 2017-10-18 | 2020-11-03 | Lifecell Corporation | Adipose tissue products and methods of production |
RU2683557C1 (ru) * | 2017-11-22 | 2019-03-28 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТИО им. ак. В.И. Шумакова" Минздрава России) | Способ получения биодеградируемых скаффолдов из фиброина шелка с улучшенными биологическими свойствами |
RU2684769C1 (ru) * | 2017-11-22 | 2019-04-12 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТИО им. ак. В.И. Шумакова" Минздрава России) | Композиция для изготовления биодеградируемых скаффолдов и способ ее получения |
US11590258B2 (en) * | 2018-01-10 | 2023-02-28 | G2Gbio, Inc. | Vitamin C-containing polycaprolactone microsphere filler and preparation method therefor |
EP3765103A1 (fr) | 2018-03-12 | 2021-01-20 | Merz Pharma GmbH & Co. KGaA | Biomatériaux poreux pour régénération tissulaire |
US20210402061A1 (en) | 2018-05-09 | 2021-12-30 | The Johns Hopkins University | Nanofiber-hydrogel composites for cell and tissue delivery |
CN109851819B (zh) * | 2019-03-08 | 2021-10-29 | 江西丝科生物科技有限公司 | 一种可注射丝素蛋白多孔水凝胶及其制备方法 |
DE112020002263T5 (de) * | 2019-05-07 | 2022-01-20 | Preco, Inc. | Umschließungsabschlussverfahren zum Umschließen von lockerem Material und umschlossenes lockeres Material |
CA3142608A1 (fr) | 2019-06-04 | 2020-12-10 | Cocoon Biotech Inc. | Produits a base de soie, formulations et procedes d'utilisation |
CN110384823B (zh) * | 2019-07-19 | 2021-08-03 | 大连医科大学 | 基于丝素蛋白支架的仿生肝小叶及构建方法 |
US20240002804A1 (en) * | 2020-11-12 | 2024-01-04 | Trustees Of Tufts College | Cultured adipose tissue |
US20240033401A1 (en) * | 2020-12-18 | 2024-02-01 | Drexel University | Injectable, cross-linkable and subcellular size microfibers for soft tissue repair |
CN112587721A (zh) * | 2020-12-30 | 2021-04-02 | 广州益诚生物科技有限公司 | 一种注射填充材料及制备工艺 |
CN113069593A (zh) * | 2021-04-10 | 2021-07-06 | 中国人民解放军总医院 | 预混氏干细胞分泌蛋白组丝素水凝胶的制作工艺 |
WO2022232090A2 (fr) * | 2021-04-29 | 2022-11-03 | Carnegie Mellon University | Biomatériaux à sensibilité acoustique |
WO2023097310A1 (fr) * | 2021-11-29 | 2023-06-01 | Massachusetts Institute Of Technology | Structure réglable de microcapsules à base de soie biodégradables pour l'administration de charge utile soluble et insoluble |
CN115105645B (zh) * | 2022-06-28 | 2023-05-26 | 北京化工大学 | 一种复合微球、伤口修复敷料的制备方法 |
WO2024119107A1 (fr) * | 2022-12-01 | 2024-06-06 | Evolved By Nature, Inc. | Formes lyophilisées et pulvérisables de fibroïne de soie et de fibroïne de soie modifiée |
CN116554507B (zh) * | 2023-07-12 | 2023-09-29 | 江西丝科生物科技有限公司 | 蚕丝蛋白双网络水凝胶及其制备方法 |
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US20070026043A1 (en) * | 2003-11-20 | 2007-02-01 | Angiotech International Ag | Medical devices combined with diblock copolymer compositions |
WO2010042798A2 (fr) * | 2008-10-09 | 2010-04-15 | Trustees Of Tufts College | Films en soie améliorés contenant du glycérol |
US20110172768A1 (en) * | 2006-10-19 | 2011-07-14 | Cragg Andrew H | Knee joint prosthesis and hyaluronate compositions for treatment of osteoarthritis |
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US6287340B1 (en) | 1999-05-14 | 2001-09-11 | Trustees Of Tufts College | Bioengineered anterior cruciate ligament |
JP3771510B2 (ja) * | 2001-04-13 | 2006-04-26 | 泰彦 田畑 | 組織の体内再生用材料 |
WO2004001103A2 (fr) | 2002-06-24 | 2003-12-31 | Tufts University | Biomateriaux a base de soie et procedes d'utilisation |
JP4638735B2 (ja) | 2002-06-24 | 2011-02-23 | タフツ ユニバーシティー | 絹糸生体材料およびその使用方法 |
WO2004062697A2 (fr) | 2003-01-07 | 2004-07-29 | Tufts University | Matières de fibroïne de soie et utilisation de celles-ci |
JP4698596B2 (ja) | 2003-04-10 | 2011-06-08 | タフツ ユニバーシティー | 濃縮された水性シルクフィブロイン溶液およびそれらの使用 |
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2012
- 2012-11-09 BR BR112014011188A patent/BR112014011188B1/pt active IP Right Grant
- 2012-11-09 WO PCT/US2012/064450 patent/WO2013071107A1/fr active Application Filing
- 2012-11-09 MX MX2014005702A patent/MX2014005702A/es unknown
- 2012-11-09 CA CA2890366A patent/CA2890366A1/fr not_active Abandoned
- 2012-11-09 JP JP2014541327A patent/JP6362540B2/ja active Active
- 2012-11-09 EP EP12846915.2A patent/EP2788040B1/fr active Active
- 2012-11-09 CN CN201280066536.2A patent/CN104363931A/zh active Pending
- 2012-11-09 AU AU2012335106A patent/AU2012335106B2/en active Active
- 2012-11-09 US US14/357,443 patent/US9931434B2/en active Active
- 2012-11-09 KR KR1020147015500A patent/KR102138152B1/ko active IP Right Grant
- 2012-11-09 KR KR1020237014603A patent/KR20230066481A/ko not_active Application Discontinuation
- 2012-11-09 KR KR1020207021207A patent/KR20200093073A/ko not_active IP Right Cessation
- 2012-11-09 EP EP23168344.2A patent/EP4257202A3/fr active Pending
- 2012-11-09 ES ES12846915T patent/ES2953309T3/es active Active
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2015
- 2015-08-17 HK HK15107915.0A patent/HK1207322A1/xx unknown
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- 2017-12-28 JP JP2017252933A patent/JP2018089388A/ja active Pending
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- 2018-02-20 US US15/899,463 patent/US20180339084A1/en not_active Abandoned
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WO2010042798A2 (fr) * | 2008-10-09 | 2010-04-15 | Trustees Of Tufts College | Films en soie améliorés contenant du glycérol |
Also Published As
Publication number | Publication date |
---|---|
EP2788040A4 (fr) | 2015-05-06 |
WO2013071107A1 (fr) | 2013-05-16 |
HK1207322A1 (en) | 2016-01-29 |
EP4257202A2 (fr) | 2023-10-11 |
EP2788040A1 (fr) | 2014-10-15 |
KR102138152B1 (ko) | 2020-07-27 |
US20180339084A1 (en) | 2018-11-29 |
CN104363931A (zh) | 2015-02-18 |
US20210244850A1 (en) | 2021-08-12 |
US20140308362A1 (en) | 2014-10-16 |
BR112014011188A8 (pt) | 2018-05-29 |
BR112014011188B1 (pt) | 2020-05-19 |
KR20140102208A (ko) | 2014-08-21 |
KR20200093073A (ko) | 2020-08-04 |
US9931434B2 (en) | 2018-04-03 |
CA2890366A1 (fr) | 2013-05-16 |
BR112014011188A2 (pt) | 2017-05-09 |
ES2953309T3 (es) | 2023-11-10 |
MX2014005702A (es) | 2015-02-17 |
JP6362540B2 (ja) | 2018-07-25 |
AU2012335106B2 (en) | 2016-09-01 |
AU2016262684A1 (en) | 2016-12-15 |
JP2015502199A (ja) | 2015-01-22 |
EP2788040B1 (fr) | 2023-05-24 |
AU2012335106A1 (en) | 2014-06-26 |
JP2018089388A (ja) | 2018-06-14 |
KR20230066481A (ko) | 2023-05-15 |
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