EP3959194A1 - Verfahren zur herstellung von verbindungen mit mindestens einer alkylengruppe und mindestens einer thiol- oder thiolatgruppe - Google Patents

Verfahren zur herstellung von verbindungen mit mindestens einer alkylengruppe und mindestens einer thiol- oder thiolatgruppe

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Publication number
EP3959194A1
EP3959194A1 EP20720449.6A EP20720449A EP3959194A1 EP 3959194 A1 EP3959194 A1 EP 3959194A1 EP 20720449 A EP20720449 A EP 20720449A EP 3959194 A1 EP3959194 A1 EP 3959194A1
Authority
EP
European Patent Office
Prior art keywords
group
compound
thiol
groups
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20720449.6A
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English (en)
French (fr)
Inventor
Peter Rudolf
Elliot CHRIST
Bernd Bruchmann
Indre THIEL
Thomas Wurm
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BASF SE
Original Assignee
BASF SE
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Application filed by BASF SE filed Critical BASF SE
Publication of EP3959194A1 publication Critical patent/EP3959194A1/de
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/12—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms
    • C07C321/14—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/26—Thiols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/28—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/28—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/30—Sulfides having the sulfur atom of at least one thio group bound to two carbon atoms of six-membered aromatic rings

Definitions

  • the present invention relates to a process for the synthesis of a compound with at least one alkylene group and at least one thiol or thiolate group, wherein
  • thiocarbonate a compound with at least one five-membered cyclic monothiocarbonate group, shortly referred to as thiocarbonate, is reacted with
  • a starter selected from compounds with at least one thiol group, from compounds with at least one hydroxy group or from basic inorganic compounds,
  • Sulfur compounds and notably sulfur comprising polymers are of interest in many technical applications.
  • the sulfur atom contributes notably to properties such as chemical resistance.
  • Thiol groups are very reactive. Compounds with thiol groups are therefore valuable
  • Polysulfides may be obtained by ring opening polymerization of episulfides, as described in US 3624052 for propylene sulfide polymers.
  • US 6525168 B2 a process for the preparation of polysulfides is disclosed, wherein di-halogeno compounds are reacted with dithiols.
  • cyclic monothiocarbonates may react with a primary amine under decarboxylation to form an amino-substituted ethylene thiol.
  • the ethylene thiol obtained may react with further thiocarbonate under decarboxylation to give a polymer.
  • US 3232936 describes a process for mercaptoethylating amines, especially a process for preparing di-n-butylaminoethylmercaptoethanethiol from a mixture of di-n-butylaminoethanethiol and ethylene monothiocarbonate in toluene.
  • the present invention relates to a process for the synthesis of a compound with at least one alkylene group and at least one thiol or thiolate group, wherein
  • thiocarbonate a compound with at least one five-membered cyclic monothiocarbonate group, shortly referred to as thiocarbonate, is reacted with
  • a starter selected from compounds with at least one thiol group, from compounds with at least one hydroxy group or from basic inorganic compounds,
  • the process of this invention is a process to obtain a compound with at least one alkylene group and at least one thiol or thiolate group.
  • the alkylene group of the compound obtained corresponds to the two carbon atoms of the five- membered cyclic monothiocarbonate group, preferably to the two carbon atoms of the five- membered cyclic monothiocarbonate group as shown in formula (I), see below; in other words, the alkylene group is notably an ethylene group substituted by R 1 to R 4 , see paragraph above.
  • the compound with at least one alkylene group and at least one thiol or thiolate group is a polyalkylenesulfide.
  • the polyalkylenesulfides have at least two alkylene groups and at least one thioether group, preferably at least two thioether groups, and at least one, preferably one thiol or thiolate group, which is usually a terminating thiol or thiolate group.
  • the alkylene groups of the polyalkylenesulfides are preferably ethylene groups substituted by R 1 to R 4 .
  • the thiocarbonate may comprise, for example, up to 1000, in particular up to 500, preferably up to 100 five-membered cyclic monothiocarbonate groups.
  • Suitable thiocarbonates with one or more thiocarbonate groups and the synthesis thereof are described in WO 2019/034470 A1 and WO 2019/034473 A1.
  • the thiocarbonate comprises 1 to 10, notably 1 to 5 five-membered cyclic monothiocarbonate groups. In a particularly preferred embodiment, the thiocarbonate comprises 1 or 2 five-membered cyclic monothiocarbonate groups. In a most preferred embodiment, the thiocarbonate comprises 1 five-membered cyclic monothiocarbonate group.
  • the thiocarbonate may be a polymeric compound with high molecular weight.
  • Preferred thiocarbonates have a molecular weight of up to 10000 g/mol, notably up to 5000 g/mol and particularly up to 1000 g/mol. Most preferred are thiocarbonates having a molecular weight of up to 500 g/mol.
  • molecular weight means the number average molecular weight Mn, as determined by GPC against polystyrene as standard.
  • a preferred thiocarbonate is a compound of formula (I)
  • R 1 to R 4 independently from each other representing hydrogen or an organic group with up to 50 carbon atoms, whereby, alternatively, R 2 , R 4 and the two carbon atoms of the
  • thiocarbonate ring may also together form a five to ten membered carbon ring.
  • any of R 1 to R 4 represent an organic group
  • such organic group is preferably an organic group with up to 30, more preferably up to 20 carbon atoms.
  • R 2 and R 4 do not form a five to ten membered carbon ring together with the two carbon atoms of the thiocarbonate group.
  • any of R 1 to R 4 represent an organic group
  • such organic group may comprise heteroatoms and functional groups.
  • it may comprise oxygen, sulfur, silicon and chloride.
  • the organic group may comprise oxygen or chloride.
  • chloride as used herein, is the trivial name of a covalently bound Cl atom.
  • R 1 to R 4 may comprise oxygen, for example, in form of ether, hydroxy, aldehyde, keto or carboxy groups.
  • the organic group is an aliphatic organic group with up to 30 carbon atoms which may comprise oxygen, nitrogen or chloride, in particular oxygen.
  • R 5 to R 8 represent an aliphatic or aromatic group, which may comprise oxygen, for example, in form of ether groups.
  • R 5 to R 8 represent an aliphatic hydrocarbon group, such as an alkyl group with 1 to 10 carbon atoms, an alkoxy group or a poly-alkoxy group.
  • R 5 to R 8 represent an aliphatic hydrocarbon group, in particular an alkyl group with 1 to 10 carbon atoms.
  • the organic group is a group -CH2-O-R 5 or a group
  • two to four groups of R 1 to R 4 in formula (I) represent hydrogen, and the remaining groups R 1 to R 4 represent an organic group.
  • R 1 to R 4 in formula (I) represent hydrogen
  • the remaining group of R 1 to R 4 represents hydrogen or an organic group, preferably an organic group with up to 20 carbon atoms.
  • R 1 or R 2 is the remaining group representing hydrogen or an organic group.
  • R 1 is the remaining group representing hydrogen or an organic group.
  • a most preferred thiocarbonate is a compound of formula (I), wherein at least three of the groups R 1 to R 4 are hydrogen, and the remaining group is hydrogen or a CrC4-alkyl group which is notably a methyl group.
  • the thiocarbonate is a compound of formula (I), wherein R 1 is hydrogen or an alkyl group, notably a methyl group, and R 2 to R 4 are hydrogen.
  • thiocarbonate shall include also mixtures of different thiocarbonates.
  • the starters are selected from compounds with at least one thiol group, from compounds with at least one hydroxy group or from basic inorganic compounds.
  • the starters do not comprise five- membered cyclic monothiocarbonate groups and do not correspond to the compound obtained by ring-opening of five-membered cyclic monothiocarbonate groups under decarboxylation.
  • the starter does not comprise amino groups, preferably primary, secondary or tertiary amino groups, more preferably primary or secondary amino groups.
  • the thiol group and the hydroxy group are, herein for short, commonly referred to as“reactive group”.
  • the compounds with at least one thiol or hydroxy group are commonly shortly also referred to as“reactive compounds”.
  • the reactive compound may comprise, for example, up to 1000, particularly up to 500 and preferably up to 100 reactive groups.
  • the reactive compound comprises 1 to 10, notably 1 to 5 reactive groups selected from thiol groups, hydroxy groups or any combination thereof. In a particularly preferred embodiment, the reactive compound comprises 1 or 3 reactive groups selected from thiol groups, hydroxy groups or any combination thereof.
  • the reactive compound comprises at least two reactive groups, notably with 2 to 5, more preferably with 2 to 3 reactive groups; the at least two reactive groups may be thiol groups, hydroxy groups or any combination thereof. In a most preferred embodiment, at least one of the at least two reactive groups is a thiol group.
  • the reactive compound may be a polymeric compound with high molecular weight.
  • Preferred reactive compounds have a molecular weight of up to 10000 g/mol, notably up to 5000 g/mol and particularly up to 1000 g/mol. Most preferred are reactive compounds having a molecular weight of up to 500 g/mol.
  • the reactive group may also be obtained in situ, for example, in case of compounds with masked reactive groups or compounds comprising a precursor of the reactive group.
  • the masked reactive group or precursor may be transformed into the reactive group in situ during the reaction.
  • Reactive compounds with thiol groups are, for example,
  • butanedithiol (ethyleneglycol-dimercaptopropylate); benzenedimethanethiol (isomers); 1 ,8- dimercapto-3,6-dioxaoctane; 2,3-dimercaptopropanol; 2,3-dimercapto-1-propanesulfonic acid (sodium salt); dimercaptosuccinic acid (salt); 2,2 ' -thiodiethanethiol; [1 ,T-biphenyl]-4,4 - dimethanethiol; dimercaptopropyl laurate; 2,2'-dimercaptoethyl-ether; 3,3'-dimercaptopropyl ether; dimercaptobenzene (isomers); biphenyl-dithiol; terphenyldithiol, or bi-thiophenyl sulfide (4,4-thiobisbenzenethiol);
  • tri/tetra/oligo-thiols such as tri/tetra/oligo-thiols, for example, 1 ,2,3- trimercaptopropane; 2,3-bis[(2-mercaptoethyl)thio]-1-propanethiol; trimethylolpropane-tris-3- mercaptopropionate; pentaerythritol-tetrakis(3-mercaptopropionate); trimercaptotriazine; or capcure ® -type mercaptanes;
  • mercaptoalcohols for example, mercaptoethanol, mercaptoglycerol, or mercaptophenol
  • a compound with at least one thiol group, used as a starter is selected from the group consisting of methylmercaptan, ethylmercaptan; ethanedithiol; butanedithiol;
  • dimercaptosuccinic acid salt
  • dimercaptopropyl laurate 2,2'-dimercaptoethyl-ether; 3,3'-dimercaptopropyl ether;
  • dimercaptobenzene derivatives
  • biphenyl-dithiol terphenyldithiol, or bi-thiophenyl sulfide
  • Preferred compounds are compounds of formulae
  • Reactive compounds with hydroxy groups are, for example,
  • - compounds with one or two hydroxy groups for example, CrC2o-alkanols, alkanediols such as ethylene glycol, propane-1 , 2-diol, propane-1 , 3-diol, butane-1 , 3-diol, butane-1 , 4-diol, pentane- 1 , 5-diol, neopentyl glycol, bis(hydroxymethyl)cyclohexanes such as 1 ,4-bis(hydroxymethyl)- cyclohexane, 2-methylpropane-1 , 3-diol, methylpentanediols, phenol, thiodiglycol, bisphenol A;
  • alkanediols such as ethylene glycol, propane-1 , 2-diol, propane-1 , 3-diol, butane-1 , 3-diol, butane-1 , 4-diol, pentane- 1 , 5-diol,
  • mercaptoalcohols for example, mercaptoethanol, mercaptoglycerol, or mercaptophenol
  • - compounds with higher molecular weight such as, for example, di- or polyetherpolyols, di- or polyesterpolyols or polymers obtained by (co)polymerization of ethylenically unsaturated compounds with hydroxy groups or polyphenols;
  • Preferred di- or polyesterpolyols have two to eight, preferably two to five hydroxy groups, more preferably two or three, in particular two hydroxy groups and are obtainable by reacting polyols, notably diols, with polycarboxyl ic acids, notably dicarboxylic acids.
  • Preferred di- or polyetherpolyols have two to eight hydroxy groups, preferably two to five hydroxy groups, most preferably two hydroxy groups and are obtainable in particular by polymerizing ethylene oxide, propylene oxide, butylene oxide, tetrahydrofuran, styrene oxide or epichlorohydrin with itself, in the presence of a catalyst.
  • Particularly preferred di- or polyetherpolyols have two to eight hydroxy groups, preferably two to five hydroxy groups, most preferably two hydroxy groups and are obtainable in particular by polymerizing ethylene oxide, propylene oxide, butylene oxide, tetrahydrofuran, styrene oxide or epichlorohydrin with itself, in the presence of a catalyst.
  • polyetherpolyols are diethylene glycol, triethylene glycol, tetraethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, and dibutylene glycol and polybutylene glycols.
  • the starter may also be a basic inorganic compound, preferably a basic inorganic salt.
  • Examples for such compounds are basic zeolites, metal oxides, metal hydroxides and metal sulfides, hydrotalcite, basic clays, and alkaline salts, including alkaline salts supported on oxides or resins.
  • the basic inorganic compound is selected from inorganic salts such as metal hydroxides, metal sulfides, metal hydrogen sulfides, metal oxides, metal phosphates and metal silicates.
  • inorganic salts such as metal hydroxides, metal sulfides, metal hydrogen sulfides, metal oxides, metal phosphates and metal silicates.
  • the term“sulfide” includes mono-, oligo- and polysulfides of formula (S x ) 2 with x being an integral number of at least 1.
  • the term“hydrogensulfides” includes mono-, oligo- and polyhydrogensulfides of formula (HS X ) 1 with x being an integral number of at least 1.
  • metal hydroxides particularly preferred are metal hydroxides, metal sulfides and metal hydrogensulfides.
  • the cation of the inorganic salt is preferably a cation with one or two positive charges, as, for example, an alkali or earth alkali cation. Most preferred is an alkali cation such as sodium or potassium.
  • Examples of preferred inorganic salts are NaOH, Na S, K S X with x being 1 to 10.
  • Preferred starters are inorganic basic compounds and reactive compounds with at least two reactive groups, notably with 2 to 5, more preferably with 2 to 3 reactive groups; the at least two reactive groups may be thiol groups, hydroxy groups or any combination thereof. In a more preferred embodiment, at least one of the at least two reactive groups is a thiol group.
  • Most preferred starters are reactive compounds with at least two reactive groups, notably with 2 to 5, more preferably with 2 to 3 reactive groups; the at least two reactive groups may be thiol groups, hydroxy groups or any combination thereof. In a particularly preferred embodiment, at least one of the at least two reactive groups of the reactive compound is a thiol group.
  • reaction schemes exemplarily show the reaction for specific starters and the thiocarbonate of formula (I) with Z being an alkyl group and X being the residual chemical group of the starter.
  • a starter with a thiol group reacts with the thiocarbonate under decarboxylation as follows:
  • the obtained compound may react with an integral number n of further thiocarbonate under decarboxylation to form a polyalkylenesulfide:
  • the obtained compound may react with an integral number n of further thiocarbonate under decarboxylation to form a polyalkylenesulfide:
  • Structural isomers which are usually less obtained are, for example, of formula Inorganic salts as starters also cause ring opening and decarboxylation of the thiocarbonate and give compounds with at least one alkylene group and at least one thiol or thiolate group.
  • the hydroxy or thiol groups of the starter are transferred into the respective alkoxylate or thiolate groups before the reaction or by a catalyst used in the reaction.
  • the reaction of starters with reactive groups (reactive compounds) and thiocarbonates is performed in the presence of a basic catalyst which forms a salt comprising the alcoholate anion or the thiolate anion derived from the starter.
  • Suitable catalysts are notably basic catalysts, such as compounds with a tertiary amino group, a guanidino group, an amidine group or a phosphine group, or basic metals salts such as, for example, metal hydroxides and metal sulfides.
  • the catalyst may be added before or during the reaction.
  • the molar ratio of the reactive groups or of the inorganic salt to the thiocarbonate determines the molecular weight of the obtained product, as is obvious from the above reaction schemes.
  • the obtained product is a mixture of compounds with different chain length and thus different molecular weight.
  • the thiol groups tend to react first. Any selectivity regarding the thiol group can be augmented or damped by selecting suitable conditions and/or starting materials. A hydroxy group of low reactivity will usually promote the selectivity with respect to the thiol group while a less reactive (hindered) thiol group will favor a hydroxy group. Selecting a highly reactive thiocarbonate will usually suppress, preferably might suppress, any selectivity with respect to the thiol group.
  • hydroxy group with low reactivity means a hydroxy group which reactivity is lower than a corresponding thiol group.
  • the reaction may, for example, be performed at temperatures of from -20 to 250°C, preferably between 20 and 100°C.
  • any activation energy for the reactions may be provided by high-energy radiation such as visible or UV light.
  • the reaction occurs at 20 to 100°C without any further activation.
  • a solvent may be used in the reaction.
  • the use of a solvent may be helpful, in case that at least one of the compounds used is solid at room temperature (about 20-25°) and the other starting materials do act already as solvent for the solid compound.
  • Suitable solvents are, for example, toluene, tetrahydrofuran and dimethylformamide. It is an advantage of the process that usually no additional solvent, preferably organic solvent, is required as the starting materials are usually liquid or at least one of the starting materials serves as solvent for any solid starting materials. If the starting materials are solid at room temperature, the reaction may be performed at temperatures above the melting point of any solid starting materials.
  • a compound with at least one five-membered cyclic monothiocarbonate group is reacted with a starter selected from a compound with at least one thiol group, from a compound with at least one hydroxy group or from a basic inorganic compound,
  • the whole amount of thiocarbonate used may be added to the reaction mixture in advance. If mixtures of different thiocarbonates are added, copolymers will be obtained.
  • the thiocarbonate may also be added continuously or in certain increments during the reaction. As the
  • the catalyst may be removed by suitable means, such as washing with water or an aqueous solution of acids such as hydrogen chloride.
  • the compound obtained by the process is a compound with at least one alkylene group and at least one thiol or thiolate group.
  • the thiol or thiolate group is the terminating group of the respective chain, see reaction schemes above.
  • the possibility to have a terminating thiolate group is due to the preferred presence of the catalyst.
  • several terminating thiol groups, respectively thiolate groups are formed accordingly.
  • the at least two functional groups may be at least two thiol groups, respectively two thiolate groups if a starter with at least two reactive groups is used.
  • the at least two functional groups may be at least one thiol, respectively one thiolate group and a further functional group that was part of the starter but was not affected by the reaction.
  • Such functional group could be a hydroxy group of the starter with low reactivity or any other functional group such as alkoxy groups, amino groups or unsaturated groups, for example, vinyl groups, allyl groups, notably vinylether groups.
  • the product of the reaction may be further reacted with a compound with at least one group that reacts with a thiol group -SH, shortly referred to as SH-reactive compound.
  • SH- reactive compounds are, for example, mentioned in the non-published patent application PCT/EP2020/053083.
  • the product of the reaction may be further reacted with a compound comprising at least one group that reacts with a further functional group of the starter.
  • the process of the invention is an easy and economic process, performed in one highly selective reaction step.
  • the process does not involve the handling of hazardous compounds such as COS.
  • the process provides an easy access to variety of polyalkylenesulfides and allows the synthesis of copolymers, including block-copolymers, of a desired, predetermined structure and allows control over end group functionality.
  • the process of this invention offers broad possibilities in synthesis as the direct products of the process may be easily further modified.
  • M-CTC Compound of formula (I) wherein R 2 to R 4 are hydrogen and R 1 is methyl
  • a figure shows the starting materials and the product. It is understood that the product is a mixture of structural isomers and polysulfides of different chain length. The figures show the main compound of the mixture of polysulfides obtained, only. In all examples, the conversion to polysulfides was complete, the starter and the thiocarbonate were fully consumed and reacted to polysulfides without any significant formation of by products.
  • Benzene dithiol 500 mg, 3.52 mmol
  • CTC 1456 mg, 14 mmol, 4 eq.
  • DBU was then added (50 mg, 0.32 mmol), and the reaction was stirred at 60°C overnight.
  • Benzene dithiol 500 mg, 3.52 mmol
  • CTC 1456 mg, 14 mmol, 4 eq.
  • NaOH was then added (10 mg, 0.25 mmol), and the reaction was stirred at 60°C overnight.
  • Benzene dithiol 500 mg, 3.52 mmol
  • CTC 1456 mg, 14 mmol, 4 eq.
  • K2S X was then added (20 mg, 0.18 mmol), and the reaction was stirred at 60°C overnight.
  • Benzene dithiol 500 g, 3.52 mmol
  • CTC 1456 mg, 14 mmol, 4 eq.
  • DMP 30 was then added (20 mg, 0,08 mmol), and the reaction was stirred at 60°C overnight.
  • Benzene dithiol 500 mg, 3.52 mmol
  • M-CTC 1650 mg, 14 mmol, 4 eq.
  • DBU was then added (50 mg, 0.32 mmol), and the reaction was stirred at 60°C overnight.
  • Example 6 Benzene dithiol (500 mg, 3.52 mmol) and CTC (1456 mg, 14 mmol, 4 eq.) were stirred together at room temperature without any solvents to obtain a homogenous solution. DBU was then added (50 mg, 0.32 mmol), and the reaction was stirred at 60°C. After one night it resulted from GC-MS that all the CTC was consumed, and then M-CTC (825 mg, 7 mmol, 2 eq.) was added to the solution. After another night at 60 °C all of the M-CTC was also consumed, and further CTC (1456 mg, 14 mmol, 4 eq.) was added again. A white polymer was obtained after nearly an hour.
  • Benzene dithiol 500 mg, 3.52 mmol
  • M-CTC 825 mg, 7 mmol, 2 eq.
  • DBU was then added (50 mg, 0.32 mmol), and the reaction was stirred at 60°C overnight. After one night it resulted from GC-MS that all the M-CTC was consumed, and then CTC (1456 mg, 14 mmol, 4 eq.) was added to the solution. After a few hours a suspension of a white polymer was obtained.
  • a liquid polymer has been obtained.
  • trimercaptan 500 mg, 1.92 mmol
  • CTC 1200 mg, 11.54 mmol, 6 eq.
  • DBU was then added (25 mg, 0.16 mmol), and the reaction was stirred at 60°C overnight.
  • the GC-MS showed that all the CTC was consumed.
  • Ethane dithiol (330 mg, 3.51 mmol) and M-CTC (1700 mg, 14.40 mmol, 4 eq.) were stirred together at room temperature without any solvents to obtain a homogenous solution.
  • DBU was then added (25 mg, 0.16 mmol), and the reaction was stirred at 60°C overnight.
  • Example 11 M-CTC (1650 mg, 14 mmol, 4 eq.) and Na2S (15 mg, 0.20 mmol) were stirred at room temperature without any solvent for 1 hour, and then the reaction mixture was heated at 60°C overnight.

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
EP20720449.6A 2019-04-26 2020-04-23 Verfahren zur herstellung von verbindungen mit mindestens einer alkylengruppe und mindestens einer thiol- oder thiolatgruppe Pending EP3959194A1 (de)

Applications Claiming Priority (2)

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EP19171361.9A EP3730478A1 (de) 2019-04-26 2019-04-26 Verfahren zur herstellung von verbindungen mit mindestens einer alkylengruppe und mindestens einer thiol- oder thiolatgruppe
PCT/EP2020/061400 WO2020216873A1 (en) 2019-04-26 2020-04-23 Process for the preparation of compounds with at least one alkylene group and at least one thiol or thiolate group

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EP3959194A1 true EP3959194A1 (de) 2022-03-02

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EP20720449.6A Pending EP3959194A1 (de) 2019-04-26 2020-04-23 Verfahren zur herstellung von verbindungen mit mindestens einer alkylengruppe und mindestens einer thiol- oder thiolatgruppe

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US (1) US11814344B2 (de)
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KR (1) KR20220004032A (de)
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JP2024030174A (ja) * 2022-08-23 2024-03-07 国立大学法人秋田大学 化合物および金属抽出剤

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3232936A (en) * 1961-04-26 1966-02-01 Eastman Kodak Co Mercaptoethylation of amines with carbamates
US3624052A (en) 1962-01-08 1971-11-30 Thiokol Chemical Corp High molecular weight poly(propylene sulfide)
BE626970A (de) * 1962-01-12
FR1431717A (fr) * 1964-12-23 1966-03-18 Aquitaine Petrole Procédé de préparation des alpha-dithiols
US6525168B2 (en) 2000-03-09 2003-02-25 Pbt Brands, Inc. Chemically resistant polythiothers and formation thereof
WO2014031181A1 (en) * 2012-04-25 2014-02-27 Dow Global Technologies Llc Polyurethanes made using bismuth thiocarbamate or thiocarbonate salts as catalysts
CN102746476B (zh) * 2012-06-18 2014-04-23 浙江理工大学 含环氧基团的三硫代碳酸酯化合物及其制备方法和应用
CN111032736A (zh) 2017-08-17 2020-04-17 巴斯夫欧洲公司 制备具有氨基甲酸酯基团的聚合物的方法
WO2019034473A1 (en) 2017-08-17 2019-02-21 Basf Se PROCESS FOR PRODUCING A POLYMER HAVING URETHAN GROUPS

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US11814344B2 (en) 2023-11-14
US20220185773A1 (en) 2022-06-16
WO2020216873A1 (en) 2020-10-29
EP3730478A1 (de) 2020-10-28

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