EP3429553A1 - Kit zur kosmetischen behandlung des auges und der haut und kosmetikum zur anwendung am auge und auf der haut - Google Patents
Kit zur kosmetischen behandlung des auges und der haut und kosmetikum zur anwendung am auge und auf der hautInfo
- Publication number
- EP3429553A1 EP3429553A1 EP17712732.1A EP17712732A EP3429553A1 EP 3429553 A1 EP3429553 A1 EP 3429553A1 EP 17712732 A EP17712732 A EP 17712732A EP 3429553 A1 EP3429553 A1 EP 3429553A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- cosmetic
- eye
- weight
- solution
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 92
- 230000000699 topical effect Effects 0.000 claims abstract description 6
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 28
- 239000000243 solution Substances 0.000 claims description 24
- 210000000744 eyelid Anatomy 0.000 claims description 16
- 239000003995 emulsifying agent Substances 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 14
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 14
- 229960004889 salicylic acid Drugs 0.000 claims description 14
- 239000003755 preservative agent Substances 0.000 claims description 13
- 241000201295 Euphrasia Species 0.000 claims description 12
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 11
- 229920002674 hyaluronan Polymers 0.000 claims description 11
- 229960003160 hyaluronic acid Drugs 0.000 claims description 11
- 239000007853 buffer solution Substances 0.000 claims description 10
- 229940098465 tincture Drugs 0.000 claims description 10
- 229920000742 Cotton Polymers 0.000 claims description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 7
- 230000002335 preservative effect Effects 0.000 claims description 7
- 239000000600 sorbitol Substances 0.000 claims description 7
- 239000007864 aqueous solution Substances 0.000 claims description 6
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 6
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 claims description 6
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 6
- 210000004907 gland Anatomy 0.000 claims description 6
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 5
- 239000001509 sodium citrate Substances 0.000 claims description 5
- 159000000000 sodium salts Chemical class 0.000 claims description 5
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 4
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 4
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 4
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 4
- JBIROUFYLSSYDX-UHFFFAOYSA-M benzododecinium chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 JBIROUFYLSSYDX-UHFFFAOYSA-M 0.000 claims description 4
- 229960004074 benzododecinium chloride Drugs 0.000 claims description 4
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 4
- 229960002798 cetrimide Drugs 0.000 claims description 4
- 229960003260 chlorhexidine Drugs 0.000 claims description 4
- 238000005338 heat storage Methods 0.000 claims description 4
- 229960005323 phenoxyethanol Drugs 0.000 claims description 4
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims description 4
- JCIIKRHCWVHVFF-UHFFFAOYSA-N 1,2,4-thiadiazol-5-amine;hydrochloride Chemical compound Cl.NC1=NC=NS1 JCIIKRHCWVHVFF-UHFFFAOYSA-N 0.000 claims description 3
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 claims description 3
- 239000005711 Benzoic acid Substances 0.000 claims description 3
- WSWCOQWTEOXDQX-MQQKCMAXSA-N E-Sorbic acid Chemical compound C\C=C\C=C\C(O)=O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 claims description 3
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims description 3
- 229920002413 Polyhexanide Polymers 0.000 claims description 3
- 235000010233 benzoic acid Nutrition 0.000 claims description 3
- 239000000872 buffer Substances 0.000 claims description 3
- VXIVSQZSERGHQP-UHFFFAOYSA-N chloroacetamide Chemical compound NC(=O)CCl VXIVSQZSERGHQP-UHFFFAOYSA-N 0.000 claims description 3
- 229960004926 chlorobutanol Drugs 0.000 claims description 3
- 229960004106 citric acid Drugs 0.000 claims description 3
- 239000004312 hexamethylene tetramine Substances 0.000 claims description 3
- 235000010299 hexamethylene tetramine Nutrition 0.000 claims description 3
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 claims description 3
- 108700019599 monomethylolglycine Proteins 0.000 claims description 3
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims description 3
- 229940096826 phenylmercuric acetate Drugs 0.000 claims description 3
- 229940116254 phosphonic acid Drugs 0.000 claims description 3
- 229940093158 polyhexanide Drugs 0.000 claims description 3
- 235000019260 propionic acid Nutrition 0.000 claims description 3
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 3
- 229940101011 sodium hydroxymethylglycinate Drugs 0.000 claims description 3
- 229960001922 sodium perborate Drugs 0.000 claims description 3
- CITBNDNUEPMTFC-UHFFFAOYSA-M sodium;2-(hydroxymethylamino)acetate Chemical compound [Na+].OCNCC([O-])=O CITBNDNUEPMTFC-UHFFFAOYSA-M 0.000 claims description 3
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 claims description 3
- LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical class [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 claims description 3
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 claims description 3
- 229960004906 thiomersal Drugs 0.000 claims description 3
- BDKLKNJTMLIAFE-UHFFFAOYSA-N 2-(3-fluorophenyl)-1,3-oxazole-4-carbaldehyde Chemical compound FC1=CC=CC(C=2OC=C(C=O)N=2)=C1 BDKLKNJTMLIAFE-UHFFFAOYSA-N 0.000 claims description 2
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 2
- 239000007983 Tris buffer Substances 0.000 claims description 2
- 239000007979 citrate buffer Substances 0.000 claims description 2
- 210000000720 eyelash Anatomy 0.000 claims description 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 2
- 239000011976 maleic acid Substances 0.000 claims description 2
- 239000008363 phosphate buffer Substances 0.000 claims description 2
- 235000017281 sodium acetate Nutrition 0.000 claims description 2
- 229940087562 sodium acetate trihydrate Drugs 0.000 claims description 2
- 229960000999 sodium citrate dihydrate Drugs 0.000 claims description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 2
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims description 2
- 229960000281 trometamol Drugs 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 6
- 235000021317 phosphate Nutrition 0.000 description 6
- 241001110062 Euphrasia officinalis Species 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 4
- 238000011109 contamination Methods 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 239000010452 phosphate Substances 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 244000052616 bacterial pathogen Species 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- -1 polyoxyethylene Polymers 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical class OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 210000004087 cornea Anatomy 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 210000004175 meibomian gland Anatomy 0.000 description 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 208000003556 Dry Eye Syndromes Diseases 0.000 description 1
- 206010013774 Dry eye Diseases 0.000 description 1
- 241000155644 Euphrasia stricta Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
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- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 239000012874 anionic emulsifier Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000001760 anti-analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 201000007717 corneal ulcer Diseases 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 150000002148 esters Chemical group 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000012676 herbal extract Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 125000005341 metaphosphate group Chemical group 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229960001790 sodium citrate Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
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- 125000002264 triphosphate group Chemical group [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
- 238000002371 ultraviolet--visible spectrum Methods 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D34/00—Containers or accessories specially adapted for handling liquid toiletry or cosmetic substances, e.g. perfumes
- A45D34/04—Appliances specially adapted for applying liquid, e.g. using roller or ball
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D44/00—Other cosmetic or toiletry articles, e.g. for hairdressers' rooms
- A45D44/002—Masks for cosmetic treatment of the face
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61Q1/14—Preparations for removing make-up
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D2200/00—Details not otherwise provided for in A45D
- A45D2200/10—Details of applicators
- A45D2200/1009—Applicators comprising a pad, tissue, sponge, or the like
- A45D2200/1036—Applicators comprising a pad, tissue, sponge, or the like containing a cosmetic substance, e.g. impregnated with liquid or containing a soluble solid substance
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D2200/00—Details not otherwise provided for in A45D
- A45D2200/15—Temperature
- A45D2200/155—Heating or cooling means, i.e. for storing or applying cosmetic products at a predetermined temperature
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D2200/00—Details not otherwise provided for in A45D
- A45D2200/25—Kits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
- A61K2800/33—Free of surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
- A61K2800/884—Sequential application
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
Definitions
- the invention relates to a kit for the topical, cosmetic treatment of the eye and the skin and a cosmetic contained therein for use on the eye and on the skin.
- Ophthalmic cosmetic formulations known in the art are similar in composition to natural ocular surface film. This means that they contain both watery and oily components. A disadvantage of these already known compositions is frequently that they contain surface-active substances (emulsifiers) in order to be able to ensure permanent dispersion and storage stability.
- surface-active substances emulsifiers
- Emulsifiers have an amphiphilic molecular structure consisting of a polar, hydrophilic and a nonpolar, lipophilic moiety, the spatially separated. They lower the interfacial tension between the phases by being located at the interface between both liquids and forming an interfacial film. Stabilization of emulsions is also often used emulsifier mixtures.
- emulsifiers may be subdivided into ionic (anionic, cationic and amphoteric) and nonionic according to their hydrophilic moiety:
- anionic emulsifier is soap, commonly referred to as the water-soluble sodium or potassium salts of the saturated and unsaturated higher fatty acids.
- cationic emulsifiers are quaternary ammonium compounds.
- the hydrophilic moiety of nonionic emulsifiers often consists of glycerol, polyglycerol, sorbitans, carbohydrates or polyoxyethylene glycols and is usually linked via ester and ether bonds with the lipophilic moiety.
- emulsifiers can cause allergic reactions in individual cases. Especially with irritated eyes anyway, such additives can lead to incompatibilities and further irritation, because emulsifiers affect the tear film.
- cosmetic formulations for use on the eye typically also contain preservatives to prevent microbial contamination by bacteria, yeasts and fungi.
- preservatives Polyquad, Purite and Thiomersal added as a preservative.
- Further preservatives are also benzoic acid, propionic acid, hexadienoic acid, formaldehyde, inorganic sulfites, 2-phenoxyethanol, benzyl alcohol, hexamethylenetetramine and chloroacetamide.
- Benzalkonium chloride, benzododecinium chloride and cetrimide reduce the stability of the tear film and cause a dry eye when used for long periods. They attack the cornea of the eye, so that the uppermost layer of the cornea becomes thinner in some places and can cause corneal ulcers. Chlorhexidine, on the other hand, leads to allergic reactions.
- Skin contains or consists of an aqueous solution, which includes or consists of hyaluronic acid or a salt of hyaluronic acid, salicylic acid or a salt of salicylic acid, sorbitol, Euphrasia mother tincture and a buffer system, wherein no emulsifiers are added to the solution.
- the cosmetic preferably also contains no preservative, in particular no preservative selected from the group consisting of benzoic acid, propionic acid, hexadienoic acid, formaldehyde, inorganic sulfites, 2-phenoxyethanol, benzyl alcohol, hexamethylenetetramine, chloroacetamide, benzalkonium chloride, benzododecinium chloride,
- Cetrimide chlorhexidine, chlorobutanol, sodium hydroxymethylglycinate, sodium perborate, phosphonic acid, phenylmercuric acetate, polyhexanide, polyquad, purites, thiomersal, and mixtures thereof.
- preservative-free cosmetics can be used by contact lens wearers and allergy sufferers throughout the entire pollen season without any concerns.
- salicylic acid does not fulfill the function of a preservative, but causes the cleaning and care of the eyelids and eye areas and supports the dissolution of adhesions and encrustations on the eye, the resolution of the and also acts locally calming and soothing.
- phosphates are understood as meaning all phosphate-containing ions, such as, for example, dihydrogen phosphates, hydrogen phosphates, phosphates, but also di-, tri- or metaphosphates.
- a freedom from phosphate is given when the cosmetic or the underlying solution contains no phosphate ions, d. H. in the cosmetic by means of common analytical
- Methods can be detected no phosphate ions.
- the cosmetic is preservative and phosphate-free.
- the aqueous solution has a pH in the range of 6.0 to 8.0, preferably in the range of 7.0 to 7.2, on.
- Salicylic acid has an anti-inflammatory and analgesic effect in this concentration.
- the solution contains sorbitol in a proportion by weight of 1.0 to 4.0% by weight, preferably 2.8% by weight. This is used as an osmoticum and contributes to the isotonicity of the solution.
- the solution contains Euphrasia mother tincture in a proportion by weight of 0.001 to 0.4% by weight, preferably of 0.3% by weight.
- Euphrasia mother tincture is a herbal extract.
- an extract can be obtained from plants or parts thereof, for example using water. Extracts can still be of liquid or solid nature.
- the Euphrasia mother tincture is obtained from the fresh or dried aerial parts of Euphrasia officinalis such as leaves, flowers and / or stems.
- extracts of the whole herb of Euphrasia officinalis also referred to as Herba Euphrasiae.
- Euphrasia eyebright
- Euphrasia stricta Euphrasia
- Euphrasia montana Euphrasia rostkoviana
- mother tincture refers to extracts of plants or parts thereof which are prepared using solvents such as water and / or alcohols such as ethanol, vegetable pressed juices or solutions of dried plants in a solvent mixture such as alcohol-water. Mixture understood.
- the cosmetic according to the present invention or the underlying solution contains at least one buffer system selected from the group consisting of citrate buffer, borate buffer, phosphate, Tris buffer, trometamol / maleic acid buffer or mixtures or combinations thereof.
- the cosmetic as above described should preferably be designed phosphate-free, must of course be dispensed with the presence of a phosphate buffer.
- the cosmetic contains or consists of a buffer system
- Sodium citrate or a hydrate of the sodium citrate preferably in a proportion by weight of from 0.2 to 1.5% by weight, particularly preferably from 0.5 to 1.0% by weight, in particular of 0.9% by weight,
- Citric acid preferably in a proportion by weight of 0.002 to 0.008 wt .-%, particularly preferably of 0.002 wt .-% and
- the solution or the cosmetic does not include a buffer system.
- a preferred embodiment of the cosmetic comprises a solution containing a sodium salt of hyaluronic acid in a proportion of 0.01 to 1.0 wt .-%, particularly preferably from 0.01 to 0.03 wt .-%, in particular of 0, 02 wt .-%, salicylic acid in a proportion of 0.01 to 2.00 wt .-%, particularly preferably from 0.01 to 0.03 wt .-%, in particular of 0.02 wt .-%, sorbitol in a proportion of 0.5 to 5.0 wt .-%, in particular of 2.80 wt .-%, sodium citrate dihydrate in a proportion of 0.25 to 2.50 wt .-%, in particular of 0.85 wt % and Euphrasia contains mother tincture in a proportion of 0.05 to 1.50 wt .-%, in particular of 0.30 wt .-%, and has a pH of 7.0 to 7.2.
- the cosmetic or the underlying solution can for example be applied directly to the eyelid for cosmetic purposes, but also indirectly by the cosmetic is applied to a cotton pad or a tissue, and thus the eyelid is moistened or cleaned.
- the cosmetic eye treatment kit according to the invention comprises the above-described cosmetic and, separately from the cosmetic, at least at least a cotton pad, a tissue and / or an eye mask.
- the kit is preferably characterized in that the eye mask is heatable and particularly preferably contains a latent heat storage, in particular a sodium acetate trihydrate-containing latent heat storage.
- the cotton pad, the tissue and / or the eye mask can be designed to receive the cosmetic or the eye mask can be designed to receive the cotton pad.
- the cosmetic or the solution on which the cosmetic is based can be stored in the above-described kit in a multi-dosing system, a single dosing system or in cosmetic wipes moistened with the cosmetic.
- a multi-dosing system may comprise, for example, a storage vessel with a pump head, by means of which individual doses of the cosmetic can be dispensed repeatedly.
- a one-dose system includes a single, separately packaged portion of the cosmetic.
- the wet wipes can be hygienic and sterile, for example, it can be provided that one or more of the wet wipes are sealed separately in a bag. Thus, easy handling and long durability can be ensured.
- the wet wipes can be used alone, but also in combination with the aforementioned eye mask and thus also as an alternative to cotton pads.
- the above-described cosmetic and / or the kit already described above are used according to the invention for the cosmetic treatment of the eye and the skin, in particular for the topical, cosmetic treatment of the skin around the eye area, for the topical, cosmetic treatment of the skin in the area of the eyelid, the upper eyelid , the lower eyelid, the bags, the corner of the eye, the eyelashes, the minor glands, the Zeis glands, the meibomian glands, preferably used for loosening dirt, encrustations, adhesions around the eyes.
- the cosmetic is preferably applied with the eye closed in the area of the eye area, in particular on the eyelid. It is advantageous if the eyelid is heated to a temperature of 45 ° C.
- the pads impregnated with the cosmetic or sterile wipes may be placed under the warming eye mask on the closed eyelids or inserted into an eye mask suitable for receiving the pads prior to being placed on the closed eyes.
- the heat in combination with the nourishing ingredients of the cosmetic cause softening and dissolving the encrustations and adhesions. These can then be easily removed with the pads or wipes to clean the closed eyes.
- An exemplary cosmetic formed from an aqueous composition containing 0.20 g per liter of the sodium salt of hyaluronic acid, 1.00 g of salicylic acid, 28.00 g of sorbitol, 3.00 g of Euphrasia mother tincture and citric acid and sodium citrate as a buffer system, I'm looking at durability and stability.
- the pH of this cosmetic was adjusted to 7.0 to 7.2 with sodium hydroxide.
- the cosmetic contains no emulsifiers and preservatives.
- Table 1 The composition of this cosmetic is shown in Table 1 below:
- Samples of this cosmetic were stored at 25 ⁇ 2 ° C and 60 ⁇ 5% relative humidity for a period of 12 months or at 40 ° C and 75% relative humidity for a period of 6 months. Stability and durability are due to different properties of the
- Cosmetic moored. Decisive are appearance, odor, osmolality, pH value, freedom from particles, viscosity, salicylic acid content, decomposition, conformity of UV-Vis spectra, spray behavior and volume of the aqueous solution.
- Dosing devices are stored sterile, without a microorganism infestation is to be recorded.
- TTI Tep Seal Integrity Tests
- the dosing system is repeatedly actuated overhead while the dropper tip of the dosing system is immersed in a germ suspension containing a high concentration of bacteria (10 7 "colony forming units" per ml).
- CVIT Closest and Ventilation Integrity Tests
- Dosing system itself is protected from aerosols from minute spores of germs, even under vacuum conditions.
- a vacuum is generated in the system during exposure of the dosing system in the wet aerosol, with high density (100 CFU / cm 2 ) to smallest spores.
- test results presented above show that the cosmetic according to the invention not only has excellent storage stability, but also has a low tendency to bacterial attack.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102016204472.9A DE102016204472A1 (de) | 2016-03-17 | 2016-03-17 | Kit zur kosmetischen Behandlung des Auges und der Haut und Kosmetikum zur Anwendung am Auge und auf der Haut |
PCT/EP2017/056390 WO2017158157A1 (de) | 2016-03-17 | 2017-03-17 | Kit zur kosmetischen behandlung des auges und der haut und kosmetikum zur anwendung am auge und auf der haut |
Publications (1)
Publication Number | Publication Date |
---|---|
EP3429553A1 true EP3429553A1 (de) | 2019-01-23 |
Family
ID=58398157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP17712732.1A Withdrawn EP3429553A1 (de) | 2016-03-17 | 2017-03-17 | Kit zur kosmetischen behandlung des auges und der haut und kosmetikum zur anwendung am auge und auf der haut |
Country Status (12)
Country | Link |
---|---|
US (1) | US20190167542A1 (es) |
EP (1) | EP3429553A1 (es) |
JP (1) | JP2019508465A (es) |
KR (1) | KR20180118676A (es) |
CN (1) | CN109069382A (es) |
AU (1) | AU2017235505A1 (es) |
BR (1) | BR112018068811A2 (es) |
CA (1) | CA3018000A1 (es) |
DE (1) | DE102016204472A1 (es) |
MX (1) | MX2018011250A (es) |
RU (1) | RU2018132390A (es) |
WO (1) | WO2017158157A1 (es) |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10161110A1 (de) * | 2001-12-12 | 2003-06-26 | Ursapharm Arzneimittel Gmbh | Pharmazeutische Zusammensetzung zur ophthalmologischen und rhinologischen Anwendung |
JP4818608B2 (ja) * | 2002-07-03 | 2011-11-16 | ペリコール・サイエンス・インコーポレーテッド | ヒアルロン酸の組成物および使用方法 |
JP2005139070A (ja) * | 2003-11-04 | 2005-06-02 | Kanebo Cosmetics Inc | 皮膚化粧料 |
FR2902290A1 (fr) * | 2005-04-28 | 2007-12-21 | Derma Dev Sarl | Nouvel agent conservateur anti bacterien et son procede d'obtention |
KR20080024426A (ko) * | 2006-09-13 | 2008-03-18 | 유니메드제약주식회사 | 히아루론산 유도체의 안정화 조성물 |
DE102009021372A1 (de) * | 2009-05-14 | 2010-11-18 | Ursapharm Arzneimittel Gmbh | Phosphatfreie pharmazeutische Zusammensetzung zur Glaukombehandlung |
CA2896646A1 (en) * | 2012-12-27 | 2014-07-03 | Hayashibara Co., Ltd. | Skin-exterior anti-ageing composition and production method therefor |
AT514540A1 (de) * | 2013-06-18 | 2015-01-15 | Apomedica Pharmazeutische Produkte Gmbh | Ophthalmische Zusammensetzung |
DE102014007423A1 (de) * | 2014-05-22 | 2015-11-26 | Bitop Ag | Zusammensetzung zur Behandlung des Auges |
-
2016
- 2016-03-17 DE DE102016204472.9A patent/DE102016204472A1/de not_active Withdrawn
-
2017
- 2017-03-17 CN CN201780017558.2A patent/CN109069382A/zh active Pending
- 2017-03-17 JP JP2018548701A patent/JP2019508465A/ja not_active Withdrawn
- 2017-03-17 EP EP17712732.1A patent/EP3429553A1/de not_active Withdrawn
- 2017-03-17 AU AU2017235505A patent/AU2017235505A1/en not_active Abandoned
- 2017-03-17 WO PCT/EP2017/056390 patent/WO2017158157A1/de active Application Filing
- 2017-03-17 KR KR1020187026694A patent/KR20180118676A/ko not_active Application Discontinuation
- 2017-03-17 RU RU2018132390A patent/RU2018132390A/ru not_active Application Discontinuation
- 2017-03-17 CA CA3018000A patent/CA3018000A1/en not_active Abandoned
- 2017-03-17 US US16/131,744 patent/US20190167542A1/en not_active Abandoned
- 2017-03-17 BR BR112018068811A patent/BR112018068811A2/pt not_active Application Discontinuation
- 2017-03-17 MX MX2018011250A patent/MX2018011250A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CN109069382A (zh) | 2018-12-21 |
CA3018000A1 (en) | 2017-09-21 |
WO2017158157A1 (de) | 2017-09-21 |
KR20180118676A (ko) | 2018-10-31 |
BR112018068811A2 (pt) | 2019-01-22 |
MX2018011250A (es) | 2019-03-28 |
AU2017235505A1 (en) | 2018-10-04 |
DE102016204472A1 (de) | 2017-09-21 |
RU2018132390A3 (es) | 2020-04-17 |
US20190167542A1 (en) | 2019-06-06 |
JP2019508465A (ja) | 2019-03-28 |
RU2018132390A (ru) | 2020-04-17 |
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