EP3612529A4 - SALT OF AMINOPYRIDINE DERIVATIVE COMPOUND, CRYSTALLINE FORM THEREOF, AND METHOD FOR MANUFACTURING THEREOF - Google Patents

SALT OF AMINOPYRIDINE DERIVATIVE COMPOUND, CRYSTALLINE FORM THEREOF, AND METHOD FOR MANUFACTURING THEREOF Download PDF

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Publication number
EP3612529A4
EP3612529A4 EP18787260.1A EP18787260A EP3612529A4 EP 3612529 A4 EP3612529 A4 EP 3612529A4 EP 18787260 A EP18787260 A EP 18787260A EP 3612529 A4 EP3612529 A4 EP 3612529A4
Authority
EP
European Patent Office
Prior art keywords
salt
preparing
same
crystalline form
derivative compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18787260.1A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP3612529A1 (en
Inventor
Sang Ho Oh
Jong Gyun Kim
Se-Woong Oh
Tae Dong Han
Soo Yong Chung
Seong Ran Lee
Kyeong Bae Kim
Young Sung Lee
Woo Seob Shin
Hyun Ju
Jeong Ki Kang
Su Min Park
Dong Kyun Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yuhan Corp
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=63857137&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP3612529(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of EP3612529A1 publication Critical patent/EP3612529A1/en
Publication of EP3612529A4 publication Critical patent/EP3612529A4/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/22—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP18787260.1A 2017-04-21 2018-04-18 SALT OF AMINOPYRIDINE DERIVATIVE COMPOUND, CRYSTALLINE FORM THEREOF, AND METHOD FOR MANUFACTURING THEREOF Pending EP3612529A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20170051687 2017-04-21
PCT/KR2018/004473 WO2018194356A1 (en) 2017-04-21 2018-04-18 Salt of an aminopyridine derivative compound, a crystalline form thereof, and a process for preparing the same

Publications (2)

Publication Number Publication Date
EP3612529A1 EP3612529A1 (en) 2020-02-26
EP3612529A4 true EP3612529A4 (en) 2020-11-18

Family

ID=63857137

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18787260.1A Pending EP3612529A4 (en) 2017-04-21 2018-04-18 SALT OF AMINOPYRIDINE DERIVATIVE COMPOUND, CRYSTALLINE FORM THEREOF, AND METHOD FOR MANUFACTURING THEREOF

Country Status (23)

Country Link
US (2) US11453656B2 (ar)
EP (1) EP3612529A4 (ar)
JP (2) JP7126514B2 (ar)
KR (2) KR102629654B1 (ar)
CN (1) CN110869367B (ar)
AR (1) AR111469A1 (ar)
AU (2) AU2018256227B2 (ar)
BR (1) BR112019021868A2 (ar)
CA (1) CA3059543A1 (ar)
CO (1) CO2019011578A2 (ar)
EA (1) EA201992501A1 (ar)
IL (2) IL270018B (ar)
MA (1) MA49696A (ar)
MX (1) MX2022006357A (ar)
MY (1) MY201919A (ar)
NZ (1) NZ758443A (ar)
PH (1) PH12019502370A1 (ar)
SA (1) SA519410342B1 (ar)
SG (1) SG11201909615YA (ar)
TW (1) TWI776882B (ar)
UA (1) UA124364C2 (ar)
WO (1) WO2018194356A1 (ar)
ZA (1) ZA201907687B (ar)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR111469A1 (es) 2017-04-21 2019-07-17 Yuhan Corp Sal de un compuesto del derivado de aminopiridina, una forma cristalina de la misma, y un proceso para preparar la misma
KR20200043618A (ko) * 2018-10-18 2020-04-28 주식회사유한양행 아미노피리미딘 유도체 또는 이의 염을 포함하는 경구투여용 약학 조성물
JP7240032B2 (ja) * 2018-12-21 2023-03-15 深▲チェン▼市塔吉瑞生物医薬有限公司 プロテインキナーゼ活性を阻害するためのアミノピリミジン系化合物
JP2022521610A (ja) 2019-02-26 2022-04-11 ヤンセン バイオテツク，インコーポレーテツド 二重特異性抗ｅｇｆｒ／ｃ－ｍｅｔ抗体による併用療法及び患者層別化
US11850248B2 (en) * 2019-05-14 2023-12-26 Yuhan Corporation Therapies with 3rd generation EGFR tyrosine kinase inhibitors
EA202193117A1 (ru) * 2019-05-14 2022-02-11 Янссен Байотек, Инк. КОМБИНИРОВАННЫЕ ТЕРАПИИ С ИСПОЛЬЗОВАНИЕМ БИСПЕЦИФИЧЕСКИХ АНТИТЕЛ К EGFR/c-MET И 3-ГО ПОКОЛЕНИЯ ИНГИБИТОРОВ ТИРОЗИНКИНАЗЫ EGFR
JOP20210304A1 (ar) 2019-05-14 2023-01-30 Janssen Biotech Inc علاجات مركبة باستخدام الأجسام المضادة ثنائية النوعية المضادة لمستقبل عامل نمو البشرة (EGFR)/ مستقبل عامل نمو خلايا الكبد (c-Met) ومثبطات كيناز التيروسين الخاصة بمستقبل عامل نمو البشرة (EGFR) من الجيل الثالث
TW202207940A (zh) * 2020-04-14 2022-03-01 美商健生生物科技公司 包含胺基嘧啶衍生物或其醫藥上可接受之鹽、水合物、或溶劑化物之用於經口投予之醫藥組成物
EP4349835A1 (en) 2021-06-01 2024-04-10 Hangzhou Solipharma Co., Ltd. Hydrate crystal form of lazertinib methanesulfonate, preparation method therefor and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160102076A1 (en) * 2014-10-13 2016-04-14 Yuhan Corporation Compounds and compositions for modulating egfr mutant kinase activities

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
CN101337931B (zh) 2003-12-25 2010-09-29 卫材R&D管理有限公司 喹啉羧酰胺的甲磺酸盐的醋酸合物的结晶(i)及其制备方法
ES2565078T3 (es) 2004-02-11 2016-03-31 Natco Pharma Limited Forma polimorfa novedosa de mesilato de imatinib y un proceso para su preparación
WO2009158571A1 (en) * 2008-06-27 2009-12-30 Avila Therapeutics And Uses Thereof Heteroaryl compounds and uses thereof
CZ2009570A3 (cs) 2009-08-26 2011-03-09 Zentiva, K. S. Príprava, stabilizace a využití polymorfu imatinib mesylátu pro vývoj lékových forem
EP2498607B1 (en) 2009-11-13 2016-02-17 Genosco Kinase inhibitors
WO2012077136A2 (en) * 2010-12-06 2012-06-14 Msn Laboratories Limited Process for the preparation of benzimidazole derivatives and its salts
EA029488B1 (ru) 2011-07-27 2018-04-30 Астразенека Аб Производные 2-(2,4,5-замещенного анилино)пиримидина в качестве модуляторов egfr, полезных для лечения рака
CN104540822B (zh) 2013-07-08 2016-08-31 杭州普晒医药科技有限公司 达拉菲尼甲磺酸盐的晶型及其制备方法
WO2015175632A1 (en) 2014-05-13 2015-11-19 Ariad Pharmaceuticals, Inc. Heteroaryl compounds for kinase inhibition
CN104788427B (zh) 2015-02-05 2017-05-31 上海泓博智源医药股份有限公司 3‑(2‑嘧啶氨基)苯基丙烯酰胺类化合物及其应用
AR111469A1 (es) * 2017-04-21 2019-07-17 Yuhan Corp Sal de un compuesto del derivado de aminopiridina, una forma cristalina de la misma, y un proceso para preparar la misma

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160102076A1 (en) * 2014-10-13 2016-04-14 Yuhan Corporation Compounds and compositions for modulating egfr mutant kinase activities

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GOULD ET AL: "Salt selection for basic drugs", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER, NL, vol. 33, no. 1-3, 1 November 1986 (1986-11-01), pages 201 - 217, XP025813036, ISSN: 0378-5173, [retrieved on 19861101], DOI: 10.1016/0378-5173(86)90055-4 *
RICHARD J BASTIN ET AL: "Salt Selection and Optimisation Procedures for Pharmaceutical New Chemical Entities", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 4, no. 5, 19 July 2000 (2000-07-19), pages 427 - 435, XP008154792, ISSN: 1083-6160, [retrieved on 20000719], DOI: 10.1021/OP000018U *
STAHL P H ET AL: "chapter 12: Monographs on acids and bases", 1 January 2002, HANDBOOK OF PHARMACEUTICAL SALTS : PROPERTIES, SELECTION, AND USE, ZÜRICH : VERL. HELVETICA CHIMICA ACTA ; WEINHEIM [U.A.] : WILEY-VCH, DE, PAGE(S) 265 - 327, ISBN: 978-3-906390-26-0, XP008145189 *

Also Published As

Publication number Publication date
KR20180118535A (ko) 2018-10-31
PH12019502370A1 (en) 2020-07-13
CN110869367B (zh) 2023-09-15
US20210139461A1 (en) 2021-05-13
TW201841910A (zh) 2018-12-01
EA201992501A1 (ru) 2020-02-18
WO2018194356A1 (en) 2018-10-25
AU2018256227B2 (en) 2022-03-03
IL294666B2 (en) 2024-05-01
MY201919A (en) 2024-03-23
BR112019021868A2 (pt) 2020-05-26
EP3612529A1 (en) 2020-02-26
UA124364C2 (uk) 2021-09-01
JP7126514B2 (ja) 2022-08-26
NZ758443A (en) 2023-03-31
TWI776882B (zh) 2022-09-11
US20230021395A1 (en) 2023-01-26
JP2022166179A (ja) 2022-11-01
IL270018B (en) 2022-08-01
AR111469A1 (es) 2019-07-17
IL270018A (ar) 2019-12-31
IL294666B1 (en) 2024-01-01
MA49696A (fr) 2020-06-03
AU2018256227A1 (en) 2019-10-31
AU2022203486A1 (en) 2022-06-09
JP2020517611A (ja) 2020-06-18
CN110869367A (zh) 2020-03-06
CO2019011578A2 (es) 2020-02-28
SA519410342B1 (ar) 2023-02-09
CA3059543A1 (en) 2018-10-25
US11453656B2 (en) 2022-09-27
AU2022203486B2 (en) 2024-06-06
SG11201909615YA (en) 2019-11-28
KR102629654B1 (ko) 2024-01-29
ZA201907687B (en) 2023-04-26
IL294666A (en) 2022-09-01
JP7390444B2 (ja) 2023-12-01
KR20230175161A (ko) 2023-12-29
US11981659B2 (en) 2024-05-14
MX2022006357A (es) 2022-06-23

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Inventor name: KANG, JEONG KI

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