EP3691600B1 - Boitiers de protection de poche de liquide biopharmaceutique - Google Patents

Boitiers de protection de poche de liquide biopharmaceutique Download PDF

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Publication number
EP3691600B1
EP3691600B1 EP18789462.1A EP18789462A EP3691600B1 EP 3691600 B1 EP3691600 B1 EP 3691600B1 EP 18789462 A EP18789462 A EP 18789462A EP 3691600 B1 EP3691600 B1 EP 3691600B1
Authority
EP
European Patent Office
Prior art keywords
shell
lower shell
shells
upper shell
protective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP18789462.1A
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German (de)
English (en)
French (fr)
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EP3691600A1 (fr
Inventor
Stéphane BAUD
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sartorius Stedim FMT SAS
Original Assignee
Sartorius Stedim FMT SAS
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Publication of EP3691600A1 publication Critical patent/EP3691600A1/fr
Application granted granted Critical
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/16—Holders for containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
    • B65D77/04—Articles or materials enclosed in two or more containers disposed one within another
    • B65D77/06—Liquids or semi-liquids or other materials or articles enclosed in flexible containers disposed within rigid containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers

Definitions

  • the invention relates to the field of biopharmaceutical liquid pocket protective casings, the field of protective assemblies integrating a protective casing and a biopharmaceutical liquid pocket, as well as the field of methods for assembling a protective assembly integrating a protective case and a bag of biopharmaceutical liquid.
  • a protective case for biopharmaceutical liquid pouches comprising on the one hand two upper and lower shells assembled one on the other, as well as two elastic plastic films located inside these hulls and enclosing two pockets of biopharmaceutical liquid.
  • the pockets of biopharmaceutical liquid are held in place between the films and protected from attacks and shocks external to the protective casing by the spaces respectively maintained between on the one hand the upper shell and the upper film and on the other hand between the lower shell and the bottom film.
  • This protective case ensures a good hold of the pockets of biopharmaceutical liquid inside.
  • this protective case has shells of a complex and delicate structure, because of the elastic plastic film to be fixed on each of the shells, and has a significant space requirement in height because of the two empty spaces stacked one on the other. , that between upper film and upper shell and that between lower film and lower shell.
  • This protective case has on the one hand the disadvantage either of insufficient lateral support of the biopharmaceutical liquid pocket (case where the pocket is smaller than the available inter-shell space) or of too much pressure exerted by the shells directly on the bag of biopharmaceutical liquid (case where the bag is just sized for the space available between the shells), because of the constitution of the housing of the bag by the cooperation of the two shells between them (each shell only defining a part of the housing), and on the other hand the disadvantage of a delicate assembly requiring the exact and precise superposition of the two shells by the cooperation of a set of pins and a bore.
  • the present invention improves the situation.
  • the biopharmaceutical liquid pocket is held laterally between the walls of the two shells, without excessive constraint on the part of the upper shell.
  • the recess of the upper shell also makes it possible to avoid movement of the pocket when the two shells are assembled on one another, while protecting the pocket from possible shocks.
  • a protective box in only two parts also allows easy assembly of the box, and limited manufacturing costs.
  • upper part means the part of the side walls located either above the mid-height of the side walls or above the mid-height and around the mid-height of the side walls.
  • the support elements are arranged on the periphery of the lower shell.
  • the side walls of the lower shell have recesses forming said support elements, on which peripheral abutments of the upper shell rest.
  • At least three of the four side walls of the lower shell have recesses forming said support elements, on which rest the peripheral stops of the upper shell.
  • the three side walls are notably the two longest side walls, and the rear side wall of the lower shell. These recesses serve in particular to stiffen the structure of the lower shell.
  • an inner surface of a side wall of the lower shell and an outer surface of a side wall of the upper shell are provided with complementary fixing elements preventing a translation of the shells relative to each other. other.
  • an inner surface of a side wall of the lower shell and an outer surface of a side wall of the upper shell are provided with complementary fixing elements preventing a vertical translation of the shells relative to each other. 'other.
  • the fastening elements comprise clips.
  • the fixing elements are located on either side of an opening of the protective casing, and/or at an end opposite to the opening of the protective casing.
  • An inner surface of a side wall of the lower shell and an outer surface of a side wall of the upper shell are provided with complementary fastening elements preventing a horizontal translation of the shells relative to each other.
  • the fastening elements comprise a set of lugs and receptacles cooperating with each other.
  • the upper shell can be inserted into the lower shell so as not to protrude out of the lower shell in height.
  • the recess has a concave shape facing the bottom of the lower shell.
  • the recess imitates the curved shape of a pocket filled with biopharmaceutical liquid, allowing, on the one hand, to cover a pocket containing a large volume of biopharmaceutical liquid, and on the other hand that the recess is directly in contact with at least one surface of the pocket, so as to wedge the pocket between the two shells.
  • the upper shell is shorter than the lower shell over at least part of its width, making the inside of the case accessible from the outside, so as to define an opening.
  • the creation of an opening at the level of the upper shell makes it possible in particular to obtain a completely sealed lower shell, since it is then not necessary to provide an opening at the level of the lower shell.
  • the location of the opening also facilitates access to the interior of the case.
  • a side wall of the lower shell has at least one inclined portion at least at the level of the bottom of the lower shell.
  • the inclined portion is located at the level of a longitudinal end located at the level of the outlet of a pocket tube.
  • the bottom of the lower shell is sealed and has a sufficient height to retain a volume of water at least equal to 5 liters.
  • the bottom of the lower shell is sealed and has a sufficient height to retain a volume of water at least equal to 10 liters.
  • the bottom of the lower shell is sealed and has a sufficient height to retain a volume of water at least equal to 20 liters.
  • the bottom of the lower shell is waterproof and has a sufficient height to retain a volume of water at least equal to 50 liters.
  • the inclined portion further improves accessibility to the contents of the box from the outside.
  • the inclined portion also has the function of maintaining the pocket at its front end, by wedging it directly against the inclined portion. Finally, this also makes it possible to make the lower shell watertight because no opening is necessary on the lower shell.
  • the lower shell can retain all of the biopharmaceutical liquid without overflowing.
  • the lower hulls are additionally sized to be able to retain 20% more water than the volume of water that can be retained.
  • the lower shell comprises at least one abutment at the level of a longitudinal end located at the level of the outlet of a pocket tube, the outer edges of the opening of the upper shell coming into contact with said abutment.
  • the abutment comprises rounded edges.
  • the abutment also makes it possible to ensure contact between the upper shell and the lower shell.
  • the front end of the pocket can also come into contact with the abutment, and the tubes of the pocket, passing over the abutment, do not risk being damaged by this contact, due to the rounded edges of the abutment.
  • the upper shell comprises a plurality of recesses capable of receiving and holding connectors from one end of a tube of the pocket.
  • the recesses are arranged on either side of the opening of the upper shell, and/or are arranged at an end opposite the opening.
  • the recesses are arranged on either side of the opening of the upper shell, but are not arranged at an end opposite the opening, the recess comprising an X shape.
  • This embodiment is advantageously used for protective casings capable of retaining a volume of 5 liters.
  • the X-shape on the upper shell allows for placement of pocket tubes, which are more difficult to arrange in the case of smaller protective cases.
  • baffles are arranged around the recess so as to be able to hold in place around the recess at least one tube of the pocket.
  • the tube or tubes can also be stored in the protective casing while being securely held in place. This good holding in place of the tubes then further improves the holding of the bag with respect to the upper shell which protects it.
  • the upper shell comprises at least one arch, preferably at least two or three arches, extending between two side walls of the upper shell, advantageously between the two longest side walls.
  • the arch comprises a flat upper part, capable of receiving an outer surface of the bottom of a lower shell of another housing.
  • the arch rests on the recess of the upper shell.
  • the flat upper part of the arches comprises a protuberance capable of being inserted into a hollow provided on an outer surface of the bottom of a lower shell, still of another casing.
  • At least some side walls comprise a gripping zone, preferably at least the inclined portion and the end opposite the opening of the lower shell comprise such a gripping zone, this gripping zone advantageously including several recesses spaced from each other.
  • the protection box is easily manipulated by a controller.
  • the lower shells of different protective boxes are able to be stacked on top of each other, so that the fastening elements of the uppermost lower shells rest on the fastening elements of the lower shells furthest up. -below.
  • the upper shells of different protective boxes are able to be stacked on top of each other, so that the fastening elements of the uppermost shells rest on the fastening elements of the uppermost shells. -below.
  • This arrangement helps to better distribute the forces over all of the lower or upper hulls, and consequently to avoid damage to the hulls when they are stacked.
  • it also makes it possible to limit the height of the stacks.
  • the two longest side walls of the lower shell are inclined towards each other in their lower parts so that, when different protective casings are stacked on top of each other, a space is formed between two adjacent lower shells along these two adjacent lower shells so as to maintain the tubes accessible to the hand of an operator.
  • a controller has easy access to pocket tubes when multiple protective cases are stacked on top of each other.
  • the gap can be wide enough to fit a hand between two adjacent bottom shells of two stacked protective cases.
  • provision may be made to place a full pocket in the beitier protective casing.
  • the manufacturing process does not include any cutting steps, thus considerably reducing the manufacturing cost.
  • the protective casing comprises only two parts, that is to say the upper and lower shells, the manufacturing cost is further reduced.
  • FIG. 1 schematically represents an exploded view of an example of a pocketless protective casing according to a first embodiment of the invention.
  • front is used to designate the part of the protective casing located at the level of the exit of the tubes from the pocket
  • rear is used to designate the part of the casing opposite to the exit of the tubes from the pocket
  • the protective casing 1 comprises a lower shell 2, and an upper shell 3 comprising a recess 4.
  • the pocket of biopharmaceutical liquid is placed in the bottom 20 of the lower shell 2, covered by the upper shell 3 so as to be covered by the recess 4, the upper shell 3 being inserted into the lower shell 2.
  • the upper shell 3 can be inserted into the lower shell 2 without exceeding in height thereof, or almost without exceeding.
  • the lower shell 2 comprises a bottom 20 and four side walls 21, among which the side side walls 21, or the longest side walls, as well as the front and rear side walls 21.
  • a side wall 21 of the lower shell 2 has at least one inclined portion 22 at least at the level of the bottom 20 of the lower shell 2, through which in particular the tubes of the pocket can come out.
  • the inclined portion 22 is located at the level of a longitudinal end located at the level of the outlet of the tubes. More specifically, the front side wall 21 includes such an inclined portion 22.
  • the side walls 21 on the side have recesses 23 on which the upper shell 3 can come to rest.
  • the recesses 23 have a height h, so that the upper shell 3 is held in the upper part of the side walls 21 of the bottom 2 when the top shell 3 rests on the recesses 23 of the bottom shell 2.
  • the inner surfaces of the side walls 21 on the side still have fixing elements 24 preventing a vertical translation of the shells 2, 3 relative to each other.
  • the fixing elements 24 comprise a hook 24a comprising a fixing member 24b.
  • the fasteners are for example clips.
  • the interior surfaces of the side walls 21 of the side also comprise horizontal shoulders 25 on which a rim 35 of the upper shell can come to bear when the shells 2, 3 are assembled.
  • the lower shell 2 further comprises at least one abutment 26 at the level of a longitudinal end located at the level of the outlet of a pocket tube, that is to say at the level of the front side wall 21 of the shell bottom 2.
  • the upper shell 3 is capable of coming into contact with the stop 26.
  • the upper shell 3 comprises a recess 4.
  • the recess 4 has a concave shape, opposite the bottom 20 of the lower shell 2.
  • the upper shell 3 also has side walls 32, in particular two side walls 32 on the side, or the two longest side walls 32, and a rear side wall 32.
  • the upper shell 3 is for example shorter than the lower shell 2 over at least part of its width, so as to define an opening 30, making the interior of the case 1 accessible from the outside.
  • the opening 30 is for example located at the front end of the upper shell 3.
  • the opening remains framed by at least one, or even two, front end portions 38 of the upper shell 3.
  • the opening 30 is in particular located at least partially opposite the inclined portion 22 of the lower shell 2, making it possible to create a passage 31 through which the tubes of the pocket can come out of the recess 4 to emerge outside the protective casing.
  • the opening 30 comprises outer edges 30a intended to bear against the stops 26 of the lower shell 2.
  • the side walls 32 on the side of the upper shell also include peripheral abutments 33, able to bear against the recesses 23 of the lower shell 2.
  • the side walls 32 of the upper shell 3 also include fastening elements 34 complementary to the fastening elements 24 of the lower shell 2.
  • the fastening elements 34 likewise include a hook 34a adapted to come into contact with the hook 24a of the fixing 24 complementary to the lower shell 2, as well as a fixing member 34b cooperating with the complementary fixing member 24b.
  • the peripheral abutments 33 of the side walls cooperate with the protuberances 36 of the side walls 41 on the side of the recess 4 to form baffles 45 in which the pocket tubes can pass and be held in place.
  • baffles 45 in which the pocket tubes can pass and be held in place.
  • annular space 37 in which a or more pocket tubes. This annular space 37 is therefore a storage space for all or part of the tubes of the pocket.
  • the recess 4 intended to cover the pocket, has a bottom 40, here in the ceiling position, side walls 41 on the side, a front side wall 43 from which the passage 31 starts, a rear side wall 42 forming the rear of the recess 4 against which comes the back of the pocket.
  • FIG. 2 schematically represents an assembled perspective view of an example of a protective casing incorporating a pocket according to one embodiment of the invention.
  • the upper shell 3 has been completely inserted into the lower shell 2.
  • the side walls 32 of the upper shell 3 have slid along the side walls 21 of the lower shell 2, and find themselves practically against them, once the upper shell 3 resting on the recesses 23 of the lower shell 2.
  • Pocket 50 not visible on the figure 2 is covered by the recess 4 and is located between the upper shell 3 and the lower shell 2.
  • the tubes 51 of the pocket come out through the passage 31, pass over the stops 26 of the lower shell 2 and the portions 38 framing the opening 30 of the upper shell 3, before going around the recess 4 in the annular space 37 passing between the baffles 45 and the protuberances 36.
  • a connector 52 at the end of the tube 51 is fixed in hollows 39 of the upper shell 3.
  • the hollows 39 are for example arranged on either side of the opening 30 of the upper shell 3.
  • the portions 38 of the upper shell framing the opening comprise such hollows 39, so as to form a chute.
  • More recesses 39 can be arranged at a rear end of the upper shell 3.
  • the bottom 40 of the recess 4 comprises such recesses 39, for example two.
  • FIG. 3 schematically represents an assembled top view of an example of a protective casing integrating a pocket according to one embodiment of the invention.
  • the upper shell 3 is inserted into the lower shell 2, the side walls 32 of the upper shell 3 being practically against the side walls 21 of the lower shell 2.
  • the tube 51 attached to the pocket 50 covered by the recess 4, comes out through the passage 31, passes over the abutment 26 and the portion 38 framing the opening, goes at least partly around the recess 4 in the annular space 37 located between the walls 41 to 43 of the housing 4 and the walls lateral 32 of the upper shell 3, crossing the baffles 45 and the protrusions 36, to come to hang by its connector 52 in one of the recesses 39 provided for this purpose.
  • THE figures 4a and 4b more precisely illustrate the passage 31, the abutment 26 of the lower shell 2 and one of the portions 38 framing the opening 30 of the upper shell 3.
  • the portion 38 of the upper shell 3 rests between the side edge 32 and the abutment 26, so that the outer edges of the opening 30 are directly in contact with the abutment 26.
  • the abutment 26 has rounded edges, in order to avoid weakening the tubes 51 of the pocket 50 when they are wound around the recess 4 in the annular space 37.
  • the stop 26 also makes it possible to maintain the pocket 50 in the space delimited by the recess 4 and the bottom 20 of the lower shell 2, in fact allowing the front of the pocket 50 to come to rest against the stop 26.
  • the inclined portion 22 of the lower shell 2 also plays this role of holding the pocket 50, since the front part of the pocket 50 bears directly against the inclined portion 22.
  • THE figures 5a to 5c schematically represent in top view four successive steps of an example of a method of assembling an assembly for protecting a pocket according to one embodiment of the invention.
  • the pocket 50 is arranged in the bottom 20 of the lower shell 2. From an upper opening 53 of pocket 50 leave tubes 51 terminated by connectors 52, these tubes 51 exiting at the level of the inclined portion 22 of the lower shell 2. The rear of the pocket 50 is on the side of the rear side wall 21 of the lower shell 2.
  • the upper shell 3 covers the pocket 50 which is therefore no longer visible. Only the tubes 51 emerging from the upper shell 3 through the passage 31 are still visible.
  • the annular space 37 goes around the recess 4. This annular space, equipped with the baffles 45 is empty, because it does not yet contain the tubes 51.
  • the rear part of the pocket 50 is in fact folded and pinched between the bottom 20 of the lower shell 2 and the rear side wall 32 of the upper pocket 3, thus ensuring the maintenance of the pocket 50 at its rear part.
  • the tubes 51 coming out of the passage 31 through the opening 30, go around the housing 4 inside the side walls 32 of the upper shell 3 passing through the baffles 45 and the protrusions 36, before the connector 52 of one of these tubes 51 is blocked in one of the recesses 39 provided for this purpose.
  • Several other tubes 51 or connectors 52 can also be wedged in the annular space 38 or in the recesses 39. The protective casing 1 is then completely closed.
  • the pocket 50 can be filled with biopharmaceutical product after closing the protective casing 1.
  • the pocket 50 can be filled before being placed in the bottom 20 of the lower shell 2, or before placing the upper shell 3.
  • the inclined portion 22 of the lower shell 2 also ensures the retention of the biopharmaceutical product in the protective casing 1 in the event of the release of the biopharmaceutical product in said casing 1, for example if the pocket 50 is pierced.
  • the retention volume may be at least equal to 5 liters, or even 10 liters, or even 20 liters, or even 50 liters.
  • the lower shell 2 is dimensioned such that it is capable of retaining a volume equivalent to 20% of the retention volume in addition to the retention volume.
  • the side walls 21 of the lower shell 2 have recesses 54 on which the upper hull 3 can rest.
  • the recesses 54 have a height E, such that the upper hull 3 is held in the upper part of the side walls 21 of the lower hull 2 when the upper hull 3 rests on the recesses 54 of the lower hull 2.
  • the height E of the recesses 54 is greater than the height h of the recesses 23 described in relation to the first embodiment.
  • the height E of the recesses 54 makes it possible on the one hand to stiffen the structure of the lower shell 2.
  • the height E of the recesses remains however lower than the height of the side walls 21. For example, there always remains a distance at least equal to 1 centimeter between the upper end of the recesses 54 and the upper end of the side walls 21.
  • This distance is chosen in particular in order to allow optimum stacking of several boxes on top of each other.
  • the arches 44 of the upper shell 3 must not or only slightly exceed the height of the upper ends of the side walls 21 of the lower shell.
  • the protrusions 44b protrude from the protective casing 1 to allow the interlocking of several protective casings 1.
  • the recesses 54 can be located on at least three of the four side walls 21 of the lower shell 2.
  • the recesses 54 are located on the side walls 21 of side and rear, as visible on the figure 7 .
  • the recesses 54 may further comprise a positioning orifice 54a at their upper end.
  • This positioning hole 54a is adapted to receive a complementary pin 54b, provided on the outer surface of the lower shell 2. This makes it possible to improve the positioning and the maintenance of the lower shells between them when they are stacked on each other. .
  • a rim 35 of the upper shell can bear against the upper ends of the recesses 54 when the shells 2, 3 are assembled.
  • the inner surfaces of the side walls 21 also have fastening elements 55 preventing a horizontal translation of the shells 2, 3 relative to each other.
  • the fixing elements 55 comprise a receptacle 55a, capable of receiving a complementary fixing element of the upper shell 3.
  • Receptacles 57 are also provided on either side of the stops 26, and at the rear ends of the side walls 21 on the side, as visible on the figure 8 .
  • the receptacles 57 cooperate with lugs 60 provided on the upper shell.
  • the receptacles 57 and the lugs 60 cooperate in such a way that they prevent the vertical translation of the lower 2 and upper 3 shells.
  • the receptacles 57 and the lugs 60 include clips, for example.
  • receptacles 57 and pins 60 can be provided.
  • receptacles 57 and lugs 60 may be provided respectively along the side walls 21 of the side of the lower shell 2 and along the side walls 32 of the side of the upper shell 3, in addition to the receptacles 57 provided on either side. and other abutments 26, and the rear ends of the side walls 21 side.
  • This alternative embodiment is illustrated on the figures 11 and 12 .
  • the clips can be irreversible. More precisely, the lugs 60 and the receptacles 57 prevent the lower and upper shells from being disengaged from each other.
  • the clips can be reversible. More precisely, the lower and upper shells can be disengaged from each other after assembly.
  • the lower shell 2 further comprises at least one gripping zone 56 preferably located at the level of the inclined portion 22.
  • the gripping zone 56 advantageously includes several hollows spaced from each other, as illustrated figure 8 .
  • Another gripping zone 56 can also be located at the level of the outer surface of the bottom 20, in particular at the rear of the lower shell 2.
  • the gripping zone 56 can also comprise hollows spaced from each other. The gripping zones allow an operator to be able to easily grasp and manipulate a protective casing 1.
  • the side walls 32 of the upper shell 3 include peripheral abutments 58, able to bear against the recesses 54 of the lower shell 2.
  • the rear side wall 32 of the upper shell 3 may also comprise peripheral stops 58, cooperating with the recesses 54 located on the rear side wall 21 of the lower shell 2.
  • the peripheral stops 58 may include positioning holes 58a at their upper end. These positioning holes 58a are suitable for receiving complementary pins (not shown), provided on the upper shell 3. This makes it possible to improve the positioning and the holding of the upper shells together when they are stacked on top of each other.
  • the side walls 32 of the upper shell 3 also include fastening elements 59 complementary to the fastening elements 55 of the lower shell 2.
  • the fastening elements 59 include lugs 59a capable of being inserted into the receptacles 55a of the fastening elements 55 of the lower hull 2.
  • Lugs 60 are also provided on the two front end portions 38 of the upper shell 3, as well as at the rear ends of the side walls 32 on the side.
  • the lugs 60 are able to be inserted into the receptacles 57 of the lower shell 2 so as to prevent a vertical translation of the shells 2 and 3 relative to each other.
  • the side walls 32 of the upper shell 3 have a greater height than the side walls 32 of the first embodiment.
  • the rim 35 of the side walls 32 of the upper shell 3 can rest on the recesses 54 of the lower shell 2, so that the protrusions 44b of the arches 44 protrude from the protective casing 1.
  • FIG. 9 is a side view of a lower shell 2 of a protective casing according to a third embodiment of the invention.
  • the lower shell 2 is particularly intended to contain a pocket of smaller volume, typically 5 liters.
  • the side walls 21 of the lower shell 2 comprise fastening elements 61 cooperating with fastening elements 62 provided on the upper shell 3.
  • the fastening elements 61 are for example provided on the side walls 21 of the side of the lower shell.
  • the fixing elements 61 make it possible to ensure the maintenance of the upper and lower shells when they are assembled, and prevent the horizontal translation of the lower and upper shells relative to each other.
  • the fixing elements 61 comprise a receptacle 61a, adapted to receive a complementary lug of the upper shell 3.
  • the receptacles 61a cooperate with lugs 62a provided on the upper shell.
  • the receptacles 61a and the lugs 62a cooperate in such a way that they prevent the vertical translation of the lower 2 and upper 3 shells.
  • the receptacles 61a and the lugs 62a include clips, for example.
  • the upper shell 3 is shown in bottom view on the figure 10a .
  • the side walls 32 of the upper shell 3 comprise fastening elements 62 cooperating with the fastening elements 61 provided on the lower shell 2.
  • the fastening elements 62 are for example provided on the side walls 32 of the side of the upper shell.
  • the fastening elements 62 of the upper shell 3 notably comprise lugs 62a cooperating with the receptacles 61a of the lower shell 2.
  • a protective box is shown in top view on the figure 10b .
  • the protective casing 1 according to this fourth embodiment is for example particularly intended to contain a bag with a volume of less than 50 liters.
  • the side walls 21 of the lower shell 2 have recesses 73, and recesses 54 described with reference to the previous embodiments.
  • the side walls 21 on the side may comprise at least one recess 73, for example located at the level of the middle of the length of the side walls 21 on the side.
  • the recesses 73 include a protrusion 73a.
  • the height of the protrusions 73a is greater than the top of the recesses 54, so that the upper end of the protrusions 73a extends beyond the horizontal shoulder 25.
  • the height of the protrusions 73a is lower than the height of the side walls 21 of the lower hull 2.
  • the recesses 73 cooperate with peripheral abutments 63 of the side walls 32 of the upper shell 3.
  • the peripheral abutments 63 comprise a protrusion 63A complementary to the protrusion 73a of the recesses 73 of the lower shell.
  • the cooperation of the projections 63A, 73a of the recesses 63, 73 makes it possible to avoid a horizontal translation of the upper and lower shells 3, 2 relative to each other.
  • the protrusions 63a and 73a form complementary fixing elements preventing a translation of the shells 2, 3 relative to each other.
  • the side walls 21 of the lower shell 2 may also include stiffening elements 74 cooperating with stiffening elements 64 included on the side walls 32 of the upper shell 3.
  • the stiffening elements 64 form peripheral abutments.
  • the stiffening elements 74 form recesses, forming support elements.
  • the stiffening elements 64, 74 are for example located on the rear side walls 21, 32 of the hulls 2, 3.
  • at least one stiffening element 64, 74 is provided at the level of the rear side wall of the hulls 2, 3, and preferably at least two stiffening elements 64, 74 are provided.
  • the stiffening elements 74 of the lower hull 2 comprise a height lower than the height of the horizontal shoulder 25, so that the stiffening elements 64 of the upper hull 3 have a height lower than the height of the rim 35 of the side walls. 32.
  • the rear side wall 21 of the lower hull does not include a horizontal shoulder 25.
  • the stiffening elements 74 of the lower shell 2 comprise a bearing portion 74a against which a bearing portion 64a of the stiffening element 64 of the upper shell 3 comes to rest, as illustrated more particularly in the figure 13 .
  • the stiffening elements 74 of the lower shell 2 further comprise an insertion portion 74b projecting from the support portion 74a, on which an insertion portion 64b complementary to the stiffening elements 64 is able to be inserted.
  • the insertion portions 64b, 74b are of complementary shape, so that after the insertion of the upper shell 3 into the lower shell 2, the insertion portions 64b, 74b prevent a horizontal translation of the two shells 2, 3 one relative to the other.
  • the insertion portions 64b, 74b form complementary fixing elements preventing the translation of the shells relative to each other.
  • stiffening elements 64, 74 make it possible to stiffen the structure of the casing 1, and make it possible to distribute the resistance forces when several casings 1 are stacked on top of each other.
  • the insertion portions 74b of the lower shell 2 make it possible to further improve the retention of the pocket in the rear part of the protective casing.
  • a pocket handle can advantageously be passed around the projecting insertion portion 74b, so as to keep it pinched between the two shells 2, 3.
  • a space 67 resides between the bearing portion 74a of the lower shell 2 and the rim 35 of the upper shell 3.
  • One end of the pocket can then be contained in this space 67, without protruding outside the box 1.
  • the lower shell 2 further comprises a gutter 66, provided on at least one of the stops 26, or on the two stops 26.
  • the gutter 66 extends for example from the inclined portion 22 of the lower shell to the point of contact of the abutment 26 with the upper shell 3.
  • one end of the gutter 66 is in contact with the outer edges 30a of the opening 30 of the upper shell 3.
  • the gutter 66 is for example intended to receive a tube connector of the type, for example, "needle less" (or “connector not requiring a needle”). This allows easy access to this tube connector.
  • the upper shell 3 may comprise at least one reinforcement 65, located for example at a front end of the recess 4.
  • the upper shell 3 comprises at least two reinforcements 65.
  • the reinforcements 65 are for example attached to the arch 44 adjacent to the opening 30.
  • the reinforcements 65 extend for example transversely to the arch 44. In the case of the stacking of several boxes 1 on top of each other, the weight of the boxes 1 supported by the arches 44 is then equally distributed over the reinforcements 65.
  • the reinforcements 65 also increase the rigidity of the protection box 1.
  • the reinforcements 65 are not attached to the arches 44.
  • Other reinforcements 65 can also be provided, in particular at the level of the rear end of the recess 4, or even between the arches 44.
  • THE figures 14 and 14a schematically represent in perspective an example of a stack of several lower shells 2, according to the first embodiment, one on top of the other.
  • the lower shells 2 are stacked on top of each other.
  • the lower shells 2 do not contain a pocket.
  • the fixing elements 24 of the side walls 21 on the side of the lower hulls 2 of the top rest on the fixing elements 24 of the side walls 21 of the side of the lower hulls 2 of the top. More precisely, the fixing elements 24b of the fixing elements of the lower hulls of the top rest on the hooks 24a of the fixing elements of the lower hulls 2 of the bottom.
  • the side walls 21 of the lower shells 2 from above touch the side walls 21 of the lower shells from below. This particular arrangement makes it possible to nest several lower shells 2 without loss of space.
  • THE figures 15 and 15a schematically represent in perspective an example of a stack of several upper shells 3, according to the first embodiment, one on top of the other.
  • the fixing elements 34 of the side walls 32 on the side of the upper shells 3 of the top rest on the fixing elements 34 of the side walls 32 of the side of the upper shells 3 of the top. More specifically, the fasteners 34b of the fasteners 34 of the upper shells above rest on the hooks 34a of the fasteners 34 of the upper shells below. According to this arrangement, the side walls 32 of the upper shells 3 above touch the side walls 32 of the upper shells 3 below. This particular arrangement makes it possible to nest several upper shells 3 without loss of space.
  • FIG 16 schematically shows in perspective an example of stacking on top of each other of several protective casings incorporating pockets according to the first embodiment of the invention.
  • the upper shell 3 further comprises at least one arch 44, preferably at least two or three arches 44.
  • the arches 44 extend between two side walls 32 of the upper shell 3, for example between the two side walls 32 of side .
  • the arches 44 in fact rest on the recess 4.
  • the arches 44 comprise a flat upper part 44a, capable of receiving the outer surface of the bottom 20 of the lower shell 2 of a protective casing, as illustrated figure 16 .
  • the flat upper part 44a of the arches 44 comprises a protrusion 44b adapted to be inserted into a complementary recess 27 provided on the outer surface of the bottom 20 of the lower shell 2 still of another housing.
  • the two longer side walls of the lower shell are inclined towards each other in their lower parts so that, when different protective boxes are stacked on top of each other, a gap is formed between two adjacent lower shells along these two adjacent lower shells so as to keep the tubes accessible to the hand of an operator.
  • a controller has easy access to pocket tubes when multiple protective cases are stacked on top of each other.
  • the gap can be large enough to fit a hand between two adjacent bottom shells of two stacked protective cases.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
EP18789462.1A 2017-10-06 2018-09-26 Boitiers de protection de poche de liquide biopharmaceutique Active EP3691600B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1771062A FR3072021B1 (fr) 2017-10-06 2017-10-06 Boitiers de protection de poche de liquide biopharmaceutique
PCT/FR2018/000225 WO2019068965A1 (fr) 2017-10-06 2018-09-26 Boitiers de protection de poche de liquide biopharmaceutique

Publications (2)

Publication Number Publication Date
EP3691600A1 EP3691600A1 (fr) 2020-08-12
EP3691600B1 true EP3691600B1 (fr) 2023-07-05

Family

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Application Number Title Priority Date Filing Date
EP18789462.1A Active EP3691600B1 (fr) 2017-10-06 2018-09-26 Boitiers de protection de poche de liquide biopharmaceutique

Country Status (6)

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US (1) US11992457B2 (enExample)
EP (1) EP3691600B1 (enExample)
JP (1) JP7224358B2 (enExample)
CN (1) CN111182878B (enExample)
FR (1) FR3072021B1 (enExample)
WO (1) WO2019068965A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023076548A1 (en) * 2021-10-29 2023-05-04 Global Life Sciences Solutions Usa Llc Apparatus and system for packaging a bioprocessing bag
CN114955154A (zh) * 2022-06-02 2022-08-30 上海玮驰仪器有限公司 一种卧式平板型冻融保护盒
WO2025131618A1 (en) * 2023-12-18 2025-06-26 Shl Medical Ag Cassette for medicament delivery device

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5163587A (en) * 1989-12-11 1992-11-17 Rehrig-Pacific Co. Syrup delivery system
FR2717782B1 (fr) * 1994-03-22 1996-06-21 Stephane Ibled Emballage de protection pour poche de transfert contenant un liquide, du type produit sanguin.
GB9702921D0 (en) * 1997-02-13 1997-04-02 Isserstedt Robert K A storage device
GB9724713D0 (en) * 1997-11-21 1998-01-21 Procter & Gamble Delivery systems
JP3547674B2 (ja) * 1999-12-22 2004-07-28 有限会社スグロ鉄工 成型品の外周用バリ取り装置
US8146762B2 (en) * 2006-03-09 2012-04-03 Nalge Nunc International Corporation Flexible container handling system
US9301520B2 (en) * 2007-12-21 2016-04-05 Sartorius Stedim North America Inc. Systems and methods for freezing, storing and thawing biopharmaceutical materials
US20120033902A1 (en) * 2010-02-05 2012-02-09 Pro-Mart Industries, Inc. Household storage container
US8490811B2 (en) * 2011-05-16 2013-07-23 Water Tech Llc Foldable pool accessory storage and organizing container
WO2013053011A1 (en) * 2011-10-12 2013-04-18 Bluechiip Limited Storage cassette
KR101655726B1 (ko) 2012-05-03 2016-09-07 쇼오트 아게 의료, 제약 또는 화장품 어플리케이션들을 위한 물질들을 저장하기 위한 컨테이너들을 처리하기 위한 방법 및 장치
FR3017122B1 (fr) * 2014-02-06 2016-02-26 Sartorius Stedim Fmt Sas Procede de chargement d'une poche souple 3d a emplir, un systeme de chargement et stockage de cette poche souple et dispositif de support associe.
CA2945070C (en) * 2014-04-16 2023-12-12 Viacyte, Inc. Tools and instruments for use with implantable encsapsulation devices

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Publication number Publication date
JP7224358B2 (ja) 2023-02-17
JP2020535946A (ja) 2020-12-10
US11992457B2 (en) 2024-05-28
EP3691600A1 (fr) 2020-08-12
FR3072021A1 (fr) 2019-04-12
FR3072021B1 (fr) 2023-06-30
CN111182878A (zh) 2020-05-19
CN111182878B (zh) 2023-04-28
WO2019068965A1 (fr) 2019-04-11
US20200237620A1 (en) 2020-07-30

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