Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
  • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
  • A61J1/14—Details; Accessories therefor
  • A61J1/1437—Locking means requiring key or combination to open the container
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
  • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
  • A61J1/14—Details; Accessories therefor
  • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
  • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
  • A61J1/2006—Piercing means
  • A61J1/2013—Piercing means having two piercing ends
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
  • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
  • A61J1/14—Details; Accessories therefor
  • A61J1/1412—Containers with closing means, e.g. caps
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
  • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
  • A61J1/14—Details; Accessories therefor
  • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
  • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
  • A61J1/14—Details; Accessories therefor
  • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
  • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
  • A61J1/2006—Piercing means
  • A61J1/201—Piercing means having one piercing end
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
  • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
  • A61J1/14—Details; Accessories therefor
  • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
  • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
  • B65D21/00—Nestable, stackable or joinable containers; Containers of variable capacity
  • B65D21/02—Containers specially shaped, or provided with fittings or attachments, to facilitate nesting, stacking, or joining together
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
  • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
  • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
  • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
  • A61J1/14—Details; Accessories therefor
  • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
  • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
  • A61J1/2048—Connecting means
  • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding

Definitions

• the invention relates to a container removal system having at least one first and at least one second container, which are connectable to one another in a media-carrying manner via a connection device.
• a container removal system having at least one first and at least one second container, which are connectable to one another in a media-carrying manner via a connection device.
• Such systems make it possible, via the connecting device, to bring into contact or to mix desired media, which are constituents of a separate container.
• Such operations are widely practiced in the medical and pharmaceutical fields to produce formulations consisting of at least two separate components which must be mixed together prior to use.
• a particularly widespread field of application relates to the preparation of preparations for parenteral applications for medical or diagnostic purposes.
• the invention has for its object to provide a container removal system that largely excludes the possibility of wrong combinations.
• an essential feature of the invention is that an encryption device is provided which enables or prevents a media-carrying connection between the respectively assignable containers. A wrong lerhafte combination of media is included ⁇ due to encryption.
• the encryption device can be effective between a container and the connection device.
• a high level of operational reliability with a simple structure can be achieved by an encryption device which operates on the mechanical key-lock principle.
• this can be provided on a container at least one physical coding exhibiting key element through which a located on the connecting device, suitably coded locking element can be unlocked, which prevents the connection function of the connecting device in the locked state.
• the locking element forms the lock of the key-lock system.
• the arrangement can be made such that the blocking element in the locked state prevents the opening movement of a hollow hollow mandrel of the connecting device producing the media connection between the containers and thus the production of the media connection.
• the key element associated with the container can be formed by a cap part surrounding a perforable opening region of the respective container, which has shape irregularities on the outside of a coding.
• the locking element as a lock for the key element of the cap part on a body with an opening which inside with coded shape irregularities of these is provided type that the cap member is inserted with a suitable coding of its key element in the opening in a functional position in which the media connection of the container can be produced. It is essential here that the interrogation of the codes of key element and blocking element can be done only with small forces and short, straight ways to make the application as intuitive and simple as possible and to avoid tilting. Furthermore, it is advantageous if the codings in the key element and blocking element are redundant, for example 2 to 3 times, are uniformly distributed over the respective circumference, which prevents tilting and facilitates orientation during insertion.
• the connecting device can have at least one locking element engaging in the opening of the blocking element, which can be unlocked upon reaching the functional position by the cap part inserted into the opening of the blocking element in order to release the locked state of the hollow hollow mandrel.
• recesses and projections may be provided as form-forming shape irregularities, for example, such that the coding of the key element on the cap portion circumferentially provided recesses and / or projections has up and that the coding of the blocking element provided by at the wall of its opening, formed with matching coding to the recesses and / or projections of the cap member complementary projections and / or recesses.
• the arrangement may be such that the coding consists of at least two subgroups with at least one respective and / or a projection is formed and that the subgroups are spatially separated from each other and one and / or several different specifics of both containers as previously mentioned (drug, dose, volume of the solvent, composition of the solvent, etc.) mark.
• the arrangement may advantageously be such that the shape of the cap portion on the outside and the opening of the body of the blocking element correspond to a Reuleaux triangle with rounded ends, wherein on each of the three sides in each case an encoding is provided.
• Such examples are characterized by a special ease of use, because for the insertion process no single, unique insertion position of container and connecting device is prescribed, but are available at three insertion positions.
• a powdered drug M1 may be able to be combined with 3 different solvents L1, L2, L3 (1: 3 assignment), while another drug M2 should only be mixed with the various solvents L1, L2 (1: 2 Assignment) and in turn another drug M3 may be combined with only the solvent L1 permissible (1: 1 assignment).
• n p assignments
• additional codings in the form of projections and recesses of different geometry at other positions of the cap (13) or ring body (25).
• the invention also provides an encryption device for a container removal system according to one of the claims 1 to 22, wherein the respective encryption device has the features of the patent claim 23 or 24.
• Fig. 1 is a perspective oblique view of an embodiment of the container-removal system according to the invention
• Figure 2 is a schematically simplified longitudinal section of a container in the form of a vial containing a media component, the content of which is to be transferred by means of the removal system according to the invention in a second container.
• an exploded drawn, perspective partial view of the embodiment wherein the state is shown prior to insertion into the connection means of the sampling system; an oblique perspective view of forming part of the connecting device media removal device; an oblique perspective view of the locking element of the connecting device of the embodiment; an oblique perspective view of the cap portion with removed cap cover part of the movable vial, as seen on the free end face; in an exploded perspective oblique view of the key-lock principle operating encryption system, wherein the key member forming the cap member of Figure 7 is shown prior to insertion into the locking system of the locking element of Figure 6.
• a schematically simplified drawn partial longitudinal section of the removal device containing connection device and the associated opening portion of the movable vial, this with his Cap member is shown in a centering position prior to insertion into the locking element of the connecting device;
• FIG. 10 in Fig. 9 corresponding representation another Stadium the removal process, wherein with appropriate coding of key element of the vial and serving as a lock locking element, the cap part of the vial is partially inserted into the locking element and wherein the upper part in the drawing Fig.lO shows a comparison with Figure 9 rotated by 90 ° cutting plane;
• Figures 1 1 to 15 similar to Figures 9 and 10 Tei Hijnstree in which successive positions are shown in the course of a removal operation.
• FIG. 16 is a perspective oblique view corresponding to FIG. 15; FIG.
• FIG. 1 to illustrate the coding principle the outline of the key element forming cap portion of the vial, wherein on each of the three sides of the Reuleaux triangle shape two coding areas for each two subgroups of coding are illustrated;
• Figures 18 and 19 show the cap member inserted in the locking member, which in turn has insertion-permitting coding;
• 26 to 28 sketchy representations to illustrate other, possible different outline shapes for the key element on the cap portion of the movable vial
• 29 is a highly schematic and partially longitudinally drawn representation of a modified embodiment of the container according to the invention.
• Figs. 30 and 31 of Fig. 29 are similar views of third and fourth embodiments, respectively;
• FIG. 32 is a sketch of a cross-section of the removal device of the embodiment of FIG. 31; FIG.
• Fig. 33 is a FIGS. 30 and 31 similar sectional view of another embodiment.
• FIG. 1 a first container in the form of an infusion container 1 in the form of a plastic container, which, for example, according to FIG produced by the known blow-fill-seal method, described by way of example in EP 2 269 558 A1 and the experts also known under the name bottelpack ® system.
• Such containers usually have at least one connection 3 for an infusion set.
• the contents of the infusion container 1, which contains, for example, a volume of a solvent, for the preparation of a special infusion liquid, a liquid or powdered further media component is to be supplied, special safety criteria must be observed.
• an additional component which is usually in a glass or polymer vial 5 in such applications, not only sterility must be considered, but it must be ensured that the media transfer from a vial 5, the contains a certain amount of each required substance, takes place in an infusion container 1.
• the connecting device contains a removal device with a piercing hollow mandrel in the form of inter-perforation between perforations and is normally locked in an inoperative position, in which both perforation tips of the hollow mandrel spaced from a perforable opening portion of the infusion bottle 1 and a perforable perforation for the 5 bottle.
• the connecting device has a predominantly cylindrical sleeve-shaped receptacle into which the vial 5 provided for the removal process can be introduced, wherein the sleeve-shaped receptacle forms a guide for a movement of the vial 5, in which the perforable opening region of the vial 5 approaches the incision hollow mandrel , while the locking of the removal device solves and moves them into an end position in which the perforated mandrel perforated the opening areas of vial 5 and infusion bottle 1 and establishes the media connection.
• the container removal system according to the invention is based on the same principle of operation.
• FIGS 1 and 2 show a movable vial 5 separately, it can be seen that on the neck portion 1 1 of the vial 5, on which the perforable opening portion 48 is located, for example in the form of an elastomeric plug not shown in detail, a cap member 13th is attached, which consists in the present example of a one-piece injection-molded plastic part.
• Figures 1 and 2 show the cap member 13 in the initial state prior to use, wherein at the top of the cap member 13 is a molded cover 15 as a telltale, which can be easily removed by the user before using the vial 5 mechanically. Instead of the cover 1 5 could be provided a removable film.
• a central opening 1 7 exposed, which is aligned with the perforable opening portion 48 on the neck portion 1 1 of the vial 5.
• a radiation-permeable film is provided instead of the cover 15, a corresponding foil with high-energy radiation, for. B. irradiate UV or beta radiation, to kill possibly on the elastomer surface (perforation surface) existing germs.
• the preferably formed from a polymer cap member 13 may, as shown in FIG. 2, be snapped on the edge 19 of the neck portion 1 1 of the vial 5.
• caps 13 according to the invention with coding can also be part of known multi-piece plastic closures, as described, for example, in WO 201 1/032798 A1, WO 201 1/039004 A1 and EP 0655042 B1, and particularly advantageously in the freeze-drying of medicaments or medical devices be used.
• the outline of the cap part 13 has the shape of a Reuleaux triangle with rounded corners.
• the cap part 13 forms a physically coded key element with the outer circumference of the re-league triangle, wherein the coding on the cap part 13 is formed by recesses 21.
• the recesses 21 are in the form of circumferentially recessed grooves, the circumferential length of which is delimited by walls 23 defining radial planes with respect to the central opening 17, of which only some walls 23 are numbered in FIG.
• the axial depth of the recesses 21 is less than the thickness of the cap part 13, so that the recesses 21 on the visible in Fig. 7 end face is open and the main part of the vial 5 facing side of the cap member 13, the in Fig. 8 is visible, is free of recesses 21.
• annular body 25 As an encodable lock for the key-lock system, an annular body 25 (see in particular Figures 6 and 8) is provided, which is a blocking element as part of the locking device of the removal device 27th forms, which is shown separately in Fig. 5.
• the annular body 25 has for the insertion of the key element formed by the cap part 1 3 an opening 29 which is adapted to the circumference of the cap part 13, that has the shape of a Reuleaux triangle.
• the opening 29 On the inside, the opening 29 is provided with a coding in the form of projections 31, which, with appropriate coding, to the recesses 21 of the key part on the cap part 13 are complementary.
• the protrusions 31 do not extend to the edge of the annular body 25 situated at the top in FIG.
• the projections 31 form upwards paragraphs which can be brought into abutment with the corresponding paragraphs on the recessed ends of the recesses 21 of the cap member 13, so that in an axial advancing movement of the container or vial fifth on the infusion container 1 to the cap member 13, the ring body 25 inevitably entrains.
• Fig. 4 shows the initial state before the beginning of a removal process, wherein the annular body 25 is located at the upper end of a sleeve-shaped receptacle 9 of the connecting device 7.
• the annular body 25 forming the blocking element has circumferentially axially continuous grooves 33 with which the annular body 25 is guided on axial guide strips (not shown) of the sleeve-shaped receptacle 9.
• the removal device 27 shown separately in Fig. 5 is guided axially movable below the ring body 25 in the sleeve-shaped receptacle 9 for their opening movement.
• Fig. 4 shows the initial state before the beginning of a removal process, wherein the annular body 25 is located at the upper end of a sleeve-shaped receptacle 9 of the connecting device 7.
• the annular body 25 forming the blocking element has circumferentially axially continuous grooves 33 with which the annular body 25 is guided on axial guide strips (not shown) of the s
• the removal device 27 has a the inner diameter of the sleeve-shaped receptacle 9 adapted disc 35 as a support for a centrally arranged piercing hollow mandrel 37 which is formed in a conventional manner as a multi-channel cannula and projecting on both sides of the disc 35 to perforate both the opening portion 50 of the infusion bottle 1 and the opening portion 48 of the vial 5 for the opening operation.
• the disc 35 At the periphery of the disc 35 are high-level functional elements. Of these, three guide plates are designated 39, with which the disc 35 is guided during movements on the inner wall of the sleeve-shaped receptacle 9.
• the annular body 25 serving as a blocking element is also in the locked position because the tongue parts 45 of the raised lugs of the disc 35 prevent the movement of the annular body 25.
• This condition is shown in FIG.
• the cap part 13 of the vial 5 and the annular body 25 are suitable, the cap part 13, as shown in FIGS. 10 and 11, can be introduced into the annular body 25.
• the hollow mandrel 37 perforates the opening area 48 of the vial 5, and the cap portion 13 comes into contact with a driving nose 53 at the tongue portions 43.
• the cap part 13 In the further insertion movement of the cap part 13 thereby the tongue parts 43, 45 for the Unlocking unlocked.
• the annular body 25 is movable toward the disk 35 of the removal device 27, the tongue parts 41, 43, 45 of the straps being guided in guide channels 55 of the annular body 25 in such a manner that the detents 49 on the tongue parts 41 are received in the locking groove 51 of the sleeve 9 to be dug.
• the achievement of this state is shown in FIG.
• the vial 5 with the cap part 13 can be retracted further, whereby the annular body 25 is entrained, which in turn bears against the disc 35 of the removal device 27 and carries it along for the opening movement, see FIG 4.
• the piercing hollow mandrel 37 also perforates the opening area 50 of the infusion container 1.
• the piercing hollow mandrel 37 ver for a removal operation via two parallel to the respective piercing direction withdrawal channels.
• a further latching groove 57 for forming a catch for the removal device 27 in the end position at the conclusion of the connection process, as shown in Figures 15 and 16.
• the lugs 47 which, as shown in FIG. 5, protrude inwards above the disc 35, form a snap connection with the cap member 13, in that they engage over its edge 59 free of the recesses 21, see FIG. 16.
• the vial 5 is secured in a form-fitting manner to the connecting device 7 when the end position of the removal process is reached.
• FIG. 1 shows that on the circumference of the cap part 13, which has the shape of a Reuleaux triangle with rounded corners, a coding region is provided on each side of the triangle, each coding region having two groups 61 and 63 with coding positions and the groups 61, 63 spatially separated from each other by a code-free intermediate region 65. are set. Since the same code groups 61, 63 are provided on each side of the triangle with Codepositi ⁇ same for the formation of a particular key, the key element can be used in three positions in a same coded each lock.
• the coding of code positions of one of the groups 61, 63 characterizes the filling volume of the relevant vial 5, while the other group 61 or 63 represents the type of an ingredient of a container.
• the coding on the cap part 13 is formed in each case by recesses 21 provided within the groups 61, 63.
• the sketch-like representation of Fig. 1 7 the raw state, without coding by recesses 21 is shown.
• the coding in the respective group 61 designates the nature of a container substance, for example the type of solvent present in the infusion bottle 1
• the coding of the group 63 designates a volume, for example the volume of a solvent, of a substance contained in the vial 5 should be added or may be added.
• the annular body 25 forming the lock correspondingly identifies the projections 31 for the respective coding groups 61, 63 the volume of the infusion bottle 1 or the type of container contents, for example the formulation of the solvent present in the infusion bottle 1.
• Fig. 18 shows an example in which the cap member 13 signals through a recess 21 in a first coding position of the group 61 that the
• Vial 5 is intended for delivery to an ingredient A of the bottle 1, while the group 63 contains no recess 21, which in turn signals that the bottle 1 contains a certain volume of solvent.
• a recess 21 is formed in the groups 63 over several coding positions, which signals a different volume of solvent, while a depression in the groups 61 a different solvent, for example a solvent B signaled, for example, 50 ml, corresponding to the recess in the group 63.
• Figures 20 to 22 show examples in which the vial 5 by more widely formed wells 21 in the groups 61st signals that it is intended for both the media supply to a solvent A and to a solvent B in the bottle 1.
• FIGS. 23 to 25 illustrate examples in which the vial 5 signals through a recess 21 in only one coding position of the group 61 that the vial 5 is intended solely for a solvent A in the bottle 1 in that, however, it is signaled by a recess 21 via two coding points of the group 63 that the combination is permitted over a larger volume range, for example for 100 to 250 ml of the solvent.
• the vial 5 fits an infusion bottle with the solvent A at 250 ml volume.
• Fig. 25 shows that the combination is excluded for both another solvent B and another solvent volume.
• Figures 26 to 28 illustrate in sketchy representation further possibilities of shaping the outline of the key element shown uncoded, wherein Fig. 26 in the extent described in the extent Embodiment selected triangular shape, while Fig. 27 shows a different, non-circular outline shape in the form of a kind of ellipse 69. Also, as shown in Fig. 28, in a circular outline shape, shape irregularities such as a pattern of protrusions and depressions, only one protrusion 71 of which is shown in Fig. 28, may be provided, which in turn may be provided in mutually remote groups , In a circular configuration, the key-lock connection is possible only in a unique, relative insertion position, while in the ellipse 69 shown in FIG.
• 27 coding groups may be provided on both long sides of the sheet, so that the key-lock connection at two relative insertion positions is possible.
• recesses of a component it is also possible for recesses of a component to occur instead of the projections which then fit into projections of the respective other component.
• Fig. 29 illustrates in a highly schematically simplified representation of an embodiment in which the piercing mandrel 37 carrying body 73 of the removal device itself forms a kind of pot, which forms the lock element with its inner wall 75, in which the cap portion 13 of the vial 5 with appropriate coding is used so that the cap member 13 moves when it rests against the body 73 for the perforation. Since the body 73 is guided during the movement with its circumferential rib 75 in a threaded track 77 of the sleeve of the receptacle 9, the perforation is carried out advantageously under a rotational movement of the piercing hollow mandrel 37th
• Fig. 30 illustrates in a highly schematically simplified representation of another embodiment of the key-lock design.
• the sleeve body forming the receptacle 9 of the connecting device as well as the body 73 of the removal device carrying the piercing mandrel 37 are already preassembled on the vial 5, with its open position. 48, however, has not yet been pierced.
• the coding of the key-lock system provides a pin 79 or more pins on the body, which are retractable into corresponding holes 81 which are formed as a lock on the neck portion 67 of the bottle 1 in a coded arrangement.
• FIG. 31 and 32 provides as a key on the cap portion 13 of the vial 5, a pattern of axial bores 83 and a corresponding pattern of pins 85 on the disc-shaped carrier 73 of the piercing hollow mandrel 37 before.
• the lock element is integrally integrated with the carrier 73.
• the cap member 13 can be applied to spring-mounted latch members 87 to release the locking of the carrier 73 on the receptacle 9 so that it can be moved by inserting the vial 5 for the connection process.
• Figures 33 and 34 provides for unlocking the mandrel 37 carrying body 73 in a separately shown in Fig. 34 ring 89 of elastically interconnected pressure bodies 91 before.
• The- The cap 13 of the vial 5, which can be retracted with suitable coding, can be expanded in such a way that the skirt 93 of the body 73 formed on the bottle neck 1 is widened, as indicated by arrows 95, so that the body 73 protrudes from a step 97 of the skirt 93 for the movement and opening movement is released.
• all types of media-carrying and media-containing containers which also include tube systems in the broadest sense, can be coupled to one another in a sterile and fluid-tight manner for media exchange.

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• Health & Medical Sciences (AREA)
• Pharmacology & Pharmacy (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Physics & Mathematics (AREA)
• Fluid Mechanics (AREA)
• Engineering & Computer Science (AREA)
• Mechanical Engineering (AREA)
• Medical Preparation Storing Or Oral Administration Devices (AREA)
• Warehouses Or Storage Devices (AREA)
• Packages (AREA)
• Closures For Containers (AREA)

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• 2015
  • 2015-05-06 RU RU2017139783A patent/RU2702333C2/ru active
  • 2015-05-06 AU AU2015393962A patent/AU2015393962B2/en not_active Ceased
  • 2015-05-06 WO PCT/EP2015/000922 patent/WO2016177384A1/de active Application Filing
  • 2015-05-06 KR KR1020177035074A patent/KR102405374B1/ko active IP Right Grant
  • 2015-05-06 BR BR112017022419-4A patent/BR112017022419A2/pt active Search and Examination
  • 2015-05-06 US US15/570,783 patent/US10675219B2/en active Active
  • 2015-05-06 MX MX2017013992A patent/MX2017013992A/es unknown
  • 2015-05-06 EP EP15723647.2A patent/EP3291787A1/de not_active Withdrawn
  • 2015-05-06 JP JP2017557465A patent/JP6595622B2/ja active Active
  • 2015-05-06 CA CA2984970A patent/CA2984970A1/en not_active Abandoned
  • 2015-05-06 CN CN201580079667.8A patent/CN107592806B/zh not_active Expired - Fee Related
  • 2015-05-06 SG SG11201708572TA patent/SG11201708572TA/en unknown

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