EP3490893B2 - Öffnungsanordnung für behälteraufnehmende beutel zur pharmazeutischen verwendung - Google Patents

Öffnungsanordnung für behälteraufnehmende beutel zur pharmazeutischen verwendung

Info

Publication number
EP3490893B2
EP3490893B2 EP17743339.8A EP17743339A EP3490893B2 EP 3490893 B2 EP3490893 B2 EP 3490893B2 EP 17743339 A EP17743339 A EP 17743339A EP 3490893 B2 EP3490893 B2 EP 3490893B2
Authority
EP
European Patent Office
Prior art keywords
bag
clamping mechanism
zone
opening assembly
clamping
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP17743339.8A
Other languages
English (en)
French (fr)
Other versions
EP3490893B1 (de
EP3490893A1 (de
Inventor
Claudio Trebbi
Gabriele Gabusi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IMA Industria Macchine Automatiche SpA
Original Assignee
IMA Industria Macchine Automatiche SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by IMA Industria Macchine Automatiche SpA filed Critical IMA Industria Macchine Automatiche SpA
Publication of EP3490893A1 publication Critical patent/EP3490893A1/de
Publication of EP3490893B1 publication Critical patent/EP3490893B1/de
Application granted granted Critical
Publication of EP3490893B2 publication Critical patent/EP3490893B2/de
Active legal-status Critical Current
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Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B69/00—Unpacking of articles or materials, not otherwise provided for
    • B65B69/0008—Opening and emptying bags
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B69/00—Unpacking of articles or materials, not otherwise provided for
    • B65B69/0033—Unpacking of articles or materials, not otherwise provided for by cutting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B69/00—Unpacking of articles or materials, not otherwise provided for
    • B65B69/005—Unpacking of articles or materials, not otherwise provided for by expelling contents, e.g. by squeezing the container
    • B65B69/0058—Solid contents

Definitions

  • the present invention relates to an opening assembly for bags housing containers for pharmaceutical use.
  • the bag of specific interest is intended for containment and segregation with respect to the outside environment of containers such as vials, bottles, syringes, carpules and the like.
  • the nest is, in turn, placed inside a sterile tub with a protective film on top which has the purpose of preventing entrance into the containers (which have an upper opening open towards the outside) of dust or other particles.
  • the upper edges of the tub (containing protective film, nest and containers) are permanently joined to a sealing film in order to completely isolate the inside of the tub from the outside.
  • the sealed tub is placed within a bag (generally made of polymeric material) which constitutes a second protective barrier (since the outside of the tub and the sealing film must in any case be sterile).
  • a bag generally made of polymeric material which constitutes a second protective barrier (since the outside of the tub and the sealing film must in any case be sterile).
  • the atmosphere inside the bag will also present a very low contamination class (such as, an ISO Class less than or equal to 5).
  • bag opening operations are such as to give rise to a risk of contamination (during the cutting step, particles may in fact detach and enter inside the bag, coming into contact with the protective film or the outside of the tub) .
  • the presence of particles on the protective film and/or the outer surface of the tub is particularly risky because removal of the film generally occurs when the tub is already in the environment with the highest contamination class (i.e., ISO 5 Class or lower, thus, with the least presence of contaminants) and could cause the diffusion of such particles (deposited on the film and/or tub) in that environment.
  • DE 10 2011 080289 discloses a device for opening a bag according to the prior art.
  • the main aim of the present invention is to solve the problems outlined above, by proposing an opening assembly for bags housing containers for pharmaceutical use capable of cutting the outer bag while preventing particles, in suspension and/or generated during the cutting step, from entering inside the bag.
  • an object of the invention is to propose an opening assembly for bags housing containers for pharmaceutical use that ensures isolation of the bag's content with respect to the outside environment even after opening the bag.
  • Another object of the invention is to propose an opening assembly for packaging of containers for pharmaceutical use capable of guaranteeing sterility of the containers transported in the nest present inside the tub, sealed by a protective film, and segregated inside the bag.
  • an opening assembly for bags B housing containers A for pharmaceutical use.
  • the bag B is generally hermetically sealed and preferably made of polymeric material.
  • the assembly 1 comprises at least one clamping mechanism 2 to clamp a portion C of the bag B spaced apart (inwardly) with respect to an end flap D of the bag.
  • the clamping mechanism 2 is arranged so as to clamp together sections of opposing sheets E, F of the bag B.
  • the assembly 1 further comprises at least one cutting element 2a for the trimming of the end flap D with respect to the portion C defined by the sections of opposing sheets E, F of the bag B mutually clamped together by the clamping mechanism 2.
  • the end flap D of the bag B (thus, the opening of the bag B) can then be removed.
  • the transfer to subsequent operating stations where it may be necessary to access the contents of the bag B will occur while the sections of opposing sheets E and F (portion C) are clamped together sealed by the clamping mechanism 2 and thus under such conditions as to prevent contamination of the contents of the bag B.
  • the bag B is in fact already opened (because it is without the end flap D) and thus subsequent access to its contents will not require any operation capable of generating contaminants and/or particles (which may in fact detach during the cutting step) thereby greatly improving the sterility and cleanliness of containers A transported inside the bag B.
  • the opening assembly further comprises gripping mechanisms 14 equipped with at least one clamping jaw 15 for gripping the end flap D of the bag B when the bag B hangs from the at least one said jaw 15 of the gripping mechanism 14.
  • the cutting element 2a is designed to separate the end flap D and is arranged between the gripping mechanisms 14 and the clamping mechanism 2.
  • these gripping mechanisms 14 are associated with a transport device 5.
  • the transport device 5 in the illustrated example comprises a proximal section 10 arranged in a first zone 9 and a distal section 12 arranged in a second zone 11, wherein the first zone 9 has a higher contamination class and a higher ambient pressure than the second zone.
  • Said transport device 5 may be a closed loop design and driven by an automatic motor drive unit connected to a control and management processor.
  • the clamping mechanism 2 is integral with a moveable terminal end 3 of a manipulator 4.
  • manipulator 4 advantageously moves between at least two end configurations.
  • a first configuration whereby the bag B is removed from the transport device 5 for the clamping of said opposing sheets E, F with the clamping mechanism 2; and a second alignment configuration whereby the bag B is brought in proximity to an opening 6 defined on a separation wall 7 separating the first zone 9 from a compartment 8 with a higher contamination class and higher ambient pressure compared to the first zone 9.
  • the first zone 9 within which the manipulator 4 operates and in which the proximal section 10 of the transport device 5 is located has a higher contamination class and a higher ambient pressure compared to the second zone 11 in which the distal section 12 of the transport device 5 is located.
  • an operating condition will occur whereby the transport of packaging A will be carried out in ambient conditions with a less stringent contamination class (i.e, ISO Class 6 or ISO Class 7), the cutting of the end flap D and thus the opening of the bag B will occur in ambient conditions with an intermediate contamination class (according to the previous example, in ISO Class 6 or ISO Class 6+ or ISO Class 5 respectively), while the extraction of the contents of the bag B will only occur in the compartment 8 in which there is a higher contamination class (according to the previous example, ISO Class 5).
  • a less stringent contamination class i.e, ISO Class 6 or ISO Class 7
  • an intermediate contamination class accordinging to the previous example, in ISO Class 6 or ISO Class 6+ or ISO Class 5 respectively
  • the manipulator 4 can be an anthropomorphic-type robot.
  • the first zone 9 there is preferably arranged at least one dispenser of a gas flow intended to flow over the proximal section 10 of the transport device 5, the bag B transported along the end section 10 and the manipulator 4.
  • Such gas flow will provide the necessary overpressure in the first zone 9, with respect to the second zone 11 in which the distal section 12 of the transport device 5 is located so as to prevent access to the first zone 9 of particles and/or contaminants present in suspension in the air in the second zone 11.
  • the gas flow present in the first zone 9 will be of the laminar type.
  • the gas relating to such flow may be air (other types of gas such as inert gas, nitrogen and the like are not excluded).
  • the transport device 5 thus adopted allows all surfaces of each bag B to be invested by the gas, favoring the detachment of any particles accumulated thereupon, while hindering the deposit of any other particles present in suspension in the air of the particular environment in question.
  • a portion C of the bag B spaced apart (inwardly) relative to an end flap D, in alignment with a clamping mechanism 2.
  • a final step of the process involves trimming by means of a cutting element 2a the end flap D with respect to the portion C corresponding to the sections of opposing sheets E, F of the bag B mutually clamped together by the clamping mechanism 2.
  • the process involves aligning the portion C of bag B to the clamping mechanism 2, keeping it sealed by isolating the contents of the bag B from the outside environment, at a subsequent operating station, so that the containers A placed inside the bag B remain isolated from the outside environment even after the trimming.
  • the present invention solves the problems outlined above, by proposing an opening assembly 1 for bags housing containers for pharmaceutical use, preventing particles, in suspension and/or generated during the cutting step, from entering inside the bag B.
  • the opening assembly 1 guarantees the isolation of the contents of the bag B from the outside environment even after cutting the bag B.
  • the opening assembly 1 according to the invention is capable of guaranteeing the sterility of the containers transported in the nest inside the tub, sealed by a protective film, and segregated inside the bag B.
  • the opening assembly 1 according to the invention is relatively simple and practical to implement, and also entails contained costs: these features make the unit 1 an innovative and safe application.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Bag Frames (AREA)
  • Packages (AREA)

Claims (10)

  1. Schneidevorrichtung für Beutel (B), in denen Behälter (A) für pharmazeutische Zwecke untergebracht sind, umfassend mindestens einen Klemmmechanismus (2) zum Zusammenklemmen eines Abschnitts (C) des genannten Beutels (B) und mindestens ein Schneidelement (2a), wobei der Klemmmechanismus (2) dazu konfiguriert ist, Abschnitte gegenüberliegender Folien (E, F) des genannten Beutels (B), die beabstandet zu einer Endlasche (D) des Beutels angeordnet sind, miteinander zu verklemmen, wobei das mindestens eine Schneidelement (2a) dazu konfiguriert ist, die gegenüber den genannten Abschnitten der gegenüberliegenden Folien (E, F) des Beutels (B), die durch den Klemmmechanismus (2) miteinander verklemmt sind, hervorstehende Endlasche (D) abzutrennen und zu entfernen, dadurch gekennzeichnet, dass die Vorrichtung ferner Greifelemente (14) umfasst, die mindestens eine Klemmbacke (15) aufweisen, um die Endlasche (D) des Beutels (B) zu greifen, wobei der genannte Beutel (B) an der mindestens einen Klemmbacke (15) des Greifelements (14) aufgehängt ist.
  2. Schneideeinheit nach Anspruch 1, in der Greiforgane einem Transportsystem zugeordnet sind.
  3. Schneideeinheit nach Anspruch 2, in der das Transportsystem umfasst:einen proximalen Abschnitt angeordnet in einem ersten Bereich, undeinen distalen Abschnitt angeordnet in einem zweiten Bereich,in dem der erste Bereich eine höhere Kontaminationsklasse und einen höheren Umgebungsdruck gegenüber dem zweiten Bereich aufweist.
  4. Schneideeinheit nach Anspruch 2 oder 3, in der das Transportsystem ringförmig geschlossen und durch eine automatische Antriebseinheit angetrieben ist, die einem Steuer- und Regelprozessor untergeordnet ist.
  5. Schneideeinheit nach einem der vorhergehenden Ansprüche, in der das Schneideorgan zwischen den Greiforganen und dem Klemmmechanismus angeordnet ist, wenn der Endlasche von den gegenüberliegenden Folienabschnitten, die durch den Klemmmechanismus zusammengeklemmt sind, getrennt ist.
  6. Schneidevorrichtung für Beutel (B), in denen Behälter (A) für pharmazeutische Zwecke untergebracht sind, umfassend mindestens einen Klemmmechanismus (2) zum Zusammenklemmen eines Abschnitts (C) des genannten Beutels (B) und mindestens ein Schneidelement (2a), wobei der Klemmmechanismus (2) dazu konfiguriert ist, Abschnitte gegenüberliegender Folien (E, F) des genannten Beutels (B), die beabstandet zu einer Endlasche (D) des Beutels angeordnet sind, miteinander zu verklemmen, wobei das mindestens eine Schneidelement (2a) dazu konfiguriert ist, die gegenüber den genannten Abschnitten der gegenüberliegenden Folien (E, F) des Beutels (B), die durch den Klemmmechanismus (2) miteinander verklemmt sind, hervorstehende Endlasche (D) abzutrennen und zu entfernen, dadurch gekennzeichnet, dass der Klemmmechanismus (2) mit einem beweglichen Endabschnitt (3) eines Manipulators (4) verbunden ist, wobei der Manipulator (4) zwischen mindestens zwei Endpositionen verstellbar ist, einer ersten Position, in der der Beutel (B) von einer Transporteinrichtung (5) aufgenommen wird, um die gegenüberliegenden Folien (E, F) mittels des Klemmmechanismus (2) zu verklemmen, und einer zweiten Position, in der der Beutel (B) in die Nähe einer Öffnung (6) gebracht wird, die in einer Trennwand (7) vorgesehen ist, welche einen ersten Bereich (9) von einem Raum (8) trennt, wobei der Raum (8) eine höhere Kontaminationsklasse und einen höheren Umgebungsdruck als der erste Bereich (9) aufweist.
  7. Schneideeinheit nach Anspruch 6, wobei der Manipulator (4) ein anthropomorpher Roboter ist.
  8. Schnittgruppe nach Anspruch 1, wobei in der genannten ersten Zone (9) mindestens ein Auslass für einen Gasstrom angeordnet ist, der den proximalen Abschnitt (10) der Fördereinrichtung (5), den entlang des proximalen Abschnitts (10) transportierten Beutel (B) und den in der ersten Zone (9) angeordneten Manipulator (4) betrifft.
  9. Schneideeinheit nach Anspruch 8, wobei der Gasstrom laminare Strömung ist.
  10. Verfahren zum Schneiden von Beuteln (B), in denen Behälter (A) für pharmazeutische Zwecke untergebracht sind, umfassend die Schritte:
    - anordnen eines Abschnitts (C) des Beutels (B), der von einem Endlaschen (D) beabstandet ist, in Ausrichtung an einem Klemmmechanismus (2);
    - zusammenklemmen von gegenüberliegenden Folien (E, F) des Beutels (B) mit dem Klemmmechanismus (2);
    - schneiden und Trennen des Endlaschens (D) mittels eines Schneideorgans (2a) gegenüber den gegenüberliegenden Folienstücken (E, F) des Beutels (B), die durch den Klemmmechanismus (2) gegenseitig zusammengeklemmt sind,
    wobei das Verfahren dadurch gekennzeichnet ist, dass es den weiteren Schritt umfasst:
    - ausrichten des durch den Klemmmechanismus (2) zusammengeklemmt gehaltenen Abschnitts des Beutels (B) an einer nachfolgenden Arbeitsstation,
    wobei das Zusammenklemmen des Beutels (B) mit dem Klemmmechanismus (2) die gegenüberliegenden Folien (E, F) zusammenhält, sodass die Behälter (A) im Inneren des Beutels (B) auch nach dem Schneiden isoliert von der Umgebung bleiben.
EP17743339.8A 2016-07-27 2017-07-26 Öffnungsanordnung für behälteraufnehmende beutel zur pharmazeutischen verwendung Active EP3490893B2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT102016000078609A IT201600078609A1 (it) 2016-07-27 2016-07-27 Gruppo di apertura per confezioni di contenitori ad uso farmaceutico
PCT/EP2017/068858 WO2018019874A1 (en) 2016-07-27 2017-07-26 Opening assembly for bags housing containers for pharmaceutical use

Publications (3)

Publication Number Publication Date
EP3490893A1 EP3490893A1 (de) 2019-06-05
EP3490893B1 EP3490893B1 (de) 2021-03-24
EP3490893B2 true EP3490893B2 (de) 2025-09-10

Family

ID=57610180

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17743339.8A Active EP3490893B2 (de) 2016-07-27 2017-07-26 Öffnungsanordnung für behälteraufnehmende beutel zur pharmazeutischen verwendung

Country Status (8)

Country Link
US (1) US20210292032A1 (de)
EP (1) EP3490893B2 (de)
JP (1) JP6971305B2 (de)
CN (1) CN109715505B (de)
CA (1) CA3032037A1 (de)
ES (1) ES2874645T3 (de)
IT (1) IT201600078609A1 (de)
WO (1) WO2018019874A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102018210747A1 (de) * 2018-06-29 2020-01-02 Robert Bosch Gmbh Vorrichtung und Verfahren zum Zuführen eines Gegenstandes
CN109625500B (zh) * 2019-01-25 2020-11-06 格瑞果汁工业（天津）有限公司 一种果酱小袋拆袋机
IT201900006552A1 (it) * 2019-05-06 2020-11-06 Ima Spa Apparato e metodo per la gestione automatizzata di una camera di lavorazione ad atmosfera controllata.
CN111513357A (zh) * 2019-12-02 2020-08-11 广州富港万嘉智能科技有限公司 一种含馅食物自动制作贩卖设备
US12030688B1 (en) * 2020-08-27 2024-07-09 Express Scripts Strategic Development, Inc. Systems and methods for pharmaceutical container processing
DE102021104221A1 (de) * 2021-02-23 2022-08-25 Syntegon Technology Gmbh Vorrichtung und Verfahren zur Überführung einer Verpackungseinheit in ein Barrieresystem für Pharmazeutika
IT202100004685A1 (it) * 2021-03-01 2022-09-01 Ima Spa Procedimento e apparato per il trattamento automatico di involucri.
DE102022110051A1 (de) * 2022-04-26 2023-10-26 Syntegon Technology Gmbh Vorrichtung, Set, pharmazeutische Anlage und Verfahren zum Entpacken einer Vielzahl von Gegenständen
DE102022110826A1 (de) 2022-05-03 2023-11-09 Tt Innovation Ag Vorrichtung zum Manipulieren von Behälter enthaltenden Beuteln
CN115043051B (zh) * 2022-05-19 2023-08-04 玉林市第一人民医院 新冠病毒核酸检测标本密封袋拆包装置及方法
WO2022195572A2 (en) * 2022-05-25 2022-09-22 Indian Institute of Technology Guwahati Sachet/pouch cutting and squeezing apparatus
DE102022118701A1 (de) * 2022-07-26 2024-02-01 Tt Innovation Ag Verfahren zum Ausbringen eines Behälters aus einem Beutel, Schneidvorrichtung, Entnahmevorrichtung und Entpackvorrichtung

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011012658A1 (de) † 2009-07-30 2011-02-03 Autefa Automation Gmbh Öffnungseinrichtung
EP2441692A1 (de) † 2010-10-14 2012-04-18 CO.RI.M.A. S.r.l. Vorrichtung und Verfahren zum Entfernen eines sterilen Produkts aus einer sterilen Verpackung mit dem Produkt darin

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITBO20060246A1 (it) 2006-04-05 2007-10-06 Ima Spa Apparato e metodo per alimentare con un prodotto una macchina confezionatrice.
WO2008016313A1 (en) 2006-08-02 2008-02-07 J.M.P. Engineering Limited A multi layer bag separator
CH702317B1 (it) * 2007-08-02 2011-06-15 Stevanato Group Internat As Struttura di confezione di flaconi in vetro ad uso farmaceutico.
CN201228095Y (zh) * 2008-05-20 2009-04-29 刘雪 开袋器
DE102010039635A1 (de) 2010-08-23 2012-02-23 Robert Bosch Gmbh Verfahren zum Entsorgen von sterilem Verpackungsmaterial sowie Vorrichtung hierzu
DE102010063892B4 (de) 2010-12-22 2023-10-19 Syntegon Technology Gmbh Vorrichtung und Verfahren zum Entnehmen eines Objekts aus einer Verpackung
DE102011080289B4 (de) * 2011-08-02 2021-07-08 Syntegon Technology Gmbh Vorrichtung und Verfahren zum Entnehmen eines sterilen Gegenstands aus einem Folienbeutel
DE102014201966B4 (de) 2014-02-04 2024-09-26 Syntegon Technology Gmbh Vorrichtung und Verfahren zum Handling eines Trays
DE102014201967B4 (de) * 2014-02-04 2024-09-26 Syntegon Technology Gmbh Vorrichtung und Verfahren zur Entnahme von Behältnissen aus einem Tray
JP6413053B2 (ja) * 2014-10-29 2018-10-31 ゼネラルパッカー株式会社 包装機
CN206871457U (zh) * 2017-07-11 2018-01-12 象山益精高分子材料有限公司 一种开袋装置

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011012658A1 (de) † 2009-07-30 2011-02-03 Autefa Automation Gmbh Öffnungseinrichtung
EP2441692A1 (de) † 2010-10-14 2012-04-18 CO.RI.M.A. S.r.l. Vorrichtung und Verfahren zum Entfernen eines sterilen Produkts aus einer sterilen Verpackung mit dem Produkt darin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JAMES L DRINKWATER, MARC VAN LAERE: "Risk-based environmental control and process monitoring in aseptic processing", EUROPEAN JOURNAL OF PARENTERAL & PHARMACEUTICAL SCIENCES, vol. 20, no. 4, 1 January 2015 (2015-01-01), pages 133 - 142, XP055909917 †

Also Published As

Publication number Publication date
CA3032037A1 (en) 2018-02-01
WO2018019874A1 (en) 2018-02-01
CN109715505A (zh) 2019-05-03
CN109715505B (zh) 2021-02-26
IT201600078609A1 (it) 2018-01-27
EP3490893B1 (de) 2021-03-24
JP6971305B2 (ja) 2021-11-24
JP2019521927A (ja) 2019-08-08
ES2874645T3 (es) 2021-11-05
EP3490893A1 (de) 2019-06-05
US20210292032A1 (en) 2021-09-23

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